MX357482B - Cepa deficiente en agse. - Google Patents

Cepa deficiente en agse.

Info

Publication number
MX357482B
MX357482B MX2015000840A MX2015000840A MX357482B MX 357482 B MX357482 B MX 357482B MX 2015000840 A MX2015000840 A MX 2015000840A MX 2015000840 A MX2015000840 A MX 2015000840A MX 357482 B MX357482 B MX 357482B
Authority
MX
Mexico
Prior art keywords
host cell
agse
microbial host
deficient strain
modified
Prior art date
Application number
MX2015000840A
Other languages
English (en)
Other versions
MX2015000840A (es
Inventor
Nicolaas Maria Elisabeth Van Peij Noël
Beishuizen Martina
Jozef Ida Van De Vondervoort Peter
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Publication of MX2015000840A publication Critical patent/MX2015000840A/es
Publication of MX357482B publication Critical patent/MX357482B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
    • C12N9/2411—Amylases
    • C12N9/2414—Alpha-amylase (3.2.1.1.)
    • C12N9/2417—Alpha-amylase (3.2.1.1.) from microbiological source
    • C12N9/242—Fungal source
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
    • C12N9/2431—Beta-fructofuranosidase (3.2.1.26), i.e. invertase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/03—Oxidoreductases acting on the CH-OH group of donors (1.1) with a oxygen as acceptor (1.1.3)
    • C12Y101/03004—Glucose oxidase (1.1.3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01183—Alpha-1,3-glucan synthase (2.4.1.183)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/01—Carboxylic ester hydrolases (3.1.1)
    • C12Y301/01003—Triacylglycerol lipase (3.1.1.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/01—Carboxylic ester hydrolases (3.1.1)
    • C12Y301/01004—Phospholipase A2 (3.1.1.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/0102—Alpha-glucosidase (3.2.1.20)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

La presente invención se refiere a una célula huésped microbiana mutante que es deficiente en la producción de la proteína AgsE o en la producción de una homóloga de la misma si se compara con una célula huésped microbiana precursora que no se ha modificado ni medido en las mismas condiciones. Se ha encontrado de forma sorprendente que cuando la célula huésped microbiana mutante según la invención se usa en un método para producir un compuesto de interés, por ejemplo una enzima, se obtiene un aumento del rendimiento de dicho compuesto si se compara con un método en que se usa una célula huésped precursora que no se ha modificado cuando se mide en las mismas condiciones.
MX2015000840A 2012-07-19 2013-07-19 Cepa deficiente en agse. MX357482B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261673596P 2012-07-19 2012-07-19
EP12177172 2012-07-19
PCT/EP2013/065348 WO2014013074A1 (en) 2012-07-19 2013-07-19 Agse-deficient strain

Publications (2)

Publication Number Publication Date
MX2015000840A MX2015000840A (es) 2015-04-08
MX357482B true MX357482B (es) 2018-07-11

Family

ID=49948320

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015000840A MX357482B (es) 2012-07-19 2013-07-19 Cepa deficiente en agse.

Country Status (13)

Country Link
US (2) US10035986B2 (es)
EP (2) EP2875119B1 (es)
JP (1) JP6468561B2 (es)
CN (1) CN105308171B (es)
AU (1) AU2013291936B2 (es)
CA (1) CA2876287C (es)
CL (1) CL2015000084A1 (es)
DK (2) DK3327112T3 (es)
EA (1) EA201500142A1 (es)
IN (1) IN2014DN11163A (es)
MX (1) MX357482B (es)
NZ (1) NZ702962A (es)
WO (1) WO2014013074A1 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014073674A1 (ja) 2012-11-09 2014-05-15 国立大学法人東北大学 糸状菌の高密度培養株を用いた有用物質生産方法
ES2706742T3 (es) 2013-12-02 2019-04-01 Dsm Ip Assets Bv Proteína estructuradora del hielo
EP3182828A1 (en) 2014-08-21 2017-06-28 DSM IP Assets B.V. Use of penicillium glucose oxidase in the baking industry for replacing bromate or azodicarbonamide
CN107075451A (zh) * 2014-10-29 2017-08-18 诺维信公司 丝状真菌双重突变体宿主细胞
WO2016110453A1 (en) 2015-01-06 2016-07-14 Dsm Ip Assets B.V. A crispr-cas system for a filamentous fungal host cell
DK3280264T3 (da) 2015-04-10 2021-03-29 Dsm Ip Assets Bv Fremgangsmåde til fremstilling af en dej
WO2016196654A1 (en) * 2015-06-01 2016-12-08 The Arizona Board Of Regents On Behalf Of The University Of Arizona Transgenic plant species engineered to inhibit biosynthesis of aspergillus aflatoxin
EP3302076A1 (en) 2015-06-02 2018-04-11 DSM IP Assets B.V. Use of ice structuring protein afp19 expressed in filamentous fungal strains for preparing food
CN105950482B (zh) * 2016-07-15 2019-04-02 南京林业大学 一株产菊粉酶的菌株及其应用
US10913938B2 (en) 2016-07-29 2021-02-09 Dsm Ip Assets B.V. Polypeptides having cellulolytic enhancing activity and uses thereof
WO2018114941A1 (en) 2016-12-21 2018-06-28 Dsm Ip Assets B.V. Lipolytic enzyme variants
WO2018114938A1 (en) 2016-12-21 2018-06-28 Dsm Ip Assets B.V. Lipolytic enzyme variants
WO2018114912A1 (en) 2016-12-21 2018-06-28 Dsm Ip Assets B.V. Lipolytic enzyme variants
EP3559221A1 (en) 2016-12-21 2019-10-30 DSM IP Assets B.V. Lipolytic enzyme variants
US20200063166A1 (en) * 2017-03-13 2020-02-27 Dsm Ip Assets B.V. Zinc binuclear cluster transcriptional regulator-deficient strain
BR112020025589A2 (pt) 2018-06-19 2021-03-23 Dsm Ip Assets B.V. variantes de enzima lipolítica
CN110184195B (zh) * 2019-04-25 2020-11-17 广东海洋大学 一株高产油脂的桔青霉Asc2-4-1及其应用
CN110713937B (zh) * 2019-09-20 2022-02-01 兰州大学 提高中华羊茅-内生真菌菌株pa次生代谢产物波胺含量的方法
CN111849809B (zh) * 2020-07-09 2021-12-24 南京农业大学 一种可降解菊粉果聚糖的菌株及其应用
CN112662572B (zh) * 2021-02-02 2022-03-15 中国科学院海洋研究所 一种高产壳聚糖酶的菌株及其应用
AU2022297881A1 (en) 2021-06-24 2024-01-18 Fonterra Co-Operative Group Limited Recombinant beta-lactoglobulin
WO2023225459A2 (en) 2022-05-14 2023-11-23 Novozymes A/S Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections
WO2023222614A1 (en) 2022-05-16 2023-11-23 Dsm Ip Assets B.V. Lipolytic enzyme variants

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5198345A (en) 1985-04-15 1993-03-30 Gist-Brocades N.V. Vectors in use in filamentous fungi
DK122686D0 (da) 1986-03-17 1986-03-17 Novo Industri As Fremstilling af proteiner
CA1341226C (en) 1988-08-16 2001-05-01 Wim Van Hartingsveldt Gene replacement as a tool for the construction of aspergillus strains
FR2679920A1 (fr) 1991-08-02 1993-02-05 Rhone Poulenc Rorer Sa Levures recombinantes hautement stables pour la production de proteines recombinantes, leur preparation et leur utilisation.
DE69432543T2 (de) 1993-07-23 2003-12-24 Dsm Nv Selektionmarker-genfreie rekombinante Stämme: Verfahren zur ihrer Herstellung und die Verwendung dieser Stämme
EP0777737B1 (en) 1994-06-30 2005-05-04 Novozymes Biotech, Inc. Non-toxic, non-toxigenic, non-pathogenic fusarium expression system and promoters and terminators for use therein
US5602004A (en) * 1994-07-20 1997-02-11 Novo Nordisk Biotech, Inc. Thermophilic fungal expression system
EP0758020B1 (en) 1995-08-03 2008-12-24 DSM IP Assets B.V. amdS gene from Aspergillus niger coding for an acetamidase
US6432672B1 (en) 1997-04-11 2002-08-13 Gerardus Cornelis Maria Selten Gene conversion as a tool for the construction of recombinant industrial filamentous fungi
DE69838106T2 (de) 1997-12-22 2008-04-03 Dsm Ip Assets B.V. Expressionsklonierung in filamentösen pilzen
DK1117798T3 (da) 1998-10-05 2007-04-10 Novozymes As Fungal transskriptionel aktivator egnet ved fremgangsmåder til produktion af polypeptider
EP1157100B1 (en) 1999-02-22 2006-01-11 Novozymes A/S Oxaloacetate hydrolase deficient fungal host cells
EP2278016B1 (en) 1999-03-22 2012-09-26 Novozymes Inc. Promoter sequences derived from Fusarium Venenatum and uses thereof
WO2001021779A2 (en) 1999-09-17 2001-03-29 Dsm N.V. Penicillium chrysogenum transcriptional activator blar, a pathway specific regulator of beta-lactam biosynthesis, and uses therof
DK1266011T3 (da) 2000-03-14 2010-07-26 Novozymes As Svampetranskriptionsaktivator, der er anvendelig i fremgangsmåder til fremstilling af polypeptider
DK1266018T3 (da) 2000-03-24 2008-09-01 Genencor Int Fremstilling af udskilte proteiner af rekombinante, eukaryotiske celler
CA2422730A1 (en) * 2000-09-19 2002-03-28 Microbia, Inc. Modulation of secondary metabolite production by zinc binuclear cluster proteins
US20060088902A1 (en) * 2001-08-28 2006-04-27 Van Den Hondel Cornelis A Methods and materials for the identification of antifungal substrates in filamentous fungi
AU2004209618B2 (en) 2003-02-05 2008-04-17 Dsm Ip Assets B.V. Use of oxalate deficient aspergillus niger strains for producing a polypeptide
EP1644542B1 (en) 2003-07-15 2011-11-02 Mintek Oxidative leach process
WO2005026356A1 (en) 2003-09-12 2005-03-24 Commonwealth Scientific And Industrial Research Organisation Modified gene-silencing nucleic acid molecules and uses thereof
EP1733040B1 (en) 2004-04-02 2010-09-08 DSM IP Assets B.V. Filamentous fungal mutants with improved homologous recombination efficiency
CA2560205A1 (en) 2004-04-16 2005-10-27 Dsm Ip Assets B.V. Fungal promoters for expressing a gene in a fungal cell
ES2274664B1 (es) * 2004-04-30 2008-04-01 Consejo Sup. Investig. Cientificas Levaduras bgs4delta autoliticas, procedimiento de obtencion y sus aplicaciones en procedimientos de expresion de proteinas.
EP1756145B1 (en) 2004-06-16 2014-06-25 DSM IP Assets B.V. Production of polypeptides by improved secretion
EP1799827A2 (en) 2004-10-12 2007-06-27 DSMIP Assets B.V. Fungal transcriptional activators useful in methods for producing a polypeptide
AU2005293578B2 (en) 2004-10-15 2010-10-21 Dsm Ip Assets B.V. Method for production of a compound in a eukaryotic cell
JP2008516594A (ja) 2004-10-15 2008-05-22 ディーエスエム アイピー アセッツ ビー．ブイ． 選択可能なマーカーとしての相同性ａｍｄｓ遺伝子
DK2410048T3 (en) 2005-01-24 2016-11-28 Dsm Ip Assets Bv A process for the preparation of a compound of interest in a filamentous fungal cell
AU2006219925A1 (en) 2005-03-01 2006-09-08 Dsm Ip Assets B.V. Aspergillus promotors for expressing a gene in a fungal cell
CN101454455A (zh) 2005-11-29 2009-06-10 帝斯曼知识产权资产管理有限公司 在基因表达中有用的转录激活因子的dna结合位点
EP2035561A1 (en) 2006-06-29 2009-03-18 DSMIP Assets B.V. A method for achieving improved polypeptide expression
WO2008053019A2 (en) 2006-11-02 2008-05-08 Dsm Ip Assets B.V. Method for reducing the expression of a gene in a filamentous fungal cell
AU2008214663B2 (en) 2007-02-15 2013-10-03 Dsm Ip Assets B.V. A recombinant host cell for the production of a compound of interest
ES2429492T3 (es) 2008-02-29 2013-11-15 Dsm Ip Assets B.V. Lipasas con alta especificidad hacia ácidos grasos de cadena corta y usos de las mismas
ES2334421B1 (es) * 2008-05-29 2011-02-28 Consejo Superior De Investigaciones Cientificas (Csic) Levaduras vinicas recombinantes.
JP2012520064A (ja) 2009-03-10 2012-09-06 ディーエスエム アイピー アセッツ ビー．ブイ． ポリペプチドの収量を改良する方法
EP2421986A1 (en) 2009-04-22 2012-02-29 DSM IP Assets B.V. Process for the production of a recombinant polypeptide of interest
CN102597241B (zh) 2009-07-22 2015-09-02 帝斯曼知识产权资产管理有限公司 用于生产感兴趣的化合物的经改进的宿主细胞
EA201300074A1 (ru) 2010-07-01 2013-06-28 ДСМ АйПи АССЕТС Б.В. Способ получения представляющего интерес соединения
CN102618606B (zh) * 2011-01-30 2014-09-10 浙江海正药业股份有限公司 一种棘白菌素生物转化方法

Also Published As

Publication number Publication date
CA2876287C (en) 2022-11-22
US20170175158A1 (en) 2017-06-22
EA201500142A1 (ru) 2015-07-30
IN2014DN11163A (es) 2015-10-02
MX2015000840A (es) 2015-04-08
CA2876287A1 (en) 2014-01-23
CN105308171B (zh) 2019-03-08
JP2015522288A (ja) 2015-08-06
JP6468561B2 (ja) 2019-02-13
EP3327112A1 (en) 2018-05-30
DK3327112T3 (en) 2020-05-04
EP2875119B1 (en) 2017-12-20
AU2013291936B2 (en) 2019-01-17
CL2015000084A1 (es) 2015-05-04
AU2013291936A1 (en) 2015-01-22
CN105308171A (zh) 2016-02-03
EP3327112B1 (en) 2020-02-12
US20150191705A1 (en) 2015-07-09
US10100344B2 (en) 2018-10-16
EP2875119A1 (en) 2015-05-27
WO2014013074A1 (en) 2014-01-23
NZ702962A (en) 2018-02-23
US10035986B2 (en) 2018-07-31
DK2875119T3 (en) 2018-04-03

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