MX2015000840A - Cepa deficiente en agse. - Google Patents

Cepa deficiente en agse.

Info

Publication number
MX2015000840A
MX2015000840A MX2015000840A MX2015000840A MX2015000840A MX 2015000840 A MX2015000840 A MX 2015000840A MX 2015000840 A MX2015000840 A MX 2015000840A MX 2015000840 A MX2015000840 A MX 2015000840A MX 2015000840 A MX2015000840 A MX 2015000840A
Authority
MX
Mexico
Prior art keywords
host cell
agse
microbial host
deficient strain
modified
Prior art date
Application number
MX2015000840A
Other languages
English (en)
Other versions
MX357482B (es
Inventor
Noël Nicolaas Maria Elisabeth Van Peij
Martina Beishuizen
Peter Jozef Ida Van De Vondervoort
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Publication of MX2015000840A publication Critical patent/MX2015000840A/es
Publication of MX357482B publication Critical patent/MX357482B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
    • C12N9/2411—Amylases
    • C12N9/2414—Alpha-amylase (3.2.1.1.)
    • C12N9/2417—Alpha-amylase (3.2.1.1.) from microbiological source
    • C12N9/242—Fungal source
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
    • C12N9/2431—Beta-fructofuranosidase (3.2.1.26), i.e. invertase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/03—Oxidoreductases acting on the CH-OH group of donors (1.1) with a oxygen as acceptor (1.1.3)
    • C12Y101/03004—Glucose oxidase (1.1.3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01183—Alpha-1,3-glucan synthase (2.4.1.183)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/01—Carboxylic ester hydrolases (3.1.1)
    • C12Y301/01003—Triacylglycerol lipase (3.1.1.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/01—Carboxylic ester hydrolases (3.1.1)
    • C12Y301/01004—Phospholipase A2 (3.1.1.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/0102—Alpha-glucosidase (3.2.1.20)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

La presente invención se refiere a una célula huésped microbiana mutante que es deficiente en la producción de la proteína AgsE o en la producción de una homóloga de la misma si se compara con una célula huésped microbiana precursora que no se ha modificado ni medido en las mismas condiciones. Se ha encontrado de forma sorprendente que cuando la célula huésped microbiana mutante según la invención se usa en un método para producir un compuesto de interés, por ejemplo una enzima, se obtiene un aumento del rendimiento de dicho compuesto si se compara con un método en que se usa una célula huésped precursora que no se ha modificado cuando se mide en las mismas condiciones.
MX2015000840A 2012-07-19 2013-07-19 Cepa deficiente en agse. MX357482B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261673596P 2012-07-19 2012-07-19
EP12177172 2012-07-19
PCT/EP2013/065348 WO2014013074A1 (en) 2012-07-19 2013-07-19 Agse-deficient strain

Publications (2)

Publication Number Publication Date
MX2015000840A true MX2015000840A (es) 2015-04-08
MX357482B MX357482B (es) 2018-07-11

Family

ID=49948320

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015000840A MX357482B (es) 2012-07-19 2013-07-19 Cepa deficiente en agse.

Country Status (13)

Country Link
US (2) US10035986B2 (es)
EP (2) EP2875119B1 (es)
JP (1) JP6468561B2 (es)
CN (1) CN105308171B (es)
AU (1) AU2013291936B2 (es)
CA (1) CA2876287C (es)
CL (1) CL2015000084A1 (es)
DK (2) DK2875119T3 (es)
EA (1) EA201500142A1 (es)
IN (1) IN2014DN11163A (es)
MX (1) MX357482B (es)
NZ (1) NZ702962A (es)
WO (1) WO2014013074A1 (es)

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WO2016026839A1 (en) 2014-08-21 2016-02-25 Dsm Ip Assets B.V. Use of penicillium glucose oxidase in the baking industry for replacing bromate or azodicarbonamide
CN107075451A (zh) * 2014-10-29 2017-08-18 诺维信公司 丝状真菌双重突变体宿主细胞
DK3242950T3 (da) 2015-01-06 2021-12-20 Dsm Ip Assets Bv Crispr-cas-system til en trådformet svampeværtscelle
US20180103650A1 (en) 2015-04-10 2018-04-19 Dsm Ip Assets B.V. Method for preparing a dough
WO2016196654A1 (en) * 2015-06-01 2016-12-08 The Arizona Board Of Regents On Behalf Of The University Of Arizona Transgenic plant species engineered to inhibit biosynthesis of aspergillus aflatoxin
MX2017015126A (es) 2015-06-02 2018-03-28 Dsm Ip Assets Bv Uso de proteina estructurante del hielo.
CN105950482B (zh) * 2016-07-15 2019-04-02 南京林业大学 一株产菊粉酶的菌株及其应用
WO2018019948A1 (en) 2016-07-29 2018-02-01 Dsm Ip Assets B.V. Polypeptides having cellulolytic enhancing activity and uses thereof
US10918113B2 (en) 2016-12-21 2021-02-16 Dsm Ip Assets B.V. Lipolytic enzyme variants
MX2019007375A (es) 2016-12-21 2019-09-18 Dsm Ip Assets Bv Variante de enzima lipolitica.
WO2018114938A1 (en) 2016-12-21 2018-06-28 Dsm Ip Assets B.V. Lipolytic enzyme variants
WO2018114912A1 (en) 2016-12-21 2018-06-28 Dsm Ip Assets B.V. Lipolytic enzyme variants
US20200063166A1 (en) * 2017-03-13 2020-02-27 Dsm Ip Assets B.V. Zinc binuclear cluster transcriptional regulator-deficient strain
MX2020014191A (es) 2018-06-19 2021-03-09 Dsm Ip Assets Bv Variantes de enzimas lipoliticas.
CN110184195B (zh) * 2019-04-25 2020-11-17 广东海洋大学 一株高产油脂的桔青霉Asc2-4-1及其应用
CN110713937B (zh) * 2019-09-20 2022-02-01 兰州大学 提高中华羊茅-内生真菌菌株pa次生代谢产物波胺含量的方法
CN111849809B (zh) * 2020-07-09 2021-12-24 南京农业大学 一种可降解菊粉果聚糖的菌株及其应用
WO2023225459A2 (en) 2022-05-14 2023-11-23 Novozymes A/S Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections
CN112662572B (zh) * 2021-02-02 2022-03-15 中国科学院海洋研究所 一种高产壳聚糖酶的菌株及其应用
WO2022269549A2 (en) 2021-06-24 2022-12-29 Fonterra Co-Operative Group Limited Recombinant proteins
WO2023222614A1 (en) 2022-05-16 2023-11-23 Dsm Ip Assets B.V. Lipolytic enzyme variants

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Also Published As

Publication number Publication date
EP3327112A1 (en) 2018-05-30
US10035986B2 (en) 2018-07-31
NZ702962A (en) 2018-02-23
JP2015522288A (ja) 2015-08-06
WO2014013074A1 (en) 2014-01-23
AU2013291936A1 (en) 2015-01-22
EP3327112B1 (en) 2020-02-12
US10100344B2 (en) 2018-10-16
EA201500142A1 (ru) 2015-07-30
EP2875119B1 (en) 2017-12-20
DK3327112T3 (en) 2020-05-04
AU2013291936B2 (en) 2019-01-17
US20150191705A1 (en) 2015-07-09
CA2876287A1 (en) 2014-01-23
DK2875119T3 (en) 2018-04-03
MX357482B (es) 2018-07-11
CA2876287C (en) 2022-11-22
US20170175158A1 (en) 2017-06-22
CN105308171B (zh) 2019-03-08
EP2875119A1 (en) 2015-05-27
JP6468561B2 (ja) 2019-02-13
CN105308171A (zh) 2016-02-03
IN2014DN11163A (es) 2015-10-02
CL2015000084A1 (es) 2015-05-04

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