MX346700B - Metodo para mejorar el rendimiento de un polipeptido. - Google Patents

Metodo para mejorar el rendimiento de un polipeptido.

Info

Publication number
MX346700B
MX346700B MX2011009059A MX2011009059A MX346700B MX 346700 B MX346700 B MX 346700B MX 2011009059 A MX2011009059 A MX 2011009059A MX 2011009059 A MX2011009059 A MX 2011009059A MX 346700 B MX346700 B MX 346700B
Authority
MX
Mexico
Prior art keywords
improving
yield
polypeptide
value
protein
Prior art date
Application number
MX2011009059A
Other languages
English (en)
Other versions
MX2011009059A (es
Inventor
Metske Laan Van Der Jan
Wu Liang
Andries Roubos Johannes
Parenicova Lucie
Pieter Los Alrik
Nicolaas Maria Elisabeth Peij Van Noël
Jan Pel Herman
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Publication of MX2011009059A publication Critical patent/MX2011009059A/es
Publication of MX346700B publication Critical patent/MX346700B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención se refiere a un método para mejorar el rendimiento de una proteína. El método comprende modificar el valor de un conjunto de características de proteína relevantes que cae dentro de un rango óptimo o llega a estar más cerca de un valor óptimo para una o más características de proteína en el anfitrión eucariótico.
MX2011009059A 2009-03-10 2010-03-08 Metodo para mejorar el rendimiento de un polipeptido. MX346700B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09154783 2009-03-10
PCT/EP2010/052918 WO2010102982A1 (en) 2009-03-10 2010-03-08 Method for improving the yield of a polypeptide

Publications (2)

Publication Number Publication Date
MX2011009059A MX2011009059A (es) 2011-11-18
MX346700B true MX346700B (es) 2017-03-28

Family

ID=40912127

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011009059A MX346700B (es) 2009-03-10 2010-03-08 Metodo para mejorar el rendimiento de un polipeptido.

Country Status (11)

Country Link
US (1) US9181573B2 (es)
EP (1) EP2406386B1 (es)
JP (1) JP2012520064A (es)
CN (1) CN102741421B (es)
AU (1) AU2010223354A1 (es)
BR (1) BRPI1009189A2 (es)
CA (1) CA2754851A1 (es)
DK (1) DK2406386T3 (es)
EA (1) EA021205B1 (es)
MX (1) MX346700B (es)
WO (1) WO2010102982A1 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012001169A1 (en) 2010-07-01 2012-01-05 Dsm Ip Assets B.V. A method for the production of a compound of interest
DK2683732T3 (en) 2011-03-11 2016-12-12 Dsm Ip Assets Bv Vector-host-system
EP2875119B1 (en) 2012-07-19 2017-12-20 DSM IP Assets B.V. Agse-deficient strain
DK2898076T3 (en) 2012-09-19 2018-06-14 Dsm Ip Assets Bv METHOD OF CELL MODIFICATION USING ESSENTIAL GENES AS MARKERS AND EVEN RECYCLING THESE
WO2014202623A2 (en) * 2013-06-19 2014-12-24 Dsm Ip Assets B.V. Rasamsonia gene and use thereof
ES2706742T3 (es) 2013-12-02 2019-04-01 Dsm Ip Assets Bv Proteína estructuradora del hielo
WO2015091455A1 (en) 2013-12-17 2015-06-25 Dpx Holdings B.V. Bioreactor
KR101996774B1 (ko) * 2014-11-03 2019-07-04 메르크 파텐트 게엠베하 생체분자를 정제하기 위한 가용성 인테인 융합 단백질 및 방법
DK3242950T3 (da) 2015-01-06 2021-12-20 Dsm Ip Assets Bv Crispr-cas-system til en trådformet svampeværtscelle
WO2016110511A1 (en) 2015-01-06 2016-07-14 Dsm Ip Assets B.V. A crispr-cas system for a lipolytic yeast host cell
US20180103650A1 (en) 2015-04-10 2018-04-19 Dsm Ip Assets B.V. Method for preparing a dough
MX2017015126A (es) 2015-06-02 2018-03-28 Dsm Ip Assets Bv Uso de proteina estructurante del hielo.
EP3484994A4 (en) 2016-07-13 2020-01-22 DSM IP Assets B.V. CRISPR-CAS-SYSTEM FOR AN ALGENE CELL
EP3516056A1 (en) 2016-09-23 2019-07-31 DSM IP Assets B.V. A guide-rna expression system for a host cell
US20200063166A1 (en) 2017-03-13 2020-02-27 Dsm Ip Assets B.V. Zinc binuclear cluster transcriptional regulator-deficient strain
CN110462044A (zh) 2017-04-06 2019-11-15 帝斯曼知识产权资产管理有限公司 自引导整合构建体(sgic)
WO2019063849A1 (en) 2017-12-20 2019-04-04 Dsm Ip Assets B.V. PURIFICATION OF A POLYPEPTIDE OF INTEREST
EP3728603A2 (en) 2017-12-20 2020-10-28 DSM IP Assets B.V. A method for genome editing in a host cell
EP3790969A1 (en) 2018-05-09 2021-03-17 DSM IP Assets B.V. Crispr transient expression construct (ctec)
US20220056460A1 (en) 2018-12-05 2022-02-24 Dsm Ip Assets B.V. Crispr guide-rna expression strategies for multiplex genome engineering
DK3715464T3 (da) 2019-03-28 2021-07-26 Dsm Ip Assets Bv Drivhusgasforbedret fermentering
WO2021228880A1 (en) 2020-05-14 2021-11-18 Dsm Ip Assets B.V. Fed-batch fermentation process
WO2023225459A2 (en) 2022-05-14 2023-11-23 Novozymes A/S Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections
CN112480139B (zh) * 2021-01-05 2022-04-19 遵义医科大学 罗丹明类荧光探针的制备方法及其检测有机自由基方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69432543T2 (de) 1993-07-23 2003-12-24 Dsm N.V., Te Heerlen Selektionmarker-genfreie rekombinante Stämme: Verfahren zur ihrer Herstellung und die Verwendung dieser Stämme
US5888773A (en) * 1994-08-17 1999-03-30 The United States Of America As Represented By The Department Of Health And Human Services Method of producing single-chain Fv molecules
CA2229043C (en) * 1995-08-18 2016-06-07 Morphosys Gesellschaft Fur Proteinoptimierung Mbh Protein/(poly)peptide libraries
US6265186B1 (en) 1997-04-11 2001-07-24 Dsm N.V. Yeast cells comprising at least two copies of a desired gene integrated into the chromosomal genome at more than one non-ribosomal RNA encoding domain, particularly with Kluyveromyces
CN1169961C (zh) 1997-04-11 2004-10-06 Dsm公司 基因转变作为工具用于构建重组的工业化丝状真菌
CA2313445C (en) 1997-12-22 2012-03-20 Dsm N.V. Expression cloning in filamentous fungi
US6544765B1 (en) 1999-02-22 2003-04-08 Novozymes, A/S Oxaloacetate hydrolase deficient fungal host cells
DE60025467T2 (de) 1999-02-22 2006-09-21 Novozymes A/S Oxalacetat-hydrolase defiziente fungale wirtszellen
WO2001021779A2 (en) 1999-09-17 2001-03-29 Dsm N.V. Penicillium chrysogenum transcriptional activator blar, a pathway specific regulator of beta-lactam biosynthesis, and uses therof
US6846653B2 (en) * 2000-10-10 2005-01-25 Genencor International, Inc. Enhanced secretion of a polypeptide by a microorganism
RU2225442C2 (ru) * 2001-02-22 2004-03-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Рекомбинантная днк для контроля экспрессии, способ контроля экспрессии целевого гена, способ получения целевого вещества
US6797493B2 (en) * 2001-10-01 2004-09-28 Lee-Hwei K. Sun Fc fusion proteins of human granulocyte colony-stimulating factor with increased biological activities
WO2005095624A2 (en) 2004-04-02 2005-10-13 Dsm Ip Assets B.V. Filamentous fungal mutants with improved homologous recombination efficiency
EP2345726A3 (en) 2004-04-16 2011-12-14 DSM IP Assets B.V. Fungal promoter for expressing a gene in a fungal cell
WO2006040312A2 (en) 2004-10-12 2006-04-20 Dsm Ip Assets B.V. Fungal transcriptional activators useful in methods for producing a polypeptide
JP2008527985A (ja) * 2005-01-24 2008-07-31 ディーエスエム アイピー アセッツ ビー．ブイ． 糸状菌細胞において目的の化合物を産生させるための方法
JP5250850B2 (ja) 2006-06-29 2013-07-31 ディーエスエム アイピー アセッツ ビー．ブイ． 改善されたポリペプチド発現を達成する方法
JP2010508043A (ja) * 2006-10-31 2010-03-18 イミュノジェン・インコーポレーテッド 抗体産生を改善するための方法
KR101637533B1 (ko) * 2007-08-20 2016-07-11 글락소 그룹 리미티드 제조 방법

Also Published As

Publication number Publication date
JP2012520064A (ja) 2012-09-06
WO2010102982A1 (en) 2010-09-16
US9181573B2 (en) 2015-11-10
CN102741421A (zh) 2012-10-17
EP2406386B1 (en) 2019-01-23
EP2406386A1 (en) 2012-01-18
MX2011009059A (es) 2011-11-18
DK2406386T3 (en) 2019-04-23
EA021205B1 (ru) 2015-04-30
CA2754851A1 (en) 2010-09-16
EA201101306A1 (ru) 2012-02-28
CN102741421B (zh) 2015-03-25
US20110318752A1 (en) 2011-12-29
AU2010223354A1 (en) 2011-09-08
BRPI1009189A2 (pt) 2015-09-15

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