MX346700B - Metodo para mejorar el rendimiento de un polipeptido. - Google Patents

Metodo para mejorar el rendimiento de un polipeptido.

Info

Publication number
MX346700B
MX346700B MX2011009059A MX2011009059A MX346700B MX 346700 B MX346700 B MX 346700B MX 2011009059 A MX2011009059 A MX 2011009059A MX 2011009059 A MX2011009059 A MX 2011009059A MX 346700 B MX346700 B MX 346700B
Authority
MX
Mexico
Prior art keywords
improving
yield
polypeptide
value
protein
Prior art date
Application number
MX2011009059A
Other languages
English (en)
Other versions
MX2011009059A (es
Inventor
Metske Laan Van Der Jan
Wu Liang
Andries Roubos Johannes
Parenicova Lucie
Pieter Los Alrik
Nicolaas Maria Elisabeth Peij Van Noël
Jan Pel Herman
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Publication of MX2011009059A publication Critical patent/MX2011009059A/es
Publication of MX346700B publication Critical patent/MX346700B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención se refiere a un método para mejorar el rendimiento de una proteína. El método comprende modificar el valor de un conjunto de características de proteína relevantes que cae dentro de un rango óptimo o llega a estar más cerca de un valor óptimo para una o más características de proteína en el anfitrión eucariótico.
MX2011009059A 2009-03-10 2010-03-08 Metodo para mejorar el rendimiento de un polipeptido. MX346700B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09154783 2009-03-10
PCT/EP2010/052918 WO2010102982A1 (en) 2009-03-10 2010-03-08 Method for improving the yield of a polypeptide

Publications (2)

Publication Number Publication Date
MX2011009059A MX2011009059A (es) 2011-11-18
MX346700B true MX346700B (es) 2017-03-28

Family

ID=40912127

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011009059A MX346700B (es) 2009-03-10 2010-03-08 Metodo para mejorar el rendimiento de un polipeptido.

Country Status (11)

Country Link
US (1) US9181573B2 (es)
EP (1) EP2406386B1 (es)
JP (1) JP2012520064A (es)
CN (1) CN102741421B (es)
AU (1) AU2010223354A1 (es)
BR (1) BRPI1009189A2 (es)
CA (1) CA2754851A1 (es)
DK (1) DK2406386T3 (es)
EA (1) EA021205B1 (es)
MX (1) MX346700B (es)
WO (1) WO2010102982A1 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012001169A1 (en) 2010-07-01 2012-01-05 Dsm Ip Assets B.V. A method for the production of a compound of interest
DK2683732T3 (en) 2011-03-11 2016-12-12 Dsm Ip Assets Bv Vector-host-system
US10035986B2 (en) 2012-07-19 2018-07-31 Dsm Ip Assets B.V. AgsE-deficient strain
US9951339B2 (en) 2012-09-19 2018-04-24 Dsm Ip Assets B.V. Cell modification method using essential genes as markers and optionally recycling these
WO2014202623A2 (en) * 2013-06-19 2014-12-24 Dsm Ip Assets B.V. Rasamsonia gene and use thereof
US10487125B2 (en) 2013-12-02 2019-11-26 Dsm Ip Assets B.V. Ice structuring protein
WO2015091455A1 (en) 2013-12-17 2015-06-25 Dpx Holdings B.V. Bioreactor
WO2016073228A1 (en) 2014-11-03 2016-05-12 Merck Patent Gmbh Soluble intein fusion proteins and methods for purifying biomolecules
WO2016110453A1 (en) 2015-01-06 2016-07-14 Dsm Ip Assets B.V. A crispr-cas system for a filamentous fungal host cell
WO2016110511A1 (en) 2015-01-06 2016-07-14 Dsm Ip Assets B.V. A crispr-cas system for a lipolytic yeast host cell
WO2016162454A1 (en) 2015-04-10 2016-10-13 Dsm Ip Assets B.V. Method for preparing a dough
MX2017015126A (es) * 2015-06-02 2018-03-28 Dsm Ip Assets Bv Uso de proteina estructurante del hielo.
CN109689856A (zh) 2016-07-13 2019-04-26 帝斯曼知识产权资产管理有限公司 用于海藻宿主细胞的CRISPR-Cas系统
WO2017216392A1 (en) 2016-09-23 2017-12-21 Dsm Ip Assets B.V. A guide-rna expression system for a host cell
CN110431224A (zh) 2017-03-13 2019-11-08 帝斯曼知识产权资产管理有限公司 锌双核簇转录调控因子缺陷型菌株
CN110462044A (zh) 2017-04-06 2019-11-15 帝斯曼知识产权资产管理有限公司 自引导整合构建体(sgic)
WO2019063849A1 (en) 2017-12-20 2019-04-04 Dsm Ip Assets B.V. PURIFICATION OF A POLYPEPTIDE OF INTEREST
EP3728603A2 (en) 2017-12-20 2020-10-28 DSM IP Assets B.V. A method for genome editing in a host cell
CN112088215A (zh) 2018-05-09 2020-12-15 帝斯曼知识产权资产管理有限公司 Crispr瞬时表达构建体(ctec)
EP3891281A1 (en) 2018-12-05 2021-10-13 DSM IP Assets B.V. Crispr guide-rna expression strategies for multiplex genome engineering
EP3715464B1 (en) 2019-03-28 2021-05-05 DSM IP Assets B.V. Greenhouse gas improved fermentation
WO2021228880A1 (en) 2020-05-14 2021-11-18 Dsm Ip Assets B.V. Fed-batch fermentation process
CN112480139B (zh) * 2021-01-05 2022-04-19 遵义医科大学 罗丹明类荧光探针的制备方法及其检测有机自由基方法
WO2023225459A2 (en) 2022-05-14 2023-11-23 Novozymes A/S Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1321523A3 (en) 1993-07-23 2004-03-03 DSM IP Assets B.V. Selection marker gene free recombinant strains; a method for obtaining them and the use of these strains
US5888773A (en) * 1994-08-17 1999-03-30 The United States Of America As Represented By The Department Of Health And Human Services Method of producing single-chain Fv molecules
DK0859841T3 (da) * 1995-08-18 2002-09-09 Morphosys Ag Protein/(poly)peptidbiblioteker
US6265186B1 (en) 1997-04-11 2001-07-24 Dsm N.V. Yeast cells comprising at least two copies of a desired gene integrated into the chromosomal genome at more than one non-ribosomal RNA encoding domain, particularly with Kluyveromyces
EP0979294B1 (en) 1997-04-11 2015-05-27 DSM IP Assets B.V. Gene conversion as a tool for the construction of recombinant industrial filamentous fungi
PL341760A1 (en) 1997-12-22 2001-05-07 Dsm Nv Expression cloning in mildew fungi
EP1157100B1 (en) 1999-02-22 2006-01-11 Novozymes A/S Oxaloacetate hydrolase deficient fungal host cells
US6544765B1 (en) 1999-02-22 2003-04-08 Novozymes, A/S Oxaloacetate hydrolase deficient fungal host cells
AU7288100A (en) 1999-09-17 2001-04-24 Dsm N.V. Regulation of secondary metabolite production
US6846653B2 (en) * 2000-10-10 2005-01-25 Genencor International, Inc. Enhanced secretion of a polypeptide by a microorganism
RU2225442C2 (ru) * 2001-02-22 2004-03-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Рекомбинантная днк для контроля экспрессии, способ контроля экспрессии целевого гена, способ получения целевого вещества
US6797493B2 (en) * 2001-10-01 2004-09-28 Lee-Hwei K. Sun Fc fusion proteins of human granulocyte colony-stimulating factor with increased biological activities
US9243043B2 (en) 2004-04-02 2016-01-26 Dsm Ip Assets B.V. Filamentous fungal mutants with improved homologous recombination efficiency
EP1776461A2 (en) 2004-04-16 2007-04-25 DSMIP Assets B.V. Fungal promoters for expressing a gene in a fungal cell
WO2006040312A2 (en) 2004-10-12 2006-04-20 Dsm Ip Assets B.V. Fungal transcriptional activators useful in methods for producing a polypeptide
CA2595056A1 (en) * 2005-01-24 2006-07-27 Dsm Ip Assets B.V. Method for producing a compound of interest in a filamentous fungal cell
EA015925B1 (ru) * 2006-06-29 2011-12-30 ДСМ АйПи АССЕТС Б.В. Способ получения полипептидов
WO2008073598A2 (en) * 2006-10-31 2008-06-19 Immunogen, Inc. Methods for improving antibody production
EP2527367A1 (en) * 2007-08-20 2012-11-28 Glaxo Group Limited Production method

Also Published As

Publication number Publication date
EP2406386B1 (en) 2019-01-23
US20110318752A1 (en) 2011-12-29
MX2011009059A (es) 2011-11-18
EP2406386A1 (en) 2012-01-18
EA201101306A1 (ru) 2012-02-28
CN102741421A (zh) 2012-10-17
BRPI1009189A2 (pt) 2015-09-15
WO2010102982A1 (en) 2010-09-16
EA021205B1 (ru) 2015-04-30
US9181573B2 (en) 2015-11-10
AU2010223354A1 (en) 2011-09-08
JP2012520064A (ja) 2012-09-06
CN102741421B (zh) 2015-03-25
CA2754851A1 (en) 2010-09-16
DK2406386T3 (en) 2019-04-23

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