MX346700B - Metodo para mejorar el rendimiento de un polipeptido. - Google Patents

Metodo para mejorar el rendimiento de un polipeptido.

Info

Publication number
MX346700B
MX346700B MX2011009059A MX2011009059A MX346700B MX 346700 B MX346700 B MX 346700B MX 2011009059 A MX2011009059 A MX 2011009059A MX 2011009059 A MX2011009059 A MX 2011009059A MX 346700 B MX346700 B MX 346700B
Authority
MX
Mexico
Prior art keywords
improving
yield
polypeptide
value
protein
Prior art date
Application number
MX2011009059A
Other languages
English (en)
Other versions
MX2011009059A (es
Inventor
Metske Laan Van Der Jan
Wu Liang
Andries Roubos Johannes
Parenicova Lucie
Pieter Los Alrik
Nicolaas Maria Elisabeth Peij Van Noël
Jan Pel Herman
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Publication of MX2011009059A publication Critical patent/MX2011009059A/es
Publication of MX346700B publication Critical patent/MX346700B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención se refiere a un método para mejorar el rendimiento de una proteína. El método comprende modificar el valor de un conjunto de características de proteína relevantes que cae dentro de un rango óptimo o llega a estar más cerca de un valor óptimo para una o más características de proteína en el anfitrión eucariótico.
MX2011009059A 2009-03-10 2010-03-08 Metodo para mejorar el rendimiento de un polipeptido. MX346700B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09154783 2009-03-10
PCT/EP2010/052918 WO2010102982A1 (en) 2009-03-10 2010-03-08 Method for improving the yield of a polypeptide

Publications (2)

Publication Number Publication Date
MX2011009059A MX2011009059A (es) 2011-11-18
MX346700B true MX346700B (es) 2017-03-28

Family

ID=40912127

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011009059A MX346700B (es) 2009-03-10 2010-03-08 Metodo para mejorar el rendimiento de un polipeptido.

Country Status (11)

Country Link
US (1) US9181573B2 (es)
EP (1) EP2406386B1 (es)
JP (1) JP2012520064A (es)
CN (1) CN102741421B (es)
AU (1) AU2010223354A1 (es)
BR (1) BRPI1009189A2 (es)
CA (1) CA2754851A1 (es)
DK (1) DK2406386T3 (es)
EA (1) EA021205B1 (es)
MX (1) MX346700B (es)
WO (1) WO2010102982A1 (es)

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AU2011273351A1 (en) 2010-07-01 2013-01-17 Dsm Ip Assets B.V. A method for the production of a compound of interest
CN103596970A (zh) 2011-03-11 2014-02-19 帝斯曼知识产权资产管理有限公司 载体-宿主系统
CN105308171B (zh) 2012-07-19 2019-03-08 帝斯曼知识产权资产管理有限公司 Agse缺陷菌株
WO2014044782A1 (en) 2012-09-19 2014-03-27 Dsm Ip Assets B.V. Cell modification method using essential genes as markers and optionally recycling these
WO2014202623A2 (en) * 2013-06-19 2014-12-24 Dsm Ip Assets B.V. Rasamsonia gene and use thereof
CN105992822A (zh) 2013-12-02 2016-10-05 帝斯曼知识产权资产管理有限公司 冰结构蛋白质
WO2015091455A1 (en) 2013-12-17 2015-06-25 Dpx Holdings B.V. Bioreactor
EP3543335A3 (en) 2014-11-03 2019-11-27 Merck Patent GmbH Soluble intein fusion proteins and methods for purifying biomolecules
WO2016110511A1 (en) 2015-01-06 2016-07-14 Dsm Ip Assets B.V. A crispr-cas system for a lipolytic yeast host cell
DK3242950T3 (da) 2015-01-06 2021-12-20 Dsm Ip Assets Bv Crispr-cas-system til en trådformet svampeværtscelle
ES2856766T3 (es) 2015-04-10 2021-09-28 Dsm Ip Assets Bv Método de preparación de una masa
AU2016273208B2 (en) * 2015-06-02 2021-01-21 Dsm Ip Assets B.V. Use of ice structuring protein AFP19 expressed in filamentous fungal strains for preparing food
KR102319845B1 (ko) 2016-07-13 2021-11-01 디에스엠 아이피 어셋츠 비.브이. 조류 숙주 세포에 대한 crispr-cas 시스템
DK3516056T3 (da) 2016-09-23 2025-02-17 Dsm Ip Assets Bv Et guide-rna-ekspressionssystem til en værtscelle
US20200063166A1 (en) 2017-03-13 2020-02-27 Dsm Ip Assets B.V. Zinc binuclear cluster transcriptional regulator-deficient strain
US20200032252A1 (en) 2017-04-06 2020-01-30 Dsm Ip Assets B.V. Self-guiding integration construct (sgic)
WO2019063849A1 (en) 2017-12-20 2019-04-04 Dsm Ip Assets B.V. PURIFICATION OF A POLYPEPTIDE OF INTEREST
WO2019012162A2 (en) 2017-12-20 2019-01-17 Dsm Ip Assets B.V. GENOMIC EDITING METHOD IN HOST CELL
US20210071174A1 (en) 2018-05-09 2021-03-11 Dsm Ip Assets B.V. Crispr transient expression construct (ctec)
US20220056460A1 (en) 2018-12-05 2022-02-24 Dsm Ip Assets B.V. Crispr guide-rna expression strategies for multiplex genome engineering
DK3715464T3 (da) 2019-03-28 2021-07-26 Dsm Ip Assets Bv Drivhusgasforbedret fermentering
US20230212634A1 (en) * 2020-01-14 2023-07-06 The Protein Brewery B.V. Expression of Ovalbumin and its Natural Variants
WO2021228880A1 (en) 2020-05-14 2021-11-18 Dsm Ip Assets B.V. Fed-batch fermentation process
CN112480139B (zh) * 2021-01-05 2022-04-19 遵义医科大学 罗丹明类荧光探针的制备方法及其检测有机自由基方法
CA3257053A1 (en) 2022-05-14 2023-11-23 Novozymes A/S COMPOSITIONS AND METHODS FOR THE PREVENTION, TREATMENT, SUPPRESSION AND/OR ELIMINATION OF PHYTOPATHOGENIC INFESTATIONS AND INFECTIONS
WO2025099225A1 (en) 2023-11-08 2025-05-15 Dsm Ip Assets B.V. Improved enzyme variants
WO2025099224A1 (en) 2023-11-08 2025-05-15 Dsm Ip Assets B.V. Improved enzyme variants

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ES2198410T3 (es) 1993-07-23 2004-02-01 Dsm Ip Assets B.V. Cepas recombinantes de hongos filamentosos libres de gen marcador de seleccion: un metodo para obtener dichas cepas y su utilizacion.
US5888773A (en) 1994-08-17 1999-03-30 The United States Of America As Represented By The Department Of Health And Human Services Method of producing single-chain Fv molecules
WO1997008320A1 (en) * 1995-08-18 1997-03-06 Morphosys Gesellschaft Für Proteinoptimierung Mbh Protein/(poly)peptide libraries
US6432672B1 (en) 1997-04-11 2002-08-13 Gerardus Cornelis Maria Selten Gene conversion as a tool for the construction of recombinant industrial filamentous fungi
US6265186B1 (en) 1997-04-11 2001-07-24 Dsm N.V. Yeast cells comprising at least two copies of a desired gene integrated into the chromosomal genome at more than one non-ribosomal RNA encoding domain, particularly with Kluyveromyces
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US6544765B1 (en) 1999-02-22 2003-04-08 Novozymes, A/S Oxaloacetate hydrolase deficient fungal host cells
ATE315638T1 (de) 1999-02-22 2006-02-15 Novozymes As Oxalacetat-hydrolase defiziente fungale wirtszellen
AU7288100A (en) 1999-09-17 2001-04-24 Dsm N.V. Regulation of secondary metabolite production
US6846653B2 (en) 2000-10-10 2005-01-25 Genencor International, Inc. Enhanced secretion of a polypeptide by a microorganism
RU2225442C2 (ru) * 2001-02-22 2004-03-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Рекомбинантная днк для контроля экспрессии, способ контроля экспрессии целевого гена, способ получения целевого вещества
US6797493B2 (en) * 2001-10-01 2004-09-28 Lee-Hwei K. Sun Fc fusion proteins of human granulocyte colony-stimulating factor with increased biological activities
CN101218348B (zh) 2004-04-02 2014-07-30 帝斯曼知识产权资产管理有限公司 具有提高的同源重组效率的丝状真菌突变体
EP2345726A3 (en) 2004-04-16 2011-12-14 DSM IP Assets B.V. Fungal promoter for expressing a gene in a fungal cell
CN101094919B (zh) 2004-10-12 2014-09-03 帝斯曼知识产权资产管理有限公司 在生产多肽的方法中有用的真菌转录活化因子
CN101107354B (zh) * 2005-01-24 2012-05-30 帝斯曼知识产权资产管理有限公司 用于在有丝真菌细胞中生产感兴趣化合物的方法
JP5250850B2 (ja) 2006-06-29 2013-07-31 ディーエスエム アイピー アセッツ ビー．ブイ． 改善されたポリペプチド発現を達成する方法
EP2069379A4 (en) * 2006-10-31 2011-02-16 Immunogen Inc METHOD FOR IMPROVING ANTIBODY PRODUCTION
WO2009024567A1 (en) * 2007-08-20 2009-02-26 Glaxo Group Limited Production method

Also Published As

Publication number Publication date
WO2010102982A1 (en) 2010-09-16
DK2406386T3 (en) 2019-04-23
CN102741421B (zh) 2015-03-25
CA2754851A1 (en) 2010-09-16
EP2406386B1 (en) 2019-01-23
MX2011009059A (es) 2011-11-18
US9181573B2 (en) 2015-11-10
BRPI1009189A2 (pt) 2015-09-15
EA201101306A1 (ru) 2012-02-28
EA021205B1 (ru) 2015-04-30
CN102741421A (zh) 2012-10-17
EP2406386A1 (en) 2012-01-18
AU2010223354A1 (en) 2011-09-08
JP2012520064A (ja) 2012-09-06
US20110318752A1 (en) 2011-12-29

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