BRPI1009189A2 - método para melhorar o rendimento de um polipetídeo - Google Patents

método para melhorar o rendimento de um polipetídeo

Info

Publication number
BRPI1009189A2
BRPI1009189A2 BRPI1009189A BRPI1009189A BRPI1009189A2 BR PI1009189 A2 BRPI1009189 A2 BR PI1009189A2 BR PI1009189 A BRPI1009189 A BR PI1009189A BR PI1009189 A BRPI1009189 A BR PI1009189A BR PI1009189 A2 BRPI1009189 A2 BR PI1009189A2
Authority
BR
Brazil
Prior art keywords
polypeptide
yield
improving
Prior art date
Application number
BRPI1009189A
Other languages
English (en)
Inventor
Alrik Pieter Los
Herman Jan Pel
Jan Metske Van Der Laan
Johannes Andries Roubos
Liang Wu
Lucie Parenicova
Noel Nicolaas Maria Elisabeth Van Peij
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Publication of BRPI1009189A2 publication Critical patent/BRPI1009189A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
BRPI1009189A 2009-03-10 2010-03-08 método para melhorar o rendimento de um polipetídeo BRPI1009189A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09154783 2009-03-10
PCT/EP2010/052918 WO2010102982A1 (en) 2009-03-10 2010-03-08 Method for improving the yield of a polypeptide

Publications (1)

Publication Number Publication Date
BRPI1009189A2 true BRPI1009189A2 (pt) 2015-09-15

Family

ID=40912127

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1009189A BRPI1009189A2 (pt) 2009-03-10 2010-03-08 método para melhorar o rendimento de um polipetídeo

Country Status (11)

Country Link
US (1) US9181573B2 (pt)
EP (1) EP2406386B1 (pt)
JP (1) JP2012520064A (pt)
CN (1) CN102741421B (pt)
AU (1) AU2010223354A1 (pt)
BR (1) BRPI1009189A2 (pt)
CA (1) CA2754851A1 (pt)
DK (1) DK2406386T3 (pt)
EA (1) EA021205B1 (pt)
MX (1) MX346700B (pt)
WO (1) WO2010102982A1 (pt)

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Publication number Priority date Publication date Assignee Title
AU2011273351A1 (en) 2010-07-01 2013-01-17 Dsm Ip Assets B.V. A method for the production of a compound of interest
CN103596970A (zh) 2011-03-11 2014-02-19 帝斯曼知识产权资产管理有限公司 载体-宿主系统
EA201500142A1 (ru) 2012-07-19 2015-07-30 ДСМ АйПи АССЕТС Б.В. ШТАММ, ДЕФИЦИТНЫЙ ПО AgsE
DK2898076T3 (en) 2012-09-19 2018-06-14 Dsm Ip Assets Bv METHOD OF CELL MODIFICATION USING ESSENTIAL GENES AS MARKERS AND EVEN RECYCLING THESE
WO2014202623A2 (en) * 2013-06-19 2014-12-24 Dsm Ip Assets B.V. Rasamsonia gene and use thereof
ES2706742T3 (es) 2013-12-02 2019-04-01 Dsm Ip Assets Bv Proteína estructuradora del hielo
WO2015091455A1 (en) 2013-12-17 2015-06-25 Dpx Holdings B.V. Bioreactor
KR101996774B1 (ko) * 2014-11-03 2019-07-04 메르크 파텐트 게엠베하 생체분자를 정제하기 위한 가용성 인테인 융합 단백질 및 방법
DK3242950T3 (da) 2015-01-06 2021-12-20 Dsm Ip Assets Bv Crispr-cas-system til en trådformet svampeværtscelle
CN108064287A (zh) 2015-01-06 2018-05-22 帝斯曼知识产权资产管理有限公司 用于解脂酵母宿主细胞的crispr-cas系统
DK3280264T3 (da) 2015-04-10 2021-03-29 Dsm Ip Assets Bv Fremgangsmåde til fremstilling af en dej
AU2016273208B2 (en) * 2015-06-02 2021-01-21 Dsm Ip Assets B.V. Use of ice structuring protein AFP19 expressed in filamentous fungal strains for preparing food
US11466269B2 (en) 2016-07-13 2022-10-11 Dsm Ip Assets B.V. CRISPR-Cas system for an algal host cell
WO2017216392A1 (en) 2016-09-23 2017-12-21 Dsm Ip Assets B.V. A guide-rna expression system for a host cell
CN110431224A (zh) 2017-03-13 2019-11-08 帝斯曼知识产权资产管理有限公司 锌双核簇转录调控因子缺陷型菌株
CN110462044A (zh) 2017-04-06 2019-11-15 帝斯曼知识产权资产管理有限公司 自引导整合构建体(sgic)
EP3728603A2 (en) 2017-12-20 2020-10-28 DSM IP Assets B.V. A method for genome editing in a host cell
WO2019063849A1 (en) 2017-12-20 2019-04-04 Dsm Ip Assets B.V. PURIFICATION OF A POLYPEPTIDE OF INTEREST
US20210071174A1 (en) 2018-05-09 2021-03-11 Dsm Ip Assets B.V. Crispr transient expression construct (ctec)
US20220056460A1 (en) 2018-12-05 2022-02-24 Dsm Ip Assets B.V. Crispr guide-rna expression strategies for multiplex genome engineering
EP3715464B1 (en) 2019-03-28 2021-05-05 DSM IP Assets B.V. Greenhouse gas improved fermentation
WO2021228880A1 (en) 2020-05-14 2021-11-18 Dsm Ip Assets B.V. Fed-batch fermentation process
CN112480139B (zh) * 2021-01-05 2022-04-19 遵义医科大学 罗丹明类荧光探针的制备方法及其检测有机自由基方法
WO2023225459A2 (en) 2022-05-14 2023-11-23 Novozymes A/S Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections

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DE69432543T2 (de) 1993-07-23 2003-12-24 Dsm N.V., Te Heerlen Selektionmarker-genfreie rekombinante Stämme: Verfahren zur ihrer Herstellung und die Verwendung dieser Stämme
US5888773A (en) * 1994-08-17 1999-03-30 The United States Of America As Represented By The Department Of Health And Human Services Method of producing single-chain Fv molecules
EP0859841B1 (en) * 1995-08-18 2002-06-19 MorphoSys AG Protein/(poly)peptide libraries
US6265186B1 (en) 1997-04-11 2001-07-24 Dsm N.V. Yeast cells comprising at least two copies of a desired gene integrated into the chromosomal genome at more than one non-ribosomal RNA encoding domain, particularly with Kluyveromyces
AU7642298A (en) 1997-04-11 1998-11-11 Gist-Brocades B.V. Gene conversion as a tool for the construction of recombinant industrial filamentous fungi
DE69838106T2 (de) 1997-12-22 2008-04-03 Dsm Ip Assets B.V. Expressionsklonierung in filamentösen pilzen
US6544765B1 (en) 1999-02-22 2003-04-08 Novozymes, A/S Oxaloacetate hydrolase deficient fungal host cells
WO2000050576A1 (en) 1999-02-22 2000-08-31 Novozymes A/S Oxaloacetate hydrolase deficient fungal host cells
AU7288100A (en) 1999-09-17 2001-04-24 Dsm N.V. Regulation of secondary metabolite production
DK1354056T3 (en) 2000-10-10 2015-02-23 Danisco Us Inc IMPROVED secretion of a polypeptide by a microorganism
RU2225442C2 (ru) * 2001-02-22 2004-03-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Рекомбинантная днк для контроля экспрессии, способ контроля экспрессии целевого гена, способ получения целевого вещества
US6797493B2 (en) * 2001-10-01 2004-09-28 Lee-Hwei K. Sun Fc fusion proteins of human granulocyte colony-stimulating factor with increased biological activities
CN101218348B (zh) 2004-04-02 2014-07-30 帝斯曼知识产权资产管理有限公司 具有提高的同源重组效率的丝状真菌突变体
CN1942586B (zh) 2004-04-16 2011-08-10 帝斯曼知识产权资产管理有限公司 用于在真菌细胞中表达基因的真菌启动子
CN101094919B (zh) 2004-10-12 2014-09-03 帝斯曼知识产权资产管理有限公司 在生产多肽的方法中有用的真菌转录活化因子
DK2410048T3 (en) 2005-01-24 2016-11-28 Dsm Ip Assets Bv A process for the preparation of a compound of interest in a filamentous fungal cell
BRPI0713795B1 (pt) 2006-06-29 2018-03-20 Dsm Ip Assets B.V. Método de otimização de uma sequência de nucleotídeos codificadora que codifica uma sequência de aminoácidos predeterminada
US20080138898A1 (en) * 2006-10-31 2008-06-12 Immunogen, Inc. Methods for improving antibody production
DK3216802T3 (da) * 2007-08-20 2021-01-04 Glaxo Group Ltd Produktionsfremgangsmåde

Also Published As

Publication number Publication date
MX346700B (es) 2017-03-28
US20110318752A1 (en) 2011-12-29
CN102741421A (zh) 2012-10-17
JP2012520064A (ja) 2012-09-06
CA2754851A1 (en) 2010-09-16
EP2406386B1 (en) 2019-01-23
EA201101306A1 (ru) 2012-02-28
CN102741421B (zh) 2015-03-25
EP2406386A1 (en) 2012-01-18
AU2010223354A1 (en) 2011-09-08
WO2010102982A1 (en) 2010-09-16
EA021205B1 (ru) 2015-04-30
DK2406386T3 (en) 2019-04-23
MX2011009059A (es) 2011-11-18
US9181573B2 (en) 2015-11-10

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B11D Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time