HUE051359T2 - Génmódosított biokatalizátorok és eljárások királis aminok szintetizálására - Google Patents

Génmódosított biokatalizátorok és eljárások királis aminok szintetizálására

Info

Publication number
HUE051359T2
HUE051359T2 HUE13864666A HUE13864666A HUE051359T2 HU E051359 T2 HUE051359 T2 HU E051359T2 HU E13864666 A HUE13864666 A HU E13864666A HU E13864666 A HUE13864666 A HU E13864666A HU E051359 T2 HUE051359 T2 HU E051359T2
Authority
HU
Hungary
Prior art keywords
methods
chiral amines
synthesizing chiral
engineered biocatalysts
biocatalysts
Prior art date
Application number
HUE13864666A
Other languages
English (en)
Inventor
Weng Lin Tang
Helen Hsieh
Son Pham
Derek Smith
Steven Collier
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis Inc filed Critical Codexis Inc
Publication of HUE051359T2 publication Critical patent/HUE051359T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P15/00—Preparation of compounds containing at least three condensed carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y206/00—Transferases transferring nitrogenous groups (2.6)
    • C12Y206/01—Transaminases (2.6.1)
HUE13864666A 2012-12-21 2013-12-16 Génmódosított biokatalizátorok és eljárások királis aminok szintetizálására HUE051359T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261745219P 2012-12-21 2012-12-21

Publications (1)

Publication Number Publication Date
HUE051359T2 true HUE051359T2 (hu) 2021-03-01

Family

ID=50979069

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE13864666A HUE051359T2 (hu) 2012-12-21 2013-12-16 Génmódosított biokatalizátorok és eljárások királis aminok szintetizálására

Country Status (10)

Country Link
US (6) US9902943B2 (hu)
EP (1) EP2935572B1 (hu)
JP (2) JP6618180B2 (hu)
CN (1) CN105008528A (hu)
CA (1) CA2895752C (hu)
DK (1) DK2935572T3 (hu)
HU (1) HUE051359T2 (hu)
IL (1) IL239346B (hu)
SG (1) SG11201504752YA (hu)
WO (1) WO2014099730A1 (hu)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013142770A1 (en) 2012-03-23 2013-09-26 Codexis, Inc. Biocatalysts and methods for synthesizing derivatives of tryptamine and tryptamine analogs
DK2935572T3 (da) 2012-12-21 2020-11-16 Codexis Inc Modificerede biokatalysatorer og fremgangsmåder til syntetisering af chirale aminer
CN111032682B (zh) * 2017-06-14 2024-04-12 科德克希思公司 用于工业生物催化的工程化转氨酶多肽
CN109957554B (zh) * 2017-12-26 2021-05-07 宁波酶赛生物工程有限公司 工程化转氨酶多肽及其应用
CN109503403B (zh) * 2018-12-21 2021-11-16 卓和药业集团股份有限公司 一种普瑞巴林的拆分方法
CA3126671A1 (en) * 2019-01-15 2020-07-23 Codexis, Inc. Engineered transaminase polypeptides
CN109777813B (zh) * 2019-01-25 2021-05-07 浙江工业大学 一种转氨酶-plp共固定化酶及其制备与应用
CN113929614B (zh) * 2020-06-29 2023-09-12 上海医药工业研究院有限公司 一种藜芦胺类化合物、其制备方法及其应用

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US5316943A (en) 1988-06-14 1994-05-31 Kidman Gene E Racemic conversion of using a transaminase
US4950606A (en) 1989-06-22 1990-08-21 Celgene Corporation Enantiomeric enrichment and stereoselective synthesis of chiral amines
US5300437A (en) 1989-06-22 1994-04-05 Celgene Corporation Enantiomeric enrichment and stereoselective synthesis of chiral amines
US5169780A (en) 1989-06-22 1992-12-08 Celgene Corporation Enantiomeric enrichment and stereoselective synthesis of chiral amines
US6335160B1 (en) 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
ES2165420T3 (es) 1994-06-03 2002-03-16 Novozymes Biotech Inc Lacasas myceliophthora purificadas y acidos nucleicos que las codifican.
CN101659926A (zh) 1994-06-30 2010-03-03 诺沃奇梅兹有限公司 非毒性、非产毒性、非致病性镰孢属表达系统及所用启动子和终止子
FI104465B (fi) 1995-06-14 2000-02-15 Valio Oy Proteiinihydrolysaatteja allergioiden hoitamiseksi tai estämiseksi, niiden valmistus ja käyttö
AU2986295A (en) 1995-07-19 1997-02-18 British Biotech Pharmaceuticals Limited N-(amino acid) substituted succinic acid amide derivatives as metalloproteinase inhibitors
US6197558B1 (en) 1997-05-19 2001-03-06 Nsc Technologies Transaminase biotransformation process
DK1036198T3 (da) 1997-12-08 2013-01-02 California Inst Of Techn Fremgangsmåde til fremstilling af polynukleotid- og polypeptidsekvenser
JP4221100B2 (ja) 1999-01-13 2009-02-12 エルピーダメモリ株式会社 半導体装置
US6376246B1 (en) 1999-02-05 2002-04-23 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
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US20050084907A1 (en) 2002-03-01 2005-04-21 Maxygen, Inc. Methods, systems, and software for identifying functional biomolecules
US20050009151A1 (en) 2003-07-10 2005-01-13 Pharmacia Corporation Methods for the stereospecific and enantiomeric enrichment of beta-amino acids
US7629157B2 (en) 2003-08-11 2009-12-08 Codexis, Inc. Ketoreductase polypeptides and related polynucleotides
US20090118130A1 (en) 2007-02-12 2009-05-07 Codexis, Inc. Structure-activity relationships
US7588923B2 (en) 2007-03-02 2009-09-15 Richmond Chemical Corporation Method to increase the yield and improve purification of products from transaminase reactions
WO2008127646A2 (en) 2007-04-11 2008-10-23 Dsm Ip Assets B.V. Transaminase-based processes for preparation of pregabalin
US20090312196A1 (en) 2008-06-13 2009-12-17 Codexis, Inc. Method of synthesizing polynucleotide variants
CN102341494B (zh) * 2009-01-08 2014-10-15 科德克希思公司 转氨酶多肽
DE102009000592A1 (de) 2009-02-04 2010-08-05 Evonik Degussa Gmbh Verfahren zur Herstellung von Aminogruppen tragenden, multizyklischen Ringsystemen
JP5707344B2 (ja) * 2009-02-26 2015-04-30 コデクシス， インコーポレイテッド トランスアミナーゼ生体触媒
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EP2582799B1 (en) * 2010-06-17 2017-12-20 Codexis, Inc. Biocatalysts and methods for the synthesis of (s)-3-(1-aminoethyl)-phenol
WO2013142770A1 (en) 2012-03-23 2013-09-26 Codexis, Inc. Biocatalysts and methods for synthesizing derivatives of tryptamine and tryptamine analogs
DK2935572T3 (da) 2012-12-21 2020-11-16 Codexis Inc Modificerede biokatalysatorer og fremgangsmåder til syntetisering af chirale aminer

Also Published As

Publication number Publication date
US11732248B2 (en) 2023-08-22
JP2020005650A (ja) 2020-01-16
US20180148698A1 (en) 2018-05-31
DK2935572T3 (da) 2020-11-16
US20150329837A1 (en) 2015-11-19
EP2935572A4 (en) 2016-09-28
SG11201504752YA (en) 2015-07-30
JP6618180B2 (ja) 2019-12-11
US10526587B2 (en) 2020-01-07
US20200109379A1 (en) 2020-04-09
WO2014099730A1 (en) 2014-06-26
IL239346A0 (en) 2015-07-30
EP2935572B1 (en) 2020-09-30
IL239346B (en) 2019-02-28
CN105008528A (zh) 2015-10-28
CA2895752C (en) 2021-09-21
US11034939B2 (en) 2021-06-15
US20210269777A1 (en) 2021-09-02
US20170022484A1 (en) 2017-01-26
US10435674B2 (en) 2019-10-08
EP2935572A1 (en) 2015-10-28
US9902943B2 (en) 2018-02-27
US20230332115A1 (en) 2023-10-19
CA2895752A1 (en) 2014-06-26
JP2016501544A (ja) 2016-01-21

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