ES2760917T3 - Tratamiento de pacientes diabéticos genotipificados con inhibidores DPP-IV como la linagliptina - Google Patents

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Publication number

ES2760917T3

ES2760917T3 ES10785054T ES10785054T ES2760917T3 ES 2760917 T3 ES2760917 T3 ES 2760917T3 ES 10785054 T ES10785054 T ES 10785054T ES 10785054 T ES10785054 T ES 10785054T ES 2760917 T3 ES2760917 T3 ES 2760917T3

Authority

ES

Spain

Prior art keywords

patient

dpp

combination

inhibitor

tcf7l2

Prior art date

2009-11-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

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• 229960002397 linagliptin Drugs 0.000 title claims abstract description 186
• 238000011282 treatment Methods 0.000 title claims abstract description 157
• 239000003112 inhibitor Substances 0.000 title claims description 38
• 206010012601 diabetes mellitus Diseases 0.000 title description 59
• 108010067722 Dipeptidyl Peptidase 4 Proteins 0.000 title description 34
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• 239000003472 antidiabetic agent Substances 0.000 claims abstract description 159
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• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims abstract description 152
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