ES2148136T3 - Nuevos conjugados de proteina-polication. - Google Patents

Nuevos conjugados de proteina-polication.

Info

Publication number
ES2148136T3
ES2148136T3 ES90104700T ES90104700T ES2148136T3 ES 2148136 T3 ES2148136 T3 ES 2148136T3 ES 90104700 T ES90104700 T ES 90104700T ES 90104700 T ES90104700 T ES 90104700T ES 2148136 T3 ES2148136 T3 ES 2148136T3
Authority
ES
Spain
Prior art keywords
cell
transferrin
nucleic acids
complex
polication
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90104700T
Other languages
English (en)
Inventor
Hartmut Dr Beug
Max L Prof Dr Birnstiel
Matthew Dr Cotten
Ernst Dr Wagner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Boehringer Ingelheim International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Application granted granted Critical
Publication of ES2148136T3 publication Critical patent/ES2148136T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/64—General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

EL INVENTO SE REFIERE A UN SISTEMA PARA EL TRANSPORTE DE ACIDOS NUCLEICOS A LA CELULA QUE PRODUCE LA ENDOZITOSIS POR MEDIOS DE RECEPTORES. CON AYUDA DE UNOS CONJUGADOS DE POLICATION/TRANSFERINA PUEDE FORMARSE UN COMPLEJO CON EL ACIDO NUCLEICO POLIANIONICO. EL COMPLEJO QUE SE REGULA EN EL RECEPTOR DE TRANSFERSAS, SE UNE CON CELULAS CRECIENTES Y SE ABSORBE EN LA CELULA. COMO ACIDOS NUCLEICOS SE UTILIZAN LOS COMPONENTES QUE INHIBEN EL GEN ESPECIFICO O LA FUNCION RNA QUE SON OLIGONUCLEOTICO-ANTIDALLE O RIBOZIMA QUE CODIFICA EL GEN. OTRO OBJETO DEL INVENTO ES UN PROCEDIMIENTO PARA INTRODUCIR ACIDOS NUCLEICOS EN LA CELULA. ASI MISMO EL INVENTO TRATA DE UN COMPLEJO DE ACIDO NUCLEICO POLICATION/TRANSFERINADA Y ADEMAS DESCRIBE EL INVENTO UN PREPARADO FARMACEUTICO CONTENIENDO EL COMPLEJO NUCLEICO/POLICATION Y TRANSFERINASA.
ES90104700T 1989-03-16 1990-03-13 Nuevos conjugados de proteina-polication. Expired - Lifetime ES2148136T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT61089 1989-03-16

Publications (1)

Publication Number Publication Date
ES2148136T3 true ES2148136T3 (es) 2000-10-16

Family

ID=3495147

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90104700T Expired - Lifetime ES2148136T3 (es) 1989-03-16 1990-03-13 Nuevos conjugados de proteina-polication.

Country Status (20)

Country Link
US (2) US5354844A (es)
EP (1) EP0388758B1 (es)
JP (1) JP3138461B2 (es)
KR (1) KR0178022B1 (es)
AT (1) ATE195144T1 (es)
AU (1) AU637085B2 (es)
CA (1) CA2012311C (es)
DD (1) DD297842A5 (es)
DE (1) DE59010910D1 (es)
DK (1) DK0388758T3 (es)
ES (1) ES2148136T3 (es)
FI (1) FI105485B (es)
GR (1) GR3034717T3 (es)
HU (2) HU218716B (es)
IL (1) IL93755A (es)
NO (1) NO301932B1 (es)
NZ (1) NZ232918A (es)
PT (1) PT93441B (es)
RU (2) RU2098487C1 (es)
ZA (1) ZA901974B (es)

Families Citing this family (396)

* Cited by examiner, † Cited by third party
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