ES2117070T3 - Derivados de acido quinolilmetoxi-fenilacetico y de quinolilmetoxi-bencilacilo sustituidos en la posicion 2, procedimientos para su preparacion y su uso como inhibidores de la sintesis de leucotrienos. - Google Patents

Derivados de acido quinolilmetoxi-fenilacetico y de quinolilmetoxi-bencilacilo sustituidos en la posicion 2, procedimientos para su preparacion y su uso como inhibidores de la sintesis de leucotrienos.

Info

Publication number
ES2117070T3
ES2117070T3 ES93112154T ES93112154T ES2117070T3 ES 2117070 T3 ES2117070 T3 ES 2117070T3 ES 93112154 T ES93112154 T ES 93112154T ES 93112154 T ES93112154 T ES 93112154T ES 2117070 T3 ES2117070 T3 ES 2117070T3
Authority
ES
Spain
Prior art keywords
carbon atoms
chain
straight
hydroxyl
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93112154T
Other languages
English (en)
Inventor
Michael Dr Matzke
Klaus-Helmut Dr Mohrs
Siegfried Dr Raddatz
Romanis Dr Fruchmann
Rainer Prof Muller-Peddinghaus
Armin Dr Hatzelmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of ES2117070T3 publication Critical patent/ES2117070T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Abstract

DERIVADO QUINOLILOMETOXI-ACIDO FENILACETICO 2-SUBSTITUIDO DE FORMULA (I) Y SUS SALES , EN LA QUE ; A,B,D,E,G Y L IGUALES O DIFERENTES , HIDROGENO, HIDROXI, HALOGENO, CIANO, CARBOXI, NITRO , TRIFLUOROMETILO, TRIFLUOROMETOXI O ALQUILO O ALCOXI DE CADENA RECTA O RAMIFICADA DE C 8 O ARILO DE C 6 A 10 SUBSTITUIDO A TRAVES DE HALOGENO, HIDROXI,NITRO O CIANO ; R(1) HALOGENO, CIANO , NITRO , ACIDO , HIDROXI, CARBOXI, TRIFLUOROMETILTIO O ALQUENILO O ALQUINILO DE CADENA RECTA O RAMIFICADA DE C 8 QUE ESTA SUBSTITUIDO A TRAVES DE FENILO O CICLOALQUILO DE C 3 A 8 O CICLOALQUILO DE C 3 A 8 O FENILO O ALCOXI O ALCOXICARBONILO DE CADENA RECTA O RAMIFICADA DE HASTA SEIS CARBONOS ;R(2) HIDROGENO O ALQUILO DE CADENA RECTA O RAMIFICADA DE HASTA SEIS CARBONOS O CICLOALQUILO DE C 3 A 12 ; R(3) HIDROXI , ALCOXI DE CADENA RECTA O RAMIFICADA DE HASTA 8 CARBONOS O UN GRUPO DE FORMULA -NR(4)SO(2)R(5) O -NR(6)R(7) ;R(4), R(6) Y R(7) IGUALES O DIFERENTES HIDROGENO , ALQUILO DE CADENA RECTA O RAMIFICADA DE HASTA SEIS ATOMOS DE CARBONO, FENILO O BENCILO Y R85) TRIFLUROMETILO O FENILO QUE ESTA SUBSTITUIDO A TRAVES DE HALOGENO ,CIANO ,HIDROXI , NITRO , TRIFLUOROMETOXI ,TRIFLUOROMETILTIO O A TRAVES DE ALQUILO O ALCOXI DE CADENA RECTA O RAMIFICADA DE HASTA SEIS ATOMOS DE CARBONO ALQUILO DE CADENA RECTA O RAMIFICADA DE HASTA SEIS ATOMOS DE CARBONO QUE ESTA SUBSTITUIDA A TRAVES DE FENILO QUE PUEDE SER SUBSTITUIDO A TRAVES DE HALOGENO, CIANO , NITRO , TRIFLUOROMETILO, TRIFLUOROMETOXI, TRIFLUOROMETILTIO, HIDROXI O ALQUILO O ALCOXI DE CADENA RECTA O RAMIFICADA DE HASTA SEIS ATOMOS DE CARBONO. DERIVADOS DE QUINOLILOMETOXI-ACIDO FENILACETICO SE PRODUCEN A TRAVES DE LA TRANSFORMACION DE FENOLES SUBSTITUIDOS CORRESPONDIENTES CON HALOGENUROS DE QUINOLILOMETOXI O A TRAVES DE LA TRANSFORMACION DE FENOLES NO SUBSTITUIDOS CON HALOGENUROS DE QUINOLILOMETOXI-ACIDO FENILACETICO Y A CONTINUACION ALQUILACION. LOS DERIVADOS DE QUINOLILOMETOXI-ACIDO FENILACETICO PUEDEN EMPLEARSE COMO SUBSTANCIAS ACTIVAS EN MEDICAMENTOS. LA SUBSTANCIA ACTIVA PUEDE ACTUAR COMO INHIBIDOR DE LAS REACCIONES ENZIMATICAS EN EL MARCO DEL INTERCAMBIO DE MATERIA DEL ACIDO ARAQUINODINICO PARTICULARMENTE LA LIPOXIGENASA
ES93112154T 1992-08-11 1993-07-29 Derivados de acido quinolilmetoxi-fenilacetico y de quinolilmetoxi-bencilacilo sustituidos en la posicion 2, procedimientos para su preparacion y su uso como inhibidores de la sintesis de leucotrienos. Expired - Lifetime ES2117070T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4226519A DE4226519A1 (de) 1992-08-11 1992-08-11 3-Substituierte Chinolylmethoxy-phenylessigsäurederivate

Publications (1)

Publication Number Publication Date
ES2117070T3 true ES2117070T3 (es) 1998-08-01

Family

ID=6465285

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93112154T Expired - Lifetime ES2117070T3 (es) 1992-08-11 1993-07-29 Derivados de acido quinolilmetoxi-fenilacetico y de quinolilmetoxi-bencilacilo sustituidos en la posicion 2, procedimientos para su preparacion y su uso como inhibidores de la sintesis de leucotrienos.

Country Status (22)

Country Link
US (1) US5597833A (es)
EP (1) EP0582908B1 (es)
JP (1) JPH06157463A (es)
KR (1) KR940003936A (es)
CN (1) CN1087337A (es)
AT (1) ATE166645T1 (es)
AU (1) AU668574B2 (es)
CA (1) CA2103521A1 (es)
CZ (1) CZ151193A3 (es)
DE (2) DE4226519A1 (es)
DK (1) DK0582908T3 (es)
ES (1) ES2117070T3 (es)
FI (1) FI933512A (es)
HU (1) HUT70041A (es)
IL (1) IL106622A (es)
MX (1) MX9304582A (es)
MY (1) MY108877A (es)
NO (1) NO179513C (es)
NZ (1) NZ248343A (es)
PL (1) PL300026A1 (es)
SK (1) SK86593A3 (es)
ZA (1) ZA935795B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4443891A1 (de) 1994-12-09 1996-06-13 Bayer Ag Heterocyclisch substituierte Oxy-phenyl-(phenyl)glycinolamide
DE4443892A1 (de) * 1994-12-09 1996-06-13 Bayer Ag 4-(Chinolin-2-yl-methoxy)-phenyl-essigsäurederivate
US6069151A (en) * 1996-11-06 2000-05-30 Darwin Discovery, Ltd. Quinolines and their therapeutic use
GB2356139A (en) * 1999-11-15 2001-05-16 Bayer Ag Use of substituted (quinolin-2-yl-methoxy)phenyl-acyl-sulphonamides and cyanamides for the treatment of diseases
BRPI0417543A (pt) 2003-12-12 2007-03-27 Wyeth Corp quinolinas úteis no tratamento de doença cardiovascular
TW200740435A (en) * 2005-08-10 2007-11-01 Takeda Pharmaceuticals Co Therapeutic agent for diabetes
JP2010511632A (ja) 2006-11-30 2010-04-15 アミラ ファーマシューティカルス，インコーポレーテッド ５−リポキシゲナーゼ活性化タンパク質インヒビターおよび一酸化窒素モジュレーターを含んでいる組成物および治療法
WO2015120038A1 (en) 2014-02-04 2015-08-13 Bioscience Pharma Partners, Llc Use of flap inhibitors to reduce neuroinflammation mediated injury in the central nervous system

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3814504A1 (de) * 1988-04-29 1989-11-09 Bayer Ag (alpha)-substituierte 4-(chinolin-2-yl-methoxy)phenylessigsaeuren und -ester, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
DE3900261A1 (de) * 1988-05-31 1989-12-07 Bayer Ag Substituierte 4-(chinolin-2-yl-methoxy) phenyl-essigsaeure-derivate
US5232916A (en) * 1988-06-27 1993-08-03 Merck Frosst Canada, Inc. Quinoline ether alkanoic acids
DE3916663A1 (de) * 1989-05-23 1990-11-29 Bayer Ag Substituierte (chinolin-2-yl-methoxy)phenyl-acyl-sulfonamide und -cyanamide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
JPH0742488Y2 (ja) * 1989-05-23 1995-10-04 川崎重工業株式会社 移動床型脱じん・反応装置
DE3927369A1 (de) * 1989-08-19 1991-02-21 Bayer Ag Substituierte n-(chinolin-2-yl-methoxy)benzyl-sulfonyl-harnstoffe
DE3927931A1 (de) * 1989-08-24 1991-02-28 Bayer Ag Disubstituierte (chinolin-2-yl-methoxy)phenylessigsaeure-derivate
DE3927930A1 (de) * 1989-08-24 1991-02-28 Bayer Ag Cyclisch substituierte (chinolin-2-yl-methoxy)phenyl-essig-saeure-derivate
US5304563A (en) * 1991-02-22 1994-04-19 Bayer Aktiengesellschaft 2-substituted quinolines, and their use in medicaments
DE4125270A1 (de) * 1991-07-31 1993-02-04 Bayer Ag Chinolin-2-yl-methoxybenzylhydroxyharnstoffe
DE4139749A1 (de) * 1991-12-03 1993-06-09 Bayer Ag, 5090 Leverkusen, De Chinolylmethoxyphenyl-essigsaeureamide
US5358955A (en) * 1992-10-30 1994-10-25 Abbott Laboratories Aryl and heteroarylmethoxyphenyl inhibitors of leukotriene biosynthesis

Also Published As

Publication number Publication date
NO932709D0 (no) 1993-07-27
EP0582908A1 (de) 1994-02-16
DE59308603D1 (de) 1998-07-02
KR940003936A (ko) 1994-03-14
CN1087337A (zh) 1994-06-01
DE4226519A1 (de) 1994-02-17
SK86593A3 (en) 1994-06-08
JPH06157463A (ja) 1994-06-03
CZ151193A3 (en) 1994-03-16
ZA935795B (en) 1994-03-07
HU9302313D0 (en) 1993-10-28
AU668574B2 (en) 1996-05-09
PL300026A1 (en) 1994-03-21
FI933512A (fi) 1994-02-12
MX9304582A (es) 1994-02-28
NO932709L (no) 1994-02-14
DK0582908T3 (da) 1999-01-18
CA2103521A1 (en) 1994-02-12
MY108877A (en) 1996-11-30
NZ248343A (en) 1995-03-28
EP0582908B1 (de) 1998-05-27
FI933512A0 (fi) 1993-08-09
AU4425393A (en) 1994-02-17
IL106622A (en) 1997-02-18
NO179513C (no) 1996-10-23
HUT70041A (en) 1995-09-28
US5597833A (en) 1997-01-28
IL106622A0 (en) 1993-12-08
ATE166645T1 (de) 1998-06-15
NO179513B (no) 1996-07-15

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