IL106622A - Substituted quinol-2-yl-methoxy-phenylacetic acid derivatives their preparation and pharmaceutical compositions containing them - Google Patents
Substituted quinol-2-yl-methoxy-phenylacetic acid derivatives their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL106622A IL106622A IL10662293A IL10662293A IL106622A IL 106622 A IL106622 A IL 106622A IL 10662293 A IL10662293 A IL 10662293A IL 10662293 A IL10662293 A IL 10662293A IL 106622 A IL106622 A IL 106622A
- Authority
- IL
- Israel
- Prior art keywords
- carbon atoms
- chain
- straight
- hydroxyl
- phenyl
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 13
- -1 2-Substituted quinolylmethoxyphenylacetic acid Chemical class 0.000 abstract 7
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 6
- 125000003545 alkoxy group Chemical group 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 5
- 150000002367 halogens Chemical class 0.000 abstract 5
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 5
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 5
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 4
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 150000004820 halides Chemical class 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 150000002989 phenols Chemical class 0.000 abstract 2
- 125000005034 trifluormethylthio group Chemical group FC(S*)(F)F 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 102000003820 Lipoxygenases Human genes 0.000 abstract 1
- 108090000128 Lipoxygenases Proteins 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 229940114079 arachidonic acid Drugs 0.000 abstract 1
- 235000021342 arachidonic acid Nutrition 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000006911 enzymatic reaction Methods 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000004060 metabolic process Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4226519A DE4226519A1 (de) | 1992-08-11 | 1992-08-11 | 3-Substituierte Chinolylmethoxy-phenylessigsäurederivate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL106622A0 IL106622A0 (en) | 1993-12-08 |
| IL106622A true IL106622A (en) | 1997-02-18 |
Family
ID=6465285
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL10662293A IL106622A (en) | 1992-08-11 | 1993-08-09 | Substituted quinol-2-yl-methoxy-phenylacetic acid derivatives their preparation and pharmaceutical compositions containing them |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5597833A (es) |
| EP (1) | EP0582908B1 (es) |
| JP (1) | JPH06157463A (es) |
| KR (1) | KR940003936A (es) |
| CN (1) | CN1087337A (es) |
| AT (1) | ATE166645T1 (es) |
| AU (1) | AU668574B2 (es) |
| CA (1) | CA2103521A1 (es) |
| CZ (1) | CZ151193A3 (es) |
| DE (2) | DE4226519A1 (es) |
| DK (1) | DK0582908T3 (es) |
| ES (1) | ES2117070T3 (es) |
| FI (1) | FI933512A7 (es) |
| HU (1) | HUT70041A (es) |
| IL (1) | IL106622A (es) |
| MX (1) | MX9304582A (es) |
| MY (1) | MY108877A (es) |
| NO (1) | NO179513C (es) |
| NZ (1) | NZ248343A (es) |
| PL (1) | PL300026A1 (es) |
| SK (1) | SK86593A3 (es) |
| ZA (1) | ZA935795B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4443892A1 (de) * | 1994-12-09 | 1996-06-13 | Bayer Ag | 4-(Chinolin-2-yl-methoxy)-phenyl-essigsäurederivate |
| DE4443891A1 (de) | 1994-12-09 | 1996-06-13 | Bayer Ag | Heterocyclisch substituierte Oxy-phenyl-(phenyl)glycinolamide |
| US6069151A (en) * | 1996-11-06 | 2000-05-30 | Darwin Discovery, Ltd. | Quinolines and their therapeutic use |
| GB2356139A (en) * | 1999-11-15 | 2001-05-16 | Bayer Ag | Use of substituted (quinolin-2-yl-methoxy)phenyl-acyl-sulphonamides and cyanamides for the treatment of diseases |
| EP2284157A1 (en) | 2003-12-12 | 2011-02-16 | Wyeth | Quinolines useful in treating cardiovascular disease |
| CA2617969A1 (en) * | 2005-08-10 | 2007-02-15 | Takeda Pharmaceutical Company Limited | Therapeutic agent for diabetes |
| JP2010511632A (ja) | 2006-11-30 | 2010-04-15 | アミラ ファーマシューティカルス，インコーポレーテッド | ５−リポキシゲナーゼ活性化タンパク質インヒビターおよび一酸化窒素モジュレーターを含んでいる組成物および治療法 |
| ES2878405T3 (es) | 2014-02-04 | 2021-11-18 | Bioscience Pharma Partners Llc | Uso de inhibidores de flap para reducir la lesión mediada por neuroinflamación en el sistema nervioso central |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3814504A1 (de) * | 1988-04-29 | 1989-11-09 | Bayer Ag | (alpha)-substituierte 4-(chinolin-2-yl-methoxy)phenylessigsaeuren und -ester, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
| DE3900261A1 (de) * | 1988-05-31 | 1989-12-07 | Bayer Ag | Substituierte 4-(chinolin-2-yl-methoxy) phenyl-essigsaeure-derivate |
| US5232916A (en) * | 1988-06-27 | 1993-08-03 | Merck Frosst Canada, Inc. | Quinoline ether alkanoic acids |
| DE3916663A1 (de) * | 1989-05-23 | 1990-11-29 | Bayer Ag | Substituierte (chinolin-2-yl-methoxy)phenyl-acyl-sulfonamide und -cyanamide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
| JPH0742488Y2 (ja) * | 1989-05-23 | 1995-10-04 | 川崎重工業株式会社 | 移動床型脱じん・反応装置 |
| DE3927369A1 (de) * | 1989-08-19 | 1991-02-21 | Bayer Ag | Substituierte n-(chinolin-2-yl-methoxy)benzyl-sulfonyl-harnstoffe |
| DE3927930A1 (de) * | 1989-08-24 | 1991-02-28 | Bayer Ag | Cyclisch substituierte (chinolin-2-yl-methoxy)phenyl-essig-saeure-derivate |
| DE3927931A1 (de) * | 1989-08-24 | 1991-02-28 | Bayer Ag | Disubstituierte (chinolin-2-yl-methoxy)phenylessigsaeure-derivate |
| US5304563A (en) * | 1991-02-22 | 1994-04-19 | Bayer Aktiengesellschaft | 2-substituted quinolines, and their use in medicaments |
| DE4125270A1 (de) * | 1991-07-31 | 1993-02-04 | Bayer Ag | Chinolin-2-yl-methoxybenzylhydroxyharnstoffe |
| DE4139749A1 (de) * | 1991-12-03 | 1993-06-09 | Bayer Ag, 5090 Leverkusen, De | Chinolylmethoxyphenyl-essigsaeureamide |
| US5358955A (en) * | 1992-10-30 | 1994-10-25 | Abbott Laboratories | Aryl and heteroarylmethoxyphenyl inhibitors of leukotriene biosynthesis |
-
1992
- 1992-08-11 DE DE4226519A patent/DE4226519A1/de not_active Withdrawn
-
1993
- 1993-07-26 CZ CZ931511A patent/CZ151193A3/cs unknown
- 1993-07-27 NO NO932709A patent/NO179513C/no unknown
- 1993-07-28 AU AU44253/93A patent/AU668574B2/en not_active Ceased
- 1993-07-29 MX MX9304582A patent/MX9304582A/es unknown
- 1993-07-29 EP EP93112154A patent/EP0582908B1/de not_active Expired - Lifetime
- 1993-07-29 DK DK93112154T patent/DK0582908T3/da active
- 1993-07-29 DE DE59308603T patent/DE59308603D1/de not_active Expired - Fee Related
- 1993-07-29 ES ES93112154T patent/ES2117070T3/es not_active Expired - Lifetime
- 1993-07-29 AT AT93112154T patent/ATE166645T1/de not_active IP Right Cessation
- 1993-08-04 US US08/102,453 patent/US5597833A/en not_active Expired - Fee Related
- 1993-08-06 CA CA002103521A patent/CA2103521A1/en not_active Abandoned
- 1993-08-06 JP JP5213596A patent/JPH06157463A/ja active Pending
- 1993-08-06 NZ NZ248343A patent/NZ248343A/en unknown
- 1993-08-09 IL IL10662293A patent/IL106622A/xx not_active IP Right Cessation
- 1993-08-09 FI FI933512A patent/FI933512A7/fi not_active Application Discontinuation
- 1993-08-10 HU HU9302313A patent/HUT70041A/hu unknown
- 1993-08-10 MY MYPI93001591A patent/MY108877A/en unknown
- 1993-08-10 ZA ZA935795A patent/ZA935795B/xx unknown
- 1993-08-10 PL PL93300026A patent/PL300026A1/xx unknown
- 1993-08-10 KR KR1019930015467A patent/KR940003936A/ko not_active Withdrawn
- 1993-08-10 SK SK865-93A patent/SK86593A3/sk unknown
- 1993-08-11 CN CN93108822A patent/CN1087337A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| NO932709L (no) | 1994-02-14 |
| EP0582908B1 (de) | 1998-05-27 |
| AU4425393A (en) | 1994-02-17 |
| ATE166645T1 (de) | 1998-06-15 |
| NO179513B (no) | 1996-07-15 |
| HUT70041A (en) | 1995-09-28 |
| IL106622A0 (en) | 1993-12-08 |
| CZ151193A3 (en) | 1994-03-16 |
| NZ248343A (en) | 1995-03-28 |
| KR940003936A (ko) | 1994-03-14 |
| CN1087337A (zh) | 1994-06-01 |
| AU668574B2 (en) | 1996-05-09 |
| PL300026A1 (en) | 1994-03-21 |
| MX9304582A (es) | 1994-02-28 |
| HU9302313D0 (en) | 1993-10-28 |
| MY108877A (en) | 1996-11-30 |
| JPH06157463A (ja) | 1994-06-03 |
| EP0582908A1 (de) | 1994-02-16 |
| FI933512A7 (fi) | 1994-02-12 |
| NO932709D0 (no) | 1993-07-27 |
| NO179513C (no) | 1996-10-23 |
| FI933512A0 (fi) | 1993-08-09 |
| DK0582908T3 (da) | 1999-01-18 |
| CA2103521A1 (en) | 1994-02-12 |
| US5597833A (en) | 1997-01-28 |
| DE4226519A1 (de) | 1994-02-17 |
| DE59308603D1 (de) | 1998-07-02 |
| ZA935795B (en) | 1994-03-07 |
| ES2117070T3 (es) | 1998-08-01 |
| SK86593A3 (en) | 1994-06-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| RH | Patent void |