ES2625636T3 - Proceso para preparar inhibidores del metabolismo de nucleósidos - Google Patents

Proceso para preparar inhibidores del metabolismo de nucleósidos Download PDF

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Publication number
ES2625636T3
ES2625636T3 ES09150953.9T ES09150953T ES2625636T3 ES 2625636 T3 ES2625636 T3 ES 2625636T3 ES 09150953 T ES09150953 T ES 09150953T ES 2625636 T3 ES2625636 T3 ES 2625636T3
Authority
ES
Spain
Prior art keywords
compound
pyrrolo
pyrimidin
amino
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES09150953.9T
Other languages
English (en)
Inventor
Richard Hubert Furneaux
Peter Charles Tyler
Vern L. Schramm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Victoria Link Ltd
Albert Einstein College of Medicine
Original Assignee
Victoria Link Ltd
Albert Einstein College of Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Victoria Link Ltd, Albert Einstein College of Medicine filed Critical Victoria Link Ltd
Application granted granted Critical
Publication of ES2625636T3 publication Critical patent/ES2625636T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Compuesto de la fórmula:**Fórmula** en donde Y es un grupo alquilo o arilalquilo sustituido o no sustituido que tiene de 1 a 8 átomos de carbono.

Description

imagen1
imagen2
imagen3
imagen4

Claims (1)

  1. imagen1
ES09150953.9T 1999-04-08 2000-04-07 Proceso para preparar inhibidores del metabolismo de nucleósidos Expired - Lifetime ES2625636T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
NZ33509099 1999-04-08
NZ33509099 1999-04-08
NZ33616899 1999-06-08
NZ33616899 1999-06-08

Publications (1)

Publication Number Publication Date
ES2625636T3 true ES2625636T3 (es) 2017-07-20

Family

ID=26652045

Family Applications (2)

Application Number Title Priority Date Filing Date
ES00917509T Expired - Lifetime ES2324016T3 (es) 1999-04-08 2000-04-07 Procedimiento para preparar inhibidores del metabolismo de nucleosidos.
ES09150953.9T Expired - Lifetime ES2625636T3 (es) 1999-04-08 2000-04-07 Proceso para preparar inhibidores del metabolismo de nucleósidos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES00917509T Expired - Lifetime ES2324016T3 (es) 1999-04-08 2000-04-07 Procedimiento para preparar inhibidores del metabolismo de nucleosidos.

Country Status (18)

Country Link
US (4) US6693193B1 (es)
EP (2) EP2077268B1 (es)
JP (2) JP4430247B2 (es)
KR (1) KR100755110B1 (es)
CN (2) CN101062928B (es)
AT (1) ATE425165T1 (es)
AU (1) AU776540C (es)
CA (3) CA2368095C (es)
CY (2) CY1109103T1 (es)
DE (1) DE60041757D1 (es)
DK (2) DK2077268T5 (es)
ES (2) ES2324016T3 (es)
HK (2) HK1116472A1 (es)
LT (1) LT2077268T (es)
NZ (1) NZ514660A (es)
PT (2) PT2077268T (es)
SI (2) SI1165564T1 (es)
WO (1) WO2000061783A2 (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5985848A (en) * 1997-10-14 1999-11-16 Albert Einstein College Of Medicine Of Yeshiva University Inhibitors of nucleoside metabolism
ATE425165T1 (de) * 1999-04-08 2009-03-15 Ind Res Ltd Verfahren zur zubereitung von inhibitoren des nukleosid-metabolismus
US7109331B2 (en) * 2000-08-29 2006-09-19 Industrial Research Limited 5H-pyrrolo[3,2-d]pyrimidine nucleoside metabolism inhibitors
US7098334B2 (en) * 2002-03-25 2006-08-29 Industrial Research Limited 4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases
SI1539783T1 (sl) 2002-08-21 2011-08-31 Einstein Coll Med Inhibitorji nukleozidnih fosforilaz in nukleozidaz
NZ523970A (en) * 2003-02-04 2005-02-25 Ind Res Ltd Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases
US6972331B2 (en) 2003-04-23 2005-12-06 Biocryst Pharmaceuticals, Inc. Carboxy pyrrole, process of preparing and use as precursor
US8017634B2 (en) 2003-12-29 2011-09-13 President And Fellows Of Harvard College Compositions for treating obesity and insulin resistance disorders
NZ533360A (en) * 2004-06-04 2007-02-23 Ind Res Ltd Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds
NZ540160A (en) * 2005-05-20 2008-03-28 Einstein Coll Med Inhibitors of nucleoside phosphorylases
US8541567B2 (en) * 2005-07-27 2013-09-24 Albert Einstein College Of Medicine Of Yeshiva University Transition state structure of 5′-methylthioadenosine/s-adenosylhomocysteine nucleosidases
NZ544187A (en) * 2005-12-15 2008-07-31 Ind Res Ltd Deazapurine analogs of 1'-aza-l-nucleosides
WO2007097643A1 (en) * 2006-02-22 2007-08-30 Industrial Research Limited Analogues of coformycin and their use for treating protozoan parasite infections
US8916571B2 (en) * 2006-02-24 2014-12-23 Albert Einstein College Of Medicine Of Yeshiva University Methods of treating cancer using inhibitors of 5′-methylthioadenosine phosphorylase
WO2007097648A1 (en) * 2006-02-24 2007-08-30 Industrial Research Limited Methods of treating diseases using inhibitors of nucleoside phosphorylases and nucleosidases
CN101094080B (zh) * 2006-06-22 2012-06-20 华为技术有限公司 一种即按即通系统中的计费方法
CA2662626C (en) 2006-09-07 2016-07-26 Industrial Research Limited Acyclic amine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase
AU2007293774C1 (en) 2006-09-07 2014-12-18 Albert Einstein College Of Medicine, Inc. Acyclic amine inhibitors of nucleoside phosphorylases and hydrolases
KR20090101278A (ko) 2006-12-22 2009-09-24 인더스트리얼 리서치 리미티드 누클레오시다제 및 포스포릴라제 억제제의 아제티딘 유사체
US11969501B2 (en) 2008-04-21 2024-04-30 Dompé Farmaceutici S.P.A. Auris formulations for treating otic diseases and conditions
KR20210107137A (ko) 2008-04-21 2021-08-31 오토노미, 인코포레이티드 귀 질환 및 병태를 치료하기 위한 귀 조제물
US8784870B2 (en) 2008-07-21 2014-07-22 Otonomy, Inc. Controlled release compositions for modulating free-radical induced damage and methods of use thereof
WO2010033236A2 (en) * 2008-09-22 2010-03-25 Albert Einstein College Of Medicine Of Yeshiva University Methods and compositions for treating bacterial infections by inhibiting quorum sensing
US9493465B2 (en) 2009-07-17 2016-11-15 Victoria Link Limited 3-hydroxypyrrolidine inhibitors of 5′-methylthioadenosine phosphorylase and nucleosidase
WO2012074912A1 (en) 2010-11-29 2012-06-07 Albert Einstein College Of Medicine Of Yeshiva University Methods, assays and compounds for treating bacterial infections by inhibiting methylthioinosine phosphorylase
US20130338178A1 (en) 2011-02-02 2013-12-19 The Trustees Of Princeton University Sirtuin modulators as inhibitors of cytomegalovirus
EP2875359A4 (en) 2012-03-30 2015-08-19 Charles R Drew University Of Medicine And Science COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING METABOLISM SYNDROME DISEASES
AR090699A1 (es) * 2012-04-18 2014-12-03 Biocryst Pharm Inc Compuestos inhibidores de la actividad de la arn polimerasa viral
CA3029281A1 (en) 2016-06-29 2018-01-04 Otonomy, Inc. Triglyceride otic formulations and uses thereof
US11114184B2 (en) 2017-02-21 2021-09-07 Albert Einstein College Of Medicine DNA methyltransferase 1 transition state structure and uses thereof
CN110590786B (zh) * 2019-09-29 2021-12-03 上海大学 9-去氮鸟嘌呤合成工艺的改进方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994011234A1 (de) * 1992-11-06 1994-05-26 Ulrich Rindlisbacher Vorrichtung zum befestigen an einem gestell eines zweiradfahrzeugs
IL107616A0 (en) 1992-11-18 1994-02-27 Univ Johns Hopkins Formation of triple helix complexes of single stranded nucleic acids using nucleoside oligomers which comprise pyrimidine analogs
AU1739097A (en) 1996-02-23 1997-09-10 Albert Einstein College Of Medicine Of Yeshiva University Enzyme detection/assay method and substrates
US5985848A (en) 1997-10-14 1999-11-16 Albert Einstein College Of Medicine Of Yeshiva University Inhibitors of nucleoside metabolism
US6187777B1 (en) * 1998-02-06 2001-02-13 Amgen Inc. Compounds and methods which modulate feeding behavior and related diseases
ATE425165T1 (de) 1999-04-08 2009-03-15 Ind Res Ltd Verfahren zur zubereitung von inhibitoren des nukleosid-metabolismus
US6448799B1 (en) * 1999-09-30 2002-09-10 Hitachi Electronics Engineering Co., Ltd. Timing adjustment method and apparatus for semiconductor IC tester
US7109331B2 (en) 2000-08-29 2006-09-19 Industrial Research Limited 5H-pyrrolo[3,2-d]pyrimidine nucleoside metabolism inhibitors
US6458799B1 (en) 2000-08-31 2002-10-01 Biocryst Pharmaceuticals, Inc. Deazaguanine analog, preparation thereof and use thereof
US7098334B2 (en) 2002-03-25 2006-08-29 Industrial Research Limited 4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases
SI1539783T1 (sl) 2002-08-21 2011-08-31 Einstein Coll Med Inhibitorji nukleozidnih fosforilaz in nukleozidaz
NZ523970A (en) 2003-02-04 2005-02-25 Ind Res Ltd Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases
NZ533360A (en) 2004-06-04 2007-02-23 Ind Res Ltd Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds
JP2008508287A (ja) 2004-07-27 2008-03-21 バイオクリスト・フアーマシユーテイカルズ・インコーポレイテツド ５’−メチルチオアデノシンホスホリラーゼ及び５’メチルチオアデノシン／ｓ−アデノシルホモシステインヌクレオシダーゼの阻害剤
NZ540160A (en) 2005-05-20 2008-03-28 Einstein Coll Med Inhibitors of nucleoside phosphorylases
NZ544187A (en) 2005-12-15 2008-07-31 Ind Res Ltd Deazapurine analogs of 1'-aza-l-nucleosides
US8916571B2 (en) 2006-02-24 2014-12-23 Albert Einstein College Of Medicine Of Yeshiva University Methods of treating cancer using inhibitors of 5′-methylthioadenosine phosphorylase
WO2007097648A1 (en) 2006-02-24 2007-08-30 Industrial Research Limited Methods of treating diseases using inhibitors of nucleoside phosphorylases and nucleosidases

Also Published As

Publication number Publication date
JP2009173673A (ja) 2009-08-06
CY1119099T1 (el) 2018-02-14
US20060089498A1 (en) 2006-04-27
KR20020018658A (ko) 2002-03-08
CN1370171A (zh) 2002-09-18
CA2368095A1 (en) 2000-10-19
US7405297B2 (en) 2008-07-29
US7211677B2 (en) 2007-05-01
CA2696826A1 (en) 2000-10-19
CA2634299A1 (en) 2000-10-19
CN101062928B (zh) 2010-10-06
CN1196704C (zh) 2005-04-13
ATE425165T1 (de) 2009-03-15
DK2077268T5 (en) 2017-08-28
EP2077268A1 (en) 2009-07-08
EP1165564B1 (en) 2009-03-11
HK1116472A1 (en) 2008-12-24
EP1165564A2 (en) 2002-01-02
JP2002542170A (ja) 2002-12-10
US20040181063A1 (en) 2004-09-16
US7022852B2 (en) 2006-04-04
HK1088310A1 (en) 2006-11-03
DK2077268T3 (en) 2017-06-06
JP4430247B2 (ja) 2010-03-10
AU776540B2 (en) 2004-09-16
AU776540C (en) 2006-01-05
CY1109103T1 (el) 2014-07-02
CA2368095C (en) 2009-10-06
PT2077268T (pt) 2017-06-12
EP2077268B1 (en) 2017-03-01
DE60041757D1 (de) 2009-04-23
PT1165564E (pt) 2009-04-16
US20070161667A1 (en) 2007-07-12
KR100755110B1 (ko) 2007-09-04
AU3846900A (en) 2000-11-14
WO2000061783A2 (en) 2000-10-19
DK1165564T3 (da) 2009-06-08
CA2696826C (en) 2013-01-08
NZ514660A (en) 2004-03-26
CN101062928A (zh) 2007-10-31
SI2077268T1 (sl) 2017-07-31
ES2324016T3 (es) 2009-07-29
US6693193B1 (en) 2004-02-17
WO2000061783A3 (en) 2001-02-08
EP1165564A4 (en) 2003-01-22
SI1165564T1 (sl) 2009-08-31
JP5070237B2 (ja) 2012-11-07
CA2634299C (en) 2011-05-31
LT2077268T (lt) 2017-08-10

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