ES2138535A1 - Procedimiento para la preparacion de los compuestos antivirales penciclovir y famciclovir. - Google Patents

Procedimiento para la preparacion de los compuestos antivirales penciclovir y famciclovir.

Info

Publication number
ES2138535A1
ES2138535A1 ES009701613A ES9701613A ES2138535A1 ES 2138535 A1 ES2138535 A1 ES 2138535A1 ES 009701613 A ES009701613 A ES 009701613A ES 9701613 A ES9701613 A ES 9701613A ES 2138535 A1 ES2138535 A1 ES 2138535A1
Authority
ES
Spain
Prior art keywords
sub
penciclovir
purine
famciclovir
translation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES009701613A
Other languages
English (en)
Other versions
ES2138535B1 (es
Inventor
Victor Witold Jacewicz
David Alan Jones
Norman John Lewis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9615252.5A external-priority patent/GB9615252D0/en
Priority claimed from GBGB9615251.7A external-priority patent/GB9615251D0/en
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of ES2138535A1 publication Critical patent/ES2138535A1/es
Application granted granted Critical
Publication of ES2138535B1 publication Critical patent/ES2138535B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Procedimiento la preparación de los compuestos antivirales penciclovir y famciclovir. Un procedimiento para la preparación de penciclovir o famciclovir que comprende una o más de las siguientes etapas: a) formar una purina mediante el cierre del anillo de imidazol o pirimidina; b) hacer reaccionar una purina con un intermedio precursor de cadena lateral en posición 9 adecuado; c) convertir la cadena lateral en posición 9 en 4-hidroxi-3- hidroximetilbut-l-ilo o 4-acetoxi-3-acetoximetilbut-l-ilo d) convertir una purina en guanina o 2-aminopurina; caracterizado porque la purina tiene la fórmula (I): en la que X{sub,1 , es SH o S-Z-R{sub,3 , (Z es opcional) y es alquileno de cadena lineal o ramificada y R{sub,3 es alquilo, arilo o heteroarilo, X{sub,2 es SH, hidrógeno o un grupo que pueda convertirse en los mismos; R{sub,1 , es amino o un grupo que pueda convertirse en el mismo; y R{sub,2 , es hidrógeno o un precursor de cadena lateral en posición 9. Dicha purina de fórmula (T) se convierte enfamciclovir o penciclovir por transformaciones posteriores.
ES9701613A 1996-07-20 1997-07-18 Procedimiento para la preparacion de los compuestos antivirales penciclovir y famciclovir. Expired - Fee Related ES2138535B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9615252.5A GB9615252D0 (en) 1996-07-20 1996-07-20 Pharmaceuticals
GBGB9615251.7A GB9615251D0 (en) 1996-07-20 1996-07-20 Pharmaceuticals

Publications (2)

Publication Number Publication Date
ES2138535A1 true ES2138535A1 (es) 2000-01-01
ES2138535B1 ES2138535B1 (es) 2000-11-16

Family

ID=26309728

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9701613A Expired - Fee Related ES2138535B1 (es) 1996-07-20 1997-07-18 Procedimiento para la preparacion de los compuestos antivirales penciclovir y famciclovir.

Country Status (4)

Country Link
AT (1) AT412211B (es)
ES (1) ES2138535B1 (es)
GR (1) GR1002949B (es)
PT (1) PT102030B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4260095A (en) * 1978-08-18 1981-04-07 Smith Phillip H Method of manufacturing a clad product
US4331283A (en) * 1979-06-27 1982-05-25 Copperweld Corporation Metal cladding

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5075445A (en) * 1983-08-18 1991-12-24 Beecham Group P.L.C. Guanine derivatives

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL73682A (en) * 1983-12-20 1991-08-16 Medivir Ab Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation
EP0152316B1 (en) * 1984-01-26 1989-07-26 Merck & Co. Inc. Substituted butyl guanines and their utilization in antiviral compositions
EP0182024B1 (en) * 1984-09-20 1991-04-03 Beecham Group Plc Purine derivatives and their pharmaceutical use
SE8406538D0 (sv) * 1984-12-21 1984-12-21 Astra Laekemedel Ab Novel derivatives of purine
DE3671227D1 (de) * 1985-07-27 1990-06-21 Beecham Group Plc 9-substituierte guaninmonohydrate.
GB8817270D0 (en) * 1988-07-20 1988-08-24 Beecham Group Plc Novel process
GB8817607D0 (en) * 1988-07-23 1988-09-01 Beecham Group Plc Novel process
GB8822236D0 (en) * 1988-09-21 1988-10-26 Beecham Group Plc Chemical process
GB8922076D0 (en) * 1989-09-28 1989-11-15 Beecham Group Plc Novel process

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5075445A (en) * 1983-08-18 1991-12-24 Beecham Group P.L.C. Guanine derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GEEN G.R. et al. The Effect of the C-6 Substituent on the Regioselectivity of N-alkylation of 2-aminopurines, Tetrahedron, Vol. 46, No 19, paginas 6903-6914, 1990, resumen; introduccion; pagina 6911, compuesto 9d. *

Also Published As

Publication number Publication date
AT412211B (de) 2004-11-25
ATA122897A (de) 2004-04-15
ES2138535B1 (es) 2000-11-16
PT102030B (pt) 1999-04-30
PT102030A (pt) 1998-01-30
GR1002949B (el) 1998-07-29
MX9705479A (es) 1998-08-30

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