DE68929277T2 - Verfahren zur Herstellung von Purinderivaten - Google Patents

Verfahren zur Herstellung von Purinderivaten

Info

Publication number
DE68929277T2
DE68929277T2 DE68929277T DE68929277T DE68929277T2 DE 68929277 T2 DE68929277 T2 DE 68929277T2 DE 68929277 T DE68929277 T DE 68929277T DE 68929277 T DE68929277 T DE 68929277T DE 68929277 T2 DE68929277 T2 DE 68929277T2
Authority
DE
Germany
Prior art keywords
acyloxymethyl
hydroxymethyl
hydrogen
converting
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE68929277T
Other languages
English (en)
Other versions
DE68929277D1 (de
Inventor
Trevor John Grinter
Peter Markham Kincey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis International Pharmaceutical Ltd
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Application granted granted Critical
Publication of DE68929277D1 publication Critical patent/DE68929277D1/de
Publication of DE68929277T2 publication Critical patent/DE68929277T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/14—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with two methyl radicals in positions 1 and 3 and two methyl radicals in positions 7, 8, or 9

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Mechanical Operated Clutches (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Steroid Compounds (AREA)
DE68929277T 1988-07-23 1989-07-18 Verfahren zur Herstellung von Purinderivaten Expired - Lifetime DE68929277T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888817607A GB8817607D0 (en) 1988-07-23 1988-07-23 Novel process

Publications (2)

Publication Number Publication Date
DE68929277D1 DE68929277D1 (de) 2001-02-08
DE68929277T2 true DE68929277T2 (de) 2001-08-23

Family

ID=10641009

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68929277T Expired - Lifetime DE68929277T2 (de) 1988-07-23 1989-07-18 Verfahren zur Herstellung von Purinderivaten

Country Status (19)

Country Link
US (1) US5017701A (de)
EP (1) EP0352953B1 (de)
JP (1) JP2856773B2 (de)
KR (1) KR0137468B1 (de)
AT (1) ATE198479T1 (de)
AU (1) AU623667B2 (de)
DE (1) DE68929277T2 (de)
DK (1) DK171991B1 (de)
ES (1) ES2153343T3 (de)
FI (1) FI893535A (de)
GB (1) GB8817607D0 (de)
HK (1) HK1012355A1 (de)
HU (1) HU204829B (de)
MA (1) MA21601A1 (de)
NO (1) NO169008C (de)
NZ (1) NZ230026A (de)
PL (1) PL161207B1 (de)
PT (1) PT91247B (de)
ZA (1) ZA895567B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5684153A (en) 1984-08-16 1997-11-04 Beecham Group Plc Process for the preparation of purine derivatives
US5175288A (en) * 1987-08-01 1992-12-29 Beecham Group P.L.C. Process for preparing purine derivatives and intermediates thereof
GB8822236D0 (en) * 1988-09-21 1988-10-26 Beecham Group Plc Chemical process
GB8829571D0 (en) * 1988-12-19 1989-02-08 Wellcome Found Antiviral compounds
GB8922076D0 (en) * 1989-09-28 1989-11-15 Beecham Group Plc Novel process
DE4020481A1 (de) * 1990-06-27 1992-01-02 Hoechst Ag Verfahren zur herstellung von substituierten acyclischen nukleosiden und dabei auftretende zwischenprodukte
CA2076886C (en) * 1991-11-22 2002-06-11 Masami Igi Method for production of 2-amino-6-halogenopurine and synthesis intermediate therefor
US5874578A (en) * 1992-07-13 1999-02-23 Bristol-Myers Squibb Process for preparing guanine-containing antiviral agents and purinyl salts useful in such process
GB9407698D0 (en) 1994-04-19 1994-06-15 Smithkline Beecham Plc Pharmaceuticals
JP3241994B2 (ja) * 1995-07-03 2001-12-25 株式会社荏原製作所 水中モータ及び防水コネクタ
GB9615275D0 (en) * 1996-07-20 1996-09-04 Smithkline Beecham Plc Pharmaceuticals
GB9615276D0 (en) * 1996-07-20 1996-09-04 Smithkline Beecham Plc Pharmaceuticals
GB9615253D0 (en) * 1996-07-20 1996-09-04 Smithkline Beecham Plc Pharmaceuticals
AT412211B (de) * 1996-07-20 2004-11-25 Novartis Int Pharm Ltd Verfahren zur herstellung von penciclovir und famciclovir
EP0827960A1 (de) * 1996-09-10 1998-03-11 Ajinomoto Co., Inc. Verfahren zur Herstellung von Purinderivaten
GB9807116D0 (en) 1998-04-02 1998-06-03 Smithkline Beecham Plc Novel process
GB9807114D0 (en) * 1998-04-02 1998-06-03 Smithkline Beecham Plc Novel process
EP1352910A1 (de) * 2002-04-10 2003-10-15 Grünenthal GmbH Neue Analoga von Nitrobenzylthioinosine
EP1532151A2 (de) 2002-08-26 2005-05-25 Teva Pharmaceutical Industries Limited Kristalline feste formen i, ii, iii des famciclovir and deren herstellung
EP1678168B1 (de) * 2003-10-24 2012-07-11 Exelixis, Inc. Modulatoren von p70s6-kinase und anwendungsverfahren
KR20080091298A (ko) * 2004-05-18 2008-10-09 테바 파마슈티컬 인더스트리즈 리미티드 결정성 고체 팜시클로버의 제조를 위한 건조방법
ES2294400T3 (es) * 2004-06-29 2008-04-01 Grunenthal Gmbh Nuevos analogos de notrobenciltioinosina.
KR100618232B1 (ko) * 2004-09-22 2006-09-04 한미약품 주식회사 팜시클로버의 제조방법
GB2426247A (en) * 2005-05-20 2006-11-22 Arrow Int Ltd Methods of preparing purine derivatives such as famciclovir

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4347187A (en) * 1980-10-20 1982-08-31 Syntex (U.S.A.) Inc. Process for preparing 5-aroyl 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids and novel intermediates therein
US4347185A (en) * 1980-10-20 1982-08-31 Syntex (U.S.A.) Inc. Processes for preparing 5-benzoyl-7-halo-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids
DE3485225D1 (de) * 1983-08-18 1991-12-05 Beecham Group Plc Antivirale guanin-derivate.
AU577303B2 (en) * 1983-08-18 1988-09-22 Novartis International Pharmaceutical Ltd 9-substituted-2-amino purines
IL73682A (en) * 1983-12-20 1991-08-16 Medivir Ab Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation
US4845084A (en) * 1984-01-26 1989-07-04 Merck & Co., Inc. Phosphate derivatives of substituted butyl guanines, antiviral compositions containing them, and methods of treating viral infections with them
DE3582399D1 (de) * 1984-09-20 1991-05-08 Beecham Group Plc Purin-derivate und ihre pharmazeutische verwendung.
EP0302644B1 (de) * 1987-08-01 1997-01-29 Beecham Group Plc Purinverbindungen und ihre Herstellung
GB8922076D0 (en) * 1989-09-28 1989-11-15 Beecham Group Plc Novel process

Also Published As

Publication number Publication date
HUT50820A (en) 1990-03-28
GB8817607D0 (en) 1988-09-01
US5017701A (en) 1991-05-21
DK362689A (da) 1990-01-24
NO169008B (no) 1992-01-20
HK1012355A1 (en) 1999-07-30
DK362689D0 (da) 1989-07-21
HU204829B (en) 1992-02-28
EP0352953B1 (de) 2001-01-03
NO169008C (no) 1992-04-29
PT91247A (pt) 1990-02-08
ZA895567B (en) 1990-07-25
NO892998D0 (no) 1989-07-21
MA21601A1 (fr) 1990-04-01
KR0137468B1 (ko) 1998-06-01
EP0352953A2 (de) 1990-01-31
AU3882289A (en) 1990-01-25
NZ230026A (en) 1992-11-25
ATE198479T1 (de) 2001-01-15
NO892998L (no) 1990-01-24
JP2856773B2 (ja) 1999-02-10
FI893535A0 (fi) 1989-07-21
PT91247B (pt) 1995-05-04
KR910002856A (ko) 1991-02-26
JPH0259583A (ja) 1990-02-28
DE68929277D1 (de) 2001-02-08
FI893535A (fi) 1990-01-24
AU623667B2 (en) 1992-05-21
DK171991B1 (da) 1997-09-08
ES2153343T3 (es) 2001-03-01
EP0352953A3 (de) 1991-10-23
PL161207B1 (en) 1993-06-30

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD., HAMILT

8364 No opposition during term of opposition