KR910002856A - 신규 방법 - Google Patents

신규 방법 Download PDF

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Publication number
KR910002856A
KR910002856A KR1019890010404A KR890010404A KR910002856A KR 910002856 A KR910002856 A KR 910002856A KR 1019890010404 A KR1019890010404 A KR 1019890010404A KR 890010404 A KR890010404 A KR 890010404A KR 910002856 A KR910002856 A KR 910002856A
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KR
South Korea
Prior art keywords
amino
compound
formula
acyloxymethyl
hydroxymethyl
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KR1019890010404A
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English (en)
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KR0137468B1 (ko
Inventor
존 그린터 트레버
마아컴 킨시 피이터
Original Assignee
데이빗 로버츠
비이참 그루우프 피이엘시이
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Publication of KR910002856A publication Critical patent/KR910002856A/ko
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Publication of KR0137468B1 publication Critical patent/KR0137468B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/14—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with two methyl radicals in positions 1 and 3 and two methyl radicals in positions 7, 8, or 9

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Mechanical Operated Clutches (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)

Abstract

내용 없음.

Description

신규 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 하기 일반식(Ⅱ)의 화합물:
    (상기식에서, 아미노 기는 임의로 보호되며, Y는 요오도, 임의 치환된 벤질티오 또는 (페나실메틸) 티오임)을 하기 일반식(Ⅲ)의 화합물:
    (상기식에서, Q는 이탈기이며, Rx및 Ry는 보호된 히드록시메틸 또는 아실옥시메틸 이거나 히드록시메틸 또는 아실옥시메틸로 전환가능한 기(들)이고; Rz는 수소 이거나 이것으로 전환가능한 기 임)과 반응시킨 다음;가수분해시켜 Y를 히드록시인 X로 전환시키거나, 환원시켜 수소인 X로 전환시키고; 히드록시메틸이나 아실옥시메틸이외의 Rx및 Ry를 히드록시메틸이나 아실옥시메틸로 전환시키고, Rx/Ry히드록시메틸을 아실옥시메틸로 또는 거꾸로 임의 전환시키고, 필요한 경우 2-아미노 기를 탈보호하고, Rz(수소 이외일때)를 수소로 전환시키고; 제약학적으로 허용가능한 이들의 염을 임의 형성시키는 것으로 구성되는 방법으로서, 하기 일반식(Ⅰ)의 화합물:
    이나 제약학적으로 허용가능한 이들의 염을 제조하는 방법.
  2. 제1항에 있어서, 일반식(Ⅲ)의 화합물이 하기 일반식(ⅢA) 또는 (ⅢB)의 화합물인 방법:
    상기식에서, Rp및 Rq는 독립적으로 수소, C1-6알킬 또는 페닐이거나 Rq및 Rq가 함께 C4-6폴리메틸렌이며, Rr은 C1-6알킬 또는 페닐 C1-6알킬이고, 여기서 임의의 페닐 부분은 제1항에서 Y에 대해 정의한 바와 같이, 임의 치환된다.
  3. 제1항 내지 제4항중 어느 한 항에 있어서, 일반식Ⅲ)의 화합물이 하기 일반식(Ⅲ')의 화합물인 방법.
    상기식에서, Q는 제1항에서 정의한 바와 같다.
  4. 제1항 내지 제3항중 어느 한 항에 있어서, Y가 요오도인 방법.
  5. 제1항 내지 제4항중 어느 한 항에 있어서, Q가 할로, 토실 옥시 또는 메틸 옥시인 방법.
  6. 제1항 내지 제5항 중 어느 한 항에 있어서, 하기 일반식(A) 또는 (B)의 화합물을 제조하는 방법.
  7. 하기 일반식(Ⅳ)의 중간체:
    상기식에서, Rx, Ry및 Rz는 제1항에서 정의한 바와 같다.
  8. 9-(4-아세톡시-3-아세톡시메틸부트-1-일)-2-아미노-6-요오도푸린, 9-(4-아세톡시-3-아세톡시메틸부트-1-일)-2-아미노-6-[(페닐메틸)티오]푸린, 9-(4-아세톡시-3-아세톡시메틸부트-1-일-)-2-아미노-6-[(4-메틸페닐)메틸티오]푸린, 9-(4-아세톡시-3-아세톡시메틸부트-1-일)-2-아미노-6-[(디페닐메틸)티오]푸린, 2-아미노-9-(에틸 2,2-디카르보에톡시부타노에이트-4-일)-6-[(페닐메틸)티오]푸린, 2-아미노-9-(에틸 2,2-디카르보에톡시부타오네이트-4-일)-6-요오도푸린, 2-아미노-9-[1-(2,2-디메틸-1,3-디옥산-4,6-디온-5-일)에이트-2-일]-6-[(페닐메틸)티오]푸린,2-아미노-6-요오도-9-[1-(2,2-디메틸-1,3-디옥산-4,6-디온-5-일)에트-2-일]푸린 칼륨 염, 또는 9-((4-아세톡시-3-아세톡시메틸부트-1-일)-2-아미노-6-[(페나실메틸)]티오 푸린.
  9. 제1항 내지 제5항중 어느 한 항의 방법에 의해 제조된, 제6항에서 정의한 바와 같은 일반식(A) 또는 (B)의 화합물, 또는 이들의 자명한 화학적 등가물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890010404A 1988-07-23 1989-07-22 푸린 유도체의 제조 방법 KR0137468B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888817607A GB8817607D0 (en) 1988-07-23 1988-07-23 Novel process
GB8817607.8 1988-07-23

Publications (2)

Publication Number Publication Date
KR910002856A true KR910002856A (ko) 1991-02-26
KR0137468B1 KR0137468B1 (ko) 1998-06-01

Family

ID=10641009

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890010404A KR0137468B1 (ko) 1988-07-23 1989-07-22 푸린 유도체의 제조 방법

Country Status (19)

Country Link
US (1) US5017701A (ko)
EP (1) EP0352953B1 (ko)
JP (1) JP2856773B2 (ko)
KR (1) KR0137468B1 (ko)
AT (1) ATE198479T1 (ko)
AU (1) AU623667B2 (ko)
DE (1) DE68929277T2 (ko)
DK (1) DK171991B1 (ko)
ES (1) ES2153343T3 (ko)
FI (1) FI893535A (ko)
GB (1) GB8817607D0 (ko)
HK (1) HK1012355A1 (ko)
HU (1) HU204829B (ko)
MA (1) MA21601A1 (ko)
NO (1) NO169008C (ko)
NZ (1) NZ230026A (ko)
PL (1) PL161207B1 (ko)
PT (1) PT91247B (ko)
ZA (1) ZA895567B (ko)

Families Citing this family (24)

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US5684153A (en) * 1984-08-16 1997-11-04 Beecham Group Plc Process for the preparation of purine derivatives
US5175288A (en) * 1987-08-01 1992-12-29 Beecham Group P.L.C. Process for preparing purine derivatives and intermediates thereof
GB8822236D0 (en) * 1988-09-21 1988-10-26 Beecham Group Plc Chemical process
GB8829571D0 (en) * 1988-12-19 1989-02-08 Wellcome Found Antiviral compounds
GB8922076D0 (en) * 1989-09-28 1989-11-15 Beecham Group Plc Novel process
DE4020481A1 (de) * 1990-06-27 1992-01-02 Hoechst Ag Verfahren zur herstellung von substituierten acyclischen nukleosiden und dabei auftretende zwischenprodukte
CA2076886C (en) * 1991-11-22 2002-06-11 Masami Igi Method for production of 2-amino-6-halogenopurine and synthesis intermediate therefor
US5874578A (en) * 1992-07-13 1999-02-23 Bristol-Myers Squibb Process for preparing guanine-containing antiviral agents and purinyl salts useful in such process
GB9407698D0 (en) * 1994-04-19 1994-06-15 Smithkline Beecham Plc Pharmaceuticals
JP3241994B2 (ja) * 1995-07-03 2001-12-25 株式会社荏原製作所 水中モータ及び防水コネクタ
GB9615253D0 (en) * 1996-07-20 1996-09-04 Smithkline Beecham Plc Pharmaceuticals
GR1002949B (el) * 1996-07-20 1998-07-29 Smithkline Beecham P.L.C. Φαρμακα
GB9615275D0 (en) * 1996-07-20 1996-09-04 Smithkline Beecham Plc Pharmaceuticals
GB9615276D0 (en) * 1996-07-20 1996-09-04 Smithkline Beecham Plc Pharmaceuticals
EP0827960A1 (en) * 1996-09-10 1998-03-11 Ajinomoto Co., Inc. Process for producing purine derivatives
GB9807116D0 (en) 1998-04-02 1998-06-03 Smithkline Beecham Plc Novel process
GB9807114D0 (en) 1998-04-02 1998-06-03 Smithkline Beecham Plc Novel process
EP1352910A1 (en) * 2002-04-10 2003-10-15 Grünenthal GmbH New analogs of nitrobenzylthioinosine
AU2003268213A1 (en) * 2002-08-26 2004-03-11 Teva Pharmaceutical Industries Ltd. Crystalline solid famciclovir forms i, ii, iii and preparation thereof
AU2004283751B2 (en) * 2003-10-24 2011-05-19 Exelixis, Inc. p70S6 kinase modulators and method of use
EP1747223A1 (en) * 2004-05-18 2007-01-31 Teva Pharmaceutical Industries Ltd. Drying process for preparing crystalline solid famciclovir
DE602004009166T2 (de) * 2004-06-29 2008-08-21 Grünenthal GmbH Neue Analoga von Nitrobenzylthioinosin
KR100618232B1 (ko) * 2004-09-22 2006-09-04 한미약품 주식회사 팜시클로버의 제조방법
GB2426247A (en) * 2005-05-20 2006-11-22 Arrow Int Ltd Methods of preparing purine derivatives such as famciclovir

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US4347187A (en) * 1980-10-20 1982-08-31 Syntex (U.S.A.) Inc. Process for preparing 5-aroyl 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids and novel intermediates therein
US4347185A (en) * 1980-10-20 1982-08-31 Syntex (U.S.A.) Inc. Processes for preparing 5-benzoyl-7-halo-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids
AU577303B2 (en) * 1983-08-18 1988-09-22 Novartis International Pharmaceutical Ltd 9-substituted-2-amino purines
DE3485225D1 (de) * 1983-08-18 1991-12-05 Beecham Group Plc Antivirale guanin-derivate.
IL73682A (en) * 1983-12-20 1991-08-16 Medivir Ab Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation
US4845084A (en) * 1984-01-26 1989-07-04 Merck & Co., Inc. Phosphate derivatives of substituted butyl guanines, antiviral compositions containing them, and methods of treating viral infections with them
EP0182024B1 (en) * 1984-09-20 1991-04-03 Beecham Group Plc Purine derivatives and their pharmaceutical use
DE3855774T2 (de) * 1987-08-01 1997-06-12 Beecham Group Plc Purinverbindungen und ihre Herstellung
GB8922076D0 (en) * 1989-09-28 1989-11-15 Beecham Group Plc Novel process

Also Published As

Publication number Publication date
HUT50820A (en) 1990-03-28
NO169008C (no) 1992-04-29
KR0137468B1 (ko) 1998-06-01
NO892998L (no) 1990-01-24
DK362689A (da) 1990-01-24
GB8817607D0 (en) 1988-09-01
FI893535A (fi) 1990-01-24
FI893535A0 (fi) 1989-07-21
JPH0259583A (ja) 1990-02-28
DE68929277T2 (de) 2001-08-23
DK362689D0 (da) 1989-07-21
ES2153343T3 (es) 2001-03-01
NO169008B (no) 1992-01-20
PL161207B1 (en) 1993-06-30
ATE198479T1 (de) 2001-01-15
MA21601A1 (fr) 1990-04-01
HK1012355A1 (en) 1999-07-30
EP0352953A3 (en) 1991-10-23
US5017701A (en) 1991-05-21
NZ230026A (en) 1992-11-25
EP0352953B1 (en) 2001-01-03
PT91247B (pt) 1995-05-04
DE68929277D1 (de) 2001-02-08
EP0352953A2 (en) 1990-01-31
JP2856773B2 (ja) 1999-02-10
AU3882289A (en) 1990-01-25
HU204829B (en) 1992-02-28
PT91247A (pt) 1990-02-08
AU623667B2 (en) 1992-05-21
DK171991B1 (da) 1997-09-08
NO892998D0 (no) 1989-07-21
ZA895567B (en) 1990-07-25

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