ES2153343T3 - Procedimiento para la preparacion de derivados de purina. - Google Patents

Procedimiento para la preparacion de derivados de purina.

Info

Publication number
ES2153343T3
ES2153343T3 ES89307271T ES89307271T ES2153343T3 ES 2153343 T3 ES2153343 T3 ES 2153343T3 ES 89307271 T ES89307271 T ES 89307271T ES 89307271 T ES89307271 T ES 89307271T ES 2153343 T3 ES2153343 T3 ES 2153343T3
Authority
ES
Spain
Prior art keywords
acyloxymethyl
hydroxymethyl
hydrogen
converting
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89307271T
Other languages
English (en)
Inventor
Trevor John Grinter
Peter Markham Kincey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Application granted granted Critical
Publication of ES2153343T3 publication Critical patent/ES2153343T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/14—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with two methyl radicals in positions 1 and 3 and two methyl radicals in positions 7, 8, or 9

Abstract

UN PROCEDIMIENTO PARA LA OBTENCION DE UN COMPUESTO DE FORMULA (I) O UNA DE SUS SALES FARMACEUTICAMENTE ACEPTABLES; PROCEDIMIENTO QUE COMPRENDE LA REACCION DE UN COMPUESTO DE FORMULA (II), DONDE EL GRUPO AMINO PUEDE ESTAR PROTEGIDO, Y ES YODO, BENCILTIO OPCIONALMENTE SUSTITUIDO O (FENACILMETIL) TIO, CON UN COMPUESTO DE FORMULA (III), DONDE Q ES UN GRUPO SALIENTE, RX Y RY SON HIDROXIMETILO O ACILOXIMETILO PROTEGIDOS, O GRUPO(S) CONVERTIBLE(S) A HIDROXIMETILO O ACILOXIMETILO; Y RZ ES HIDROGENO O UN GRUPO CONVERTIBLE EN EL; Y DEPUES CONVERTIR Y A X, ES HIDROXI POR MEDIO DE HIDROLISIS O A X ES HIDROGENO POR MEDIO DE REDUCCION; CONVERTIR RX O RY SI SON DISTINTOS DE HIDROXIMETIL O ACILOXIMETIL, EN HIDROXIMETIL O ACILOXIMETIL; OPCIONALMENTE CONVERTIR RX/RY HIDROXIMETIL EN ACILOXIMETIL O VICEVERSA; DESPROTEGER EL GRUPO 2-AMINO, SI ES NECESARIO, Y CONVERTIR RZ (SI ES DISTINTO DE HIDROGENO) EN HIDROGENO Y, OPCIONALMENTE, FORMAR UNA DE SUS SALES FARMACEUTICAMENTE ACEPTABLES.
ES89307271T 1988-07-23 1989-07-18 Procedimiento para la preparacion de derivados de purina. Expired - Lifetime ES2153343T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888817607A GB8817607D0 (en) 1988-07-23 1988-07-23 Novel process

Publications (1)

Publication Number Publication Date
ES2153343T3 true ES2153343T3 (es) 2001-03-01

Family

ID=10641009

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89307271T Expired - Lifetime ES2153343T3 (es) 1988-07-23 1989-07-18 Procedimiento para la preparacion de derivados de purina.

Country Status (19)

Country Link
US (1) US5017701A (es)
EP (1) EP0352953B1 (es)
JP (1) JP2856773B2 (es)
KR (1) KR0137468B1 (es)
AT (1) ATE198479T1 (es)
AU (1) AU623667B2 (es)
DE (1) DE68929277T2 (es)
DK (1) DK171991B1 (es)
ES (1) ES2153343T3 (es)
FI (1) FI893535A (es)
GB (1) GB8817607D0 (es)
HK (1) HK1012355A1 (es)
HU (1) HU204829B (es)
MA (1) MA21601A1 (es)
NO (1) NO169008C (es)
NZ (1) NZ230026A (es)
PL (1) PL161207B1 (es)
PT (1) PT91247B (es)
ZA (1) ZA895567B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5684153A (en) 1984-08-16 1997-11-04 Beecham Group Plc Process for the preparation of purine derivatives
US5175288A (en) * 1987-08-01 1992-12-29 Beecham Group P.L.C. Process for preparing purine derivatives and intermediates thereof
GB8822236D0 (en) * 1988-09-21 1988-10-26 Beecham Group Plc Chemical process
GB8829571D0 (en) * 1988-12-19 1989-02-08 Wellcome Found Antiviral compounds
GB8922076D0 (en) * 1989-09-28 1989-11-15 Beecham Group Plc Novel process
DE4020481A1 (de) * 1990-06-27 1992-01-02 Hoechst Ag Verfahren zur herstellung von substituierten acyclischen nukleosiden und dabei auftretende zwischenprodukte
CA2076886C (en) * 1991-11-22 2002-06-11 Masami Igi Method for production of 2-amino-6-halogenopurine and synthesis intermediate therefor
US5874578A (en) * 1992-07-13 1999-02-23 Bristol-Myers Squibb Process for preparing guanine-containing antiviral agents and purinyl salts useful in such process
GB9407698D0 (en) * 1994-04-19 1994-06-15 Smithkline Beecham Plc Pharmaceuticals
JP3241994B2 (ja) * 1995-07-03 2001-12-25 株式会社荏原製作所 水中モータ及び防水コネクタ
GB9615253D0 (en) * 1996-07-20 1996-09-04 Smithkline Beecham Plc Pharmaceuticals
GB9615276D0 (en) * 1996-07-20 1996-09-04 Smithkline Beecham Plc Pharmaceuticals
GR1002949B (el) * 1996-07-20 1998-07-29 Smithkline Beecham P.L.C. Φαρμακα
GB9615275D0 (en) * 1996-07-20 1996-09-04 Smithkline Beecham Plc Pharmaceuticals
EP0827960A1 (en) * 1996-09-10 1998-03-11 Ajinomoto Co., Inc. Process for producing purine derivatives
GB9807116D0 (en) * 1998-04-02 1998-06-03 Smithkline Beecham Plc Novel process
GB9807114D0 (en) 1998-04-02 1998-06-03 Smithkline Beecham Plc Novel process
EP1352910A1 (en) * 2002-04-10 2003-10-15 Grünenthal GmbH New analogs of nitrobenzylthioinosine
US20040097528A1 (en) * 2002-08-26 2004-05-20 Ben-Zion Dolitzky Crystalline solid famciclovir forms I, II, III and preparation thereof
JP4800216B2 (ja) * 2003-10-24 2011-10-26 エグゼリクシス， インコーポレイテッド ｐ７０Ｓ６キナーゼモジュレーターおよび使用方法
JP2007538087A (ja) * 2004-05-18 2007-12-27 テバ ファーマシューティカル インダストリーズ リミティド 結晶固形ファムシクロビルを調製するための乾燥方法
ATE374202T1 (de) * 2004-06-29 2007-10-15 Gruenenthal Gmbh Neue analoga von nitrobenzylthioinosin
KR100618232B1 (ko) * 2004-09-22 2006-09-04 한미약품 주식회사 팜시클로버의 제조방법
GB2426247A (en) 2005-05-20 2006-11-22 Arrow Int Ltd Methods of preparing purine derivatives such as famciclovir

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4347185A (en) * 1980-10-20 1982-08-31 Syntex (U.S.A.) Inc. Processes for preparing 5-benzoyl-7-halo-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids
US4347187A (en) * 1980-10-20 1982-08-31 Syntex (U.S.A.) Inc. Process for preparing 5-aroyl 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids and novel intermediates therein
AU577303B2 (en) * 1983-08-18 1988-09-22 Novartis International Pharmaceutical Ltd 9-substituted-2-amino purines
DE3485225D1 (de) * 1983-08-18 1991-12-05 Beecham Group Plc Antivirale guanin-derivate.
IL73682A (en) * 1983-12-20 1991-08-16 Medivir Ab Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation
US4845084A (en) * 1984-01-26 1989-07-04 Merck & Co., Inc. Phosphate derivatives of substituted butyl guanines, antiviral compositions containing them, and methods of treating viral infections with them
DE3582399D1 (de) * 1984-09-20 1991-05-08 Beecham Group Plc Purin-derivate und ihre pharmazeutische verwendung.
EP0302644B1 (en) * 1987-08-01 1997-01-29 Beecham Group Plc Purine compounds and their preparation
GB8922076D0 (en) * 1989-09-28 1989-11-15 Beecham Group Plc Novel process

Also Published As

Publication number Publication date
KR0137468B1 (ko) 1998-06-01
AU3882289A (en) 1990-01-25
NO892998L (no) 1990-01-24
ZA895567B (en) 1990-07-25
FI893535A0 (fi) 1989-07-21
KR910002856A (ko) 1991-02-26
GB8817607D0 (en) 1988-09-01
FI893535A (fi) 1990-01-24
NZ230026A (en) 1992-11-25
DE68929277D1 (de) 2001-02-08
HUT50820A (en) 1990-03-28
EP0352953A3 (en) 1991-10-23
JPH0259583A (ja) 1990-02-28
PT91247B (pt) 1995-05-04
US5017701A (en) 1991-05-21
JP2856773B2 (ja) 1999-02-10
HU204829B (en) 1992-02-28
EP0352953A2 (en) 1990-01-31
MA21601A1 (fr) 1990-04-01
DK362689D0 (da) 1989-07-21
DK171991B1 (da) 1997-09-08
DK362689A (da) 1990-01-24
HK1012355A1 (en) 1999-07-30
NO169008C (no) 1992-04-29
EP0352953B1 (en) 2001-01-03
ATE198479T1 (de) 2001-01-15
DE68929277T2 (de) 2001-08-23
AU623667B2 (en) 1992-05-21
NO892998D0 (no) 1989-07-21
PT91247A (pt) 1990-02-08
NO169008B (no) 1992-01-20
PL161207B1 (en) 1993-06-30

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