AR247208A1 - Procedimiento para obtener 3n-oxido de 2,4-diamino-6-piperidinil-pirimidina. - Google Patents

Procedimiento para obtener 3n-oxido de 2,4-diamino-6-piperidinil-pirimidina.

Info

Publication number
AR247208A1
AR247208A1 AR90315858A AR31585890A AR247208A1 AR 247208 A1 AR247208 A1 AR 247208A1 AR 90315858 A AR90315858 A AR 90315858A AR 31585890 A AR31585890 A AR 31585890A AR 247208 A1 AR247208 A1 AR 247208A1
Authority
AR
Argentina
Prior art keywords
oxide
diamino
piperidinyl
pyrimidine
preparation
Prior art date
Application number
AR90315858A
Other languages
English (en)
Original Assignee
Lonza Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza Ag filed Critical Lonza Ag
Application granted granted Critical
Publication of AR247208A1 publication Critical patent/AR247208A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/50—Three nitrogen atoms

Abstract

PROCEDIMIENTO PARA OBTENER 3-N-OXIDO DE 2,4-DIAMINO-6-PIPERIDINIL- PIRIMIDINA, DONDE SE HACE REACCIONAR HIDROXIGUANIDINA CON UN ESTER DEL ACIDO CIANOACETICO PARA FORMAR, CON CICLACION, EL 3-N-OXIDO DE 2,4-DIAMINO- 6-HIDROXIPIRIMIDINA, QUE SE CLORA CON POCL3, EN PRESENCIA DE UN CATALIZADOR CONSTITUIDO POR UNA AMINA, A UNA TEMPERATURA COMPRENDIDA ENTRE 70 Y 100*C Y DURANTE UN TIEMPO DE 10 A80 HORAS, PARA OBTENER EL 3-N-OXIDO DE 2,4-DIAMINO 6-CLOROPIRIMIDINA, QUE A SU VEZ SE HACE REACCIONAR CON PIPERIDINA, A UNA TEMPERATURA COMPRENDIDA ENTRE 70 Y 104*C Y DURANTE UN TIEMPO DE REACCION DE 2 A 5 HORAS, PARA OBTENER EL PRODUCTO FINAL DESEADO.
AR90315858A 1989-01-04 1990-01-02 Procedimiento para obtener 3n-oxido de 2,4-diamino-6-piperidinil-pirimidina. AR247208A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH2089 1989-01-04

Publications (1)

Publication Number Publication Date
AR247208A1 true AR247208A1 (es) 1994-11-30

Family

ID=4177565

Family Applications (1)

Application Number Title Priority Date Filing Date
AR90315858A AR247208A1 (es) 1989-01-04 1990-01-02 Procedimiento para obtener 3n-oxido de 2,4-diamino-6-piperidinil-pirimidina.

Country Status (14)

Country Link
US (1) US4959475A (es)
EP (1) EP0377437B1 (es)
JP (1) JPH02225474A (es)
AR (1) AR247208A1 (es)
AT (1) ATE115139T1 (es)
CA (1) CA2007047A1 (es)
CZ (1) CZ5390A3 (es)
DD (1) DD291324A5 (es)
DE (1) DE59007890D1 (es)
DK (1) DK0377437T3 (es)
ES (1) ES2064491T3 (es)
HU (1) HU204809B (es)
IL (1) IL92948A0 (es)
RU (1) RU1795970C (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2706896B1 (es) * 1993-06-23 1996-04-12 Caillot Jean Luc
CN110272391B (zh) * 2019-07-03 2022-10-28 天津药物研究院药业有限责任公司 一种米诺地尔的精制方法
CN114965738B (zh) * 2022-04-15 2024-03-29 武汉海特生物创新医药研究有限公司 一种2,4-二氨基-6-羟基嘧啶起始物料纯度的hplc-uv检测方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1915668A1 (de) 1969-03-27 1970-10-08 Sueddeutsche Kalkstickstoff Verfahren zur Herstellung von Halogenformamidiniumhalogeniden
US3644364A (en) * 1970-03-31 1972-02-22 Upjohn Co Compounds and process
US3910928A (en) * 1974-04-26 1975-10-07 Upjohn Co 3-(Cyanimino)-propionitriles
HU177601B (en) * 1978-10-27 1981-11-28 Egyt Gyogyszervegyeszeti Gyar New process for preparing 6-piperidino-2,4-diamino-pyrimidine-3-oxide
CH660589A5 (de) * 1983-01-28 1987-05-15 Lonza Ag Verfahren zur herstellung von 2-substituierten 5-nitroso-4,6-diamino-pyrimidinen.
DE8618514U1 (de) * 1986-07-10 1986-08-28 Alfi Zitzmann GmbH & Co, 6980 Wertheim Vorrichtung zum Kühlen von Getränkebehältern, insbesondere Flaschen
HU196061B (en) 1986-07-10 1988-09-28 Richter Gedeon Vegyeszet Process for production of pirimidine-derivatives
HU196067B (en) * 1986-07-10 1988-09-28 Richter Gedeon Vegyeszet Process for production of 6-amin-1,2-dihydro-1-hydroxi-2-imino-4-piperidin-piramidin

Also Published As

Publication number Publication date
CZ5390A3 (en) 1995-07-12
DK0377437T3 (da) 1995-02-06
DD291324A5 (de) 1991-06-27
ES2064491T3 (es) 1995-02-01
RU1795970C (ru) 1993-02-15
HU204809B (en) 1992-02-28
EP0377437B1 (de) 1994-12-07
CA2007047A1 (en) 1990-07-04
JPH02225474A (ja) 1990-09-07
HU900036D0 (en) 1990-03-28
DE59007890D1 (de) 1995-01-19
IL92948A0 (en) 1990-09-17
US4959475A (en) 1990-09-25
HUT53898A (en) 1990-12-28
EP0377437A1 (de) 1990-07-11
ATE115139T1 (de) 1994-12-15

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