EA021644B1 - Человеческое моноклональное антитело против cd20 и его применение - Google Patents

Человеческое моноклональное антитело против cd20 и его применение Download PDF

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Publication number
EA021644B1
EA021644B1 EA200500679A EA200500679A EA021644B1 EA 021644 B1 EA021644 B1 EA 021644B1 EA 200500679 A EA200500679 A EA 200500679A EA 200500679 A EA200500679 A EA 200500679A EA 021644 B1 EA021644 B1 EA 021644B1
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Eurasian Patent Office
Prior art keywords
antibody
cells
human
cell
antibodies
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EA200500679A
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English (en)
Russian (ru)
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EA200500679A1 (ru
Inventor
Джесика Телинг
Зигрид Руулс
Мартин Гленни
Ян Г.Й. Ван Де Винкель
Пауль Паррен
Йорген Петерсен
Оле Д.М.Ск. Бодсгорд
Хайчан Хуанг
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Генмаб А/С
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Application filed by Генмаб А/С filed Critical Генмаб А/С
Publication of EA200500679A1 publication Critical patent/EA200500679A1/ru
Publication of EA021644B1 publication Critical patent/EA021644B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
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    • C07K16/4258—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • G—PHYSICS
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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EA200500679A 2002-10-17 2003-10-17 Человеческое моноклональное антитело против cd20 и его применение EA021644B1 (ru)

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US41916302P 2002-10-17 2002-10-17
US46002803P 2003-04-02 2003-04-02
PCT/US2003/033057 WO2004035607A2 (en) 2002-10-17 2003-10-17 Human monoclonal antibodies against cd20

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EA200500679A1 EA200500679A1 (ru) 2006-02-24
EA021644B1 true EA021644B1 (ru) 2015-08-31

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EA200500679A EA021644B1 (ru) 2002-10-17 2003-10-17 Человеческое моноклональное антитело против cd20 и его применение
EA201492217A EA201492217A1 (ru) 2002-10-17 2003-10-17 Человеческие моноклональные антитела против cd20

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