DE69110084T2 - In-vitro Verfahren zur Amplifikation von antigenspezifishe monoklonale Antikörper produzierenden menschlichen Lymphozyten des peripheren Blutes. - Google Patents

In-vitro Verfahren zur Amplifikation von antigenspezifishe monoklonale Antikörper produzierenden menschlichen Lymphozyten des peripheren Blutes.

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Publication number
DE69110084T2
DE69110084T2 DE69110084T DE69110084T DE69110084T2 DE 69110084 T2 DE69110084 T2 DE 69110084T2 DE 69110084 T DE69110084 T DE 69110084T DE 69110084 T DE69110084 T DE 69110084T DE 69110084 T2 DE69110084 T2 DE 69110084T2
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DE
Germany
Prior art keywords
peripheral blood
blood lymphocytes
human peripheral
antigen
amplification
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69110084T
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English (en)
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DE69110084D1 (de
Inventor
Goroff Diana Keenan
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Akzo Nobel NV
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Akzo Nobel NV
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Publication of DE69110084T2 publication Critical patent/DE69110084T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • C12N5/163—Animal cells one of the fusion partners being a B or a T lymphocyte
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/40—Nucleotides, nucleosides, bases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
DE69110084T 1990-04-26 1991-04-17 In-vitro Verfahren zur Amplifikation von antigenspezifishe monoklonale Antikörper produzierenden menschlichen Lymphozyten des peripheren Blutes. Expired - Fee Related DE69110084T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/514,775 US5229275A (en) 1990-04-26 1990-04-26 In-vitro method for producing antigen-specific human monoclonal antibodies

Publications (2)

Publication Number Publication Date
DE69110084D1 DE69110084D1 (de) 1995-07-06
DE69110084T2 true DE69110084T2 (de) 1995-10-19

Family

ID=24048643

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69110084T Expired - Fee Related DE69110084T2 (de) 1990-04-26 1991-04-17 In-vitro Verfahren zur Amplifikation von antigenspezifishe monoklonale Antikörper produzierenden menschlichen Lymphozyten des peripheren Blutes.

Country Status (14)

Country Link
US (1) US5229275A (de)
EP (1) EP0454225B1 (de)
JP (1) JPH0686690A (de)
KR (1) KR0151408B1 (de)
AT (1) ATE123311T1 (de)
AU (1) AU647112B2 (de)
CA (1) CA2041213A1 (de)
DE (1) DE69110084T2 (de)
DK (1) DK0454225T3 (de)
ES (1) ES2075327T3 (de)
FI (1) FI97392C (de)
GR (1) GR3017162T3 (de)
IE (1) IE66523B1 (de)
ZA (1) ZA912998B (de)

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CA2041213A1 (en) 1991-10-27
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US5229275A (en) 1993-07-20
FI97392B (fi) 1996-08-30
AU647112B2 (en) 1994-03-17
EP0454225B1 (de) 1995-05-31
FI912016A (fi) 1991-10-27
AU7599991A (en) 1991-11-07
ES2075327T3 (es) 1995-10-01
KR910018543A (ko) 1991-11-30
FI97392C (fi) 1996-12-10
DE69110084D1 (de) 1995-07-06
IE66523B1 (en) 1996-01-10
ZA912998B (en) 1992-09-30
EP0454225A1 (de) 1991-10-30
FI912016A0 (fi) 1991-04-25
ATE123311T1 (de) 1995-06-15
IE911402A1 (en) 1991-11-06
JPH0686690A (ja) 1994-03-29
DK0454225T3 (da) 1995-10-02

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