BR112021026492A2 - Formulações líquidas, formulação liofilizada, artigos de fabricação e método para preparar uma formulação líquida - Google Patents

Formulações líquidas, formulação liofilizada, artigos de fabricação e método para preparar uma formulação líquida

Info

Publication number
BR112021026492A2
BR112021026492A2 BR112021026492A BR112021026492A BR112021026492A2 BR 112021026492 A2 BR112021026492 A2 BR 112021026492A2 BR 112021026492 A BR112021026492 A BR 112021026492A BR 112021026492 A BR112021026492 A BR 112021026492A BR 112021026492 A2 BR112021026492 A2 BR 112021026492A2
Authority
BR
Brazil
Prior art keywords
liquid
formulation
liquid formulations
articles
manufacture
Prior art date
Application number
BR112021026492A
Other languages
English (en)
Inventor
Anthony Tomlinson
Luc Demeule Barthelemy
Angelo Eleazar Zarraga Isidro
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of BR112021026492A2 publication Critical patent/BR112021026492A2/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591Stabilisation, fragmentation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

formulações líquidas, formulação liofilizada, artigos de fabricação e método para preparar uma formulação líquida. a presente divulgação fornece formulações líquidas compreendendo polipeptídeos e surfactantes. em particular, divulga uma formulação líquida compreendendo um polipeptídeo e um surfactante, em que pelo menos cerca de 70% (% em peso) do surfactante são ésteres de ácido graxo de isossorbida polioxietileno (poe). a invenção também fornece métodos para fazer tais formulações líquidas, artigos de fabricação compreendendo tais formulações líquidas e métodos para tratar um paciente com tais formulações líquidas.
BR112021026492A 2019-06-28 2020-06-26 Formulações líquidas, formulação liofilizada, artigos de fabricação e método para preparar uma formulação líquida BR112021026492A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962868615P 2019-06-28 2019-06-28
PCT/US2020/039827 WO2020264300A1 (en) 2019-06-28 2020-06-26 Composition and methods for stabilizing liquid protein formulations

Publications (1)

Publication Number Publication Date
BR112021026492A2 true BR112021026492A2 (pt) 2022-02-08

Family

ID=71728902

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021026492A BR112021026492A2 (pt) 2019-06-28 2020-06-26 Formulações líquidas, formulação liofilizada, artigos de fabricação e método para preparar uma formulação líquida

Country Status (13)

Country Link
US (2) US11865177B2 (pt)
EP (1) EP3989937A1 (pt)
JP (1) JP2022538293A (pt)
KR (1) KR20220027940A (pt)
CN (1) CN114040754A (pt)
AR (1) AR119293A1 (pt)
AU (1) AU2020304649A1 (pt)
BR (1) BR112021026492A2 (pt)
CA (1) CA3141050A1 (pt)
IL (1) IL289219A (pt)
MX (1) MX2021015694A (pt)
TW (1) TW202114641A (pt)
WO (1) WO2020264300A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023520249A (ja) * 2020-05-15 2023-05-16 エフ. ホフマン-ラ ロシュ アーゲー 非経口タンパク質溶液中の可視粒子形成の防止方法

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ATE105585T1 (de) 1987-12-21 1994-05-15 Univ Toledo Transformation von keimenden pflanzensamen mit hilfe von agrobacterium.
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WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
DE69334255D1 (de) 1992-02-06 2009-02-12 Novartis Vaccines & Diagnostic Marker für Krebs und biosynthetisches Bindeprotein dafür
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Also Published As

Publication number Publication date
US20210015920A1 (en) 2021-01-21
AU2020304649A1 (en) 2022-01-06
MX2021015694A (es) 2022-03-11
EP3989937A1 (en) 2022-05-04
TW202114641A (zh) 2021-04-16
CA3141050A1 (en) 2020-12-30
CN114040754A (zh) 2022-02-11
US11865177B2 (en) 2024-01-09
KR20220027940A (ko) 2022-03-08
US20240123066A1 (en) 2024-04-18
AR119293A1 (es) 2021-12-09
WO2020264300A1 (en) 2020-12-30
JP2022538293A (ja) 2022-09-01
IL289219A (en) 2022-02-01

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