CL2011003003A1 - Composicion tensioactiva reconstituida que comprende un polipeptido análogo a la proteína surfactante c nativa, un polipeptido análogo a la proteína surfactante b nativa, un fosfolipido monoinsaturado y un fosfolipido saturado, útil para el tratamiento del síndrome de dificultad respiratoria. - Google Patents

Composicion tensioactiva reconstituida que comprende un polipeptido análogo a la proteína surfactante c nativa, un polipeptido análogo a la proteína surfactante b nativa, un fosfolipido monoinsaturado y un fosfolipido saturado, útil para el tratamiento del síndrome de dificultad respiratoria.

Info

Publication number
CL2011003003A1
CL2011003003A1 CL2011003003A CL2011003003A CL2011003003A1 CL 2011003003 A1 CL2011003003 A1 CL 2011003003A1 CL 2011003003 A CL2011003003 A CL 2011003003A CL 2011003003 A CL2011003003 A CL 2011003003A CL 2011003003 A1 CL2011003003 A1 CL 2011003003A1
Authority
CL
Chile
Prior art keywords
phospholipid
analog polypeptide
native
surfactant protein
useful
Prior art date
Application number
CL2011003003A
Other languages
English (en)
Inventor
Fausto Pivetti
Monica Bocchi
Raschini Annamaria Soliani
Original Assignee
Chiesi Farm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41055357&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2011003003(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chiesi Farm Spa filed Critical Chiesi Farm Spa
Publication of CL2011003003A1 publication Critical patent/CL2011003003A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/395—Alveolar surfactant peptides; Pulmonary surfactant peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0082—Lung surfactant, artificial mucus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Cosmetics (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)

Abstract

Composición tensioactiva reconstituida que comprende un polipéptido análogo a la proteína tensioactiva sp-c nativa; agente tensioactivo; formulación farmacéutica; kit.
CL2011003003A 2009-06-05 2011-11-25 Composicion tensioactiva reconstituida que comprende un polipeptido análogo a la proteína surfactante c nativa, un polipeptido análogo a la proteína surfactante b nativa, un fosfolipido monoinsaturado y un fosfolipido saturado, útil para el tratamiento del síndrome de dificultad respiratoria. CL2011003003A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP09162052 2009-06-05

Publications (1)

Publication Number Publication Date
CL2011003003A1 true CL2011003003A1 (es) 2012-05-18

Family

ID=41055357

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2011003003A CL2011003003A1 (es) 2009-06-05 2011-11-25 Composicion tensioactiva reconstituida que comprende un polipeptido análogo a la proteína surfactante c nativa, un polipeptido análogo a la proteína surfactante b nativa, un fosfolipido monoinsaturado y un fosfolipido saturado, útil para el tratamiento del síndrome de dificultad respiratoria.

Country Status (35)

Country Link
US (1) US8399406B2 (es)
EP (1) EP2438086B1 (es)
JP (1) JP5666569B2 (es)
KR (1) KR101668137B1 (es)
CN (1) CN102459327B (es)
AR (1) AR076973A1 (es)
AU (1) AU2010256066B2 (es)
BR (1) BRPI1010120B1 (es)
CA (1) CA2764454C (es)
CL (1) CL2011003003A1 (es)
CO (1) CO6470858A2 (es)
CY (1) CY1118676T1 (es)
DK (1) DK2438086T3 (es)
EA (1) EA021163B1 (es)
ES (1) ES2621974T3 (es)
GE (1) GEP20135967B (es)
HR (1) HRP20170445T1 (es)
HU (1) HUE034053T2 (es)
IL (1) IL216718A (es)
JO (1) JO3226B1 (es)
LT (1) LT2438086T (es)
MA (1) MA33374B1 (es)
ME (1) ME01279B (es)
MX (1) MX2011012951A (es)
MY (1) MY159464A (es)
NZ (1) NZ596848A (es)
PE (1) PE20120541A1 (es)
PL (1) PL2438086T3 (es)
PT (1) PT2438086T (es)
SG (1) SG176305A1 (es)
SI (1) SI2438086T1 (es)
TN (1) TN2011000558A1 (es)
TW (1) TWI457132B (es)
UA (1) UA103526C2 (es)
WO (1) WO2010139442A1 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2170283B1 (en) 2007-06-22 2019-01-09 Board of Regents, The University of Texas System Formation of stable submicron peptide or protein particles by thin film freezing
CA2829629A1 (en) * 2011-03-10 2012-09-13 Board Of Regents, The University Of Texas System Protein nanoparticle dispersions
EP3459556A1 (en) 2012-02-09 2019-03-27 Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center Synthetic analogs of lung surfactant protein sp-c and their use
EP2922868B1 (en) 2012-11-21 2017-09-27 Chiesi Farmaceutici S.p.A. Reconstituted pulmonary surfactants
CN104382942A (zh) * 2014-11-05 2015-03-04 烟台东诚药业集团股份有限公司 一种猪肺表面活性物质混悬液制备新工艺
US20180110948A1 (en) 2015-04-22 2018-04-26 Chiesi Farmaceutici S.P.A Method and system for effective breath-synchronized delivery of medicament to the lungs
EP3106090A1 (en) 2015-06-15 2016-12-21 CHIESI FARMACEUTICI S.p.A. System for effective breath-synchronized delivery of medicament to the lungs
WO2016173634A1 (en) 2015-04-28 2016-11-03 Chiesi Farmaceutici S.P.A Device for facilitating the administration of a medicament to the lung by a catheter
EP3452041B1 (en) * 2016-03-07 2026-01-14 Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center Compositions and methods for administering ppar-gamma-agonists, surfactant peptides and phospholipids
MA45772A (fr) 2016-07-28 2021-04-28 Chiesi Farm Spa Procédé et système d'administration d'un médicament sous forme d'aérosol
RU2748417C2 (ru) 2016-08-24 2021-05-25 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Стабильная фармацевтическая композиция, включающая восстановленную композицию легочного сурфактанта
AU2017349790A1 (en) 2016-10-26 2019-05-02 Chiesi Farmaceutici S.P.A. Device for facilitating the administration of a medicament to the lung by a catheter
CN110099695B (zh) 2016-12-22 2022-01-25 奇斯药制品公司 用于治疗进展性bpd的包含肺表面活性物质和类固醇的治疗组合
TW201927286A (zh) 2017-12-15 2019-07-16 義大利商凱西製藥公司 用於噴霧投藥之包含肺表面張力素的藥學調配物
WO2019115771A1 (en) 2017-12-15 2019-06-20 Pari Pharma Gmbh Nebuliser system, holding system, combination comprising nebuliser system and holding system, and aerosol administration method
JP7378425B2 (ja) 2018-04-23 2023-11-13 シエシー ファルマセウティチィ ソシエタ ペル アチオニ 肺サーファクタントおよびｂｐｄの予防のためのステロイドを含む治療的組合せ
EP3666315A1 (en) 2018-12-14 2020-06-17 PARI Pharma GmbH Aerosol delivery device and method of operating the aerosol delivery device
EP3666316A1 (en) 2018-12-14 2020-06-17 PARI Pharma GmbH Aerosol delivery device and method of operating the aerosol delivery device
EP3843105A1 (en) 2019-12-23 2021-06-30 PARI Pharma GmbH Control device for aerosol nebulizer system
WO2021151853A1 (en) 2020-01-28 2021-08-05 Chiesi Farmaceutici S.P.A. Polypeptides having improved properties
US20240366682A1 (en) 2021-07-05 2024-11-07 Chiesi Farmaceutici S.P.A. Process for the preparation of a pulmonary surfactant
EP4411745A1 (en) 2023-02-01 2024-08-07 Pari Medical Holding GmbH Medical evaluation method, aerosol nebulizer and medical evaluation system
EP4464236A1 (en) 2023-05-15 2024-11-20 Pari Medical Holding GmbH Method of operating an inhalation device, inhalation device and inhalation device system for providing inhalation process feedback
EP4464354A1 (en) 2023-05-15 2024-11-20 Pari Medical Holding GmbH Method of operating an inhalation device, inhalation device and inhalation device system for providing inhalation process/breath guiding
WO2025024609A1 (en) * 2023-07-25 2025-01-30 Biosuperior Technology, Inc. Polypeptides for lung surfactant compositions
WO2025245275A1 (en) * 2024-05-21 2025-11-27 Molecular Express, Inc. Surfactant preparations for pulmonary delivery, and methods for the preparation and use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000076535A1 (en) 1999-06-11 2000-12-21 Byk Gulden Lomberg Chemische Fabrik Gmbh Pharmaceutical preparation containing modifications of surfactant protein b (sp-b) and surfactant protein c (sp-c)
ITMI20021058A1 (it) * 2002-05-17 2003-11-17 Chiesi Farma Spa Miscele di lipidi sintetici ottimizzate per la preparazione di un surfattante ricostituito
EP1481665A1 (en) * 2003-05-30 2004-12-01 CHIESI FARMACEUTICI S.p.A. Novel lipid mixtures for synthetic surfactants
CN101171514B (zh) * 2005-05-11 2011-07-20 雅玛山酱油株式会社 肺表面活性蛋白的稳定化方法
WO2008011559A2 (en) 2006-07-20 2008-01-24 University Of Rochester Synthetic lung surfactant and use thereof
CN103169947B (zh) 2006-10-13 2014-10-29 奇斯药制品公司 具有改进性质的重组表面活性剂
EP1997502A1 (en) * 2007-06-01 2008-12-03 CHIESI FARMACEUTICI S.p.A. Reconstituted surfactants having improved properties

Also Published As

Publication number Publication date
AU2010256066A1 (en) 2012-01-12
HUE034053T2 (en) 2018-01-29
PL2438086T3 (pl) 2017-07-31
TWI457132B (zh) 2014-10-21
ES2621974T3 (es) 2017-07-05
TW201102083A (en) 2011-01-16
UA103526C2 (ru) 2013-10-25
CO6470858A2 (es) 2012-06-29
JP2012528810A (ja) 2012-11-15
JP5666569B2 (ja) 2015-02-12
GEP20135967B (en) 2013-11-11
EA021163B1 (ru) 2015-04-30
TN2011000558A1 (en) 2013-05-24
CN102459327B (zh) 2015-06-03
BRPI1010120A2 (pt) 2019-03-26
AU2010256066B2 (en) 2015-11-26
KR20120028892A (ko) 2012-03-23
EP2438086B1 (en) 2017-01-11
SG176305A1 (en) 2012-01-30
CA2764454C (en) 2018-06-12
US20110003733A1 (en) 2011-01-06
HRP20170445T1 (hr) 2017-05-19
HK1166332A1 (en) 2012-10-26
CY1118676T1 (el) 2017-07-12
MY159464A (en) 2017-01-13
NZ596848A (en) 2013-06-28
ME01279B (me) 2013-06-20
BRPI1010120B1 (pt) 2022-12-06
JO3226B1 (ar) 2018-03-08
PT2438086T (pt) 2017-04-18
EP2438086A1 (en) 2012-04-11
IL216718A (en) 2016-08-31
MA33374B1 (fr) 2012-06-01
CN102459327A (zh) 2012-05-16
LT2438086T (lt) 2017-04-10
US8399406B2 (en) 2013-03-19
SI2438086T1 (sl) 2017-05-31
AR076973A1 (es) 2011-07-20
DK2438086T3 (en) 2017-04-10
IL216718A0 (en) 2012-02-29
CA2764454A1 (en) 2010-12-09
KR101668137B1 (ko) 2016-10-20
PE20120541A1 (es) 2012-05-12
MX2011012951A (es) 2011-12-16
WO2010139442A1 (en) 2010-12-09
EA201190292A1 (ru) 2012-06-29

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