ECSP21003171A - Dinucleótidos cíclicos como agonistas de sting - Google Patents
Dinucleótidos cíclicos como agonistas de stingInfo
- Publication number
- ECSP21003171A ECSP21003171A ECSENADI20213171A ECDI202103171A ECSP21003171A EC SP21003171 A ECSP21003171 A EC SP21003171A EC SENADI20213171 A ECSENADI20213171 A EC SENADI20213171A EC DI202103171 A ECDI202103171 A EC DI202103171A EC SP21003171 A ECSP21003171 A EC SP21003171A
- Authority
- EC
- Ecuador
- Prior art keywords
- sting agonists
- cyclic dinucleotides
- sting
- compounds
- dinucleotides
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
Abstract
Se describen compuestos, composiciones y métodos para tratar enfermedades, síndromes o trastornos que se ven afectados por la modulación de STING. Tales compuestos se representan mediante la Fórmula (I): (VER ANEXO) En donde R1, R1, X1, B1, R2, R2, B2, X2, R3, Z-M-Y y Y1-M1-Z1 son como se definen en la presente descripción.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862699001P | 2018-07-17 | 2018-07-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP21003171A true ECSP21003171A (es) | 2021-02-26 |
Family
ID=67999987
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ECSENADI20213171A ECSP21003171A (es) | 2018-07-17 | 2021-01-15 | Dinucleótidos cíclicos como agonistas de sting |
Country Status (20)
Country | Link |
---|---|
US (2) | US11597746B2 (es) |
EP (1) | EP3823976A1 (es) |
JP (1) | JP2021531277A (es) |
KR (1) | KR20210033026A (es) |
CN (1) | CN112424212A (es) |
AR (1) | AR122240A1 (es) |
AU (1) | AU2019304230B2 (es) |
BR (1) | BR112021000693A2 (es) |
CA (1) | CA3106602A1 (es) |
EA (1) | EA202190298A1 (es) |
EC (1) | ECSP21003171A (es) |
IL (1) | IL280105A (es) |
MA (1) | MA53178A (es) |
MX (1) | MX2021000625A (es) |
PE (1) | PE20211636A1 (es) |
PH (1) | PH12020552172A1 (es) |
SG (1) | SG11202012624RA (es) |
TW (1) | TW202030199A (es) |
UY (1) | UY38304A (es) |
WO (1) | WO2020016782A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3724205B1 (en) * | 2017-12-15 | 2022-06-22 | Janssen Biotech, Inc. | Cyclic dinucleotides as sting agonists |
TW202030199A (zh) * | 2018-07-17 | 2020-08-16 | 美商健生生物科技公司 | 作為sting促效劑之環狀二核苷酸 |
WO2021206158A1 (ja) | 2020-04-10 | 2021-10-14 | 小野薬品工業株式会社 | がん治療方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX363780B (es) * | 2015-12-03 | 2019-04-03 | Glaxosmithkline Ip Dev Ltd | Dinucleótidos de purina cíclica como moduladores del estimulador de los genes de interferón. |
CN109451740B (zh) * | 2016-01-11 | 2022-09-02 | 先天肿瘤免疫公司 | 用于治疗与sting活性相关的病症诸如癌症的环状二核苷酸 |
US10723756B2 (en) * | 2016-01-11 | 2020-07-28 | Innate Tumor Immunity Inc. | Cyclic dinucleotides for treating conditions associated with STING activity such as cancer |
HRP20221263T1 (hr) | 2016-03-18 | 2023-03-03 | Immune Sensor, Llc | Ciklički di-nukleotidni spojevi i postupci uporabe |
AU2017293781B2 (en) * | 2016-07-06 | 2022-12-22 | F-star Therapeutics, Inc. | Compounds, compositions, and methods for the treatment of disease |
WO2018045204A1 (en) | 2016-08-31 | 2018-03-08 | Ifm Therapeutics, Inc | Cyclic dinucleotide analogs for treating conditions associated with sting (stimulator of interferon genes) activity |
JOP20170188A1 (ar) * | 2016-11-25 | 2019-01-30 | Janssen Biotech Inc | ثنائي النوكليوتيدات الحلقية كمنبهات ستينغ (sting) |
TW202030199A (zh) * | 2018-07-17 | 2020-08-16 | 美商健生生物科技公司 | 作為sting促效劑之環狀二核苷酸 |
-
2019
- 2019-07-15 TW TW108124846A patent/TW202030199A/zh unknown
- 2019-07-16 PE PE2021000048A patent/PE20211636A1/es unknown
- 2019-07-16 KR KR1020217004700A patent/KR20210033026A/ko not_active Application Discontinuation
- 2019-07-16 US US17/260,886 patent/US11597746B2/en active Active
- 2019-07-16 CN CN201980047682.2A patent/CN112424212A/zh active Pending
- 2019-07-16 EP EP19773171.4A patent/EP3823976A1/en active Pending
- 2019-07-16 MA MA053178A patent/MA53178A/fr unknown
- 2019-07-16 CA CA3106602A patent/CA3106602A1/en active Pending
- 2019-07-16 EA EA202190298A patent/EA202190298A1/ru unknown
- 2019-07-16 SG SG11202012624RA patent/SG11202012624RA/en unknown
- 2019-07-16 WO PCT/IB2019/056075 patent/WO2020016782A1/en active Application Filing
- 2019-07-16 MX MX2021000625A patent/MX2021000625A/es unknown
- 2019-07-16 JP JP2021502559A patent/JP2021531277A/ja active Pending
- 2019-07-16 BR BR112021000693-1A patent/BR112021000693A2/pt unknown
- 2019-07-16 AU AU2019304230A patent/AU2019304230B2/en not_active Expired - Fee Related
- 2019-07-17 AR ARP190102015A patent/AR122240A1/es unknown
- 2019-07-17 UY UY0001038304A patent/UY38304A/es unknown
-
2020
- 2020-12-14 PH PH12020552172A patent/PH12020552172A1/en unknown
-
2021
- 2021-01-11 IL IL280105A patent/IL280105A/en unknown
- 2021-01-15 EC ECSENADI20213171A patent/ECSP21003171A/es unknown
-
2023
- 2023-03-03 US US18/177,864 patent/US20230287034A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2020016782A1 (en) | 2020-01-23 |
AU2019304230A1 (en) | 2021-01-14 |
PE20211636A1 (es) | 2021-08-24 |
US20230287034A1 (en) | 2023-09-14 |
KR20210033026A (ko) | 2021-03-25 |
PH12020552172A1 (en) | 2021-06-07 |
CN112424212A (zh) | 2021-02-26 |
UY38304A (es) | 2020-01-31 |
US11597746B2 (en) | 2023-03-07 |
CA3106602A1 (en) | 2020-01-23 |
IL280105A (en) | 2021-03-01 |
US20210277046A1 (en) | 2021-09-09 |
AU2019304230B2 (en) | 2023-08-31 |
AR122240A1 (es) | 2022-08-31 |
TW202030199A (zh) | 2020-08-16 |
JP2021531277A (ja) | 2021-11-18 |
EA202190298A1 (ru) | 2021-04-16 |
SG11202012624RA (en) | 2021-02-25 |
MA53178A (fr) | 2021-05-26 |
MX2021000625A (es) | 2021-03-25 |
BR112021000693A2 (pt) | 2021-04-13 |
EP3823976A1 (en) | 2021-05-26 |
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