DE3587806D1 - Tricyclische Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzung. - Google Patents
Tricyclische Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzung.Info
- Publication number
- DE3587806D1 DE3587806D1 DE3587806T DE3587806T DE3587806D1 DE 3587806 D1 DE3587806 D1 DE 3587806D1 DE 3587806 T DE3587806 T DE 3587806T DE 3587806 T DE3587806 T DE 3587806T DE 3587806 D1 DE3587806 D1 DE 3587806D1
- Authority
- DE
- Germany
- Prior art keywords
- processes
- preparation
- pharmaceutical compositions
- compositions containing
- tricyclic compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
- C12R2001/55—Streptomyces hygroscopicus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
- Y10S435/898—Streptomyces hygroscopicus
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB848430455A GB8430455D0 (en) | 1984-12-03 | 1984-12-03 | Fr-900506 substance |
GB858502869A GB8502869D0 (en) | 1985-02-05 | 1985-02-05 | Ws 7238 substances |
GB858508420A GB8508420D0 (en) | 1985-04-01 | 1985-04-01 | Fr-900506 & fr-900525 substances |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3587806D1 true DE3587806D1 (de) | 1994-06-01 |
DE3587806T2 DE3587806T2 (de) | 1994-08-25 |
Family
ID=27262535
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3587806T Expired - Lifetime DE3587806T2 (de) | 1984-12-03 | 1985-11-30 | Tricyclische Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzung. |
DE1995175026 Active DE19575026I2 (de) | 1984-12-03 | 1985-11-30 | Tricyclische Verbindungen Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzung |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE1995175026 Active DE19575026I2 (de) | 1984-12-03 | 1985-11-30 | Tricyclische Verbindungen Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzung |
Country Status (24)
Country | Link |
---|---|
US (15) | US4894366A (de) |
EP (1) | EP0184162B1 (de) |
JP (6) | JPH0720970B2 (de) |
KR (5) | KR930010704B1 (de) |
CN (1) | CN1013687B (de) |
AT (1) | ATE104984T1 (de) |
AU (1) | AU592067B2 (de) |
CA (1) | CA1338491C (de) |
CY (1) | CY1912A (de) |
DE (2) | DE3587806T2 (de) |
DK (1) | DK169550B1 (de) |
ES (1) | ES8705038A1 (de) |
FI (2) | FI87803C (de) |
GR (1) | GR852904B (de) |
HK (1) | HK18596A (de) |
HU (1) | HU195250B (de) |
IE (1) | IE62865B1 (de) |
IL (2) | IL77222A (de) |
LU (1) | LU90317I2 (de) |
MX (1) | MX9202943A (de) |
NL (1) | NL960023I2 (de) |
NO (1) | NO168372C (de) |
NZ (1) | NZ214407A (de) |
PT (1) | PT81589B (de) |
Families Citing this family (312)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4894366A (en) * | 1984-12-03 | 1990-01-16 | Fujisawa Pharmaceutical Company, Ltd. | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same |
US5254562A (en) * | 1984-12-03 | 1993-10-19 | Fujisawa Pharmaceutical Company, Ltd. | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same |
US5266692A (en) * | 1984-12-03 | 1993-11-30 | Fujisawa Pharmaceutical Co., Ltd. | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same |
GB8608080D0 (en) * | 1986-04-02 | 1986-05-08 | Fujisawa Pharmaceutical Co | Solid dispersion composition |
ES2060621T3 (es) * | 1987-06-05 | 1994-12-01 | Fujisawa Pharmaceutical Co | Anticuerpos anti-sustancia fr-900506 y metodo de inmunoensayo enzimatico altamente sensible. |
DE3737523A1 (de) * | 1987-11-05 | 1989-05-18 | Bayer Ag | Verwendung von substituierten hydroxypiperidinen als antivirale mittel |
DE3838035C2 (de) * | 1987-11-09 | 1994-03-24 | Sandoz Ag | Neue Verwendung von 11,28-dioxa-4-azatricyclo[22.3.1.O·4··,··9·]octacos-18-en-Derivaten |
AT400808B (de) * | 1987-11-09 | 1996-03-25 | Sandoz Ag | Verwendung von tricyclischen verbindungen zur herstellung von topischen arzneimitteln |
DE3844904C2 (de) * | 1987-11-09 | 1997-01-30 | Sandoz Ag | Neue Verwendung von 11,28-Dioxa-4-azatricyclo-[22.3.1.0·4·,·9·]octacos-18-en-Derivaten |
US5366971A (en) * | 1987-11-09 | 1994-11-22 | Sandoz Ltd. | Use of 11,28-dioxa-4-azatricyclo[22.3.1.04,9 ]octacos-18-ene derivatives and pharmaceutical compositions containing them |
GB2212061B (en) * | 1987-11-09 | 1991-08-28 | Sandoz Ltd | Topical compositions comprising 11,28-dioxa-4-azatricyclo [22.3.1.0(4,9)] octacos-18-ene derivatives |
GB8728820D0 (en) * | 1987-12-09 | 1988-01-27 | Fisons Plc | Compounds |
JP2799208B2 (ja) | 1987-12-09 | 1998-09-17 | フアイソンズ・ピーエルシー | マクロ環状化合物 |
AT407957B (de) * | 1987-12-17 | 2001-07-25 | Novartis Erfind Verwalt Gmbh | Neue verwendung von 11,28-dioxa-4-azatricyclo- (22.3.1.04,9)octacos-18-en-derivaten und sie enthaltende pharmazeutische zubereitungen |
EP0323865A1 (de) * | 1988-01-07 | 1989-07-12 | Merck & Co. Inc. | Immunopressantes Mittel |
US4981792A (en) * | 1988-06-29 | 1991-01-01 | Merck & Co., Inc. | Immunosuppressant compound |
DE68921934T2 (de) * | 1988-06-29 | 1995-10-19 | Merck & Co Inc | Immunsuppressives Agens. |
US5290772A (en) * | 1988-06-29 | 1994-03-01 | Merck & Co., Inc. | Immunosuppressant agent |
ATE131536T1 (de) * | 1988-08-01 | 1995-12-15 | Fujisawa Pharmaceutical Co | Fr-901154- und fr-901155-derivate, verfahren zu ihrer herstellung |
US5202258A (en) * | 1988-08-05 | 1993-04-13 | Merck & Co., Inc. | Immunosuppressant-producing culture |
EP0356399A3 (de) * | 1988-08-26 | 1991-03-20 | Sandoz Ag | Substituierte 4-Azatricyclo (22.3.1.04.9) octacos-18-en-Derivate, Verfahren zu ihrer Herstellung und die sie enthaltenden pharmazeutischen Zusammensetzungen |
EP0358508A3 (de) * | 1988-09-08 | 1991-03-20 | Merck & Co. Inc. | Verbindung zur Unterdrückung der Immunabwehr |
CA1316916C (en) * | 1988-10-12 | 1993-04-27 | David Askin | Hydroxide mediated fk-506 rearrangement product |
DE68904037T2 (de) * | 1988-10-12 | 1993-06-03 | Merck & Co Inc | Verfahren zur umlagerung von fk-506 unter beteiligung von hydroxid. |
US4980466A (en) * | 1988-10-12 | 1990-12-25 | Merck & Co., Inc. | Hydroxide mediated FK-506 rearrangement product |
CH678855A5 (de) * | 1988-11-29 | 1991-11-15 | Sandoz Ag | |
US5268370A (en) * | 1989-01-13 | 1993-12-07 | Merck & Co., Inc. | Microbial transformation product of L-679,934 |
EP0378320A3 (de) * | 1989-01-13 | 1990-11-28 | Merck & Co. Inc. | Mikrobielles Umwandlungsprodukt |
US4975372A (en) * | 1989-01-13 | 1990-12-04 | Merck & Co., Inc. | Microbial transformation product of L-683,590 |
EP0378317A3 (de) * | 1989-01-13 | 1990-11-28 | Merck & Co. Inc. | Mikrobisches Umbildungsprodukt von L-679,934 |
EP0388152B1 (de) * | 1989-03-15 | 1994-10-12 | Merck & Co. Inc. | Verfahren zur Herstellung einer immunosuppressiven Substanz (demethimmunomycin) durch Verwendung eines Stamm-Mutanten eines Mikroorganismus |
US5272068A (en) * | 1989-03-15 | 1993-12-21 | Merck & Co., Inc. | Process for producing immunosuppressant agent L-683942 by fermentation |
DE69015393T2 (de) * | 1989-03-15 | 1995-06-01 | Merck & Co Inc | Immunosuppressives Mittel. |
US5155228A (en) * | 1989-03-23 | 1992-10-13 | Merck & Co., Inc. | FK-506 C10-C18 process intermediates |
US4940797A (en) * | 1989-03-23 | 1990-07-10 | Merck & Co., Inc. | Process for synthesis of FK-506 C10-C18 intermediates |
US5068323A (en) * | 1989-04-21 | 1991-11-26 | Merck & Co., Inc. | Thermally re-arranged FK-506 derivatives having immunosuppressant activity |
CA2014841A1 (en) * | 1989-04-21 | 1990-10-21 | Byron H. Arison | Macrolides having immunosuppressive activity |
US5057608A (en) * | 1989-04-21 | 1991-10-15 | Merck & Co., Inc. | Immunoregulants, immunosuppressants, process to make ring expanded macrolide related to FK-506/FK-520 |
US5270187A (en) * | 1989-05-05 | 1993-12-14 | Merck & Co., Inc. | Microbial transformation product |
JPH0368583A (ja) * | 1989-05-05 | 1991-03-25 | Merck & Co Inc | 新規微生物変換物質 |
US4987139A (en) * | 1989-05-05 | 1991-01-22 | Merck & Co., Inc. | FK-520 microbial transformation product |
IE64214B1 (en) * | 1989-06-06 | 1995-07-26 | Fujisawa Pharmaceutical Co | Macrolides for the treatment of reversible obstructive airways diseases |
CA2018710A1 (en) * | 1989-06-13 | 1990-12-13 | Shieh-Shung T. Chen | L-683,590 microbial transformation product |
US5138052A (en) * | 1989-06-13 | 1992-08-11 | Merck & Co., Inc. | L-683,590 microbial transformation product |
JPH04500372A (ja) * | 1989-06-14 | 1992-01-23 | サンド・リミテッド | 異種原子含有三環式化合物 |
US5235066A (en) * | 1989-06-30 | 1993-08-10 | Merck & Co., Inc. | FK-506 type macrolide intermediate |
US5164525A (en) * | 1989-06-30 | 1992-11-17 | Merck & Co., Inc. | Synthetic process for fk-506 type macrolide intermediates |
EP0413532A3 (en) * | 1989-08-18 | 1991-05-15 | Fisons Plc | Macrocyclic compounds |
WO1991002736A1 (en) * | 1989-08-18 | 1991-03-07 | Fisons Plc | Macrocyclic compounds |
US5011943A (en) * | 1989-08-28 | 1991-04-30 | Merck Frosst Canada, Inc. | FK-506 C10 -C24 process intermediates |
GR1001225B (el) * | 1989-09-14 | 1993-06-30 | Fisons Plc | Νέαι μακροκυκλικαί ενώσεις και νέα μέ?οδος χρήσεως τους. |
US5215995A (en) * | 1989-10-16 | 1993-06-01 | Fujisawa Pharmaceutical Co., Ltd. | Hair revitalizing agent |
ES2077663T3 (es) * | 1989-11-09 | 1995-12-01 | Sandoz Ltd | Compuestos triciclicos que contienen heteroatomos. |
US5208228A (en) * | 1989-11-13 | 1993-05-04 | Merck & Co., Inc. | Aminomacrolides and derivatives having immunosuppressive activity |
IE904050A1 (en) * | 1989-11-13 | 1991-05-22 | Merck & Co Inc | Aminomacrolides and derivatives having immunosuppressive¹activity |
GB8925797D0 (en) * | 1989-11-15 | 1990-01-04 | Fisons Plc | Compositions |
EP0444829A3 (en) * | 1990-02-27 | 1992-06-03 | Fisons Plc | Immunosuppressive compounds |
US5260301A (en) * | 1990-03-01 | 1993-11-09 | Fujisawa Pharmaceutical Co., Ltd. | Pharmaceutical solution containing FK-506 |
US5064835A (en) * | 1990-03-01 | 1991-11-12 | Merck & Co., Inc. | Hydroxymacrolide derivatives having immunosuppressive activity |
JPH05504956A (ja) * | 1990-03-12 | 1993-07-29 | 藤沢薬品工業株式会社 | トリシクロ化合物 |
US5296489A (en) * | 1990-03-13 | 1994-03-22 | Fisons | Immunosuppressive macrocyclic compounds |
EP0594600A1 (de) * | 1990-03-13 | 1994-05-04 | FISONS plc | Immunosuppressive makrozyklische verbindungen |
EP0455427A1 (de) * | 1990-04-30 | 1991-11-06 | Merck & Co. Inc. | Deoxyaycrolid-Derivate mit immunsuppressiver Wirkung |
WO1991017754A1 (en) * | 1990-05-11 | 1991-11-28 | Fujisawa Pharmaceutical Co., Ltd. | Methods for treating and preventing inflammation of mucosa and blood vessels using fk 506 and related compounds |
US5643901A (en) * | 1990-06-11 | 1997-07-01 | Fujisawa Pharmaceutical Co., Ltd. | Medicament for treating idiopathic thrombocytopenic purpura |
WO1991019495A1 (en) * | 1990-06-11 | 1991-12-26 | Fujisawa Pharmaceutical Co., Ltd. | Use of a macrolide compound such as fk 506 for manufacturing a medicament for treating idiopathic thrombocytopenic purpura and basedow's disease |
US5210030A (en) * | 1990-06-25 | 1993-05-11 | Merck & Co., Inc. | Process for selectively acylating immunomycin |
US5190950A (en) * | 1990-06-25 | 1993-03-02 | Merck & Co., Inc. | Antagonists of immunosuppressive macrolides |
US5342935A (en) * | 1990-06-25 | 1994-08-30 | Merck & Co., Inc. | Antagonists of immunosuppressive macrolides |
CA2044846A1 (en) * | 1990-06-25 | 1991-12-26 | Thomas R. Beattie | Antagonists of immunosuppressive macrolides |
GB9014136D0 (en) * | 1990-06-25 | 1990-08-15 | Fujisawa Pharmaceutical Co | Tricyclo compounds,a process for their production and a pharmaceutical composition containing the same |
MY110418A (en) * | 1990-07-02 | 1998-05-30 | Novartis Ag | Heteroatoms-containing tricyclic compounds. |
GB9014681D0 (en) * | 1990-07-02 | 1990-08-22 | Fujisawa Pharmaceutical Co | Tricyclo compounds,a process for their production and a pharmaceutical composition containing the same |
EP0466365A3 (en) * | 1990-07-03 | 1992-04-15 | Merck & Co. Inc. | Novel immunosuppressant fermentation products of a microorganism |
GB2245891A (en) * | 1990-07-09 | 1992-01-15 | Fujisawa Pharmaceutical Co | Tricyclo compounds |
GB2246350A (en) * | 1990-07-23 | 1992-01-29 | Fujisawa Pharmaceutical Co | Tricyclo compounds |
US5089517A (en) * | 1990-08-03 | 1992-02-18 | The Board Of Trustees Of The Leland Stanford Junior University | Neuroprotection by indolactam v and derivatives thereof |
AU8394291A (en) * | 1990-08-18 | 1992-03-17 | Fisons Plc | Macrocyclic compounds |
GB2247620A (en) * | 1990-09-07 | 1992-03-11 | Fujisawa Pharmaceutical Co | The use of macrolide compounds for cytomegalovirus infection |
CA2051872A1 (en) * | 1990-09-24 | 1992-03-25 | Kevin M. Byrne | Directed biosynthesis process for prolyl-immunomycin |
GB2248184A (en) * | 1990-09-28 | 1992-04-01 | Fujisawa Pharmaceutical Co | New use of macrolide compounds for active oxygen-mediated diseases |
US5143918A (en) * | 1990-10-11 | 1992-09-01 | Merck & Co., Inc. | Halomacrolides and derivatives having immunosuppressive activity |
US5233036A (en) * | 1990-10-16 | 1993-08-03 | American Home Products Corporation | Rapamycin alkoxyesters |
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