ITMI20042098A1 - Processo per la purificazione di tacrolimus - Google Patents
Processo per la purificazione di tacrolimusInfo
- Publication number
- ITMI20042098A1 ITMI20042098A1 IT002098A ITMI20042098A ITMI20042098A1 IT MI20042098 A1 ITMI20042098 A1 IT MI20042098A1 IT 002098 A IT002098 A IT 002098A IT MI20042098 A ITMI20042098 A IT MI20042098A IT MI20042098 A1 ITMI20042098 A1 IT MI20042098A1
- Authority
- IT
- Italy
- Prior art keywords
- tacrolimus
- purification
- tacrolimus purification
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B63/00—Purification; Separation; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/32—Bonded phase chromatography
- B01D15/322—Normal bonded phase
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/32—Bonded phase chromatography
- B01D15/325—Reversed phase
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Transplantation (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT002098A ITMI20042098A1 (it) | 2004-11-03 | 2004-11-03 | Processo per la purificazione di tacrolimus |
JP2007539497A JP2008518984A (ja) | 2004-11-03 | 2005-10-24 | タクロリムスの精製方法 |
KR1020077010048A KR20070083930A (ko) | 2004-11-03 | 2005-10-24 | 타크롤리무스 정제 방법 |
US11/718,415 US20080160586A1 (en) | 2004-11-03 | 2005-10-24 | Process for the Purification of Tacrolimus |
EP05807586A EP1812447A1 (en) | 2004-11-03 | 2005-10-24 | Process for the purification of tacrolimus |
CA002586193A CA2586193A1 (en) | 2004-11-03 | 2005-10-24 | Process for the purification of tacrolimus |
CNA2005800370313A CN101048415A (zh) | 2004-11-03 | 2005-10-24 | 藤霉素的纯化方法 |
PCT/EP2005/011393 WO2006048145A1 (en) | 2004-11-03 | 2005-10-24 | Process for the purification of tacrolimus |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT002098A ITMI20042098A1 (it) | 2004-11-03 | 2004-11-03 | Processo per la purificazione di tacrolimus |
Publications (1)
Publication Number | Publication Date |
---|---|
ITMI20042098A1 true ITMI20042098A1 (it) | 2005-02-03 |
Family
ID=35542958
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT002098A ITMI20042098A1 (it) | 2004-11-03 | 2004-11-03 | Processo per la purificazione di tacrolimus |
Country Status (8)
Country | Link |
---|---|
US (1) | US20080160586A1 (it) |
EP (1) | EP1812447A1 (it) |
JP (1) | JP2008518984A (it) |
KR (1) | KR20070083930A (it) |
CN (1) | CN101048415A (it) |
CA (1) | CA2586193A1 (it) |
IT (1) | ITMI20042098A1 (it) |
WO (1) | WO2006048145A1 (it) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007013017A1 (en) * | 2005-07-29 | 2007-02-01 | Ranbaxy Laboratories Limited | A process for purification of macrolides |
ITMI20051549A1 (it) * | 2005-08-05 | 2007-02-06 | Antibioticos Spa | Purificazione del tacrolimus su supporti dimorigine vegetale |
KR100891313B1 (ko) * | 2007-08-17 | 2009-03-31 | (주) 제노텍 | 담체로 작용하는 흡착성 수지의 제공에 의한 트리사이클로화합물의 생산 및 추출 방법 |
KR101033845B1 (ko) * | 2008-09-18 | 2011-05-16 | (주) 제노텍 | 은 이온 용액 결정화에 의한 불포화 알킬기를 가진 락톤 화합물 정제방법 |
CN101712685B (zh) * | 2009-06-22 | 2012-07-04 | 鲁南制药集团股份有限公司 | 一种他克莫司粗品的精制方法 |
KR101261131B1 (ko) | 2010-08-24 | 2013-05-06 | 이화여자대학교 산학협력단 | 신규 타크롤리무스 유도체, 상기 유도체를 포함하는 신경 보호용 조성물, 상기 유도체를 포함하는 면역 억제용 조성물, 상기 유도체의 생산 방법 및 상기 유도체의 생산 균주 |
WO2012026665A1 (en) * | 2010-08-24 | 2012-03-01 | Ewha University - Industry Collaboration Foundation | Novel tacrolimus derivatives, a neuroprotective composition comprising the same, an immunosuppressive composition comprising the same, a method for preparing the same, and a mutant for producing the same |
KR102098843B1 (ko) * | 2012-05-23 | 2020-04-09 | 란자테크 뉴질랜드 리미티드 | 발효 및 모사 이동층 공정 |
CN107556327A (zh) * | 2017-10-31 | 2018-01-09 | 无锡福祈制药有限公司 | 一种分离纯化他克莫司的方法 |
KR102645011B1 (ko) | 2023-10-17 | 2024-03-07 | 주식회사 라이프슈티컬 | 고상 추출법을 이용한 타크롤리무스의 정제방법 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8430455D0 (en) * | 1984-12-03 | 1985-01-09 | Fujisawa Pharmaceutical Co | Fr-900506 substance |
US4894366A (en) * | 1984-12-03 | 1990-01-16 | Fujisawa Pharmaceutical Company, Ltd. | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same |
CA2018710A1 (en) * | 1989-06-13 | 1990-12-13 | Shieh-Shung T. Chen | L-683,590 microbial transformation product |
JPH03275689A (ja) * | 1990-03-23 | 1991-12-06 | Fujisawa Pharmaceut Co Ltd | Fr900506物質の脱メチル体およびヒドロキシ体 |
JP3067183B2 (ja) * | 1990-09-18 | 2000-07-17 | 藤沢薬品工業株式会社 | Fr900506物質の製造法 |
EP0480623A1 (en) * | 1990-10-11 | 1992-04-15 | Merck & Co. Inc. | New halomacrolides and derivatives having immunosuppressive activity |
US5194378A (en) * | 1991-01-28 | 1993-03-16 | Merck & Co., Inc. | Process for producing fk-506 |
WO2000071546A1 (en) * | 1999-05-25 | 2000-11-30 | Fujisawa Pharmaceutical Co., Ltd. | Method for separating analogous organic compounds |
TW553946B (en) * | 1999-09-08 | 2003-09-21 | Fujisawa Pharmaceutical Co | Method for separating lactone-containing high-molecular weight compounds |
WO2005054253A1 (en) * | 2003-12-05 | 2005-06-16 | Biocon Limited | Process for the purification of macrolides |
EP1756290B1 (en) * | 2004-04-12 | 2016-05-04 | Biocon Limited | Streptomyces sp. bicc 7522 and its use for the production of macrolides |
-
2004
- 2004-11-03 IT IT002098A patent/ITMI20042098A1/it unknown
-
2005
- 2005-10-24 JP JP2007539497A patent/JP2008518984A/ja active Pending
- 2005-10-24 KR KR1020077010048A patent/KR20070083930A/ko not_active Application Discontinuation
- 2005-10-24 WO PCT/EP2005/011393 patent/WO2006048145A1/en active Application Filing
- 2005-10-24 CN CNA2005800370313A patent/CN101048415A/zh active Pending
- 2005-10-24 US US11/718,415 patent/US20080160586A1/en not_active Abandoned
- 2005-10-24 EP EP05807586A patent/EP1812447A1/en not_active Withdrawn
- 2005-10-24 CA CA002586193A patent/CA2586193A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20080160586A1 (en) | 2008-07-03 |
JP2008518984A (ja) | 2008-06-05 |
KR20070083930A (ko) | 2007-08-24 |
CA2586193A1 (en) | 2006-05-11 |
WO2006048145A1 (en) | 2006-05-11 |
EP1812447A1 (en) | 2007-08-01 |
CN101048415A (zh) | 2007-10-03 |
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