ATE138807T1 - 29-demethoxyrapamycin zur induktion der immunosuppression - Google Patents

29-demethoxyrapamycin zur induktion der immunosuppression

Info

Publication number
ATE138807T1
ATE138807T1 AT93302288T AT93302288T ATE138807T1 AT E138807 T1 ATE138807 T1 AT E138807T1 AT 93302288 T AT93302288 T AT 93302288T AT 93302288 T AT93302288 T AT 93302288T AT E138807 T1 ATE138807 T1 AT E138807T1
Authority
AT
Austria
Prior art keywords
demethoxyrapamycin
inducing immunosuppression
rejection
immunosuppression
inducing
Prior art date
Application number
AT93302288T
Other languages
English (en)
Inventor
Suren Nath Sehgal
Jay Joseph Armstrong
Chee Ping Eng
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Application granted granted Critical
Publication of ATE138807T1 publication Critical patent/ATE138807T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
AT93302288T 1992-03-27 1993-03-25 29-demethoxyrapamycin zur induktion der immunosuppression ATE138807T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US85892392A 1992-03-27 1992-03-27

Publications (1)

Publication Number Publication Date
ATE138807T1 true ATE138807T1 (de) 1996-06-15

Family

ID=25329511

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93302288T ATE138807T1 (de) 1992-03-27 1993-03-25 29-demethoxyrapamycin zur induktion der immunosuppression

Country Status (9)

Country Link
EP (1) EP0562853B1 (de)
JP (1) JP3179235B2 (de)
AT (1) ATE138807T1 (de)
CA (1) CA2092729A1 (de)
DE (1) DE69302945T2 (de)
DK (1) DK0562853T3 (de)
ES (1) ES2089723T3 (de)
GR (1) GR3020310T3 (de)
MX (1) MX9301707A (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5527907A (en) * 1993-11-19 1996-06-18 Abbott Laboratories Macrolide immunomodulators
CA2175215C (en) * 1993-11-19 2008-06-03 Yat Sun Or Semisynthetic analogs of rapamycin (macrolides) being immunomodulators
PT956034E (pt) 1996-07-30 2002-12-31 Novartis Ag Composicoes farmaceuticas para o tratamento da rejeicao de transplantes estados inflamatorios ou auto-imunes compreendendo ciclosporina a e 40-o-(2-hidroxietil)-rapamicina
WO2000043030A1 (en) * 1999-01-22 2000-07-27 Fujisawa Pharmaceutical Co., Ltd. Method of suppressing ongoing acute allograff rejection
WO2006119018A2 (en) * 2005-04-29 2006-11-09 Atrium Medical Corporation Drug delivery coating for use with a medical device and methods of treating vascular injury
US9428845B1 (en) 2010-12-28 2016-08-30 Warp Drive Bio, Inc. Identifying new therapeutic agents
EP4289950A3 (de) 2015-01-09 2024-01-24 Revolution Medicines, Inc. Makrozyklische verbindungen mit beteiligung an einer kooperativen bindung und medizinische verwendungen davon
TW201629069A (zh) 2015-01-09 2016-08-16 霍普驅動生物科技股份有限公司 參與協同結合之化合物及其用途
CA3000822A1 (en) 2015-10-01 2017-04-06 Warp Drive Bio, Inc. Methods and reagents for analyzing protein-protein interfaces
KR102359972B1 (ko) 2016-04-12 2022-02-10 징코 바이오웍스, 인크. 화합물의 제조를 위한 조성물 및 방법
JP2020501519A (ja) 2016-10-28 2020-01-23 ギンゴー バイオワークス， インコーポレイテッド 化合物の生産のための組成物および方法
MX2022005359A (es) 2019-11-04 2022-06-02 Revolution Medicines Inc Inhibidores de ras.
US11608346B2 (en) 2019-11-04 2023-03-21 Revolution Medicines, Inc. Ras inhibitors
JP2022553857A (ja) 2019-11-04 2022-12-26 レボリューション メディシンズ インコーポレイテッド Ｒａｓ阻害剤
TW202227460A (zh) 2020-09-15 2022-07-16 美商銳新醫藥公司 Ｒａｓ抑制劑

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA737247B (en) 1972-09-29 1975-04-30 Ayerst Mckenna & Harrison Rapamycin and process of preparation
US4375464A (en) 1981-11-19 1983-03-01 Ayerst, Mckenna & Harrison Inc. Antibiotic AY24,668 and process of preparation
US4894366A (en) * 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
US5100899A (en) 1989-06-06 1992-03-31 Roy Calne Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof
US5023262A (en) * 1990-08-14 1991-06-11 American Home Products Corporation Hydrogenated rapamycin derivatives
GB9103430D0 (en) * 1991-02-19 1991-04-03 Smithkline Beecham Plc Novel compound
US5080899A (en) 1991-02-22 1992-01-14 American Home Products Corporation Method of treating pulmonary inflammation
US5078999A (en) 1991-02-22 1992-01-07 American Home Products Corporation Method of treating systemic lupus erythematosus
US5091389A (en) 1991-04-23 1992-02-25 Merck & Co., Inc. Lipophilic macrolide useful as an immunosuppressant

Also Published As

Publication number Publication date
DK0562853T3 (da) 1996-07-01
JP3179235B2 (ja) 2001-06-25
EP0562853A1 (de) 1993-09-29
DE69302945T2 (de) 1996-10-10
DE69302945D1 (de) 1996-07-11
GR3020310T3 (en) 1996-09-30
MX9301707A (es) 1993-09-01
ES2089723T3 (es) 1996-10-01
EP0562853B1 (de) 1996-06-05
JPH0616674A (ja) 1994-01-25
CA2092729A1 (en) 1993-09-28

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee