CZ304734B6 - Způsob přípravy 9-[2-(fosfonomethoxy)propyl]adeninu a 9-[2-(fosfonomethoxy)ethyl]adeninu - Google Patents

Způsob přípravy 9-[2-(fosfonomethoxy)propyl]adeninu a 9-[2-(fosfonomethoxy)ethyl]adeninu Download PDF

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Publication number
CZ304734B6
CZ304734B6 CZ2013-310A CZ2013310A CZ304734B6 CZ 304734 B6 CZ304734 B6 CZ 304734B6 CZ 2013310 A CZ2013310 A CZ 2013310A CZ 304734 B6 CZ304734 B6 CZ 304734B6
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Czechia
Prior art keywords
adenine
phosphonomethoxy
propyl
ethyl
mol
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CZ2013-310A
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Czech (cs)
English (en)
Inventor
Mark W. Becker
Harlan H. Chapman
Tomas Cihlar
Eugene J. Eisenberg
Gong-Xin He
Michael R. Kernan
William A. Lee
Ernest J. Prisbe
John C. Rohloff
Mark L. Sparacino
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Gilead Sciences, Inc.
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Application filed by Gilead Sciences, Inc. filed Critical Gilead Sciences, Inc.
Publication of CZ304734B6 publication Critical patent/CZ304734B6/cs

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • C07H19/10Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
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    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
    • C07H19/20Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
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    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity

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CZ2013-310A 2000-07-21 2001-07-20 Způsob přípravy 9-[2-(fosfonomethoxy)propyl]adeninu a 9-[2-(fosfonomethoxy)ethyl]adeninu CZ304734B6 (cs)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22002100P 2000-07-21 2000-07-21

Publications (1)

Publication Number Publication Date
CZ304734B6 true CZ304734B6 (cs) 2014-09-10

Family

ID=22821718

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CZ2013-310A CZ304734B6 (cs) 2000-07-21 2001-07-20 Způsob přípravy 9-[2-(fosfonomethoxy)propyl]adeninu a 9-[2-(fosfonomethoxy)ethyl]adeninu
CZ2003-413A CZ304886B6 (cs) 2000-07-21 2001-07-20 Prekurzory léčiv na bázi fosfonátových analogů nukleotidů a způsoby jejich výběru a přípravy

Family Applications After (1)

Application Number Title Priority Date Filing Date
CZ2003-413A CZ304886B6 (cs) 2000-07-21 2001-07-20 Prekurzory léčiv na bázi fosfonátových analogů nukleotidů a způsoby jejich výběru a přípravy

Country Status (37)

Country Link
US (10) US20040018150A1 (instruction)
EP (3) EP3235823A1 (instruction)
JP (4) JP4651264B2 (instruction)
KR (2) KR100749160B1 (instruction)
CN (2) CN100402539C (instruction)
AP (1) AP1466A (instruction)
AU (3) AU2001282941C1 (instruction)
BE (1) BE2016C018I2 (instruction)
BG (1) BG66037B1 (instruction)
BR (1) BRPI0112646B8 (instruction)
CA (3) CA2416757C (instruction)
CY (2) CY2016008I2 (instruction)
CZ (2) CZ304734B6 (instruction)
DK (2) DK2682397T3 (instruction)
EA (1) EA004926B1 (instruction)
EE (1) EE05366B1 (instruction)
ES (2) ES2536972T5 (instruction)
FR (1) FR16C0013I2 (instruction)
HK (1) HK1243711A1 (instruction)
HR (2) HRP20160074B1 (instruction)
HU (2) HU230960B1 (instruction)
IL (1) IL153658A0 (instruction)
IS (1) IS2985B (instruction)
LT (2) LT2682397T (instruction)
LU (1) LU93029I2 (instruction)
MX (1) MXPA03000587A (instruction)
NL (1) NL300803I2 (instruction)
NO (6) NO336718B1 (instruction)
NZ (3) NZ535408A (instruction)
OA (1) OA12393A (instruction)
PL (1) PL213214B1 (instruction)
PT (2) PT1301519E (instruction)
SI (2) SI2682397T1 (instruction)
TR (1) TR200300055T2 (instruction)
UA (1) UA75889C2 (instruction)
WO (1) WO2002008241A2 (instruction)
ZA (1) ZA200210271B (instruction)

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