ATE534377T1 - Verfahren und zusammensetzungen zur behandlung von hämatologischen erkrankungen - Google Patents

Verfahren und zusammensetzungen zur behandlung von hämatologischen erkrankungen

Info

Publication number
ATE534377T1
ATE534377T1 AT07794933T AT07794933T ATE534377T1 AT E534377 T1 ATE534377 T1 AT E534377T1 AT 07794933 T AT07794933 T AT 07794933T AT 07794933 T AT07794933 T AT 07794933T AT E534377 T1 ATE534377 T1 AT E534377T1
Authority
AT
Austria
Prior art keywords
compositions
methods
hematological diseases
treating hematological
compound
Prior art date
Application number
AT07794933T
Other languages
English (en)
Inventor
Lee Chong
William Lee
Adrian Ray
Hans Reiser
Daniel Tumas
William Watkins
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Application granted granted Critical
Publication of ATE534377T1 publication Critical patent/ATE534377T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
AT07794933T 2006-05-16 2007-05-16 Verfahren und zusammensetzungen zur behandlung von hämatologischen erkrankungen ATE534377T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US80098306P 2006-05-16 2006-05-16
US83180506P 2006-07-18 2006-07-18
PCT/US2007/011726 WO2007136650A2 (en) 2006-05-16 2007-05-16 Method and compositions for treating hematological malignancies

Publications (1)

Publication Number Publication Date
ATE534377T1 true ATE534377T1 (de) 2011-12-15

Family

ID=38578698

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07794933T ATE534377T1 (de) 2006-05-16 2007-05-16 Verfahren und zusammensetzungen zur behandlung von hämatologischen erkrankungen

Country Status (20)

Country Link
US (3) US20080039427A1 (de)
EP (1) EP2020996B1 (de)
JP (2) JP5544165B2 (de)
KR (1) KR101424832B1 (de)
CN (1) CN101442994B (de)
AT (1) ATE534377T1 (de)
AU (1) AU2007254309B2 (de)
BR (1) BRPI0711646C1 (de)
CA (1) CA2652048C (de)
CY (1) CY1112377T1 (de)
DK (1) DK2020996T3 (de)
EA (1) EA016995B1 (de)
ES (1) ES2377467T3 (de)
HK (1) HK1127913A1 (de)
MX (1) MX2008014665A (de)
NZ (1) NZ572368A (de)
PL (1) PL2020996T3 (de)
PT (1) PT2020996E (de)
SI (1) SI2020996T1 (de)
WO (1) WO2007136650A2 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
US7501426B2 (en) 2004-02-18 2009-03-10 Boehringer Ingelheim International Gmbh 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
DE102005035891A1 (de) * 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
PE20110235A1 (es) 2006-05-04 2011-04-14 Boehringer Ingelheim Int Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
CN101437823B (zh) 2006-05-04 2014-12-10 勃林格殷格翰国际有限公司 多晶型
EP1852108A1 (de) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG Zusammensetzungen von DPP-IV-Inhibitoren
ATE534377T1 (de) * 2006-05-16 2011-12-15 Gilead Sciences Inc Verfahren und zusammensetzungen zur behandlung von hämatologischen erkrankungen
TWI444384B (zh) 2008-02-20 2014-07-11 Gilead Sciences Inc 核苷酸類似物及其在治療惡性腫瘤上的用途
PE20091730A1 (es) 2008-04-03 2009-12-10 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
BRPI0916997A2 (pt) 2008-08-06 2020-12-15 Boehringer Ingelheim International Gmbh Inibidor de dpp-4 e seu uso
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
KR20110067096A (ko) 2008-09-10 2011-06-21 베링거 인겔하임 인터내셔날 게엠베하 당뇨병 및 관련 상태를 치료하기 위한 병용 요법
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
KR20110103968A (ko) 2008-12-23 2011-09-21 베링거 인겔하임 인터내셔날 게엠베하 유기 화합물의 염 형태
AR074990A1 (es) 2009-01-07 2011-03-02 Boehringer Ingelheim Int Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina
EA034869B1 (ru) 2009-11-27 2020-03-31 Бёрингер Ингельхайм Интернациональ Гмбх Лечение генотипированных пациентов с диабетом ингибиторами дпп-4, такими как линаглиптин
BR112012028136A2 (pt) 2010-05-05 2016-08-09 Boehringer Ingelheim Int terapia de combinaçao
KR20130093012A (ko) 2010-06-24 2013-08-21 베링거 인겔하임 인터내셔날 게엠베하 당뇨병 요법
US9034883B2 (en) 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy
EP2731947B1 (de) 2011-07-15 2019-01-16 Boehringer Ingelheim International GmbH Substituiertes dimeres chinazolin derivat, dessen herstellung und verwendung in pharmazeutischen zusammensetzungen zur behandlung von typ i und typ ii diabetes
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
JP6224084B2 (ja) 2012-05-14 2017-11-01 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 糸球体上皮細胞関連障害及び／又はネフローゼ症候群の治療に用いるｄｐｐ−４阻害薬としてのキサンチン誘導体
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
CN103665043B (zh) 2012-08-30 2017-11-10 江苏豪森药业集团有限公司 一种替诺福韦前药及其在医药上的应用
ES2950384T3 (es) 2014-02-28 2023-10-09 Boehringer Ingelheim Int Uso médico de un inhibidor de DPP-4
US10155000B2 (en) 2016-06-10 2018-12-18 Boehringer Ingelheim International Gmbh Medical use of pharmaceutical combination or composition
JP2021528363A (ja) * 2018-06-12 2021-10-21 シチュアン ケルン−バイオテック バイオファーマシューティカル カンパニー リミテッド ホスホンアミドエステル化合物、その塩、その関連する結晶体、その製造方法及びその使用
CN112168829B (zh) * 2020-09-24 2022-02-15 华南理工大学 抗病毒药物在制备治疗骨髓增生异常综合征药物中的应用及制得的骨髓增生异常综合征药物

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5795909A (en) * 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
AP1466A (en) 2000-07-21 2005-09-22 Gilead Sciences Inc Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same.
DE60221642T3 (de) * 2001-02-12 2017-10-26 Wyeth LLC (n.d.Ges.d. Staates Delaware) O-desmethyl-venlafaxine succinat salz
WO2003045394A1 (en) * 2001-11-29 2003-06-05 Pfizer Products Inc. Succinic acid salts of 5,8,14-triazatetracyclo'10.3.1.0<2,11>.0<4,9>-hexadeca-2(11),3,5,7,9-pentaene and pharmaceutical compositions thereof
NZ532436A (en) * 2001-12-12 2006-01-27 Pfizer Prod Inc Salt forms of E-2-Methoxy-N-(3-{4-[3-methyl-4-(6-methyl-pyridin-3-yloxy)-phenylamino]-quinazolin-6-yl}-allyl)-acetamide and method of production
WO2004037161A2 (en) * 2002-05-13 2004-05-06 Metabasis Therapeutics, Inc. Cyclic prodrugs of pmea one of its analogues
US7563748B2 (en) 2003-06-23 2009-07-21 Cognis Ip Management Gmbh Alcohol alkoxylate carriers for pesticide active ingredients
US7767683B2 (en) * 2003-08-18 2010-08-03 H. Lundbeck A/S Hydrogen succinate salts of trans-4-((1R, 3S)-6-chloro-3-phenylindan-1-YL)-1,2,2-trimethylpiperazine and the use as a medicament
PT2204374E (pt) * 2003-12-30 2012-09-17 Gilead Sciences Inc Fosfonatos nucleosídeos e seus análogos para o tratamento de infecções com hpv
CA2553455A1 (en) 2004-01-21 2005-08-11 Gilead Sciences, Inc. Use of adefovir or tenofovir for inhibiting mmtv-like viruses involved in breast cancer and primary biliary cirrhosis
DE102005041860A1 (de) * 2005-09-02 2007-03-08 Schering Ag Nanopartikulärer Einschluss- und Ladungskomplex für pharmazeutische Formulierungen
JP2009519952A (ja) * 2005-12-16 2009-05-21 ワイス トリアゾロピリミジン化合物の凍結乾燥組成物
ATE534377T1 (de) * 2006-05-16 2011-12-15 Gilead Sciences Inc Verfahren und zusammensetzungen zur behandlung von hämatologischen erkrankungen

Also Published As

Publication number Publication date
BRPI0711646B1 (pt) 2020-12-01
US20110172192A1 (en) 2011-07-14
CA2652048C (en) 2012-12-11
EP2020996A2 (de) 2009-02-11
AU2007254309A1 (en) 2007-11-29
US8435969B2 (en) 2013-05-07
SI2020996T1 (sl) 2012-03-30
PL2020996T3 (pl) 2012-04-30
KR20090015122A (ko) 2009-02-11
US20080039427A1 (en) 2008-02-14
NZ572368A (en) 2011-04-29
DK2020996T3 (da) 2012-02-27
CN101442994A (zh) 2009-05-27
MX2008014665A (es) 2008-11-28
EA016995B1 (ru) 2012-09-28
BRPI0711646B8 (pt) 2021-04-06
EP2020996B1 (de) 2011-11-23
HK1127913A1 (en) 2009-10-09
JP2009537539A (ja) 2009-10-29
AU2007254309B2 (en) 2012-05-03
BRPI0711646A2 (pt) 2011-11-29
BRPI0711646C1 (pt) 2021-05-25
CA2652048A1 (en) 2007-11-29
CN101442994B (zh) 2013-03-06
JP5544165B2 (ja) 2014-07-09
PT2020996E (pt) 2012-02-20
ES2377467T3 (es) 2012-03-27
EA200802333A1 (ru) 2009-04-28
WO2007136650A3 (en) 2008-01-24
JP2013100324A (ja) 2013-05-23
CY1112377T1 (el) 2015-12-09
US20090258840A1 (en) 2009-10-15
KR101424832B1 (ko) 2014-08-06
WO2007136650A2 (en) 2007-11-29

Similar Documents

Publication Publication Date Title
ATE534377T1 (de) Verfahren und zusammensetzungen zur behandlung von hämatologischen erkrankungen
DE602006010442D1 (de) Verwendung von benzokondensierten heterocyclischen sulfamid-derivaten zur behandlung von schmerzen
EA200600689A1 (ru) Замещённые бензазолы и их применение в качестве ингибиторов raf киназы
EA201100447A1 (ru) Органические соединения
ATE536349T1 (de) In der 2-stellung durch phenyl substituierte 1h- benzimidazol-4-carbonsäureamide sind wirksame parp-inhibitoren
DE602005026508D1 (de) Monozyklische heterozyklen als kinase-hemmer
EA200970932A1 (ru) Способы лечения с применением пиридопиримидиноновых ингибиторов pi3k альфа
CO6270257A2 (es) Derivados de piridazinona
EA200970935A1 (ru) Способы лечения с применением хинаксолиновых ингибиторов pi3k-альфа
DE602004012079D1 (de) Verwendung eines ibat-hemmers zur behandlung oder vorbeugung von verstopfung
EA200802213A1 (ru) Способы лечения заболеваний крови
DE602004019198D1 (de) Chinolin-2-on-derivate zur behandlung von erkankungen der atemwege
EA200870089A1 (ru) Применение производных бензоконденсированного гетероциклического сульфамида для лечения злоупотребления психоактивным веществом и аддикции
DE502005008058D1 (de) Gesättigte und ungesättigte 3-pyridyl-benzocycloalkylmethyl-amine zur behandlung von schmerzen, depressionen und angstzuständen
EA200802223A1 (ru) 1,5-дифенилпиразолы ii в качестве ингибиторов hsp90
ATE538651T1 (de) Spiropiperidininhibitoren von beta-secretase zur behandlung von alzheimer-krankheit
EA201000098A1 (ru) Производные хиназолинамида
RU2010144637A (ru) Замещенные гамма-лактамы в качестве терапевтических агентов
DE602004011255D1 (de) Phosphinsäurederivate, inhibitoren von beta-sekretase zur behandlung von alzheimer-krankheit
EA201200087A1 (ru) 2-карбоксамиды циклоаминомочевин, которые являются ингибиторами pi3k
SE0401969D0 (sv) Piperidine derivatives
ATE429916T1 (de) Verwendung von sulfonamid-derivaten bei der behandlung von adipositas oder zur verringerung der nahrungsaufnahme
ATE538796T1 (de) Piperidin- und pyrrolidin-beta-secretase-hemmer zur behandlung von alzheimer-krankheit
EA200701813A1 (ru) Новые амидозамещенные 6-фенилфенантридины
EA200701584A1 (ru) Органические соединения, применяемые для лечения болезни альцгеймера, их применение и способ получения