IN2014MU00118A - - Google Patents

Download PDF

Info

Publication number
IN2014MU00118A
IN2014MU00118A IN118MU2014A IN2014MU00118A IN 2014MU00118 A IN2014MU00118 A IN 2014MU00118A IN 118MU2014 A IN118MU2014 A IN 118MU2014A IN 2014MU00118 A IN2014MU00118 A IN 2014MU00118A
Authority
IN
India
Prior art keywords
phenoxyphosphinyl
isopropoxycarbonyl
adenine
methoxy
propyl
Prior art date
Application number
Other languages
English (en)
Inventor
Siva Ram Prasad Vellanki
Raja Babu Balusu
Subba Rayudu Putta
Mastan Rao Raavi
Sivalakshmi Devi Arikatla
Original Assignee
Mylan Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mylan Lab Ltd filed Critical Mylan Lab Ltd
Priority to PCT/IB2015/050239 priority Critical patent/WO2015107451A2/en
Priority to EP15705378.6A priority patent/EP3077404B1/en
Priority to IN118MU2014 priority patent/IN2014MU00118A/en
Priority to ES15705378T priority patent/ES2842123T3/es
Publication of IN2014MU00118A publication Critical patent/IN2014MU00118A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IN118MU2014 2014-01-14 2015-01-13 IN2014MU00118A (instruction)

Priority Applications (4)

Application Number Priority Date Filing Date Title
PCT/IB2015/050239 WO2015107451A2 (en) 2014-01-14 2015-01-13 Purification of tenofovir alafenamide and its intermediates
EP15705378.6A EP3077404B1 (en) 2014-01-14 2015-01-13 Purification of tenofovir alafenamide and its intermediates
IN118MU2014 IN2014MU00118A (instruction) 2014-01-14 2015-01-13
ES15705378T ES2842123T3 (es) 2014-01-14 2015-01-13 Purificación de tenofovir alafenamida y sus intermedios

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN118MU2014 IN2014MU00118A (instruction) 2014-01-14 2015-01-13

Publications (1)

Publication Number Publication Date
IN2014MU00118A true IN2014MU00118A (instruction) 2015-08-28

Family

ID=52484522

Family Applications (1)

Application Number Title Priority Date Filing Date
IN118MU2014 IN2014MU00118A (instruction) 2014-01-14 2015-01-13

Country Status (4)

Country Link
EP (1) EP3077404B1 (instruction)
ES (1) ES2842123T3 (instruction)
IN (1) IN2014MU00118A (instruction)
WO (1) WO2015107451A2 (instruction)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ2015384A3 (cs) * 2015-06-05 2016-12-14 Zentiva, K.S. Pevné formy Tenofovir alafenamidu
CA2987085A1 (en) * 2015-06-17 2016-12-22 Gilead Sciences, Inc. Co-crystals, salts and solid forms of tenofovir alafenamide
CN106699812A (zh) * 2015-11-12 2017-05-24 江苏豪森药业集团有限公司 替诺福韦前药的制备和纯化方法
WO2017118928A1 (en) 2016-01-06 2017-07-13 Lupin Limited Process for the separation of diastereomers of tenofovir alafenamide
PT3411378T (pt) 2016-02-02 2020-07-28 Sandoz Ag Formas cristalinas de monofumarato de tenofovir alafenamida
CN107179355B (zh) * 2016-03-11 2021-08-10 广东东阳光药业有限公司 一种分离检测替诺福韦艾拉酚胺及其有关物质的方法
CZ2016156A3 (cs) * 2016-03-17 2017-09-27 Zentiva, K.S. Způsob přípravy diastereomerně čistého Tenofoviru Alafenamidu nebo jeho solí
CN107226826A (zh) * 2016-03-25 2017-10-03 江苏奥赛康药业股份有限公司 替诺福韦艾拉酚胺富马酸盐化合物及其药物组合物
CN106478725B (zh) * 2016-10-14 2018-11-09 上海礼泰医药科技有限公司 高纯度膦丙替诺福韦中间体的制备方法及其应用
CN113072583A (zh) * 2016-11-28 2021-07-06 正大天晴药业集团股份有限公司 一种替诺福韦艾拉酚胺半富马酸盐的结晶及其制备方法
CN108341841B (zh) * 2017-01-22 2020-07-17 成都倍特药业股份有限公司 一种替诺福韦艾拉酚胺与门冬氨酸的盐
AR110768A1 (es) * 2017-01-31 2019-05-02 Gilead Sciences Inc Formas cristalinas de tenofovir alafenamida
CN106946935B (zh) * 2017-04-28 2020-01-07 福建广生堂药业股份有限公司 一种非对映异构体核苷衍生物的制备方法
CN109942632B (zh) * 2017-12-20 2021-08-31 上海博志研新药物研究有限公司 替诺福韦艾拉酚胺中间体的制备方法
CN109942633B (zh) * 2017-12-20 2021-08-31 上海新礼泰药业有限公司 替诺福韦艾拉酚胺中间体的制备方法
CN108467410B (zh) * 2018-04-09 2021-04-09 重庆三圣实业股份有限公司 一种taf中间体的制备方法及产品和应用
CN108484672A (zh) * 2018-05-23 2018-09-04 中国药科大学制药有限公司 磷丙替诺福韦的手性拆分方法
CN110283208B (zh) * 2018-06-22 2022-07-08 南京济群医药科技股份有限公司 一种替诺福韦艾拉酚胺的手性拆分方法
CN110105392A (zh) * 2019-06-04 2019-08-09 石家庄凯赛医药科技有限公司 一种替诺福韦艾拉酚胺的高效合成工艺
WO2021165995A1 (en) 2020-02-20 2021-08-26 Cipla Limited Novel salts and/or co-crystals of tenofovir alafenamide
US11667656B2 (en) 2021-01-27 2023-06-06 Apotex Inc. Crystalline forms of Tenofovir alafenamide
CN114907409A (zh) * 2022-06-21 2022-08-16 辰欣药业股份有限公司 一种丙酚替诺福韦的制备方法
KR20240109533A (ko) * 2023-01-04 2024-07-11 주식회사 종근당 테노포비르 알라페나미드 또는 이의 약제학적으로 허용가능한 염을 포함하는 안정성이 향상된 약제학적 조성물

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5798340A (en) * 1993-09-17 1998-08-25 Gilead Sciences, Inc. Nucleotide analogs
PL213214B1 (pl) * 2000-07-21 2013-01-31 Gilead Sciences Diastereoizomerycznie wzbogacone proleki fosfonianowych analogów nukleotydowych oraz kompozycje zawierajace takie zwiazki
CN101712692A (zh) * 2009-12-21 2010-05-26 巢杰 泰诺福韦酯的药用酸加成盐及其制备方法和药物应用
TWI709567B (zh) 2011-10-07 2020-11-11 美商基利科學股份有限公司 抗病毒核苷酸類似物的製備方法
WO2013115916A1 (en) * 2012-02-03 2013-08-08 Gilead Sciences, Inc. Combination therapy comprising gs-7340 and cobicistat for use in the treatment of viral infections
IN2013MU01967A (instruction) * 2013-06-07 2015-06-12 Cipla Ltd

Also Published As

Publication number Publication date
EP3077404B1 (en) 2020-10-07
ES2842123T3 (es) 2021-07-12
WO2015107451A2 (en) 2015-07-23
WO2015107451A3 (en) 2015-12-10
EP3077404A2 (en) 2016-10-12

Similar Documents

Publication Publication Date Title
IN2014MU00118A (instruction)
CR20140204A (es) Métodos para preparar análogos nucleotídicos antivirales
IN2013MU01967A (instruction)
MX2021013118A (es) Compuestos polifluorados que actuan como inhibidores de la tirosina cinasa de bruton.
EP3778605A3 (en) Lrrk2 inhibitors and methods of making and using the same
AU2015208932A8 (en) (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase I inhibitors
PH12016501192A1 (en) Tetrahydropyridopyrazines modulators of gpr6
ZA201701384B (en) Compound targeting il-23a and tnf-alpha and uses thereof
HK1256033A1 (zh) 用於刺激免疫系统的肽
PH12016502229A1 (en) Process for preparing phosphorus-containing cyanohydrins
MY191352A (en) Aldosterone synthase inhibitors
HUE049661T2 (hu) Eljárás biomassza hidrolizátum tisztítására
IN2014MU00455A (instruction)
GEP201706626B (en) Synthesis of (s)-nifuratel
WO2015168617A3 (en) Compositions and methods for modulating mtorc1
MX2017012342A (es) Compuestos biciclicos fusionados para el tratamiento de enfermedades,.
PH12014501327A1 (en) Processes for making magnolol analogs
MX2017012027A (es) Desaminacion de nucleosidos organofosforados.
EP3549582A3 (en) Novel capsazepine analogs for the treatment of cancer and other proliferative diseases
UA103197C2 (uk) Застосування ніфуртимоксу для лікування хвороб, спричинених трихомонадами
MX2019002017A (es) Derivados de sofosbuvir para el tratamiento de la hepatitis c.
MX2017003415A (es) Un derivado de tetrahidropirrolo [3,4-d] [1,3]tiazina como inhibidor de bace.
MX388587B (es) Procedimiento para la preparacion de 4-amino-1-((1s,4r,5s)-2-fluoro-4,5-dihidroxi-3-hidroximetil-ciclopent-2-enil)-1h-pirimidin-2-ona.
AU2015221431A8 (en) Novel 6,7-dihydro-3H-oxazolo[3,4-a]pyrazine-5,8-dione derivative compounds
IN2014CH01391A (instruction)