IN2014MU00118A - - Google Patents
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- Publication number
- IN2014MU00118A IN2014MU00118A IN118MU2014A IN2014MU00118A IN 2014MU00118 A IN2014MU00118 A IN 2014MU00118A IN 118MU2014 A IN118MU2014 A IN 118MU2014A IN 2014MU00118 A IN2014MU00118 A IN 2014MU00118A
- Authority
- IN
- India
- Prior art keywords
- phenoxyphosphinyl
- isopropoxycarbonyl
- adenine
- methoxy
- propyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IB2015/050239 WO2015107451A2 (en) | 2014-01-14 | 2015-01-13 | Purification of tenofovir alafenamide and its intermediates |
| EP15705378.6A EP3077404B1 (en) | 2014-01-14 | 2015-01-13 | Purification of tenofovir alafenamide and its intermediates |
| IN118MU2014 IN2014MU00118A (instruction) | 2014-01-14 | 2015-01-13 | |
| ES15705378T ES2842123T3 (es) | 2014-01-14 | 2015-01-13 | Purificación de tenofovir alafenamida y sus intermedios |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN118MU2014 IN2014MU00118A (instruction) | 2014-01-14 | 2015-01-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014MU00118A true IN2014MU00118A (instruction) | 2015-08-28 |
Family
ID=52484522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN118MU2014 IN2014MU00118A (instruction) | 2014-01-14 | 2015-01-13 |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP3077404B1 (instruction) |
| ES (1) | ES2842123T3 (instruction) |
| IN (1) | IN2014MU00118A (instruction) |
| WO (1) | WO2015107451A2 (instruction) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ2015384A3 (cs) * | 2015-06-05 | 2016-12-14 | Zentiva, K.S. | Pevné formy Tenofovir alafenamidu |
| CA2987085A1 (en) * | 2015-06-17 | 2016-12-22 | Gilead Sciences, Inc. | Co-crystals, salts and solid forms of tenofovir alafenamide |
| CN106699812A (zh) * | 2015-11-12 | 2017-05-24 | 江苏豪森药业集团有限公司 | 替诺福韦前药的制备和纯化方法 |
| WO2017118928A1 (en) | 2016-01-06 | 2017-07-13 | Lupin Limited | Process for the separation of diastereomers of tenofovir alafenamide |
| PT3411378T (pt) | 2016-02-02 | 2020-07-28 | Sandoz Ag | Formas cristalinas de monofumarato de tenofovir alafenamida |
| CN107179355B (zh) * | 2016-03-11 | 2021-08-10 | 广东东阳光药业有限公司 | 一种分离检测替诺福韦艾拉酚胺及其有关物质的方法 |
| CZ2016156A3 (cs) * | 2016-03-17 | 2017-09-27 | Zentiva, K.S. | Způsob přípravy diastereomerně čistého Tenofoviru Alafenamidu nebo jeho solí |
| CN107226826A (zh) * | 2016-03-25 | 2017-10-03 | 江苏奥赛康药业股份有限公司 | 替诺福韦艾拉酚胺富马酸盐化合物及其药物组合物 |
| CN106478725B (zh) * | 2016-10-14 | 2018-11-09 | 上海礼泰医药科技有限公司 | 高纯度膦丙替诺福韦中间体的制备方法及其应用 |
| CN113072583A (zh) * | 2016-11-28 | 2021-07-06 | 正大天晴药业集团股份有限公司 | 一种替诺福韦艾拉酚胺半富马酸盐的结晶及其制备方法 |
| CN108341841B (zh) * | 2017-01-22 | 2020-07-17 | 成都倍特药业股份有限公司 | 一种替诺福韦艾拉酚胺与门冬氨酸的盐 |
| AR110768A1 (es) * | 2017-01-31 | 2019-05-02 | Gilead Sciences Inc | Formas cristalinas de tenofovir alafenamida |
| CN106946935B (zh) * | 2017-04-28 | 2020-01-07 | 福建广生堂药业股份有限公司 | 一种非对映异构体核苷衍生物的制备方法 |
| CN109942632B (zh) * | 2017-12-20 | 2021-08-31 | 上海博志研新药物研究有限公司 | 替诺福韦艾拉酚胺中间体的制备方法 |
| CN109942633B (zh) * | 2017-12-20 | 2021-08-31 | 上海新礼泰药业有限公司 | 替诺福韦艾拉酚胺中间体的制备方法 |
| CN108467410B (zh) * | 2018-04-09 | 2021-04-09 | 重庆三圣实业股份有限公司 | 一种taf中间体的制备方法及产品和应用 |
| CN108484672A (zh) * | 2018-05-23 | 2018-09-04 | 中国药科大学制药有限公司 | 磷丙替诺福韦的手性拆分方法 |
| CN110283208B (zh) * | 2018-06-22 | 2022-07-08 | 南京济群医药科技股份有限公司 | 一种替诺福韦艾拉酚胺的手性拆分方法 |
| CN110105392A (zh) * | 2019-06-04 | 2019-08-09 | 石家庄凯赛医药科技有限公司 | 一种替诺福韦艾拉酚胺的高效合成工艺 |
| WO2021165995A1 (en) | 2020-02-20 | 2021-08-26 | Cipla Limited | Novel salts and/or co-crystals of tenofovir alafenamide |
| US11667656B2 (en) | 2021-01-27 | 2023-06-06 | Apotex Inc. | Crystalline forms of Tenofovir alafenamide |
| CN114907409A (zh) * | 2022-06-21 | 2022-08-16 | 辰欣药业股份有限公司 | 一种丙酚替诺福韦的制备方法 |
| KR20240109533A (ko) * | 2023-01-04 | 2024-07-11 | 주식회사 종근당 | 테노포비르 알라페나미드 또는 이의 약제학적으로 허용가능한 염을 포함하는 안정성이 향상된 약제학적 조성물 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5798340A (en) * | 1993-09-17 | 1998-08-25 | Gilead Sciences, Inc. | Nucleotide analogs |
| PL213214B1 (pl) * | 2000-07-21 | 2013-01-31 | Gilead Sciences | Diastereoizomerycznie wzbogacone proleki fosfonianowych analogów nukleotydowych oraz kompozycje zawierajace takie zwiazki |
| CN101712692A (zh) * | 2009-12-21 | 2010-05-26 | 巢杰 | 泰诺福韦酯的药用酸加成盐及其制备方法和药物应用 |
| TWI709567B (zh) | 2011-10-07 | 2020-11-11 | 美商基利科學股份有限公司 | 抗病毒核苷酸類似物的製備方法 |
| WO2013115916A1 (en) * | 2012-02-03 | 2013-08-08 | Gilead Sciences, Inc. | Combination therapy comprising gs-7340 and cobicistat for use in the treatment of viral infections |
| IN2013MU01967A (instruction) * | 2013-06-07 | 2015-06-12 | Cipla Ltd |
-
2015
- 2015-01-13 IN IN118MU2014 patent/IN2014MU00118A/en unknown
- 2015-01-13 WO PCT/IB2015/050239 patent/WO2015107451A2/en active Application Filing
- 2015-01-13 EP EP15705378.6A patent/EP3077404B1/en active Active
- 2015-01-13 ES ES15705378T patent/ES2842123T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3077404B1 (en) | 2020-10-07 |
| ES2842123T3 (es) | 2021-07-12 |
| WO2015107451A2 (en) | 2015-07-23 |
| WO2015107451A3 (en) | 2015-12-10 |
| EP3077404A2 (en) | 2016-10-12 |
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