IN2014MU00118A - - Google Patents

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Publication number
IN2014MU00118A
IN2014MU00118A IN118MU2014A IN2014MU00118A IN 2014MU00118 A IN2014MU00118 A IN 2014MU00118A IN 118MU2014 A IN118MU2014 A IN 118MU2014A IN 2014MU00118 A IN2014MU00118 A IN 2014MU00118A
Authority
IN
India
Prior art keywords
phenoxyphosphinyl
isopropoxycarbonyl
adenine
methoxy
propyl
Prior art date
Application number
Other languages
English (en)
Inventor
Siva Ram Prasad Vellanki
Raja Babu Balusu
Subba Rayudu Putta
Mastan Rao Raavi
Sivalakshmi Devi Arikatla
Original Assignee
Mylan Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mylan Lab Ltd filed Critical Mylan Lab Ltd
Priority to PCT/IB2015/050239 priority Critical patent/WO2015107451A2/en
Priority to IN118MU2014 priority patent/IN2014MU00118A/en
Priority to EP15705378.6A priority patent/EP3077404B1/en
Priority to ES15705378T priority patent/ES2842123T3/es
Publication of IN2014MU00118A publication Critical patent/IN2014MU00118A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IN118MU2014 2014-01-14 2015-01-13 IN2014MU00118A (instruction)

Priority Applications (4)

Application Number Priority Date Filing Date Title
PCT/IB2015/050239 WO2015107451A2 (en) 2014-01-14 2015-01-13 Purification of tenofovir alafenamide and its intermediates
IN118MU2014 IN2014MU00118A (instruction) 2014-01-14 2015-01-13
EP15705378.6A EP3077404B1 (en) 2014-01-14 2015-01-13 Purification of tenofovir alafenamide and its intermediates
ES15705378T ES2842123T3 (es) 2014-01-14 2015-01-13 Purificación de tenofovir alafenamida y sus intermedios

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN118MU2014 IN2014MU00118A (instruction) 2014-01-14 2015-01-13

Publications (1)

Publication Number Publication Date
IN2014MU00118A true IN2014MU00118A (instruction) 2015-08-28

Family

ID=52484522

Family Applications (1)

Application Number Title Priority Date Filing Date
IN118MU2014 IN2014MU00118A (instruction) 2014-01-14 2015-01-13

Country Status (4)

Country Link
EP (1) EP3077404B1 (instruction)
ES (1) ES2842123T3 (instruction)
IN (1) IN2014MU00118A (instruction)
WO (1) WO2015107451A2 (instruction)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ2015384A3 (cs) * 2015-06-05 2016-12-14 Zentiva, K.S. Pevné formy Tenofovir alafenamidu
HK1252631A1 (zh) * 2015-06-17 2019-05-31 Gilead Sciences, Inc. 替諾福韋艾拉酚胺的共晶體，鹽和固體形式
CN106699812A (zh) * 2015-11-12 2017-05-24 江苏豪森药业集团有限公司 替诺福韦前药的制备和纯化方法
WO2017118928A1 (en) 2016-01-06 2017-07-13 Lupin Limited Process for the separation of diastereomers of tenofovir alafenamide
WO2017134089A1 (en) 2016-02-02 2017-08-10 Sandoz Ag Crystalline forms of tenofovir alafenamide monofumarate
CN107179355B (zh) * 2016-03-11 2021-08-10 广东东阳光药业有限公司 一种分离检测替诺福韦艾拉酚胺及其有关物质的方法
CZ2016156A3 (cs) * 2016-03-17 2017-09-27 Zentiva, K.S. Způsob přípravy diastereomerně čistého Tenofoviru Alafenamidu nebo jeho solí
CN107226826A (zh) * 2016-03-25 2017-10-03 江苏奥赛康药业股份有限公司 替诺福韦艾拉酚胺富马酸盐化合物及其药物组合物
CN106478725B (zh) * 2016-10-14 2018-11-09 上海礼泰医药科技有限公司 高纯度膦丙替诺福韦中间体的制备方法及其应用
CN113072583A (zh) * 2016-11-28 2021-07-06 正大天晴药业集团股份有限公司 一种替诺福韦艾拉酚胺半富马酸盐的结晶及其制备方法
CN108341841B (zh) * 2017-01-22 2020-07-17 成都倍特药业股份有限公司 一种替诺福韦艾拉酚胺与门冬氨酸的盐
TWI868958B (zh) 2017-01-31 2025-01-01 美商基利科學股份有限公司 替諾福韋埃拉酚胺(tenofovir alafenamide)之晶型
CN106946935B (zh) * 2017-04-28 2020-01-07 福建广生堂药业股份有限公司 一种非对映异构体核苷衍生物的制备方法
CN109942633B (zh) * 2017-12-20 2021-08-31 上海新礼泰药业有限公司 替诺福韦艾拉酚胺中间体的制备方法
CN109942632B (zh) * 2017-12-20 2021-08-31 上海博志研新药物研究有限公司 替诺福韦艾拉酚胺中间体的制备方法
CN108467410B (zh) * 2018-04-09 2021-04-09 重庆三圣实业股份有限公司 一种taf中间体的制备方法及产品和应用
CN108484672A (zh) * 2018-05-23 2018-09-04 中国药科大学制药有限公司 磷丙替诺福韦的手性拆分方法
CN110283208B (zh) * 2018-06-22 2022-07-08 南京济群医药科技股份有限公司 一种替诺福韦艾拉酚胺的手性拆分方法
CN110105392A (zh) * 2019-06-04 2019-08-09 石家庄凯赛医药科技有限公司 一种替诺福韦艾拉酚胺的高效合成工艺
EP4085062A1 (en) 2020-02-20 2022-11-09 Cipla Limited Novel salts and/or co-crystals of tenofovir alafenamide
US11667656B2 (en) 2021-01-27 2023-06-06 Apotex Inc. Crystalline forms of Tenofovir alafenamide
CN114907409A (zh) * 2022-06-21 2022-08-16 辰欣药业股份有限公司 一种丙酚替诺福韦的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5798340A (en) * 1993-09-17 1998-08-25 Gilead Sciences, Inc. Nucleotide analogs
PT2682397T (pt) * 2000-07-21 2017-05-31 Gilead Sciences Inc Pró-fármacos de análogos de nucleótido fosfonato e métodos para selecionar e produzir os mesmos
CN101712692A (zh) * 2009-12-21 2010-05-26 巢杰 泰诺福韦酯的药用酸加成盐及其制备方法和药物应用
UY34361A (es) 2011-10-07 2013-05-31 Gilead Sciences Inc Métodos para preparar análogos nucleotídicos anti virales.
AU2012327170A1 (en) * 2012-02-03 2013-08-22 Gilead Sciences, Inc. Therapeutic compounds
IN2013MU01967A (instruction) * 2013-06-07 2015-06-12 Cipla Ltd

Also Published As

Publication number Publication date
EP3077404A2 (en) 2016-10-12
EP3077404B1 (en) 2020-10-07
WO2015107451A2 (en) 2015-07-23
WO2015107451A3 (en) 2015-12-10
ES2842123T3 (es) 2021-07-12

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