MX2017012027A - Desaminacion de nucleosidos organofosforados. - Google Patents

Desaminacion de nucleosidos organofosforados.

Info

Publication number
MX2017012027A
MX2017012027A MX2017012027A MX2017012027A MX2017012027A MX 2017012027 A MX2017012027 A MX 2017012027A MX 2017012027 A MX2017012027 A MX 2017012027A MX 2017012027 A MX2017012027 A MX 2017012027A MX 2017012027 A MX2017012027 A MX 2017012027A
Authority
MX
Mexico
Prior art keywords
deamination
organophosphorus
nucleosides
formula
compounds
Prior art date
Application number
MX2017012027A
Other languages
English (en)
Inventor
Castells Boliart Josep
PÉREZ OZCÁRIZ Sergio
Pascual Gilabert Marta
ALONSO FERNÁNDEZ Javier
LÓPEZ GÓMEZ Cristina
María FERNÁNDEZ FERNÁNDEZ Carmen
Original Assignee
Inst Univ Ciencia I Tecnologia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP15382419.8A external-priority patent/EP3128013A1/en
Application filed by Inst Univ Ciencia I Tecnologia filed Critical Inst Univ Ciencia I Tecnologia
Publication of MX2017012027A publication Critical patent/MX2017012027A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/12Disaccharides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/26Preparation of nitrogen-containing carbohydrates
    • C12P19/28N-glycosides
    • C12P19/30Nucleotides
    • C12P19/305Pyrimidine nucleotides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • C07H19/10Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12Triazine radicals
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/26Preparation of nitrogen-containing carbohydrates
    • C12P19/28N-glycosides
    • C12P19/30Nucleotides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y305/00Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/04Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
    • C12Y305/04005Cytidine deaminase (3.5.4.5)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La invención se refiere a un nuevo proceso de síntesis para obtener compuestos de fórmula (I) a partir de compuestos de fórmula (II) por medio de enzima citidina deaminasa.
MX2017012027A 2015-03-19 2016-03-18 Desaminacion de nucleosidos organofosforados. MX2017012027A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15382131 2015-03-19
EP15382419.8A EP3128013A1 (en) 2015-08-07 2015-08-07 Deamination of organophosphorous-nucleosides
PCT/EP2016/055939 WO2016146808A1 (en) 2015-03-19 2016-03-18 Deamination of organophosphorus-nucleosides

Publications (1)

Publication Number Publication Date
MX2017012027A true MX2017012027A (es) 2018-01-10

Family

ID=55642425

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017012027A MX2017012027A (es) 2015-03-19 2016-03-18 Desaminacion de nucleosidos organofosforados.

Country Status (8)

Country Link
US (1) US20180066295A1 (es)
EP (1) EP3271468B1 (es)
JP (1) JP2018509165A (es)
KR (1) KR20170129228A (es)
CN (1) CN107849594B (es)
CA (1) CA2979596A1 (es)
MX (1) MX2017012027A (es)
WO (1) WO2016146808A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116437930A (zh) * 2020-10-30 2023-07-14 上海岸阔医药科技有限公司 尿苷衍生物在制备药物中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL102407A (en) * 1991-07-05 1997-01-10 Pro Neuron Inc Use of acylates of non-methylated pyrimidine nucleosides in medicaments for preventing or treating undesirable side-effects in anticancer or antiviral chemotherapy and pharmaceutical compositions containing the acylates
WO2001068806A2 (en) * 2000-03-10 2001-09-20 Millennium Pharmaceuticals, Inc. 26934, a novel cytidine deaminase-like molecule and uses thereof
JP2009504704A (ja) * 2005-08-15 2009-02-05 エフ.ホフマン−ラ ロシュ アーゲー 抗ウイルス4′−置換プロヌクレオチドホスホルアミダート
KR20140033446A (ko) * 2011-05-19 2014-03-18 알에프에스 파마 엘엘씨 바이러스 감염 치료용 퓨린 모노포스페이트 프로드럭

Also Published As

Publication number Publication date
EP3271468A1 (en) 2018-01-24
CN107849594A (zh) 2018-03-27
JP2018509165A (ja) 2018-04-05
CA2979596A1 (en) 2016-09-22
CN107849594B (zh) 2022-01-18
US20180066295A1 (en) 2018-03-08
WO2016146808A1 (en) 2016-09-22
EP3271468B1 (en) 2022-12-14
KR20170129228A (ko) 2017-11-24

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