CN1918131B - 谷氨酰胺酰基环化酶抑制剂 - Google Patents
谷氨酰胺酰基环化酶抑制剂 Download PDFInfo
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- CN1918131B CN1918131B CN2005800042893A CN200580004289A CN1918131B CN 1918131 B CN1918131 B CN 1918131B CN 2005800042893 A CN2005800042893 A CN 2005800042893A CN 200580004289 A CN200580004289 A CN 200580004289A CN 1918131 B CN1918131 B CN 1918131B
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Classifications
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- C07D233/61—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54213304P | 2004-02-05 | 2004-02-05 | |
| US60/542,133 | 2004-02-05 | ||
| US10/838,993 US7371871B2 (en) | 2003-05-05 | 2004-05-05 | Inhibitors of glutaminyl cyclase |
| US10/838,993 | 2004-05-05 | ||
| US63436404P | 2004-12-08 | 2004-12-08 | |
| US60/634,364 | 2004-12-08 | ||
| PCT/EP2005/001153 WO2005075436A2 (en) | 2004-02-05 | 2005-02-04 | Novel inhibitors of glutaminyl cyclase |
Publications (2)
| Publication Number | Publication Date |
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| CN1918131A CN1918131A (zh) | 2007-02-21 |
| CN1918131B true CN1918131B (zh) | 2011-05-04 |
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| CN2005800042893A Expired - Fee Related CN1918131B (zh) | 2004-02-05 | 2005-02-04 | 谷氨酰胺酰基环化酶抑制剂 |
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| Country | Link |
|---|---|
| US (2) | US7304086B2 (enExample) |
| EP (1) | EP1713780B1 (enExample) |
| JP (1) | JP4996926B2 (enExample) |
| KR (1) | KR101099206B1 (enExample) |
| CN (1) | CN1918131B (enExample) |
| AU (1) | AU2005210004B2 (enExample) |
| BR (1) | BRPI0507485A (enExample) |
| CA (1) | CA2554809C (enExample) |
| WO (1) | WO2005075436A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110903292A (zh) * | 2019-11-27 | 2020-03-24 | 深圳大学 | 一种作用于QC和GSK-3β的多靶向抑制剂 |
Families Citing this family (86)
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| RU2328498C9 (ru) * | 2002-12-04 | 2008-12-10 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Соединения с конденсированным 1,3-дигидроимидазольным циклом |
| KR20050122220A (ko) | 2003-03-25 | 2005-12-28 | 다케다 샌디에고, 인코포레이티드 | 디펩티딜 펩티다제 억제제 |
| ATE462432T1 (de) * | 2003-05-05 | 2010-04-15 | Probiodrug Ag | Glutaminylcyclase-hemmer |
| US8338120B2 (en) | 2003-05-05 | 2012-12-25 | Probiodrug Ag | Method of treating inflammation with glutaminyl cyclase inhibitors |
| US7732162B2 (en) * | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
| DE602004026712D1 (de) * | 2003-05-05 | 2010-06-02 | Probiodrug Ag | Medizinische verwendung von hemmern von glutaminyl und glutamatcyclasen |
| US7579357B2 (en) | 2003-08-13 | 2009-08-25 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| WO2005026148A1 (en) | 2003-09-08 | 2005-03-24 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
| WO2006058720A2 (en) * | 2003-11-03 | 2006-06-08 | Probiodrug Ag | Novel compounds for the treatment of neurological disorders |
| US20100099721A1 (en) * | 2003-11-03 | 2010-04-22 | Probiodrug Ag | Novel compounds for the treatment of neurological disorders |
| US7667044B2 (en) | 2003-11-03 | 2010-02-23 | Probiodrug Ag | Compounds for the treatment of neurological disorders |
| US20050171112A1 (en) * | 2003-11-03 | 2005-08-04 | Probiodrug Ag | Combinations useful for the treatment of neuronal disorders |
| CN1918131B (zh) | 2004-02-05 | 2011-05-04 | 前体生物药物股份公司 | 谷氨酰胺酰基环化酶抑制剂 |
| MXPA06010571A (es) * | 2004-03-15 | 2007-02-16 | Takeda Pharmaceutical | Inhibidores de dipeptidil peptidasa. |
| EP1828192B1 (en) | 2004-12-21 | 2014-12-03 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| KR100650278B1 (ko) * | 2004-12-27 | 2006-11-27 | 김성진 | 엔-아릴 엔' 모르폴리노/ 피페리디노 티오카르바마이드유도체를 유효성분으로 함유하는 당뇨병, 당뇨병 합병증,인슐린저항성 및 그로 인한 인슐린 저항성 증후군의 예방및 치료용 약학적 조성물 |
| BRPI0608469A2 (pt) | 2005-04-22 | 2010-01-05 | Alantos Pharmaceuticals Holding Inc | inibidores de dipeptidil peptidase-iv |
| PL1942898T5 (pl) | 2005-09-14 | 2014-10-31 | Takeda Pharmaceuticals Co | Inhibitory peptydazy dipeptydylowej do leczenia cukrzycy |
| WO2007035629A2 (en) | 2005-09-16 | 2007-03-29 | Takeda Pharmaceutical Company Limited | Process for the preparation of pyrimidinedione derivatives |
| AR062760A1 (es) * | 2006-09-13 | 2008-12-03 | Takeda Pharmaceutical | Administracion de inhibidores de dipeptidilpetidasa |
| US8324383B2 (en) * | 2006-09-13 | 2012-12-04 | Takeda Pharmaceutical Company Limited | Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile |
| CN101573450B (zh) * | 2006-09-21 | 2015-12-16 | 前体生物药物股份公司 | 与谷氨酰环化酶相关的新基因 |
| US9277737B2 (en) | 2006-09-21 | 2016-03-08 | Probiodrug Ag | Mouse models carrying a knock-out mutation of the QPCTL-gene |
| EP2082041B1 (en) | 2006-09-21 | 2018-03-14 | Probiodrug AG | Novel genes related to glutaminyl cyclase |
| US8889709B2 (en) | 2006-09-21 | 2014-11-18 | Probiodrug Ag | Use of isoQC inhibitors in the treatment and prevention of inflammatory diseases or conditions |
| US8278345B2 (en) | 2006-11-09 | 2012-10-02 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| JP5599614B2 (ja) * | 2006-11-09 | 2014-10-01 | プロビオドルグ エージー | グルタミニルシクラーゼの新規阻害剤 |
| US8420684B2 (en) * | 2006-11-09 | 2013-04-16 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| TW200838536A (en) | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
| SI2091948T1 (sl) * | 2006-11-30 | 2012-07-31 | Probiodrug Ag | Novi inhibitorji glutaminil ciklaze |
| KR100867978B1 (ko) * | 2006-12-12 | 2008-11-10 | 이화여자대학교 산학협력단 | 이중 작용기를 가지는 새로운 이온성 액체 및 그의제조방법 |
| ES2372229T3 (es) * | 2007-01-19 | 2012-01-17 | Probiodrug Ag | Modelos de selección in vivo para el tratamiento de la enfermedad de alzheimer y otros trastornos relacionados con qpct. |
| KR20140133897A (ko) * | 2007-03-01 | 2014-11-20 | 프로비오드룩 아게 | 글루타미닐 사이클라제 저해제의 신규 용도 |
| EA200901140A1 (ru) | 2007-03-01 | 2010-04-30 | Пробиодруг Аг | Новое применение ингибиторов глутаминилциклазы |
| GB2447017A (en) * | 2007-03-01 | 2008-09-03 | Probiodrug Ag | New use for inhibitors of glutaminyl peptide cyclotransferinase |
| US7803810B2 (en) * | 2007-03-09 | 2010-09-28 | Probiodrug Ag | Inhibitors |
| US8093236B2 (en) * | 2007-03-13 | 2012-01-10 | Takeda Pharmaceuticals Company Limited | Weekly administration of dipeptidyl peptidase inhibitors |
| PE20090015A1 (es) * | 2007-03-13 | 2009-01-30 | Takeda Pharmaceutical | Preparacion solida |
| DK2160389T3 (da) * | 2007-04-18 | 2014-06-23 | Probiodrug Ag | Thioxoquinazolinonderivater som glutaminylcyclaseinhibitorer |
| WO2008128981A1 (en) * | 2007-04-18 | 2008-10-30 | Probiodrug Ag | Nitrovinyl-diamine derivatives as glutaminyl cyclase inhibitors |
| EP2142514B1 (en) * | 2007-04-18 | 2014-12-24 | Probiodrug AG | Thiourea derivatives as glutaminyl cyclase inhibitors |
| WO2008128987A1 (en) * | 2007-04-18 | 2008-10-30 | Probiodrug Ag | Novel inhibitors |
| WO2008128986A1 (en) * | 2007-04-18 | 2008-10-30 | Probiodrug Ag | Urea derivatives as glutaminyl cyclase inhibitors |
| EP2160380B1 (en) * | 2007-04-18 | 2014-04-02 | Probiodrug AG | Cyano-guanidine derivatives as glutaminyl cyclase inhibitors |
| EP2142536B1 (en) * | 2007-04-20 | 2015-10-21 | Probiodrug AG | Aminopyrimidine derivatives as glutaminyl cyclase inhibitors |
| US8524654B2 (en) * | 2007-05-21 | 2013-09-03 | The Uab Research Foundation | Prolyl endopeptidase inhibitors for reducing or preventing neutrophilic inflammation |
| WO2009034158A2 (en) * | 2007-09-12 | 2009-03-19 | Probiodrug Ag | Transgenic mice |
| US9462793B2 (en) * | 2008-01-14 | 2016-10-11 | Probiodrug Ag | Mouse carrying a knock-out mutation of the Qpct-gene |
| KR101706789B1 (ko) | 2008-07-21 | 2017-02-14 | 프로비오드룩 아게 | 진단용 항체 검사법 |
| AU2009275869B2 (en) * | 2008-07-31 | 2015-05-21 | Vivoryon Therapeutics N.V. | Glutaminyl cyclase as a diagnostic / prognostic indicator for neurodegenerative diseases |
| EP2344157B1 (en) * | 2008-09-04 | 2016-05-25 | Probiodrug AG | Novel inhibitors |
| US20100144140A1 (en) * | 2008-12-10 | 2010-06-10 | Novellus Systems, Inc. | Methods for depositing tungsten films having low resistivity for gapfill applications |
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Also Published As
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| KR101099206B1 (ko) | 2011-12-27 |
| US20090018087A1 (en) | 2009-01-15 |
| CN1918131A (zh) | 2007-02-21 |
| JP2007520520A (ja) | 2007-07-26 |
| CA2554809C (en) | 2014-04-29 |
| WO2005075436A2 (en) | 2005-08-18 |
| EP1713780A2 (en) | 2006-10-25 |
| US7304086B2 (en) | 2007-12-04 |
| WO2005075436A3 (en) | 2005-12-08 |
| US7897633B2 (en) | 2011-03-01 |
| JP4996926B2 (ja) | 2012-08-08 |
| BRPI0507485A (pt) | 2007-07-10 |
| KR20060125884A (ko) | 2006-12-06 |
| US20050215573A1 (en) | 2005-09-29 |
| AU2005210004A1 (en) | 2005-08-18 |
| AU2005210004B2 (en) | 2010-10-28 |
| CA2554809A1 (en) | 2005-08-18 |
| EP1713780B1 (en) | 2012-01-18 |
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