CN1458844A - 二酮基哌嗪和包含它们的组合物的使用方法 - Google Patents
二酮基哌嗪和包含它们的组合物的使用方法 Download PDFInfo
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- CN1458844A CN1458844A CN01815837A CN01815837A CN1458844A CN 1458844 A CN1458844 A CN 1458844A CN 01815837 A CN01815837 A CN 01815837A CN 01815837 A CN01815837 A CN 01815837A CN 1458844 A CN1458844 A CN 1458844A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
Description
Claims (28)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22284900P | 2000-08-04 | 2000-08-04 | |
US60/222,849 | 2000-08-04 | ||
US60/222.849 | 2000-08-04 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2009101456824A Division CN101632669B (zh) | 2000-08-04 | 2001-08-02 | 二酮基哌嗪和包含它们的组合物的使用方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1458844A true CN1458844A (zh) | 2003-11-26 |
CN100553636C CN100553636C (zh) | 2009-10-28 |
Family
ID=22833957
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2009101456824A Expired - Lifetime CN101632669B (zh) | 2000-08-04 | 2001-08-02 | 二酮基哌嗪和包含它们的组合物的使用方法 |
CNB018158374A Expired - Lifetime CN100553636C (zh) | 2000-08-04 | 2001-08-02 | 二酮基哌嗪和包含它们的组合物的使用方法 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2009101456824A Expired - Lifetime CN101632669B (zh) | 2000-08-04 | 2001-08-02 | 二酮基哌嗪和包含它们的组合物的使用方法 |
Country Status (15)
Country | Link |
---|---|
US (9) | US6555543B2 (zh) |
EP (1) | EP1311269B1 (zh) |
JP (2) | JP5048201B2 (zh) |
CN (2) | CN101632669B (zh) |
AT (1) | ATE547101T1 (zh) |
AU (2) | AU7931301A (zh) |
BR (1) | BR0112969A (zh) |
CA (2) | CA2774959C (zh) |
CY (1) | CY1112687T1 (zh) |
DK (1) | DK1311269T3 (zh) |
ES (1) | ES2381775T3 (zh) |
HK (1) | HK1135333A1 (zh) |
PT (1) | PT1311269E (zh) |
WO (1) | WO2002011676A2 (zh) |
ZA (1) | ZA200300934B (zh) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101027057A (zh) * | 2004-08-23 | 2007-08-29 | 曼金德公司 | 用于药物输送的二酮哌嗪盐、二酮吗啉盐或二酮二氧杂环己烷盐 |
CN103841974A (zh) * | 2011-10-28 | 2014-06-04 | 安皮奥制药股份有限公司 | 鼻炎的治疗 |
CN105101965A (zh) * | 2013-03-15 | 2015-11-25 | 安皮奥制药股份有限公司 | 用于干细胞活动化、归巢、扩增和分化的组合物及其使用方法 |
CN105218526A (zh) * | 2014-06-10 | 2016-01-06 | 首都医科大学 | (3s,6s)-3,6二取代哌嗪-2,5-二酮,其制备及治疗作用 |
CN105294660A (zh) * | 2014-06-10 | 2016-02-03 | 首都医科大学 | (3r,6s)-3,6-二取代哌嗪-2,5-二酮,其制备及应用 |
CN105503833A (zh) * | 2014-10-20 | 2016-04-20 | 首都医科大学 | 吲哚哌嗪-二酮,其制备及治疗作用 |
CN108929320A (zh) * | 2017-05-22 | 2018-12-04 | 首都医科大学 | 3r-吲哚甲基-6r-恶唑烷酮修饰的哌嗪-2,5-二酮,其合成,活性和应用 |
CN109925315A (zh) * | 2017-12-15 | 2019-06-25 | 长庚生物科技股份有限公司 | 环状酪氨酸-缬氨酸及其类似物用于治疗气喘及呼吸道过敏的用途 |
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US9006175B2 (en) * | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
EP2280021B1 (en) | 1999-06-29 | 2016-02-17 | MannKind Corporation | Pharmaceutical formulations comprising insulin complexed with a diketopiperazine |
US6967202B2 (en) * | 2000-08-04 | 2005-11-22 | Dmi Biosciences, Inc. | Method of synthesizing diketopiperazines |
JP5048201B2 (ja) | 2000-08-04 | 2012-10-17 | ディーエムアイ バイオサイエンシズ インコーポレイテッド | ジケトピペラジン類の使用方法とジケトピペラジン類を含む組成物 |
WO2002062797A2 (en) * | 2000-12-29 | 2002-08-15 | Celltech R & D, Inc. | Pharmaceutical uses and synthesis of diketopiperazines |
US7985425B1 (en) * | 2001-12-07 | 2011-07-26 | Smith Jack V | Non-pharmacological method for treating depression, skin disorders and improving overall health and wellness |
US20030171379A1 (en) * | 2001-12-28 | 2003-09-11 | Jacobs Robert S. | Methods of treating, preventing, or inhibiting inflammation with Mactanamide compounds |
SI1494732T1 (sl) | 2002-03-20 | 2008-08-31 | Mannking Corp | Inhalacijski aparat |
US20080260838A1 (en) * | 2003-08-01 | 2008-10-23 | Mannkind Corporation | Glucagon-like peptide 1 (glp-1) pharmaceutical formulations |
US20040038865A1 (en) * | 2002-08-01 | 2004-02-26 | Mannkind Corporation | Cell transport compositions and uses thereof |
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NZ574520A (en) | 2002-11-27 | 2011-02-25 | Dmi Biosciences Inc | Use of casein which is at least 10% dephosphorylated for the treatment of diseases and conditions mediated by increased phosphorylation |
AU2013270553B2 (en) * | 2003-05-15 | 2016-09-15 | Ampio Pharmaceuticals, Inc. | Treatment of t-cell mediated diseases |
ES2572975T3 (es) * | 2003-05-15 | 2016-06-03 | Ampio Pharmaceuticals, Inc. | Tratamiento de enfermedades mediadas por los linfocitos T |
KR20060088543A (ko) * | 2003-09-25 | 2006-08-04 | 디엠아이 바이오사이언스 인코포레이티드 | 앤-아실-엘-아스파틱산을 이용하는 방법 및 제품 |
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ATE486064T1 (de) | 2004-08-20 | 2010-11-15 | Mannkind Corp | Katalyse der diketopiperazinsynthese |
AU2012203627B2 (en) * | 2004-08-23 | 2014-11-13 | Mannkind Corporation | Diketopiperazine salts, diketomorpholine salts or diketodioxane salts for drug delivery |
JP5271540B2 (ja) | 2005-01-20 | 2013-08-21 | インスティチュート フォー モレキュラー メディスン インコーポレイテッド | メチルフェニデート誘導体を含む治療剤及び医薬組成物 |
CN103169714A (zh) | 2005-07-12 | 2013-06-26 | Dmi生物科学公司 | 治疗疾病的方法和产品 |
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RU2403059C2 (ru) | 2006-02-22 | 2010-11-10 | Маннкайнд Корпорейшн | Способ улучшения фармацевтических свойств микрочастиц, содержащих дикетопиперазин и активный агент |
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US7829709B1 (en) | 2007-08-10 | 2010-11-09 | Marquette University | Cysteine prodrugs to treat schizophrenia and drug addiction |
JP5813323B2 (ja) * | 2007-10-24 | 2015-11-17 | マンカインド コーポレイション | 活性薬剤の送達方法 |
US8785396B2 (en) | 2007-10-24 | 2014-07-22 | Mannkind Corporation | Method and composition for treating migraines |
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JP5856843B2 (ja) * | 2008-05-27 | 2016-02-10 | アンピオ ファーマシューティカルズ,インコーポレイテッド | ジケトピペラジンを用いた医薬組成物 |
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BR112015014261A8 (pt) | 2012-12-19 | 2019-10-08 | Ampio Pharmaceuticals Inc | composto de danazol, seu uso e formulação farmacêutica compreendendo este |
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CN105294660B (zh) * | 2014-06-10 | 2018-01-09 | 首都医科大学 | (3r,6s)‑3,6‑二取代哌嗪‑2,5‑二酮,其制备及应用 |
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CN108929320A (zh) * | 2017-05-22 | 2018-12-04 | 首都医科大学 | 3r-吲哚甲基-6r-恶唑烷酮修饰的哌嗪-2,5-二酮,其合成,活性和应用 |
CN108929320B (zh) * | 2017-05-22 | 2020-10-16 | 首都医科大学 | 3r-吲哚甲基-6r-恶唑烷酮修饰的哌嗪-2,5-二酮,其合成,活性和应用 |
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