CN1303067C - 用作半光氨酸蛋白酶可逆抑制剂的螺杂环腈 - Google Patents

用作半光氨酸蛋白酶可逆抑制剂的螺杂环腈 Download PDF

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CN1303067C
CN1303067C CNB018153143A CN01815314A CN1303067C CN 1303067 C CN1303067 C CN 1303067C CN B018153143 A CNB018153143 A CN B018153143A CN 01815314 A CN01815314 A CN 01815314A CN 1303067 C CN1303067 C CN 1303067C
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cyano
piperidin
methyl
cyclohexyl
ylcarbamoyl
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Expired - Fee Related
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CNB018153143A
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Chinese (zh)
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CN1471511A (zh
Inventor
尤尼斯·贝卡利
尤金·R·希基
刘为民
尤萨·R·帕特尔
丹尼斯·M·斯佩罗
孙三兴
戴维·S·汤姆森
扬西·D·沃德
埃里克·R·R·扬
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Boehringer Ingelheim Pharmaceuticals Inc
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Boehringer Ingelheim Pharmaceuticals Inc
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
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  • Diabetes (AREA)
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  • Pulmonology (AREA)
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  • Biomedical Technology (AREA)
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CNB018153143A 2000-09-08 2001-03-14 用作半光氨酸蛋白酶可逆抑制剂的螺杂环腈 Expired - Fee Related CN1303067C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/655,351 US6420364B1 (en) 1999-09-13 2000-09-08 Compound useful as reversible inhibitors of cysteine proteases
US09/655351 2000-09-08

Publications (2)

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CN1471511A CN1471511A (zh) 2004-01-28
CN1303067C true CN1303067C (zh) 2007-03-07

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US (10) US6420364B1 (enExample)
EP (1) EP1322613A1 (enExample)
JP (1) JP2004508356A (enExample)
KR (1) KR20030051644A (enExample)
CN (1) CN1303067C (enExample)
AU (1) AU2001245694A1 (enExample)
BG (1) BG107585A (enExample)
BR (1) BR0113740A (enExample)
CA (1) CA2417177A1 (enExample)
CZ (1) CZ2003603A3 (enExample)
EA (1) EA005203B1 (enExample)
EE (1) EE200300093A (enExample)
HR (1) HRP20030163A2 (enExample)
HU (1) HUP0303934A2 (enExample)
IL (1) IL154080A0 (enExample)
MX (1) MXPA03001947A (enExample)
NO (1) NO20031065L (enExample)
NZ (1) NZ525169A (enExample)
PL (1) PL361038A1 (enExample)
SK (1) SK2862003A3 (enExample)
UA (1) UA73378C2 (enExample)
WO (1) WO2002020485A1 (enExample)
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CN105102424A (zh) * 2013-01-15 2015-11-25 默克专利股份公司 用于治疗关节病的酰基胍类

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US6420364B1 (en) * 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
US6773704B1 (en) * 1999-10-28 2004-08-10 The Brigham And Women's Hospital, Inc. Methods of treating vascular disease associated with cystatin C deficiency
GB0003111D0 (en) * 2000-02-10 2000-03-29 Novartis Ag Organic compounds
US7030116B2 (en) 2000-12-22 2006-04-18 Aventis Pharmaceuticals Inc. Compounds and compositions as cathepsin inhibitors
WO2002051983A2 (en) 2000-12-22 2002-07-04 Axys Pharmaceuticals, Inc. Novel compounds and compositions as cathepsin inhibitors
DE60229114D1 (en) * 2001-03-02 2008-11-13 Axys Pharm Inc Cathepsincystein-proteasehemmer
US6982263B2 (en) * 2001-06-08 2006-01-03 Boehringer Ingelheim Pharmaceuticals, Inc. Nitriles useful as reversible inhibitors of cysteine proteases
DE10141650C1 (de) 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen
MXPA04002282A (es) 2001-09-14 2005-03-07 Axis Pharmaceutical Inc Nuevos compuestos y preparaciones como inhibidores de la catepsina.
EP1434769A2 (en) * 2001-10-02 2004-07-07 Boehringer Ingelheim Pharmaceuticals Inc. Compounds useful as reversible inhibitors of cysteine proteases
CA2463770A1 (en) * 2001-10-29 2003-05-08 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as reversible inhibitors of cysteine proteases
EP1446392A1 (en) 2001-11-14 2004-08-18 Aventis Pharmaceuticals, Inc. Oligopeptides and compositions containing them as cathepsin s inhibitors
US7101880B2 (en) * 2002-06-24 2006-09-05 Schering Aktiengesellschaft Peptidic compounds as cysteine protease inhibitors
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