HK1048807A1 - 用作半胱氨酸蛋白酶的可逆抑制劑的新穎螺旋雜環化合物 - Google Patents

用作半胱氨酸蛋白酶的可逆抑制劑的新穎螺旋雜環化合物

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Publication number
HK1048807A1
HK1048807A1 HK03100843.6A HK03100843A HK1048807A1 HK 1048807 A1 HK1048807 A1 HK 1048807A1 HK 03100843 A HK03100843 A HK 03100843A HK 1048807 A1 HK1048807 A1 HK 1048807A1
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HK
Hong Kong
Prior art keywords
compounds useful
cysteine proteases
reversible inhibitors
spiroheterocyclic compounds
novel
Prior art date
Application number
HK03100843.6A
Other languages
English (en)
Inventor
米歇爾‧J‧伊曼紐爾
利厄‧L‧弗賴伊
尤金‧R‧希基
劉為民
蒂納‧M‧莫威克
德尼斯‧M‧斯佩羅
孫三興
戴維‧S‧湯姆森
揚西‧D‧沃德
埃里克‧R‧R‧揚
Original Assignee
貝林格爾‧英格海姆藥物公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 貝林格爾‧英格海姆藥物公司 filed Critical 貝林格爾‧英格海姆藥物公司
Publication of HK1048807A1 publication Critical patent/HK1048807A1/zh

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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • General Chemical & Material Sciences (AREA)
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  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Neurology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK03100843.6A 1999-09-13 2003-02-06 用作半胱氨酸蛋白酶的可逆抑制劑的新穎螺旋雜環化合物 HK1048807A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15373899P 1999-09-13 1999-09-13
US22290000P 2000-08-03 2000-08-03
PCT/US2000/023584 WO2001019816A1 (en) 1999-09-13 2000-08-28 Novel spiroheterocyclic compounds useful as reversible inhibitors of cysteine proteases

Publications (1)

Publication Number Publication Date
HK1048807A1 true HK1048807A1 (zh) 2003-04-17

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HK03100843.6A HK1048807A1 (zh) 1999-09-13 2003-02-06 用作半胱氨酸蛋白酶的可逆抑制劑的新穎螺旋雜環化合物

Country Status (30)

Country Link
EP (1) EP1218372B1 (zh)
JP (1) JP2003529546A (zh)
KR (1) KR20030024651A (zh)
CN (1) CN100410250C (zh)
AR (1) AR032136A1 (zh)
AT (1) ATE244235T1 (zh)
AU (1) AU782246B2 (zh)
BG (1) BG106483A (zh)
BR (1) BR0013966A (zh)
CA (1) CA2385130C (zh)
CZ (1) CZ2002844A3 (zh)
DE (1) DE60003702T2 (zh)
DK (1) DK1218372T3 (zh)
EE (1) EE200200132A (zh)
ES (1) ES2199856T3 (zh)
HK (1) HK1048807A1 (zh)
HR (1) HRP20020221A2 (zh)
HU (1) HUP0302380A2 (zh)
IL (2) IL148184A0 (zh)
MY (1) MY122696A (zh)
NO (1) NO323354B1 (zh)
NZ (1) NZ518255A (zh)
PL (1) PL364045A1 (zh)
PT (1) PT1218372E (zh)
RU (1) RU2255937C2 (zh)
SA (1) SA00210456B1 (zh)
SK (1) SK286463B6 (zh)
TW (1) TWI230159B (zh)
WO (1) WO2001019816A1 (zh)
YU (1) YU17402A (zh)

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US6936606B2 (en) 2001-10-02 2005-08-30 Boehringer Ingelheim Pharmaceuticals, Inc. Cyanoamido-containing heterocyclic compounds useful as reversible inhibitors of cysteine proteases
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US7109243B2 (en) 2003-03-24 2006-09-19 Irm Llc Inhibitors of cathepsin S
WO2004108661A1 (en) * 2003-06-04 2004-12-16 Axys Pharmaceuticals Amidino compounds as cysteine protease inhibitors
US7173051B2 (en) 2003-06-13 2007-02-06 Irm, Llc Inhibitors of cathepsin S
US7256207B2 (en) 2003-08-20 2007-08-14 Irm Llc Inhibitors of cathepsin S
BRPI0410979A (pt) * 2003-09-18 2006-07-04 Axys Pharm Inc composto, composição farmacêutica, e, métodos para tratar uma doença em um animal mediada pela catepsina s e para tratar um paciente submetido a uma terapia
US7297714B2 (en) * 2003-10-21 2007-11-20 Irm Llc Inhibitors of cathepsin S
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NZ561681A (en) 2005-03-21 2011-01-28 Virobay Inc Alpha ketoamide compounds as cysteine protease inhibitors
JP5215167B2 (ja) 2005-03-22 2013-06-19 ビロベイ，インコーポレイティド システインプロテアーゼ阻害剤としてのスルホニル基含有化合物
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