CN103524392B - 作为用于治疗增生性疾病的mek 抑制剂的吖丁啶 - Google Patents

作为用于治疗增生性疾病的mek 抑制剂的吖丁啶 Download PDF

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CN103524392B
CN103524392B CN201310366896.0A CN201310366896A CN103524392B CN 103524392 B CN103524392 B CN 103524392B CN 201310366896 A CN201310366896 A CN 201310366896A CN 103524392 B CN103524392 B CN 103524392B
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alkyl
hydrogen
cycloalkyl
amino
alkenyl
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CN103524392A (zh
Inventor
N.艾
N.K.阿南德
O.J.鲍尔斯
J.布塞纽斯
S.科斯坦佐
J.K.柯蒂斯
L.杜本科
A.A.乔希
A.R.肯尼迪
A.I.金
E.科尔通
J-C.L.马纳罗
C.J.皮托
K.D.赖斯
T.H.曾
S.C.德菲纳
C.M.布莱齐
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Exelixis Inc
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Exelixis Inc
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A61P17/00—Drugs for dermatological disorders
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
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    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)
CN201310366896.0A 2005-10-07 2006-10-05 作为用于治疗增生性疾病的mek 抑制剂的吖丁啶 Active CN103524392B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US72457805P 2005-10-07 2005-10-07
US60/724,578 2005-10-07
US80284006P 2006-05-23 2006-05-23
US60/802,840 2006-05-23
CN2006800449476A CN101365676B (zh) 2005-10-07 2006-10-05 作为用于治疗增生性疾病的mek抑制剂的吖丁啶

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CN2006800449476A Division CN101365676B (zh) 2005-10-07 2006-10-05 作为用于治疗增生性疾病的mek抑制剂的吖丁啶

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CN103524392A CN103524392A (zh) 2014-01-22
CN103524392B true CN103524392B (zh) 2018-06-01

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ID=37728416

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CN201310366896.0A Active CN103524392B (zh) 2005-10-07 2006-10-05 作为用于治疗增生性疾病的mek 抑制剂的吖丁啶
CN201810489110.7A Active CN109053523B (zh) 2005-10-07 2006-10-05 作为用于治疗增生性疾病的mek抑制剂的吖丁啶
CN2006800449476A Active CN101365676B (zh) 2005-10-07 2006-10-05 作为用于治疗增生性疾病的mek抑制剂的吖丁啶
CN201910851634.0A Pending CN110668988A (zh) 2005-10-07 2006-10-05 作为用于治疗增生性疾病的mek抑制剂的吖丁啶
CN201510197206.2A Active CN104892582B (zh) 2005-10-07 2006-10-05 作为用于治疗增生性疾病的mek抑制剂的吖丁啶

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CN201810489110.7A Active CN109053523B (zh) 2005-10-07 2006-10-05 作为用于治疗增生性疾病的mek抑制剂的吖丁啶
CN2006800449476A Active CN101365676B (zh) 2005-10-07 2006-10-05 作为用于治疗增生性疾病的mek抑制剂的吖丁啶
CN201910851634.0A Pending CN110668988A (zh) 2005-10-07 2006-10-05 作为用于治疗增生性疾病的mek抑制剂的吖丁啶
CN201510197206.2A Active CN104892582B (zh) 2005-10-07 2006-10-05 作为用于治疗增生性疾病的mek抑制剂的吖丁啶

Country Status (31)

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US (9) US7803839B2 (enExample)
EP (1) EP1934174B1 (enExample)
JP (8) JP5129143B2 (enExample)
KR (2) KR20130058072A (enExample)
CN (5) CN103524392B (enExample)
AT (1) ATE504565T1 (enExample)
AU (1) AU2006302415B2 (enExample)
BR (1) BRPI0617165B1 (enExample)
CA (3) CA2927656C (enExample)
CY (2) CY1111670T1 (enExample)
DE (1) DE602006021205D1 (enExample)
DK (1) DK1934174T3 (enExample)
EA (3) EA019983B1 (enExample)
ES (1) ES2365070T3 (enExample)
FR (1) FR16C0021I2 (enExample)
GE (1) GEP20125456B (enExample)
HR (1) HRP20110498T1 (enExample)
HU (1) HUS1600021I1 (enExample)
IL (5) IL189900A (enExample)
LT (1) LTC1934174I2 (enExample)
LU (1) LU93078I2 (enExample)
MY (1) MY162174A (enExample)
NL (1) NL300809I2 (enExample)
NO (4) NO347091B1 (enExample)
NZ (1) NZ567140A (enExample)
PL (1) PL1934174T3 (enExample)
PT (1) PT1934174E (enExample)
RS (1) RS51782B (enExample)
SI (1) SI1934174T1 (enExample)
WO (1) WO2007044515A1 (enExample)
ZA (1) ZA200802075B (enExample)

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ZA200802075B (en) 2009-08-26
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US20200031770A1 (en) 2020-01-30
EA200801041A1 (ru) 2009-02-27
BRPI0617165A2 (pt) 2015-01-06
SI1934174T1 (sl) 2011-08-31
KR101341792B1 (ko) 2013-12-23
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JP2018058907A (ja) 2018-04-12
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RS51782B (sr) 2011-12-31
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US7915250B2 (en) 2011-03-29
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