HK1047895A1 - 使用mek抑制劑治療慢性疼痛的方法 - Google Patents

使用mek抑制劑治療慢性疼痛的方法

Info

Publication number
HK1047895A1
HK1047895A1 HK03100164.7A HK03100164A HK1047895A1 HK 1047895 A1 HK1047895 A1 HK 1047895A1 HK 03100164 A HK03100164 A HK 03100164A HK 1047895 A1 HK1047895 A1 HK 1047895A1
Authority
HK
Hong Kong
Prior art keywords
chronic pain
treating chronic
mek inhibitors
mek
inhibitors
Prior art date
Application number
HK03100164.7A
Other languages
English (en)
Inventor
A‧J‧布裡吉斯
理查德‧J‧布斯
H‧泰可
Y‧斯卡吉斯
邁克爾‧考夫曼
S‧D‧布萊特
A‧迪克森
K‧李
R‧D‧皮諾克
Original Assignee
沃尼爾‧朗伯公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 沃尼爾‧朗伯公司 filed Critical 沃尼爾‧朗伯公司
Publication of HK1047895A1 publication Critical patent/HK1047895A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK03100164.7A 1999-07-16 2003-01-07 使用mek抑制劑治療慢性疼痛的方法 HK1047895A1 (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US14441999P 1999-07-16 1999-07-16
US14432099P 1999-07-16 1999-07-16
US14465999P 1999-07-16 1999-07-16
US14465899P 1999-07-16 1999-07-16
US14465599P 1999-07-16 1999-07-16
US14428099P 1999-07-16 1999-07-16
PCT/US2000/018348 WO2001005393A2 (en) 1999-07-16 2000-07-05 Method for treating chronic pain using mek inhibitors

Publications (1)

Publication Number Publication Date
HK1047895A1 true HK1047895A1 (zh) 2003-03-14

Family

ID=27558291

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03100164.7A HK1047895A1 (zh) 1999-07-16 2003-01-07 使用mek抑制劑治療慢性疼痛的方法

Country Status (17)

Country Link
EP (1) EP1202724B1 (zh)
JP (1) JP2003504401A (zh)
KR (1) KR20020016899A (zh)
CN (1) CN1365277A (zh)
AT (1) ATE250932T1 (zh)
AU (1) AU5912500A (zh)
CA (1) CA2378381A1 (zh)
DE (1) DE60005688T2 (zh)
DK (1) DK1202724T3 (zh)
ES (1) ES2208364T3 (zh)
HK (1) HK1047895A1 (zh)
HU (1) HUP0202180A3 (zh)
IL (1) IL147618A0 (zh)
PL (1) PL352712A1 (zh)
PT (1) PT1202724E (zh)
TR (1) TR200200205T2 (zh)
WO (1) WO2001005393A2 (zh)

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US8063050B2 (en) 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
CA2656618C (en) 2006-07-06 2014-08-26 Array Biopharma Inc. Cyclopenta [d] pyrimidines as akt protein kinase inhibitors
ATE493418T1 (de) 2006-07-06 2011-01-15 Array Biopharma Inc Dihydrofuropyrimidine als akt- proteinkinaseinhibitoren
CN101605540A (zh) 2006-12-14 2009-12-16 埃克塞利希斯股份有限公司 使用mek抑制剂的方法
CN101801955B (zh) 2007-07-05 2013-05-08 阵列生物制药公司 作为akt蛋白激酶抑制剂的嘧啶基环戊烷
JP5542282B2 (ja) 2007-07-05 2014-07-09 アレイ バイオファーマ、インコーポレイテッド Ａｋｔプロテインキナーゼ阻害剤としてのピリミジルシクロペンタン
US9409886B2 (en) 2007-07-05 2016-08-09 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
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Also Published As

Publication number Publication date
CN1365277A (zh) 2002-08-21
HUP0202180A3 (en) 2004-10-28
DE60005688D1 (de) 2003-11-06
AU5912500A (en) 2001-02-05
DE60005688T2 (de) 2004-04-29
DK1202724T3 (da) 2004-01-26
ES2208364T3 (es) 2004-06-16
TR200200205T2 (tr) 2002-06-21
CA2378381A1 (en) 2001-01-25
ATE250932T1 (de) 2003-10-15
PT1202724E (pt) 2004-02-27
EP1202724B1 (en) 2003-10-01
IL147618A0 (en) 2002-08-14
WO2001005393A2 (en) 2001-01-25
EP1202724A2 (en) 2002-05-08
PL352712A1 (en) 2003-09-08
JP2003504401A (ja) 2003-02-04
WO2001005393A3 (en) 2001-05-10
HUP0202180A2 (en) 2002-10-28
KR20020016899A (ko) 2002-03-06

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