HUP0202180A3 - Method for treating chronic pain using mek inhibitors - Google Patents

Method for treating chronic pain using mek inhibitors

Info

Publication number
HUP0202180A3
HUP0202180A3 HU0202180A HUP0202180A HUP0202180A3 HU P0202180 A3 HUP0202180 A3 HU P0202180A3 HU 0202180 A HU0202180 A HU 0202180A HU P0202180 A HUP0202180 A HU P0202180A HU P0202180 A3 HUP0202180 A3 HU P0202180A3
Authority
HU
Hungary
Prior art keywords
chronic pain
treating chronic
mek inhibitors
mek
inhibitors
Prior art date
Application number
HU0202180A
Other languages
Hungarian (hu)
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of HUP0202180A2 publication Critical patent/HUP0202180A2/en
Publication of HUP0202180A3 publication Critical patent/HUP0202180A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HU0202180A 1999-07-16 2000-07-05 Method for treating chronic pain using mek inhibitors HUP0202180A3 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US14432099P 1999-07-16 1999-07-16
US14465999P 1999-07-16 1999-07-16
US14428099P 1999-07-16 1999-07-16
US14441999P 1999-07-16 1999-07-16
US14465899P 1999-07-16 1999-07-16
US14465599P 1999-07-16 1999-07-16

Publications (2)

Publication Number Publication Date
HUP0202180A2 HUP0202180A2 (en) 2002-10-28
HUP0202180A3 true HUP0202180A3 (en) 2004-10-28

Family

ID=27558291

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0202180A HUP0202180A3 (en) 1999-07-16 2000-07-05 Method for treating chronic pain using mek inhibitors

Country Status (17)

Country Link
EP (1) EP1202724B1 (en)
JP (1) JP2003504401A (en)
KR (1) KR20020016899A (en)
CN (1) CN1365277A (en)
AT (1) ATE250932T1 (en)
AU (1) AU5912500A (en)
CA (1) CA2378381A1 (en)
DE (1) DE60005688T2 (en)
DK (1) DK1202724T3 (en)
ES (1) ES2208364T3 (en)
HK (1) HK1047895A1 (en)
HU (1) HUP0202180A3 (en)
IL (1) IL147618A0 (en)
PL (1) PL352712A1 (en)
PT (1) PT1202724E (en)
TR (1) TR200200205T2 (en)
WO (1) WO2001005393A2 (en)

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US7235537B2 (en) 2002-03-13 2007-06-26 Array Biopharma, Inc. N3 alkylated benzimidazole derivatives as MEK inhibitors
US7144907B2 (en) 2003-09-03 2006-12-05 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
US7538120B2 (en) 2003-09-03 2009-05-26 Array Biopharma Inc. Method of treating inflammatory diseases
US7781595B2 (en) * 2003-09-22 2010-08-24 S*Bio Pte Ltd. Benzimidazole derivatives: preparation and pharmaceutical applications
EP1682495A1 (en) 2003-10-21 2006-07-26 Warner-Lambert Company LLC Polymorphic form of n- (r)-2,3-dihydroxy-propoxy -3,4-d ifluoro-2-(2-fluoro-4-iodophenylamino)-benzamide
EP1529951A1 (en) 2003-11-06 2005-05-11 Gaveco AB A method and a system for disconnection of a fuel supply
US7517994B2 (en) 2003-11-19 2009-04-14 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
US7732616B2 (en) 2003-11-19 2010-06-08 Array Biopharma Inc. Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof
WO2005051302A2 (en) 2003-11-19 2005-06-09 Array Biopharma Inc. Bicyclic inhibitors of mek and methods of use thereof
CN1882347A (en) 2003-11-21 2006-12-20 阿雷生物药品公司 AKT protein kinase inhibitors
US7378423B2 (en) 2004-06-11 2008-05-27 Japan Tobacco Inc. Pyrimidine compound and medical use thereof
ES2397825T3 (en) 2004-06-11 2013-03-11 Japan Tobacco, Inc. 5-Amino-2,4,7-trioxo-3,4,7,8-tetrahydro-2H-pyrido [2,3-d] pyrimidine derivatives and related compounds for cancer treatment
EP1967516B1 (en) 2005-05-18 2009-11-04 Array Biopharma, Inc. 4-(phenylamino)-6-oxo-1,6-dihydropyridazine-3-carboxamide derivatives as MEK inhibitors for the treatment of hyperproliferative diseases
ES2567133T3 (en) 2005-06-23 2016-04-20 Array Biopharma, Inc. Process for preparing benzoimidazole compounds
BRPI0617165B1 (en) 2005-10-07 2023-10-03 Exelixis Inc MEK INHIBITOR COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND METHODS OF USE THEREOF
JP5116245B2 (en) * 2006-03-24 2013-01-09 地方独立行政法人 東京都立産業技術研究センター Calibration curve compound for use in automated analyzers
US8063050B2 (en) 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
EP2054418B1 (en) 2006-07-06 2011-11-09 Array Biopharma Inc. Dihydrothieno pyrimidines as akt protein kinase inhibitors
US8329701B2 (en) 2006-07-06 2012-12-11 Array Biopharma Inc. Dihydrofuro pyrimidines as AKT protein kinase inhibitors
BRPI0713555A2 (en) 2006-07-06 2012-03-20 Array Biopharma, Inc. cyclopenta [d] pyrimidines as akt protein kinase inhibitors
CN111643496A (en) 2006-12-14 2020-09-11 埃克塞利希斯股份有限公司 Methods of using MEK inhibitors
AU2008272830B8 (en) 2007-07-05 2013-12-12 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
US9409886B2 (en) 2007-07-05 2016-08-09 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
US8846683B2 (en) 2007-07-05 2014-09-30 Array Biopharma, Inc. Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
CA2692506C (en) 2007-07-05 2015-11-24 Array Biopharma Inc. Pyrimidyl cyclopentanes as akt protein kinase inhibitors
GB0723794D0 (en) 2007-12-05 2008-01-16 Lectus Therapeutics Ltd Potassium ion channel modulators and uses thereof
NZ586346A (en) 2008-01-09 2012-02-24 Array Biopharma Inc Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors
MX2010007546A (en) 2008-01-09 2010-09-30 Array Biopharma Inc Hydroxylated pyrimidyl cyclopentane as akt protein kinase inhibitor.
WO2010051933A2 (en) 2008-11-10 2010-05-14 Bayer Schering Pharma Aktiengesellschaft Substituted sulphonamido phenoxybenzamides
JP2013508318A (en) 2009-10-21 2013-03-07 バイエル・ファルマ・アクチェンゲゼルシャフト Substituted benzosulfonamide derivatives
CA2777430A1 (en) 2009-10-21 2011-04-28 Bayer Pharma Aktiengesellschaft Substituted benzosulphonamides
WO2011047796A1 (en) 2009-10-21 2011-04-28 Bayer Schering Pharma Aktiengesellschaft Substituted halophenoxybenzamide derivatives
WO2012004714A2 (en) 2010-07-09 2012-01-12 Pfizer Limited Chemical compounds
WO2012055953A1 (en) 2010-10-29 2012-05-03 Bayer Pharma Aktiengesellschaft Substituted phenoxypyridines
HUE036513T2 (en) 2011-04-01 2018-07-30 Genentech Inc Combination of akt inhibitor compound and abiraterone for use in therapeutic treatments
CN103841976A (en) 2011-04-01 2014-06-04 基因泰克公司 Combinations of AKT AND MEK inhibitor compounds, and methods of use
CN104837826B (en) 2012-10-12 2018-07-27 埃克塞里艾克西斯公司 Prepare the novel method of the compound for treating cancer
AR108257A1 (en) 2016-05-02 2018-08-01 Mei Pharma Inc POLYMORPHIC FORMS OF 3- [2-BUTIL-1- (2-DIETILAMINO-ETIL) -1H-BENCIMIDAZOL-5-IL] -N-HYDROXY-ACRYLAMIDE AND USES OF THE SAME
CA3023465A1 (en) 2016-05-20 2017-11-23 Xenon Pharmaceuticals Inc. Benzenesulfonamide compounds and their use as therapeutic agents
BR112019011121A2 (en) 2016-12-09 2019-10-01 Xenon Pharmaceuticals Inc benzenesulfonamide compounds and their use as therapeutic agents
JP7046968B2 (en) * 2017-03-02 2022-04-04 上海 インスティテュート オブ マテリア メディカ、チャイニーズ アカデミー オブ サイエンシーズ 2- (Substituted Phenyl Hetero) Aromatic Carboxylic Acid FTO Inhibitor, Its Production Method and Its Use
CA3103600A1 (en) 2018-06-13 2019-12-19 Xenon Pharmaceuticals Inc. Benzenesulfonamide compounds and their use as therapeutic agents
CN112638879B (en) 2018-08-31 2024-06-18 泽农医药公司 Heteroaryl substituted sulfonamide compounds and their use as therapeutic agents
EP3844158A1 (en) 2018-08-31 2021-07-07 Xenon Pharmaceuticals Inc. Heteroaryl-substituted sulfonamide compounds and their use as sodium channel inhibitors
TW202340177A (en) 2021-12-30 2023-10-16 美商拜歐米富士恩股份有限公司 Pyrazine compounds as inhibitors of flt3

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL62219C (en) * 1945-05-07
US5155110A (en) * 1987-10-27 1992-10-13 Warner-Lambert Company Fenamic acid hydroxamate derivatives having cyclooxygenase and 5-lipoxygenase inhibition
JP2773836B2 (en) * 1988-07-12 1998-07-09 富士通株式会社 Net extraction method for layout wiring for integrated circuits
AU5610398A (en) * 1997-02-28 1998-09-18 Warner-Lambert Company Method of treating or preventing septic shock by administering a mek inhibitor
ATE344791T1 (en) * 1997-07-01 2006-11-15 Warner Lambert Co 2-(4-BROMINE OR 4-IODINE PHENYLAMINO)BENZOIC ACID DERIVATIVES AND THEIR USE AS MEK INHIBITORS
ES2251851T3 (en) * 1999-01-13 2006-05-01 Warner-Lambert Company Llc SULFOHYDROXAMIC AND SULFOHYDROXAMATE ACIDS AND ITS USE WITH MEK INHIBITORS.
CA2348236A1 (en) * 1999-01-13 2000-07-20 Stephen Douglas Barrett 4-arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective mek inhibitors
JP2002534446A (en) * 1999-01-13 2002-10-15 ワーナー−ランバート・カンパニー 4'heteroaryldiarylamine
WO2000042003A1 (en) * 1999-01-13 2000-07-20 Warner-Lambert Company Benzenesulfonamide derivatives and their use as mek inhibitors

Also Published As

Publication number Publication date
ES2208364T3 (en) 2004-06-16
WO2001005393A3 (en) 2001-05-10
DE60005688D1 (en) 2003-11-06
AU5912500A (en) 2001-02-05
JP2003504401A (en) 2003-02-04
WO2001005393A2 (en) 2001-01-25
PL352712A1 (en) 2003-09-08
PT1202724E (en) 2004-02-27
ATE250932T1 (en) 2003-10-15
HK1047895A1 (en) 2003-03-14
EP1202724A2 (en) 2002-05-08
DK1202724T3 (en) 2004-01-26
DE60005688T2 (en) 2004-04-29
HUP0202180A2 (en) 2002-10-28
KR20020016899A (en) 2002-03-06
EP1202724B1 (en) 2003-10-01
IL147618A0 (en) 2002-08-14
CA2378381A1 (en) 2001-01-25
TR200200205T2 (en) 2002-06-21
CN1365277A (en) 2002-08-21

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