HUP0202180A3 - Method for treating chronic pain using mek inhibitors - Google Patents

Method for treating chronic pain using mek inhibitors

Info

Publication number
HUP0202180A3
HUP0202180A3 HU0202180A HUP0202180A HUP0202180A3 HU P0202180 A3 HUP0202180 A3 HU P0202180A3 HU 0202180 A HU0202180 A HU 0202180A HU P0202180 A HUP0202180 A HU P0202180A HU P0202180 A3 HUP0202180 A3 HU P0202180A3
Authority
HU
Hungary
Prior art keywords
chronic pain
treating chronic
mek inhibitors
mek
inhibitors
Prior art date
Application number
HU0202180A
Other languages
Hungarian (hu)
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of HUP0202180A2 publication Critical patent/HUP0202180A2/en
Publication of HUP0202180A3 publication Critical patent/HUP0202180A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
HU0202180A 1999-07-16 2000-07-05 Method for treating chronic pain using mek inhibitors HUP0202180A3 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US14428099P 1999-07-16 1999-07-16
US14465999P 1999-07-16 1999-07-16
US14465899P 1999-07-16 1999-07-16
US14465599P 1999-07-16 1999-07-16
US14441999P 1999-07-16 1999-07-16
US14432099P 1999-07-16 1999-07-16

Publications (2)

Publication Number Publication Date
HUP0202180A2 HUP0202180A2 (en) 2002-10-28
HUP0202180A3 true HUP0202180A3 (en) 2004-10-28

Family

ID=27558291

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0202180A HUP0202180A3 (en) 1999-07-16 2000-07-05 Method for treating chronic pain using mek inhibitors

Country Status (17)

Country Link
EP (1) EP1202724B1 (en)
JP (1) JP2003504401A (en)
KR (1) KR20020016899A (en)
CN (1) CN1365277A (en)
AT (1) ATE250932T1 (en)
AU (1) AU5912500A (en)
CA (1) CA2378381A1 (en)
DE (1) DE60005688T2 (en)
DK (1) DK1202724T3 (en)
ES (1) ES2208364T3 (en)
HK (1) HK1047895A1 (en)
HU (1) HUP0202180A3 (en)
IL (1) IL147618A0 (en)
PL (1) PL352712A1 (en)
PT (1) PT1202724E (en)
TR (1) TR200200205T2 (en)
WO (1) WO2001005393A2 (en)

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US7235537B2 (en) 2002-03-13 2007-06-26 Array Biopharma, Inc. N3 alkylated benzimidazole derivatives as MEK inhibitors
US7144907B2 (en) 2003-09-03 2006-12-05 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
US7538120B2 (en) 2003-09-03 2009-05-26 Array Biopharma Inc. Method of treating inflammatory diseases
US7781595B2 (en) 2003-09-22 2010-08-24 S*Bio Pte Ltd. Benzimidazole derivatives: preparation and pharmaceutical applications
KR101013932B1 (en) 2003-10-21 2011-02-14 워너-램버트 캄파니 엘엘씨 Polymorphic form of n-[r-2,3-dihydroxy-propoxy]-3,4-difluoro-2-2-fluoro-4-iodophenylamino-benzamide
EP1529951A1 (en) 2003-11-06 2005-05-11 Gaveco AB A method and a system for disconnection of a fuel supply
US7517994B2 (en) 2003-11-19 2009-04-14 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
US7772234B2 (en) 2003-11-19 2010-08-10 Array Biopharma Inc. Bicyclic inhibitors of MEK and methods of use thereof
US7732616B2 (en) 2003-11-19 2010-06-08 Array Biopharma Inc. Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof
NZ590160A (en) 2003-11-21 2012-07-27 Array Biopharma Inc AKT protein kinase inhibitors
RS52670B (en) 2004-06-11 2013-06-28 Japan Tobacco Inc. 5-amino-2,4,7-trioxo-3,4,7,8-tetrahydro-2h-pyrido[2,3-d]pyrimidine derivatives and related compounds for the treatment of cancer
US7378423B2 (en) 2004-06-11 2008-05-27 Japan Tobacco Inc. Pyrimidine compound and medical use thereof
KR20080019236A (en) 2005-05-18 2008-03-03 어레이 바이오파마 인크. Heterocyclic inhibitors of mek and methods of use thereof
EP1904481B1 (en) 2005-06-23 2016-02-17 Array Biopharma, Inc. Process for preparing benzimidazole compounds
KR20130058072A (en) 2005-10-07 2013-06-03 엑셀리시스, 인코포레이티드 Azetidines as mek inhibitors for the treatment of proliferative diseases
JP5116245B2 (en) * 2006-03-24 2013-01-09 地方独立行政法人 東京都立産業技術研究センター Calibration curve compound for use in automated analyzers
US8063050B2 (en) 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
DE602007011628D1 (en) 2006-07-06 2011-02-10 Array Biopharma Inc DIHYDROFUROPYRIMIDINES AS ACT PROTEIN KINASE INHIBITORS
AU2007269052B2 (en) 2006-07-06 2014-10-23 Array Biopharma Inc. Cyclopenta [D] pyrimidines as AKT protein kinase inhibitors
SI2054418T1 (en) 2006-07-06 2012-02-29 Array Biopharma Inc Dihydrothieno pyrimidines as akt protein kinase inhibitors
CN101605540A (en) 2006-12-14 2009-12-16 埃克塞利希斯股份有限公司 Use the method for mek inhibitor
RU2486181C2 (en) 2007-07-05 2013-06-27 Эррэй Биофарма Инк. Pyrimidyl cyclopentanes as akt/protein kinase inhibitors
MX2009014013A (en) 2007-07-05 2010-01-28 Array Biopharma Inc Pyrimidyl cyclopentanes as akt protein kinase inhibitors.
US8846683B2 (en) 2007-07-05 2014-09-30 Array Biopharma, Inc. Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
US9409886B2 (en) 2007-07-05 2016-08-09 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
GB0723794D0 (en) 2007-12-05 2008-01-16 Lectus Therapeutics Ltd Potassium ion channel modulators and uses thereof
JP5346345B2 (en) 2008-01-09 2013-11-20 アレイ バイオファーマ、インコーポレイテッド Hydroxylated pyrimidylcyclopentanes as AKT protein kinase inhibitors
CA2711692A1 (en) 2008-01-09 2009-07-16 Array Biopharma Inc. Hydroxylated pyrimidyl cyclopentane as akt protein kinase inhibitor
EP2346818B1 (en) 2008-11-10 2012-12-05 Bayer Intellectual Property GmbH Substituted sulphonamido phenoxybenzamides
JP2013508320A (en) 2009-10-21 2013-03-07 バイエル・ファルマ・アクチェンゲゼルシャフト Substituted halophenoxybenzamide derivatives
CN102656142A (en) 2009-10-21 2012-09-05 拜耳制药股份公司 Substituted benzosulphonamides
EP2491016A1 (en) 2009-10-21 2012-08-29 Bayer Pharma Aktiengesellschaft Substituted benzosulphonamides
JP5860045B2 (en) 2010-07-09 2016-02-16 ファイザー・リミテッドＰｆｉｚｅｒ Ｌｉｍｉｔｅｄ Compound
US9045429B2 (en) 2010-10-29 2015-06-02 Bayer Intellectual Property Gmbh Substituted phenoxypyridines
EP2694073B1 (en) 2011-04-01 2018-08-08 Genentech, Inc. Combinations of akt and mek inhibitors for treating cancer
KR20140021646A (en) 2011-04-01 2014-02-20 제넨테크, 인크. Combinations of akt inhibitor compounds and erlotinib, and methods of use
BR112015008113B1 (en) 2012-10-12 2022-05-24 Exelixis, Inc. New process to prepare compounds for use in cancer treatment
AR108257A1 (en) 2016-05-02 2018-08-01 Mei Pharma Inc POLYMORPHIC FORMS OF 3- [2-BUTIL-1- (2-DIETILAMINO-ETIL) -1H-BENCIMIDAZOL-5-IL] -N-HYDROXY-ACRYLAMIDE AND USES OF THE SAME
TN2018000385A1 (en) 2016-05-20 2020-06-15 Xenon Pharmaceuticals Inc Benzenesulfonamide compounds and their use as therapeutic agents
TN2019000175A1 (en) 2016-12-09 2020-10-05 Xenon Pharmaceuticals Inc Benzenesulfonamide compounds and their use as therapeutic agents
EP3590920A4 (en) * 2017-03-02 2021-01-06 Shanghai Institute of Materia Medica, Chinese Academy of Sciences 2-(substituted benzene matrix) aromatic formate fto inhibitor, preparation method therefor, and applications thereof
MX2020013317A (en) 2018-06-13 2021-04-13 Xenon Pharmaceuticals Inc Benzenesulfonamide compounds and their use as therapeutic agents.
WO2020047312A1 (en) 2018-08-31 2020-03-05 Xenon Pharmaceuticals Inc. Heteroaryl-substituted sulfonamide compounds and their use as sodium channel inhibitors
US10981905B2 (en) 2018-08-31 2021-04-20 Xenon Pharmaceuticals Inc. Heteroaryl-substituted sulfonamide compounds and their use as therapeutic agents
TW202340177A (en) 2021-12-30 2023-10-16 美商拜歐米富士恩股份有限公司 Pyrazine compounds as inhibitors of flt3

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL62219C (en) * 1945-05-07
US5155110A (en) * 1987-10-27 1992-10-13 Warner-Lambert Company Fenamic acid hydroxamate derivatives having cyclooxygenase and 5-lipoxygenase inhibition
JP2773836B2 (en) * 1988-07-12 1998-07-09 富士通株式会社 Net extraction method for layout wiring for integrated circuits
WO1998037881A1 (en) * 1997-02-28 1998-09-03 Warner Lambert Company Method of treating or preventing septic shock by administering a mek inhibitor
NZ501277A (en) * 1997-07-01 2002-12-20 Warner Lambert Co -2(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors
CA2348236A1 (en) * 1999-01-13 2000-07-20 Stephen Douglas Barrett 4-arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective mek inhibitors
ES2251851T3 (en) * 1999-01-13 2006-05-01 Warner-Lambert Company Llc SULFOHYDROXAMIC AND SULFOHYDROXAMATE ACIDS AND ITS USE WITH MEK INHIBITORS.
WO2000041505A2 (en) * 1999-01-13 2000-07-20 Warner-Lambert Company Anthranilic acid derivatives
JP2002534498A (en) * 1999-01-13 2002-10-15 ワーナー−ランバート・カンパニー Benzenesulfonamide derivatives and their use as MEK inhibitors

Also Published As

Publication number Publication date
DE60005688T2 (en) 2004-04-29
ES2208364T3 (en) 2004-06-16
EP1202724B1 (en) 2003-10-01
ATE250932T1 (en) 2003-10-15
EP1202724A2 (en) 2002-05-08
HK1047895A1 (en) 2003-03-14
PL352712A1 (en) 2003-09-08
CN1365277A (en) 2002-08-21
JP2003504401A (en) 2003-02-04
DE60005688D1 (en) 2003-11-06
PT1202724E (en) 2004-02-27
AU5912500A (en) 2001-02-05
WO2001005393A2 (en) 2001-01-25
IL147618A0 (en) 2002-08-14
TR200200205T2 (en) 2002-06-21
WO2001005393A3 (en) 2001-05-10
HUP0202180A2 (en) 2002-10-28
KR20020016899A (en) 2002-03-06
DK1202724T3 (en) 2004-01-26
CA2378381A1 (en) 2001-01-25

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