IL147619A0 - Method for treating chronic pain using mek inhibitors - Google Patents
Method for treating chronic pain using mek inhibitorsInfo
- Publication number
- IL147619A0 IL147619A0 IL14761900A IL14761900A IL147619A0 IL 147619 A0 IL147619 A0 IL 147619A0 IL 14761900 A IL14761900 A IL 14761900A IL 14761900 A IL14761900 A IL 14761900A IL 147619 A0 IL147619 A0 IL 147619A0
- Authority
- IL
- Israel
- Prior art keywords
- chronic pain
- treating chronic
- mek inhibitors
- mek
- inhibitors
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Addiction (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dermatology (AREA)
- Biotechnology (AREA)
- Nutrition Science (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14429299P | 1999-07-16 | 1999-07-16 | |
PCT/US2000/018347 WO2001005392A2 (en) | 1999-07-16 | 2000-07-05 | Method for treating chronic pain using mek inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
IL147619A0 true IL147619A0 (en) | 2002-08-14 |
Family
ID=22507940
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL14761900A IL147619A0 (en) | 1999-07-16 | 2000-07-05 | Method for treating chronic pain using mek inhibitors |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP1202726A2 (en) |
JP (1) | JP2003504400A (en) |
KR (1) | KR20020012315A (en) |
CN (1) | CN1373660A (en) |
AR (1) | AR024732A1 (en) |
AU (1) | AU5786000A (en) |
CA (1) | CA2374052A1 (en) |
CO (1) | CO5300398A1 (en) |
HU (1) | HUP0202623A3 (en) |
IL (1) | IL147619A0 (en) |
NZ (1) | NZ515567A (en) |
PE (1) | PE20010545A1 (en) |
PL (1) | PL352684A1 (en) |
TR (1) | TR200200082T2 (en) |
WO (1) | WO2001005392A2 (en) |
ZA (1) | ZA200109907B (en) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DZ3401A1 (en) | 2000-07-19 | 2002-01-24 | Warner Lambert Co | OXYGEN ESTERS OF 4-IODOPHENYLAMINO BENZHYDROXAMIC ACIDS |
IL149462A0 (en) | 2001-05-09 | 2002-11-10 | Warner Lambert Co | Method of treating or inhibiting neutrophil chemotaxis by administering a mek inhibitor |
KR100984573B1 (en) | 2002-03-13 | 2010-09-30 | 어레이 바이오파마 인크. | N3 Alkylated Benzimidazole Derivatives as MEK Inhibitors |
US7235537B2 (en) | 2002-03-13 | 2007-06-26 | Array Biopharma, Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
US7632866B2 (en) | 2002-10-21 | 2009-12-15 | Ramot At Tel Aviv University | Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators |
BRPI0412851A (en) | 2003-07-24 | 2006-10-03 | Warner Lambert Co | n-methyl-substituted benzamidazoles |
US7538120B2 (en) | 2003-09-03 | 2009-05-26 | Array Biopharma Inc. | Method of treating inflammatory diseases |
US7144907B2 (en) | 2003-09-03 | 2006-12-05 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
AU2004279721A1 (en) * | 2003-10-08 | 2005-04-21 | Teijin Pharma Limited | Process for producing aminopyrrolidine derivative and intermediate compound |
KR101013932B1 (en) | 2003-10-21 | 2011-02-14 | 워너-램버트 캄파니 엘엘씨 | Polymorphic form of n-[r-2,3-dihydroxy-propoxy]-3,4-difluoro-2-2-fluoro-4-iodophenylamino-benzamide |
US7732616B2 (en) | 2003-11-19 | 2010-06-08 | Array Biopharma Inc. | Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof |
AU2004293017B2 (en) | 2003-11-19 | 2010-08-19 | Array Biopharma Inc. | Bicyclic inhibitors of MEK and methods of use thereof |
US7517994B2 (en) | 2003-11-19 | 2009-04-14 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
KR101223914B1 (en) | 2003-11-21 | 2013-01-18 | 어레이 바이오파마 인크. | Akt protein kinase inhibitors |
MY144232A (en) * | 2004-07-26 | 2011-08-15 | Chugai Pharmaceutical Co Ltd | 5-substituted-2-phenylamino benzamides as mek inhibitors |
ES2378760T3 (en) | 2005-05-18 | 2012-04-17 | Array Biopharma, Inc. | MEK heterocyclic inhibitors and methods of use thereof |
CN110668988A (en) | 2005-10-07 | 2020-01-10 | 埃克塞利希斯股份有限公司 | Azetidines as MEK inhibitors for the treatment of proliferative diseases |
RU2481336C2 (en) | 2006-07-06 | 2013-05-10 | Эррэй Биофарма Инк. | Cyclopenta(d)pyrimidines as protein kinase akt inhibitors |
US8063050B2 (en) | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
CA2656566C (en) | 2006-07-06 | 2014-06-17 | Array Biopharma Inc. | Dihydrofuro pyrimidines as akt protein kinase inhibitors |
EP2054418B1 (en) | 2006-07-06 | 2011-11-09 | Array Biopharma Inc. | Dihydrothieno pyrimidines as akt protein kinase inhibitors |
AU2007334402B2 (en) | 2006-12-14 | 2014-02-13 | Exelixis, Inc. | Methods of using MEK inhibitors |
US9409886B2 (en) | 2007-07-05 | 2016-08-09 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
KR101624361B1 (en) | 2007-07-05 | 2016-05-25 | 어레이 바이오파마 인크. | Pyrimidyl cyclopentanes as akt protein kinase inhibitors |
NZ582692A (en) | 2007-07-05 | 2012-05-25 | Array Biopharma Inc | Pyrimidyl cyclopentanes as akt protein kinase inhibitors |
US8846683B2 (en) | 2007-07-05 | 2014-09-30 | Array Biopharma, Inc. | Pyrimidyl cyclopentanes as Akt protein kinase inhibitors |
EP2203411B1 (en) * | 2007-09-20 | 2016-01-06 | Ramot at Tel-Aviv University Ltd. | N-phenyl anthranilic acid derivatives and uses thereof |
NZ586418A (en) | 2007-12-19 | 2012-09-28 | Cancer Rec Tech Ltd | Pyrido[2,3-b]pyrazine-8-substituted compounds and their use |
NZ586720A (en) | 2008-01-09 | 2012-11-30 | Array Biopharma Inc | Hydroxylated pyrimidyl cyclopentane as akt protein kinase inhibitor |
ES2422733T3 (en) | 2008-01-09 | 2013-09-13 | Array Biopharma Inc | Hydroxylated pyrimidylcyclopentanes as AKT protein kinase inhibitors |
US8993630B2 (en) | 2008-11-10 | 2015-03-31 | Bayer Intellectual Property Gmbh | Substituted sulphonamido phenoxybenzamides |
EP2491016A1 (en) | 2009-10-21 | 2012-08-29 | Bayer Pharma Aktiengesellschaft | Substituted benzosulphonamides |
JP2013508320A (en) | 2009-10-21 | 2013-03-07 | バイエル・ファルマ・アクチェンゲゼルシャフト | Substituted halophenoxybenzamide derivatives |
JP2013508318A (en) | 2009-10-21 | 2013-03-07 | バイエル・ファルマ・アクチェンゲゼルシャフト | Substituted benzosulfonamide derivatives |
PL2531502T3 (en) | 2010-02-01 | 2014-08-29 | Cancer Research Tech Ltd | 1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-7-yloxy)-phenyl]-urea and related compounds and their use in therapy |
JP2013542214A (en) | 2010-10-29 | 2013-11-21 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Substituted phenoxypyridines |
CN110433165A (en) | 2011-04-01 | 2019-11-12 | 基因泰克公司 | The combination and its application method of AKT and mek inhibitor compound |
BR112013025353A8 (en) | 2011-04-01 | 2018-01-02 | Genentech Inc | combination of a) a compound of formula ia, compound of formula ia or a pharmaceutically acceptable salt thereof, method for treating a hyperproliferative disorder in a mammal, use of a compound of formula ia or a pharmaceutically acceptable salt thereof, kit and product |
NZ706723A (en) | 2012-10-12 | 2018-07-27 | Exelixis Inc | Novel process for making compounds for use in the treatment of cancer |
WO2015038743A1 (en) | 2013-09-11 | 2015-03-19 | The Administrators Of The Tulane Educational Fund | Novel anthranilic amides and the use thereof |
GB201320729D0 (en) | 2013-11-25 | 2014-01-08 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
GB201320732D0 (en) | 2013-11-25 | 2014-01-08 | Cancer Rec Tech Ltd | Methods of chemical synthesis |
CA3001879A1 (en) | 2015-10-27 | 2017-05-04 | Acetylon Pharmaceuticals, Inc. | Hdac inhibitors for the treatment of diabetic peripheral neuropathy |
EP3973960A1 (en) | 2017-10-17 | 2022-03-30 | Atriva Therapeutics GmbH | Novel mek-inhibitor for the treatment of viral and bacterial infections |
CN114008013A (en) * | 2019-06-28 | 2022-02-01 | 哥本哈根大学 | Treatment of CNS disorders with sleep disorders |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU5610398A (en) * | 1997-02-28 | 1998-09-18 | Warner-Lambert Company | Method of treating or preventing septic shock by administering a mek inhibitor |
ATE344791T1 (en) * | 1997-07-01 | 2006-11-15 | Warner Lambert Co | 2-(4-BROMINE OR 4-IODINE PHENYLAMINO)BENZOIC ACID DERIVATIVES AND THEIR USE AS MEK INHIBITORS |
ES2229515T3 (en) * | 1997-07-01 | 2005-04-16 | Warner-Lambert Company Llc | 4-BROMO OR 4-IODINE DERIVATIVES OF BENZHYDROXAMIC PHENYLAMINE ACID AND ITS USE AS INHIBITORS OF THE MEK. |
AU776788C (en) * | 1998-12-16 | 2005-10-27 | Warner-Lambert Company | Treatment of arthritis with MEK inhibitors |
-
2000
- 2000-07-05 AU AU57860/00A patent/AU5786000A/en not_active Abandoned
- 2000-07-05 PL PL00352684A patent/PL352684A1/en not_active Application Discontinuation
- 2000-07-05 CN CN00809801A patent/CN1373660A/en active Pending
- 2000-07-05 JP JP2001510449A patent/JP2003504400A/en active Pending
- 2000-07-05 HU HU0202623A patent/HUP0202623A3/en unknown
- 2000-07-05 TR TR2002/00082T patent/TR200200082T2/en unknown
- 2000-07-05 EP EP00943383A patent/EP1202726A2/en not_active Withdrawn
- 2000-07-05 CA CA002374052A patent/CA2374052A1/en not_active Abandoned
- 2000-07-05 KR KR1020027000609A patent/KR20020012315A/en not_active Application Discontinuation
- 2000-07-05 IL IL14761900A patent/IL147619A0/en unknown
- 2000-07-05 WO PCT/US2000/018347 patent/WO2001005392A2/en not_active Application Discontinuation
- 2000-07-05 NZ NZ515567A patent/NZ515567A/en unknown
- 2000-07-13 AR ARP000103604A patent/AR024732A1/en unknown
- 2000-07-14 PE PE2000000705A patent/PE20010545A1/en not_active Application Discontinuation
- 2000-07-14 CO CO00053304A patent/CO5300398A1/en not_active Application Discontinuation
-
2001
- 2001-11-30 ZA ZA200109907A patent/ZA200109907B/en unknown
Also Published As
Publication number | Publication date |
---|---|
CO5300398A1 (en) | 2003-07-31 |
HUP0202623A2 (en) | 2002-11-28 |
CN1373660A (en) | 2002-10-09 |
TR200200082T2 (en) | 2002-04-22 |
PE20010545A1 (en) | 2001-06-04 |
KR20020012315A (en) | 2002-02-15 |
PL352684A1 (en) | 2003-09-08 |
EP1202726A2 (en) | 2002-05-08 |
WO2001005392A2 (en) | 2001-01-25 |
HUP0202623A3 (en) | 2003-03-28 |
ZA200109907B (en) | 2003-02-28 |
NZ515567A (en) | 2004-03-26 |
JP2003504400A (en) | 2003-02-04 |
AU5786000A (en) | 2001-02-05 |
AR024732A1 (en) | 2002-10-23 |
CA2374052A1 (en) | 2001-01-25 |
WO2001005392A3 (en) | 2001-07-19 |
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