TR200200082T2 - Treating chronic pain using MEK inhibitors. - Google Patents
Treating chronic pain using MEK inhibitors.Info
- Publication number
- TR200200082T2 TR200200082T2 TR2002/00082T TR200200082T TR200200082T2 TR 200200082 T2 TR200200082 T2 TR 200200082T2 TR 2002/00082 T TR2002/00082 T TR 2002/00082T TR 200200082 T TR200200082 T TR 200200082T TR 200200082 T2 TR200200082 T2 TR 200200082T2
- Authority
- TR
- Turkey
- Prior art keywords
- chronic pain
- treating chronic
- mek inhibitors
- formula
- mek
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
Abstract
Bulus formül (I) ve formül I(A)'dan seçilen bir bilesik kullanilarak kronik agrinin tedavi edilmesi için olan bir yöntemle ilgilidir.The invention relates to a method for treating chronic pain using a compound selected from formula (I) and formula I (A).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14429299P | 1999-07-16 | 1999-07-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200200082T2 true TR200200082T2 (en) | 2002-04-22 |
Family
ID=22507940
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2002/00082T TR200200082T2 (en) | 1999-07-16 | 2000-07-05 | Treating chronic pain using MEK inhibitors. |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP1202726A2 (en) |
JP (1) | JP2003504400A (en) |
KR (1) | KR20020012315A (en) |
CN (1) | CN1373660A (en) |
AR (1) | AR024732A1 (en) |
AU (1) | AU5786000A (en) |
CA (1) | CA2374052A1 (en) |
CO (1) | CO5300398A1 (en) |
HU (1) | HUP0202623A3 (en) |
IL (1) | IL147619A0 (en) |
NZ (1) | NZ515567A (en) |
PE (1) | PE20010545A1 (en) |
PL (1) | PL352684A1 (en) |
TR (1) | TR200200082T2 (en) |
WO (1) | WO2001005392A2 (en) |
ZA (1) | ZA200109907B (en) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EE05450B1 (en) | 2000-07-19 | 2011-08-15 | Warner-Lambert Company | Oxygenated esters of 4-iodophen laminobenzh droxamic acids, their crystalline forms and pharmaceutical compositions and their use |
NZ518726A (en) | 2001-05-09 | 2004-06-25 | Warner Lambert Co | Method of treating or inhibiting neutrophil chemotaxis by administering a mek inhibitor |
US7235537B2 (en) | 2002-03-13 | 2007-06-26 | Array Biopharma, Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
PL401637A1 (en) | 2002-03-13 | 2013-05-27 | Array Biopharma Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
US7632866B2 (en) | 2002-10-21 | 2009-12-15 | Ramot At Tel Aviv University | Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators |
CA2532067C (en) | 2003-07-24 | 2010-12-21 | Stephen Douglas Barrett | N-methyle-substituted benzamidazoles |
US7144907B2 (en) | 2003-09-03 | 2006-12-05 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
US7538120B2 (en) | 2003-09-03 | 2009-05-26 | Array Biopharma Inc. | Method of treating inflammatory diseases |
JPWO2005035493A1 (en) * | 2003-10-08 | 2006-12-21 | 帝人ファーマ株式会社 | Process for producing aminopyrrolidine derivative and intermediate compound |
KR101013932B1 (en) | 2003-10-21 | 2011-02-14 | 워너-램버트 캄파니 엘엘씨 | Polymorphic form of n-[r-2,3-dihydroxy-propoxy]-3,4-difluoro-2-2-fluoro-4-iodophenylamino-benzamide |
WO2005051302A2 (en) | 2003-11-19 | 2005-06-09 | Array Biopharma Inc. | Bicyclic inhibitors of mek and methods of use thereof |
US7517994B2 (en) | 2003-11-19 | 2009-04-14 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
US7732616B2 (en) | 2003-11-19 | 2010-06-08 | Array Biopharma Inc. | Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof |
WO2005051304A2 (en) | 2003-11-21 | 2005-06-09 | Array Biopharma Inc. | Akt protein kinase inhibitors |
MY144232A (en) * | 2004-07-26 | 2011-08-15 | Chugai Pharmaceutical Co Ltd | 5-substituted-2-phenylamino benzamides as mek inhibitors |
KR20080019236A (en) | 2005-05-18 | 2008-03-03 | 어레이 바이오파마 인크. | Heterocyclic inhibitors of mek and methods of use thereof |
NZ567140A (en) | 2005-10-07 | 2011-09-30 | Exelixis Inc | Azetidines as MEK inhibitors for the treatment of proliferative diseases |
SI2054418T1 (en) | 2006-07-06 | 2012-02-29 | Array Biopharma Inc | Dihydrothieno pyrimidines as akt protein kinase inhibitors |
BRPI0713555A2 (en) | 2006-07-06 | 2012-03-20 | Array Biopharma, Inc. | cyclopenta [d] pyrimidines as akt protein kinase inhibitors |
US8063050B2 (en) | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
ATE493418T1 (en) | 2006-07-06 | 2011-01-15 | Array Biopharma Inc | DIHYDROFUROPYRIMIDINES AS ACT PROTEIN KINASE INHIBITORS |
US7999006B2 (en) | 2006-12-14 | 2011-08-16 | Exelixis, Inc. | Methods of using MEK inhibitors |
CN101918373B (en) | 2007-07-05 | 2013-06-05 | 阵列生物制药公司 | Pyrimidyl cyclopentanes as akt protein kinase inhibitors |
KR20150089099A (en) | 2007-07-05 | 2015-08-04 | 어레이 바이오파마 인크. | Pyrimidyl cyclopentanes as akt protein kinase inhibitors |
US8846683B2 (en) | 2007-07-05 | 2014-09-30 | Array Biopharma, Inc. | Pyrimidyl cyclopentanes as Akt protein kinase inhibitors |
US9409886B2 (en) | 2007-07-05 | 2016-08-09 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
US8765815B2 (en) * | 2007-09-20 | 2014-07-01 | Ramot At Tel-Aviv University Ltd. | N-phenyl anthranilic acid derivatives and uses thereof |
CA2709257C (en) | 2007-12-19 | 2016-12-13 | Cancer Research Technology Limited | Pyrido[2,3-b]pyrazine-8-substituted compounds and their use |
JP5346345B2 (en) | 2008-01-09 | 2013-11-20 | アレイ バイオファーマ、インコーポレイテッド | Hydroxylated pyrimidylcyclopentanes as AKT protein kinase inhibitors |
WO2009089453A1 (en) | 2008-01-09 | 2009-07-16 | Array Biopharma Inc. | Hydroxylated pyrimidyl cyclopentane as akt protein kinase inhibitor |
JP5746630B2 (en) | 2008-11-10 | 2015-07-08 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Intellectual Property GmbH | Substituted sulfonamidophenoxybenzamide |
EP2491014A1 (en) | 2009-10-21 | 2012-08-29 | Bayer Pharma Aktiengesellschaft | Substituted halophenoxybenzamide derivatives |
WO2011047795A1 (en) | 2009-10-21 | 2011-04-28 | Bayer Schering Pharma Aktiengesellschaft | Substituted benzosulphonamides |
CA2777304A1 (en) | 2009-10-21 | 2011-04-28 | Marion Hitchcock | Substituted benzosulphonamides |
BR112012018415A2 (en) | 2010-02-01 | 2020-08-04 | Cancer Research Technology Limited | compound, composition, methods of preparing a composition and treatment, and, use of a compound. |
US9045429B2 (en) | 2010-10-29 | 2015-06-02 | Bayer Intellectual Property Gmbh | Substituted phenoxypyridines |
EP2694073B1 (en) | 2011-04-01 | 2018-08-08 | Genentech, Inc. | Combinations of akt and mek inhibitors for treating cancer |
CN107233343A (en) | 2011-04-01 | 2017-10-10 | 基因泰克公司 | The combination of AKT inhibitor compounds and chemotherapeutics and application method |
SI2909188T1 (en) | 2012-10-12 | 2018-07-31 | Exelixis, Inc. | Novel process for making compounds for use in the treatment of cancer |
CA2923835C (en) * | 2013-09-11 | 2022-11-29 | The Administrators Of The Tulane Educational Fund | Novel anthranilic amides and the use thereof |
GB201320729D0 (en) | 2013-11-25 | 2014-01-08 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
GB201320732D0 (en) | 2013-11-25 | 2014-01-08 | Cancer Rec Tech Ltd | Methods of chemical synthesis |
JP7080812B2 (en) | 2015-10-27 | 2022-06-06 | アセチロン ファーマシューティカルズ インコーポレイテッド | HDAC inhibitors for the treatment of diabetic peripheral neuropathy |
EA202090693A1 (en) | 2017-10-17 | 2020-10-19 | Атрива Терапьютикс Гмбх | NEW MEK INHIBITOR FOR TREATMENT OF VIRAL AND BACTERIAL INFECTIONS |
JP2022538569A (en) * | 2019-06-28 | 2022-09-05 | ユニバーシティ オブ コペンハーゲン | Treatment of CNS Disorders with Sleep Disorders |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998037881A1 (en) * | 1997-02-28 | 1998-09-03 | Warner Lambert Company | Method of treating or preventing septic shock by administering a mek inhibitor |
PT993439E (en) * | 1997-07-01 | 2004-12-31 | Warner Lambert Co | 4-BROMINE OR 4-IODOPHENYLAMINOBENZYDROXYM ACID DERIVATIVES AND THEIR USE AS MEK INHIBITORS |
NZ501277A (en) * | 1997-07-01 | 2002-12-20 | Warner Lambert Co | -2(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors |
HUP0104693A3 (en) * | 1998-12-16 | 2003-12-29 | Warner Lambert Co | Treatment of arthritis with mek inhibitors |
-
2000
- 2000-07-05 NZ NZ515567A patent/NZ515567A/en unknown
- 2000-07-05 AU AU57860/00A patent/AU5786000A/en not_active Abandoned
- 2000-07-05 JP JP2001510449A patent/JP2003504400A/en active Pending
- 2000-07-05 WO PCT/US2000/018347 patent/WO2001005392A2/en not_active Application Discontinuation
- 2000-07-05 HU HU0202623A patent/HUP0202623A3/en unknown
- 2000-07-05 CA CA002374052A patent/CA2374052A1/en not_active Abandoned
- 2000-07-05 EP EP00943383A patent/EP1202726A2/en not_active Withdrawn
- 2000-07-05 TR TR2002/00082T patent/TR200200082T2/en unknown
- 2000-07-05 KR KR1020027000609A patent/KR20020012315A/en not_active Application Discontinuation
- 2000-07-05 CN CN00809801A patent/CN1373660A/en active Pending
- 2000-07-05 IL IL14761900A patent/IL147619A0/en unknown
- 2000-07-05 PL PL00352684A patent/PL352684A1/en not_active Application Discontinuation
- 2000-07-13 AR ARP000103604A patent/AR024732A1/en unknown
- 2000-07-14 PE PE2000000705A patent/PE20010545A1/en not_active Application Discontinuation
- 2000-07-14 CO CO00053304A patent/CO5300398A1/en not_active Application Discontinuation
-
2001
- 2001-11-30 ZA ZA200109907A patent/ZA200109907B/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN1373660A (en) | 2002-10-09 |
EP1202726A2 (en) | 2002-05-08 |
CA2374052A1 (en) | 2001-01-25 |
PE20010545A1 (en) | 2001-06-04 |
WO2001005392A2 (en) | 2001-01-25 |
ZA200109907B (en) | 2003-02-28 |
IL147619A0 (en) | 2002-08-14 |
WO2001005392A3 (en) | 2001-07-19 |
KR20020012315A (en) | 2002-02-15 |
AR024732A1 (en) | 2002-10-23 |
HUP0202623A3 (en) | 2003-03-28 |
CO5300398A1 (en) | 2003-07-31 |
PL352684A1 (en) | 2003-09-08 |
AU5786000A (en) | 2001-02-05 |
HUP0202623A2 (en) | 2002-11-28 |
JP2003504400A (en) | 2003-02-04 |
NZ515567A (en) | 2004-03-26 |
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