NZ705910A - Pyrrolobenzodiazepines and conjugates thereof - Google Patents

Pyrrolobenzodiazepines and conjugates thereof

Info

Publication number
NZ705910A
NZ705910A NZ705910A NZ70591013A NZ705910A NZ 705910 A NZ705910 A NZ 705910A NZ 705910 A NZ705910 A NZ 705910A NZ 70591013 A NZ70591013 A NZ 70591013A NZ 705910 A NZ705910 A NZ 705910A
Authority
NZ
New Zealand
Prior art keywords
conjugates
pyrrolobenzodiazepines
relates
pyrrolobenzodiazepine
pbd
Prior art date
Application number
NZ705910A
Inventor
Philip Wilson Howard
Original Assignee
Medimmune Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medimmune Ltd filed Critical Medimmune Ltd
Priority to NZ745069A priority Critical patent/NZ745069A/en
Publication of NZ705910A publication Critical patent/NZ705910A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/68035—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a pyrrolobenzodiazepine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6855—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

The present invention relates to a pyrrolobenzodiazepine (PBD) compound B and salts and solvates thereof, conjugates thereof with cell binding agents, compositions thereof and use of the conjugates in the preparation of a medicament for treating cancer, particularly chronic myeloid leukaemia. The invention further or alternatively relates to a method of preparing the conjugates.
NZ705910A 2012-10-12 2013-10-11 Pyrrolobenzodiazepines and conjugates thereof NZ705910A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NZ745069A NZ745069A (en) 2012-10-12 2013-10-11 Pyrrolobenzodiazepines and conjugates thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261712924P 2012-10-12 2012-10-12
PCT/EP2013/071235 WO2014057073A1 (en) 2012-10-12 2013-10-11 Pyrrolobenzodiazepines and conjugates thereof

Publications (1)

Publication Number Publication Date
NZ705910A true NZ705910A (en) 2018-09-28

Family

ID=49474386

Family Applications (2)

Application Number Title Priority Date Filing Date
NZ745069A NZ745069A (en) 2012-10-12 2013-10-11 Pyrrolobenzodiazepines and conjugates thereof
NZ705910A NZ705910A (en) 2012-10-12 2013-10-11 Pyrrolobenzodiazepines and conjugates thereof

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NZ745069A NZ745069A (en) 2012-10-12 2013-10-11 Pyrrolobenzodiazepines and conjugates thereof

Country Status (24)

Country Link
US (1) US9415117B2 (en)
EP (2) EP3470086B1 (en)
JP (2) JP6367811B2 (en)
KR (3) KR20200003278A (en)
CN (2) CN104703630A (en)
AU (1) AU2013328674B2 (en)
BR (1) BR112015008251B1 (en)
CA (2) CA2885315C (en)
CY (2) CY1121390T1 (en)
DK (2) DK3470086T3 (en)
ES (2) ES2713164T3 (en)
HK (1) HK1213183A1 (en)
HR (2) HRP20190366T1 (en)
HU (2) HUE052835T2 (en)
LT (2) LT3470086T (en)
MX (2) MX362004B (en)
NZ (2) NZ745069A (en)
PL (2) PL3470086T3 (en)
PT (2) PT3470086T (en)
RS (2) RS58203B1 (en)
SI (2) SI2906248T1 (en)
TR (1) TR201902494T4 (en)
WO (1) WO2014057073A1 (en)
ZA (1) ZA201501781B (en)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0819095D0 (en) 2008-10-17 2008-11-26 Spirogen Ltd Pyrrolobenzodiazepines
BR112012026801B8 (en) 2010-04-15 2021-05-25 Medimmune Ltd targeted pyrrolobenzodiazepine conjugates, pharmaceutical composition, use thereof for treatment of a proliferative or autoimmune disease and drug binding
EP2558475A1 (en) 2010-04-15 2013-02-20 Spirogen Sàrl Pyrrolobenzodiazepines used to treat proliferative diseases
EP2751120B1 (en) 2011-09-20 2018-08-22 MedImmune Limited Pyrrolobenzodiazepines as unsymmetrical dimeric pbd compounds for inclusion in targeted conjugates
US9388187B2 (en) 2011-10-14 2016-07-12 Medimmune Limited Pyrrolobenzodiazepines
WO2013055990A1 (en) 2011-10-14 2013-04-18 Seattle Genetics, Inc. Pyrrolobenzodiazepines and targeted conjugates
EA026643B1 (en) 2011-10-14 2017-04-28 Сиэтл Дженетикс, Инк. Pyrrolobenzodiazepines and targeted conjugates
US9399073B2 (en) 2011-10-14 2016-07-26 Seattle Genetics, Inc. Pyrrolobenzodiazepines
RU2015106673A (en) * 2012-08-02 2016-09-20 Дженентек, Инк. ANTIBODIES TO TYPE B ENDOTHELIN RECEPTOR (ETBR) AND IMMUNOCONJUGATES
PL3470086T3 (en) 2012-10-12 2021-05-31 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
DK2766048T3 (en) 2012-10-12 2015-03-02 Spirogen Sarl PYRROLOBENZODIAZEPINS AND CONJUGATES THEREOF
PL2906251T3 (en) 2012-10-12 2018-02-28 Adc Therapeutics Sa Pyrrolobenzodiazepine-anti-cd22 antibody conjugates
US10695433B2 (en) 2012-10-12 2020-06-30 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
PL2906253T3 (en) 2012-10-12 2019-02-28 Adc Therapeutics Sa Pyrrolobenzodiazepine - anti-psma antibody conjugates
CA2887897C (en) 2012-10-12 2020-02-18 Adc Therapeutics Sarl Pyrrolobenzodiazepine-anti-cd25 antibody conjugates
JP6367204B2 (en) 2012-10-12 2018-08-01 メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation
US9931414B2 (en) 2012-10-12 2018-04-03 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
WO2014057114A1 (en) 2012-10-12 2014-04-17 Adc Therapeutics Sàrl Pyrrolobenzodiazepine-anti-psma antibody conjugates
US9567340B2 (en) 2012-12-21 2017-02-14 Medimmune Limited Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases
JP6307519B2 (en) 2012-12-21 2018-04-04 メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ Pyrrolobenzodiazepine and its conjugates
JP6340019B2 (en) 2013-03-13 2018-06-06 メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ Pyrrolobenzodiazepine and its conjugates
CA2901941C (en) 2013-03-13 2020-04-07 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
WO2014202775A1 (en) * 2013-06-21 2014-12-24 Innate Pharma Enzymatic conjugation of polypeptides
GB201317982D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
GB201317981D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
US9950078B2 (en) 2013-10-11 2018-04-24 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
US10010624B2 (en) 2013-10-11 2018-07-03 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
EP3054986B1 (en) 2013-10-11 2019-03-20 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
TW201617368A (en) 2014-09-05 2016-05-16 史坦森特瑞斯公司 Novel anti-MFI2 antibodies and methods of use
CN106687141A (en) 2014-09-10 2017-05-17 麦迪穆有限责任公司 Pyrrolobenzodiazepines and conjugates thereof
GB201416112D0 (en) 2014-09-12 2014-10-29 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
CN107001479B (en) 2014-09-12 2021-09-28 基因泰克公司 anti-HER 2 antibodies and immunoconjugates
BR112017011111A2 (en) 2014-11-25 2017-12-26 Adc Therapeutics Sa pyrrolobenzodiazepine-antibody conjugates
JP6498773B2 (en) 2015-01-14 2019-04-10 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Benzodiazepine dimers, conjugates thereof, and methods of manufacture and use
WO2016115201A1 (en) 2015-01-14 2016-07-21 Bristol-Myers Squibb Company Heteroarylene-bridged benzodiazepine dimers, conjugates thereof, and methods of making and using
GB201506402D0 (en) * 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
GB201506389D0 (en) 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
GB201506411D0 (en) 2015-04-15 2015-05-27 Bergenbio As Humanized anti-axl antibodies
GB201506394D0 (en) * 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
GB201506405D0 (en) * 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
CA2990030A1 (en) 2015-06-23 2016-12-29 Bristol-Myers Squibb Company Macrocyclic benzodiazepine dimers, conjugates thereof, preparation and uses
MA43345A (en) 2015-10-02 2018-08-08 Hoffmann La Roche PYRROLOBENZODIAZEPINE ANTIBODY-DRUG CONJUGATES AND METHODS OF USE
TWI726942B (en) 2015-11-30 2021-05-11 美商輝瑞股份有限公司 Site specific her2 antibody drug conjugates
GB201601431D0 (en) 2016-01-26 2016-03-09 Medimmune Ltd Pyrrolobenzodiazepines
GB201602359D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201602356D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
CA3021098A1 (en) 2016-04-21 2017-10-26 Abbvie Stemcentrx Llc Novel anti-bmpr1b antibodies and methods of use
GB201607478D0 (en) 2016-04-29 2016-06-15 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
TW201808936A (en) 2016-05-18 2018-03-16 美商梅爾莎納醫療公司 Pyrrolobenzodiazepines and conjugates thereof
WO2017223275A1 (en) 2016-06-24 2017-12-28 Mersana Therapeutics, Inc. Pyrrolobenzodiazepines and conjugates thereof
GB201617466D0 (en) 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
GB201619490D0 (en) * 2016-11-17 2017-01-04 Medimmune Ltd Pyrrolobenzodiazepine conjugates
EP3348560A1 (en) * 2017-01-16 2018-07-18 Spago Nanomedical AB Chemical compounds for coating of nanostructures
UA125198C2 (en) 2017-02-08 2022-01-26 Ейдісі Терапьютікс Са Pyrrolobenzodiazepine-antibody conjugates
GB201702031D0 (en) 2017-02-08 2017-03-22 Medlmmune Ltd Pyrrolobenzodiazepine-antibody conjugates
ES2926144T3 (en) 2017-04-18 2022-10-24 Medimmune Ltd Pyrrolobenzodiazepine conjugates
KR20190141666A (en) 2017-04-20 2019-12-24 에이디씨 테라퓨틱스 에스에이 Combination Therapy with Anti-AXL Antibody-Drug Conjugates
UA127900C2 (en) 2017-06-14 2024-02-07 Ейдісі Терапьютікс Са Dosage regimes for the administration of an anti-cd19 adc
PL3668874T3 (en) 2017-08-18 2022-03-28 Medimmune Limited Pyrrolobenzodiazepine conjugates
SG11202001430SA (en) 2017-09-29 2020-04-29 Daiichi Sankyo Co Ltd Antibody-pyrrolobenzodiazepine derivative conjugate
US20200289660A1 (en) 2017-11-14 2020-09-17 Medimmune Limited Pyrrolobenzodiazepine conjugates
EP3717021A1 (en) 2017-11-27 2020-10-07 Mersana Therapeutics, Inc. Pyrrolobenzodiazepine antibody conjugates
CU24558B1 (en) * 2017-11-28 2021-12-08 Ct Inmunologia Molecular MONOCLONAL ANTIBODIES RECOGNIZING THE EPIDERMAL GROWTH FACTOR RECEPTOR AND ITS DERIVED FRAGMENTS
CN111757757A (en) 2017-12-21 2020-10-09 梅尔莎纳医疗公司 Pyrrolobenzodiazepine antibody conjugates
GB201803342D0 (en) 2018-03-01 2018-04-18 Medimmune Ltd Methods
CA3094827A1 (en) 2018-03-28 2019-10-03 Mitsubishi Tanabe Pharma Corporation Drug conjugates of cmet monoclonal binding agents, and uses thereof
GB201806022D0 (en) 2018-04-12 2018-05-30 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
GB201811364D0 (en) * 2018-07-11 2018-08-29 Adc Therapeutics Sa Combination therapy
GB201902495D0 (en) 2019-02-25 2019-04-10 Medimmune Ltd Methods of synthesis and intermediates
KR20220016083A (en) 2019-04-30 2022-02-08 센티 바이오사이언시스, 인코포레이티드 Chimeric receptors and methods of use thereof
MX2022001812A (en) 2019-08-12 2022-03-11 Regeneron Pharma Macrophage stimulating 1 receptor (mst1r) variants and uses thereof.
US20240123081A1 (en) 2019-10-25 2024-04-18 Medimmune, Llc Branched moiety for use in conjugates
US11124568B1 (en) * 2020-08-19 2021-09-21 Vitruviae LLC CD3/CD25 antibodies for neuro-immune diseases
UY39638A (en) * 2021-02-19 2022-08-31 Janssen Biotech Inc MATERIALS AND METHODS FOR TARGETING REGULATORY T CELLS TO ENHANCE IMMUNE SURVEILLANCE
KR102285542B1 (en) 2021-03-09 2021-08-04 주식회사 레젠 A Reflector for a Floodlight and the Floodlight with the Same
WO2023173096A1 (en) * 2022-03-11 2023-09-14 Sigma-Aldrich Co. Llc Pyrrolobenzodiazepine intermediates and uses thereof

Family Cites Families (130)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3361742A (en) 1964-12-07 1968-01-02 Hoffmann La Roche 5-oxo-1h-pyrrolo-[2, 1-c][1, 4]-benzodiazepin-2-crylamides
US3523941A (en) 1967-03-06 1970-08-11 Hoffmann La Roche Benzodiazepine compounds and process for their preparation
US3524849A (en) 1967-10-27 1970-08-18 Hoffmann La Roche Process for the preparation of pyrrolo-benzodiazepine acrylamides and intermediates useful therein
IL33558A (en) 1968-12-30 1973-10-25 Fujisawa Pharmaceutical Co Antibiotic pyrrolo-benzodiazepine compound,its derivatives and processes for their production
JPS4843755B1 (en) 1969-06-26 1973-12-20
DE1965304A1 (en) 1968-12-30 1970-07-23 Fujisawa Pharmaceutical Co Benzdiazepinone compounds and processes for their preparation
JPS5382792U (en) 1976-12-10 1978-07-08
JPS585916B2 (en) 1977-12-27 1983-02-02 株式会社ミドリ十字 New benzodiazepine compounds
JPS5615289A (en) 1979-07-17 1981-02-14 Green Cross Corp:The Novel benzodiazepinnbased compound 3
JPH0353356Y2 (en) 1981-02-06 1991-11-21
CA1185602A (en) 1981-02-27 1985-04-16 Emilio Kyburz Imidazodiazepines
CA1184175A (en) 1981-02-27 1985-03-19 Walter Hunkeler Imidazodiazepines
CA1173441A (en) 1981-02-27 1984-08-28 Hoffmann-La Roche Limited Imidazodiazepines
JPS58180487A (en) 1982-04-16 1983-10-21 Kyowa Hakko Kogyo Co Ltd Antibiotic dc-81 and its preparation
JPS58180487U (en) 1982-05-28 1983-12-02 松下電工株式会社 Light beam alarm assembly
US4427588A (en) 1982-11-08 1984-01-24 Bristol-Myers Company Process for conversion of oxotomaymycin to tomaymycin
US4427587A (en) 1982-11-10 1984-01-24 Bristol-Myers Company Total synthesis of antitumor antibiotics BBM-2040A and BBM-2040B
JPS59152329A (en) 1983-02-17 1984-08-31 Green Cross Corp:The Local disorder inhibitor
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
FR2586683B1 (en) 1985-08-29 1988-07-01 Centre Nat Rech Scient NOVEL NEOTHRAMYCIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS
US5583024A (en) 1985-12-02 1996-12-10 The Regents Of The University Of California Recombinant expression of Coleoptera luciferase
JP2660201B2 (en) 1988-08-05 1997-10-08 塩野義製薬株式会社 Novel pyrrolo [1,4] benzodiazepine derivatives and senile dementia drugs
FR2676230B1 (en) 1991-05-07 1993-08-27 Centre Nat Rech Scient NOVEL PYRROLO [1,4] -BENZODIAZEPINES DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM.
GB9205051D0 (en) 1992-03-09 1992-04-22 Cancer Res Campaign Tech Pyrrolobenzodiazepine derivatives,their preparation,and compositions containing them
FR2696176B1 (en) 1992-09-28 1994-11-10 Synthelabo Piperidine derivatives, their preparation and their therapeutic application.
US6214345B1 (en) 1993-05-14 2001-04-10 Bristol-Myers Squibb Co. Lysosomal enzyme-cleavable antitumor drug conjugates
GB9316162D0 (en) 1993-08-04 1993-09-22 Zeneca Ltd Fungicides
JPH08336393A (en) 1995-04-13 1996-12-24 Mitsubishi Chem Corp Production of optically active gamma-substituted-beta-hydroxybutyric ester
US6602677B1 (en) 1997-09-19 2003-08-05 Promega Corporation Thermostable luciferases and methods of production
DE69920228T2 (en) 1998-07-08 2005-01-27 E-Ink Corp., Cambridge METHOD FOR IMPROVING COLOR REPRODUCTION IN ELECTROPHORETIC DEVICES USING MICROCAPSULES
GB9818730D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Collections of compounds
DE69907977T2 (en) 1998-08-27 2004-07-22 Spirogen Ltd., Ryde Pyrrolobenzodiazepine
GB9818731D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Compounds
GB9818732D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Collection of compounds
US6909006B1 (en) 1999-08-27 2005-06-21 Spirogen Limited Cyclopropylindole derivatives
US7608681B2 (en) 1999-12-24 2009-10-27 Genentech, Inc. Methods and compositions for prolonging elimination half-times of bioactive compounds
US20040001827A1 (en) 2002-06-28 2004-01-01 Dennis Mark S. Serum albumin binding peptides for tumor targeting
WO2002030894A2 (en) 2000-09-19 2002-04-18 Taiho Pharmaceutical Co., Ltd. Compositions and methods of the use thereof achiral analogues of cc-1065 and the duocarmycins
US6362331B1 (en) 2001-03-30 2002-03-26 Council Of Scientific And Industrial Research Process for the preparation of antitumor agents
US6660856B2 (en) 2002-03-08 2003-12-09 Kaohsiung Medical University Synthesis of pyrrolo[2,1-c][1,4]benzodiazepine analogues
PT1545613E (en) 2002-07-31 2011-09-27 Seattle Genetics Inc Auristatin conjugates and their use for treating cancer, an autoimmune disease or an infectious disease
US20040138269A1 (en) 2002-10-11 2004-07-15 Sugen, Inc. Substituted pyrroles as kinase inhibitors
GB0226593D0 (en) 2002-11-14 2002-12-24 Consultants Ltd Compounds
US6884799B2 (en) 2003-03-31 2005-04-26 Council Of Scientific And Industrial Research Non-cross-linking pyrrolo[2,1-c][1,4]benzodiazepines and process thereof
GB0321295D0 (en) 2003-09-11 2003-10-15 Spirogen Ltd Synthesis of protected pyrrolobenzodiazepines
US7511032B2 (en) 2003-10-22 2009-03-31 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Pyrrolobenzodiazepine derivatives, compositions comprising the same and methods related thereto
GB0416511D0 (en) 2003-10-22 2004-08-25 Spirogen Ltd Pyrrolobenzodiazepines
AU2004316290C1 (en) 2003-11-06 2012-02-02 Seagen Inc. Monomethylvaline compounds capable of conjugation to ligands
EP1720908A2 (en) 2004-02-17 2006-11-15 Absalus, Inc. Super-humanized antibodies against respiratory syncytial virus
WO2005082023A2 (en) 2004-02-23 2005-09-09 Genentech, Inc. Heterocyclic self-immolative linkers and conjugates
GB0404578D0 (en) 2004-03-01 2004-04-07 Spirogen Ltd Pyrrolobenzodiazepines
EP1720881B9 (en) 2004-03-01 2013-04-17 Spirogen Sàrl 11-hydroxy-5h-pyrrolo[2,1-c][1,4]benzodiazepin-5-one derivatives as key intermediates for the preparation of c2 substituted pyrrolobenzodiazepins
GB0404577D0 (en) 2004-03-01 2004-04-07 Spirogen Ltd Pyrrolobenzodiazepines
GB0404574D0 (en) 2004-03-01 2004-04-07 Spirogen Ltd Amino acids
DE102004010943A1 (en) 2004-03-03 2005-09-29 Degussa Ag Process for the preparation of N-protected 4-ketproline derivatives
US7528126B2 (en) 2004-03-09 2009-05-05 Spirogen Limited Pyrrolobenzodiazepines
FR2869231B1 (en) 2004-04-27 2008-03-14 Sod Conseils Rech Applic THERAPEUTIC COMPOSITION CONTAINING AT LEAST ONE PYRROLOBENZODIAZEPINE DERIVATIVE AND FLUDARABINE
GB0410725D0 (en) 2004-05-13 2004-06-16 Spirogen Ltd Pyrrolobenzodiazepine therapeutic agents
NZ580115A (en) 2004-09-23 2010-10-29 Genentech Inc Cysteine engineered antibody light chains and conjugates
WO2006068325A2 (en) 2004-12-24 2006-06-29 Showa Denko K. K. Production method of thermoelectric semiconductor alloy, thermoelectric conversion module and thermoelectric power generating device
KR101385886B1 (en) 2005-02-03 2014-04-24 안티토페 리미티드 Human antibodies and proteins
JP5122441B2 (en) 2005-04-19 2013-01-16 シアトル ジェネティックス， インコーポレイテッド Humanized anti-CD70 binding agents and uses thereof
ES2338696T3 (en) 2005-04-21 2010-05-11 Spirogen Limited PIRROLOBENZODIAZEPINAS.
EP1931671B1 (en) 2005-10-05 2009-04-08 Spirogen Limited Alkyl 4- [4- (5-oxo-2, 3, 5, 11a-tetrahyd0-5h-pyrr0l0 [2, 1-c][1, 4]benzodiazepine-8-yloxy) -butyrylamino]-1h-pyrrole-2-carboxylate derivatives and related compounds for the treatment of a proliferative disease
US20070154906A1 (en) 2005-10-05 2007-07-05 Spirogen Ltd. Methods to identify therapeutic candidates
CN101365676B (en) 2005-10-07 2013-09-11 埃克塞利希斯股份有限公司 Azetidines as mek inhibitors for the treatment of proliferative diseases
DK1813614T3 (en) 2006-01-25 2012-01-23 Sanofi Sa Cytotoxic agents comprising novel tomaymycin derivatives
ME00581B (en) 2006-07-18 2011-12-20 Sanofi Aventis Antagonist antibody against epha2 for the treatment of cancer
EP1914242A1 (en) 2006-10-19 2008-04-23 Sanofi-Aventis Novel anti-CD38 antibodies for the treatment of cancer
WO2008050140A2 (en) 2006-10-27 2008-05-02 Spirogen Limited Compounds for treatment of parasitic infection
ES2523915T5 (en) 2006-12-01 2022-05-26 Seagen Inc Variant Target Binding Agents and Uses Thereof
AR066476A1 (en) 2007-05-08 2009-08-19 Genentech Inc ANTI-MUC16 ANTIBODIES DESIGNED WITH CYSTEINE AND ANTIBODIES AND PHARMACOS CONJUGAODS
DK2019104T3 (en) 2007-07-19 2013-12-16 Sanofi Sa Cytotoxic agents comprising novel tomaymycin derivatives and therapeutic use thereof
AU2008312457B2 (en) 2007-10-19 2014-04-17 Genentech, Inc. Cysteine engineered anti-TENB2 antibodies and antibody drug conjugates
GB0722087D0 (en) 2007-11-09 2007-12-19 Spirogen Ltd Polyamides
GB0722088D0 (en) 2007-11-09 2007-12-19 Spirogen Ltd Pyrrolobenzodiazepines
CA2711736A1 (en) * 2008-01-18 2009-07-23 Medimmune, Llc Cysteine engineered antibodies for site-specific conjugation
CA2718942A1 (en) 2008-03-18 2009-09-24 Seattle Genetics, Inc. Auristatin drug linker conjugates
GB0813432D0 (en) 2008-07-22 2008-08-27 Spirogen Ltd Pyrrolobenzodiazepines
EP2349040B9 (en) 2008-10-15 2014-12-17 Zimmer GmbH Intramedullary nail
GB0819095D0 (en) 2008-10-17 2008-11-26 Spirogen Ltd Pyrrolobenzodiazepines
GB0819097D0 (en) 2008-10-17 2008-11-26 Spirogen Ltd Pyrrolobenzodiazepines
ES2604668T3 (en) 2009-02-05 2017-03-08 Immunogen, Inc. New benzodiazepine derivatives
FR2949469A1 (en) 2009-08-25 2011-03-04 Sanofi Aventis ANTICANCER DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
JP2013505944A (en) 2009-09-24 2013-02-21 シアトル ジェネティックス， インコーポレイテッド DR5 ligand drug conjugate
US9040526B2 (en) 2010-02-09 2015-05-26 Bristol-Myers Squibb Company Benzylpyrrolidinone derivatives as modulators of chemokine receptor activity
GB201006340D0 (en) 2010-04-15 2010-06-02 Spirogen Ltd Synthesis method and intermediates
ES2430567T3 (en) 2010-04-15 2013-11-21 Spirogen Sàrl Pyrrolobenzodiazepines and conjugates thereof
BR112012026801B8 (en) 2010-04-15 2021-05-25 Medimmune Ltd targeted pyrrolobenzodiazepine conjugates, pharmaceutical composition, use thereof for treatment of a proliferative or autoimmune disease and drug binding
WO2011130615A2 (en) 2010-04-15 2011-10-20 Dr. Reddy's Laboratories Ltd. Preparation of lacosamide
EP2558475A1 (en) 2010-04-15 2013-02-20 Spirogen Sàrl Pyrrolobenzodiazepines used to treat proliferative diseases
EP3666289A1 (en) 2011-02-15 2020-06-17 ImmunoGen, Inc. Cytotoxic benzodiazepine derivatives
EP2751120B1 (en) * 2011-09-20 2018-08-22 MedImmune Limited Pyrrolobenzodiazepines as unsymmetrical dimeric pbd compounds for inclusion in targeted conjugates
PT2750713E (en) 2011-10-14 2016-01-20 Genentech Inc Pyrrolobenzodiazepines and conjugates thereof
CN104011018B (en) 2011-10-14 2016-12-14 麦迪穆有限责任公司 Can be used for preparing the tall and erect synthetic method of Pyrrolobenzodiazepines and intermediate
WO2013055990A1 (en) 2011-10-14 2013-04-18 Seattle Genetics, Inc. Pyrrolobenzodiazepines and targeted conjugates
US9399073B2 (en) 2011-10-14 2016-07-26 Seattle Genetics, Inc. Pyrrolobenzodiazepines
US9388187B2 (en) 2011-10-14 2016-07-12 Medimmune Limited Pyrrolobenzodiazepines
EA026643B1 (en) 2011-10-14 2017-04-28 Сиэтл Дженетикс, Инк. Pyrrolobenzodiazepines and targeted conjugates
KR101960130B1 (en) 2012-04-30 2019-03-19 메디뮨 리미티드 Pyrrolobenzodiazepines
EP2855482B1 (en) 2012-04-30 2017-03-01 MedImmune Limited Pyrrolobenzodiazepines
JP2015523380A (en) 2012-07-09 2015-08-13 ジェネンテック， インコーポレイテッド Immune complex comprising anti-CD79B antibody
EP2869849A1 (en) 2012-07-09 2015-05-13 Genentech, Inc. Immunoconjugates comprising anti-cd22 antibodies
RU2015106673A (en) 2012-08-02 2016-09-20 Дженентек, Инк. ANTIBODIES TO TYPE B ENDOTHELIN RECEPTOR (ETBR) AND IMMUNOCONJUGATES
PL2906251T3 (en) 2012-10-12 2018-02-28 Adc Therapeutics Sa Pyrrolobenzodiazepine-anti-cd22 antibody conjugates
JP6367204B2 (en) 2012-10-12 2018-08-01 メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation
US10695433B2 (en) 2012-10-12 2020-06-30 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
WO2014057114A1 (en) 2012-10-12 2014-04-17 Adc Therapeutics Sàrl Pyrrolobenzodiazepine-anti-psma antibody conjugates
WO2014057118A1 (en) 2012-10-12 2014-04-17 Adc Therapeutics Sarl Pyrrolobenzodiazepine-anti-cd22 antibody conjugates
CA2887897C (en) 2012-10-12 2020-02-18 Adc Therapeutics Sarl Pyrrolobenzodiazepine-anti-cd25 antibody conjugates
US9931414B2 (en) 2012-10-12 2018-04-03 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
DK2766048T3 (en) 2012-10-12 2015-03-02 Spirogen Sarl PYRROLOBENZODIAZEPINS AND CONJUGATES THEREOF
PL3470086T3 (en) 2012-10-12 2021-05-31 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
PL2906253T3 (en) 2012-10-12 2019-02-28 Adc Therapeutics Sa Pyrrolobenzodiazepine - anti-psma antibody conjugates
CN104955485B (en) 2012-10-12 2018-01-30 Adc疗法责任有限公司 Pyrrolobenzodiazepines Zhuo Anti-HER 2 conjugate
US9567340B2 (en) 2012-12-21 2017-02-14 Medimmune Limited Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases
JP6307519B2 (en) 2012-12-21 2018-04-04 メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ Pyrrolobenzodiazepine and its conjugates
TR201908761T4 (en) 2013-02-22 2019-07-22 Abbvie Stemcentrx Llc Antidll3-antibody-pbd conjugates and their uses.
JP6444902B2 (en) 2013-03-13 2018-12-26 メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ Pyrrolobenzodiazepine and its conjugates
CA2901941C (en) 2013-03-13 2020-04-07 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
JP6340019B2 (en) 2013-03-13 2018-06-06 メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ Pyrrolobenzodiazepine and its conjugates
US20160106861A1 (en) 2013-04-26 2016-04-21 Spirogen Sarl Axl antibody-drug conjugate and its use for the treatment of cancer
GB201317981D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
US10010624B2 (en) 2013-10-11 2018-07-03 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
EP3054986B1 (en) 2013-10-11 2019-03-20 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
US20160256561A1 (en) 2013-10-11 2016-09-08 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
US9950078B2 (en) 2013-10-11 2018-04-24 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
GB201317982D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
CA2931798C (en) 2013-12-16 2023-06-27 Genentech, Inc. Peptidomimetic compounds and antibody-drug conjugates thereof
GB201406767D0 (en) 2014-04-15 2014-05-28 Cancer Rec Tech Ltd Humanized anti-Tn-MUC1 antibodies anf their conjugates

Also Published As

Publication number Publication date
EP3470086A1 (en) 2019-04-17
ES2713164T3 (en) 2019-05-20
EP2906248A1 (en) 2015-08-19
KR20190126197A (en) 2019-11-08
LT2906248T (en) 2019-02-11
DK3470086T3 (en) 2020-12-21
CN110256469B (en) 2022-05-17
CY1123778T1 (en) 2022-05-27
EP3470086B1 (en) 2020-11-25
CY1121390T1 (en) 2020-05-29
JP6367811B2 (en) 2018-08-01
SI3470086T1 (en) 2021-03-31
HUE043738T2 (en) 2019-09-30
MX362004B (en) 2019-01-03
US20140120118A1 (en) 2014-05-01
ES2847050T3 (en) 2021-07-30
CN110256469A (en) 2019-09-20
KR20200003278A (en) 2020-01-08
EP2906248B1 (en) 2018-12-05
US9415117B2 (en) 2016-08-16
AU2013328674A1 (en) 2015-04-02
PL3470086T3 (en) 2021-05-31
ZA201501781B (en) 2016-06-29
HUE052835T2 (en) 2021-05-28
SI2906248T1 (en) 2019-02-28
KR102138220B1 (en) 2020-07-27
CA2885315C (en) 2020-06-23
CA3060520A1 (en) 2014-04-17
NZ745069A (en) 2019-05-31
RS61294B1 (en) 2021-02-26
TR201902494T4 (en) 2019-03-21
MX366303B (en) 2019-07-04
LT3470086T (en) 2021-02-25
KR20150083994A (en) 2015-07-21
MX2015004560A (en) 2015-07-21
JP2018168182A (en) 2018-11-01
DK2906248T3 (en) 2019-03-04
BR112015008251B1 (en) 2023-09-26
HRP20210126T1 (en) 2021-03-19
WO2014057073A1 (en) 2014-04-17
JP6516909B2 (en) 2019-05-22
CA2885315A1 (en) 2014-04-17
HK1213183A1 (en) 2016-06-30
CA3060520C (en) 2022-05-17
CN104703630A (en) 2015-06-10
PT2906248T (en) 2019-03-04
PT3470086T (en) 2021-02-01
AU2013328674B2 (en) 2017-06-22
HRP20190366T1 (en) 2019-04-19
PL2906248T3 (en) 2019-05-31
HUE043738T4 (en) 2020-05-28
JP2015533141A (en) 2015-11-19
BR112015008251A2 (en) 2017-07-04
RS58203B1 (en) 2019-03-29

Similar Documents

Publication Publication Date Title
NZ705910A (en) Pyrrolobenzodiazepines and conjugates thereof
NZ718826A (en) Pyrrolobenzodiazepines and conjugates thereof
PH12016502066A1 (en) Methods of treating bladder cancer
IN2014DN10889A (en)
MX346375B (en) Spiro-oxindole mdm2 antagonists.
UA109464C2 (en) Spiro-oxindoles as mdm2 antagonists
TN2012000161A1 (en) Spiro-oxindole mdm2 antagonists
NZ707086A (en) Anti-cd40 antibodies and methods of use
NZ710746A (en) Pyrrolobenzodiazepines and conjugates thereof
CA2900335C (en) Synthetic analogs of epipolythiodioxopiperazines and uses thereof
GB201106750D0 (en) Novel compounds
SG194701A1 (en) Anti-cd40 antibodies and methods of use
PH12014502406B1 (en) Anti-il-23p19 antibodies
IL239007B (en) Eribulin for use in the treatment of breast cancer
MX2014012477A (en) Pyrrolopyrazone inhibitors of tankyrase.
PH12015501088A1 (en) Dimeric compounds
MX365392B (en) Procaspase 3 activation by combination therapy.
MX2014008702A (en) Chitosan-derived compositions.
NZ716765A (en) Pharmaceutical combinations for the treatment of cancer
TN2013000333A1 (en) Combinations comprising macitentan for the treatment of glioblastoma multiforme
MX359209B (en) Procaspase combination therapy for glioblastoma.
IN2015MN00001A (en)
ZA201209452B (en) Gold complexes for use in the treatment of cancer
MX2013010947A (en) Gallium complexes, pharmaceutical compositions and methods of use.
EP2836217A4 (en) Compositions and methods for treatment of the side-effects associated with administration of cancer chemotherapeutic agents

Legal Events

Date Code Title Description
ASS Change of ownership

Owner name: MEDIMMUNE LIMITED, GB

Effective date: 20151217

PSEA Patent sealed
RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 11 OCT 2020 BY MEWBURN ELLIS LLP

Effective date: 20191009

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 11 OCT 2021 BY MEWBURN ELLIS LLP

Effective date: 20201006

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 11 OCT 2022 BY MEWBURN ELLIS LLP

Effective date: 20211002

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 11 OCT 2023 BY MEWBURN ELLIS LLP

Effective date: 20220923

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 11 OCT 2024 BY MEWBURN ELLIS LLP

Effective date: 20231006