PL4073025T3 - Sole metali i ich zastosowania - Google Patents

Sole metali i ich zastosowania

Info

Publication number
PL4073025T3
PL4073025T3 PL20897654.8T PL20897654T PL4073025T3 PL 4073025 T3 PL4073025 T3 PL 4073025T3 PL 20897654 T PL20897654 T PL 20897654T PL 4073025 T3 PL4073025 T3 PL 4073025T3
Authority
PL
Poland
Prior art keywords
applications
metal salts
salts
metal
Prior art date
Application number
PL20897654.8T
Other languages
English (en)
Inventor
Stephen Wald
Eduardo J. Martinez
Samuel STRATFORD
Amanda BUIST
Joseph Benson
Jonathan LOUGHREY
Original Assignee
Inspirna, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inspirna, Inc. filed Critical Inspirna, Inc.
Publication of PL4073025T3 publication Critical patent/PL4073025T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL20897654.8T 2019-12-13 2020-12-11 Sole metali i ich zastosowania PL4073025T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962947968P 2019-12-13 2019-12-13
PCT/US2020/064456 WO2021119397A1 (en) 2019-12-13 2020-12-11 Metal salts and uses thereof

Publications (1)

Publication Number Publication Date
PL4073025T3 true PL4073025T3 (pl) 2024-09-16

Family

ID=76320705

Family Applications (1)

Application Number Title Priority Date Filing Date
PL20897654.8T PL4073025T3 (pl) 2019-12-13 2020-12-11 Sole metali i ich zastosowania

Country Status (14)

Country Link
US (4) US11174220B2 (pl)
EP (1) EP4073025B1 (pl)
JP (1) JP7689964B2 (pl)
CN (1) CN114728875A (pl)
AU (1) AU2020401286A1 (pl)
CA (1) CA3161274A1 (pl)
ES (1) ES2982346T3 (pl)
HU (1) HUE067466T2 (pl)
MX (1) MX2022007164A (pl)
PL (1) PL4073025T3 (pl)
RS (1) RS65646B1 (pl)
TW (1) TWI888447B (pl)
WO (1) WO2021119397A1 (pl)
ZA (1) ZA202206588B (pl)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3150729A1 (en) * 2019-09-11 2021-03-18 Inspirna, Inc. Methods of treating cancer
PL4073025T3 (pl) 2019-12-13 2024-09-16 Inspirna, Inc. Sole metali i ich zastosowania

Family Cites Families (204)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL275743A (pl) 1961-03-20
DD150456A5 (de) 1979-03-01 1981-09-02 Ciba Geigy Ag Verfahren zur herstellung von derivaten des 3-amino-1,2-propandiols
DE2951400A1 (de) 1979-12-20 1981-07-02 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n,n'-diarylaethylendiaminen oder n, n',n''-triaryldiaethylen-triaminen
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
DK196688A (da) 1987-04-28 1988-10-29 Fujisawa Pharmaceutical Co Bicykliske forbindelser og fremgangsmaade til fremstilling deraf
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5324731A (en) 1989-02-14 1994-06-28 Amira, Inc. Method of inhibiting transformation of cells in which purine metabolic enzyme activity is elevated
US5676978A (en) 1989-02-14 1997-10-14 Amira, Inc. Methods of inhibiting undesirable cell growth using a combination of a cyclocreatine compound and a hyperplastic inhibitory agent
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5215882A (en) 1989-11-30 1993-06-01 Ortho Diagnostic Systems, Inc. Method of immobilizing nucleic acid on a solid surface for use in nucleic acid hybridization assays
EP0519596B1 (en) 1991-05-17 2005-02-23 Merck & Co. Inc. A method for reducing the immunogenicity of antibody variable domains
US5565332A (en) 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
US5639641A (en) 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
US5837832A (en) 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
CA2111503A1 (en) 1993-12-15 1995-06-16 Mcgill University Apolipoprotein e polymorphism and alzheimer's disease
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5707807A (en) 1995-03-28 1998-01-13 Research Development Corporation Of Japan Molecular indexing for expressed gene analysis
US5843974A (en) 1995-06-06 1998-12-01 Eli Lilly And Company Methods of inhibiting melanoma using Benzothiophenes as cytotoxic agents per se
US5958342A (en) 1996-05-17 1999-09-28 Incyte Pharmaceuticals, Inc. Jet droplet device
US6060240A (en) 1996-12-13 2000-05-09 Arcaris, Inc. Methods for measuring relative amounts of nucleic acids in a complex mixture and retrieval of specific sequences therefrom
US5945289A (en) 1996-12-20 1999-08-31 Lehrer; Steven Method for detecting prostate cancer by apolipoprotein E (Apo-E) genotyping
US6090556A (en) 1997-04-07 2000-07-18 Japan Science & Technology Corporation Method for quantitatively determining the expression of a gene
US5994076A (en) 1997-05-21 1999-11-30 Clontech Laboratories, Inc. Methods of assaying differential expression
US20030153541A1 (en) 1997-10-31 2003-08-14 Robert Dudley Novel anticholesterol compositions and method for using same
EP1036174B1 (en) 1997-12-12 2006-08-30 The University Of Western Ontario Novel peptide, apoep1.b, compositions and uses thereof
US6004755A (en) 1998-04-07 1999-12-21 Incyte Pharmaceuticals, Inc. Quantitative microarray hybridizaton assays
US6048695A (en) 1998-05-04 2000-04-11 Baylor College Of Medicine Chemically modified nucleic acids and methods for coupling nucleic acids to solid support
US6087112A (en) 1998-12-30 2000-07-11 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
US6906069B1 (en) 1999-01-08 2005-06-14 Amgen Inc. LXR modulators
US6316503B1 (en) 1999-03-15 2001-11-13 Tularik Inc. LXR modulators
US8257750B2 (en) 1999-04-30 2012-09-04 Kibow Biotech, Inc. Calcium carbonate compositions for preventing or treating hyperphosphatemia
MXPA01011070A (es) 1999-04-30 2003-06-30 Arch Dev Corp Derivados de esteroides.
WO2001066534A2 (en) 2000-03-09 2001-09-13 Abbott Laboratories Cyclic and bicyclic diamino histamine-3 receptor antagonists
US6716622B2 (en) 2000-07-18 2004-04-06 Uab Research Foundation Tissue-specific self-inactivating gene therapy vector
WO2002013594A1 (en) 2000-08-17 2002-02-21 Northland Seed & Grain Corp. Method for minimizing contamination of crops and products derived therefrom
AU2001288955A1 (en) 2000-09-07 2002-03-22 Vanderbilt University Genome engineering by cell-permeable dna site-specific recombinases
JP2004509161A (ja) 2000-09-18 2004-03-25 グラクソ　グループ　リミテッド Ｌｘｒのアゴニストとして有用な置換アミノプロポキシアリール誘導体
HUP0302891A2 (hu) * 2001-01-31 2003-12-29 Pfizer Products Inc. PDE4 izoenzimek inhibitoraiként alkalmazható éterszármazékok, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények
CN1498222A (zh) 2001-02-08 2004-05-19 芝加哥大学 类固醇衍生物
DK1392713T3 (da) 2001-05-03 2008-02-18 Univ Chicago Lever-X-receptoragonister
US6908934B2 (en) 2001-06-11 2005-06-21 Merck & Co., Inc. Therapeutic compounds for treating dyslipidemic conditions
JP2003033179A (ja) 2001-07-05 2003-02-04 Asahi Kasei Corp 可逆的遺伝子導入ベクター
AU2002336433A1 (en) 2001-10-08 2003-04-22 Eli Lilly And Company Tricyclic compounds useful for modulating lxr
WO2003043998A1 (en) 2001-11-15 2003-05-30 Incyte San Diego Incorporated N-substituted heterocycles for the treatment of hypercholesteremia, dyslipidemia and other metabolic disorders, cancer, and other diseases
CA2467165A1 (en) 2001-11-21 2003-06-05 Merck & Co., Inc. Therapeutic compounds for treating dyslipidemic conditions
EP1463726A2 (en) 2001-12-21 2004-10-06 Pharmacia Corporation Aromatic thioether liver x-receptor modulators
US6696473B2 (en) 2001-12-21 2004-02-24 X-Ceptor Therapeutics, Inc. Heterocyclic modulators of nuclear receptors
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
CA2469435A1 (en) 2001-12-21 2003-07-24 X-Ceptor Therapeutics, Inc. Modulators of lxr
JP2005521721A (ja) 2002-03-27 2005-07-21 スミスクライン・ビーチャム・コーポレイション 酸およびエステル化合物ならびにその使用方法
AU2003220521A1 (en) 2002-03-27 2003-10-13 Smithkline Beecham Corporation Methods of treatment with lxr modulators
JP2006512280A (ja) * 2002-03-27 2006-04-13 スミスクライン・ビーチャム・コーポレイション 化合物および方法
AU2003220558A1 (en) 2002-03-27 2004-06-03 Smithkline Beecham Corporation Amide compounds and methods of using the same
WO2003090869A1 (en) 2002-04-23 2003-11-06 Chugai Seiyaku Kabushiki Kaisha Lxr modulators
AU2003222667A1 (en) 2002-04-23 2003-11-10 Chugai Seiyaku Kabushiki Kaisha 1,3-thiazoles as lxr modulators in the treatment of cardiovascular diseases
WO2003090732A1 (en) 2002-04-23 2003-11-06 Chugai Seiyaku Kabushiki Kaisha Lxr modulators for the treatment of cardiovascular diseases
MXPA04011691A (es) 2002-05-24 2005-09-12 Pharmacia Corp Moduladores del receptor x anilino hepaticos.
US6822120B2 (en) 2002-05-24 2004-11-23 Pharmacia Corporation Sulfone liver X-receptor modulators
EP1521584A1 (en) 2002-06-17 2005-04-13 Glaxo Group Limited Purine derivatives as liver x receptor agonists
WO2003106435A1 (en) 2002-06-18 2003-12-24 Sankyo Company, Limited Fused-ring pyrimidin-4(3h)-one derivatives, processes for the preparation and uses thereof
CA2491023A1 (en) 2002-07-19 2004-01-29 Althea Technologies, Inc. Strategies for gene expression analysis
US7125865B2 (en) 2002-07-25 2006-10-24 Merck & Co., Inc. Therapeutic compounds for treating dyslipidemic conditions
DK1529116T3 (da) 2002-08-07 2009-11-09 Novartis Ag Fremgangsmåde til forudsigelse af respons på behandling med rivastigmin baseret på ApoE-genotypen hos demenspatienter
EP1407774A1 (en) 2002-09-10 2004-04-14 LION Bioscience AG 2-Amino-4-quinazolinones as LXR nuclear receptor binding compounds
JP2005539081A (ja) 2002-09-17 2005-12-22 ファルマシア コーポレイション 芳香族肝臓ｘ受容体モジュレーター
EP1572660B1 (en) 2002-12-20 2011-01-26 X-Ceptor Therapeutics, Inc. Isoquinolinone derivatives and their use as therapeutic agents
WO2004072041A1 (en) 2003-02-12 2004-08-26 Care X S.A. Tetrahydroquinolines as agonists of liver- x receptors
WO2004072042A2 (en) 2003-02-12 2004-08-26 Carex S.A. Quinoline derivative and their use for modulation of lxr activity
WO2004072046A2 (en) 2003-02-12 2004-08-26 Carex S.A. Quinoline derivatives and their use for modulation of lxr activity
US20040216178A1 (en) 2003-03-03 2004-10-28 Jones Stephen N Regulation of mdm2 function
US7135575B2 (en) 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
GB0316237D0 (en) 2003-07-11 2003-08-13 Astrazeneca Ab Therapeutic agents
GB0316232D0 (en) 2003-07-11 2003-08-13 Astrazeneca Ab Therapeutic agents
WO2005007877A2 (en) 2003-07-18 2005-01-27 University Of Massachusetts Regulatable promoters for synthesis of small hairpin rna
WO2005016277A2 (en) 2003-08-12 2005-02-24 Amgen Inc. Arylsulfonamidobenzylic compounds
PL1661890T3 (pl) 2003-09-03 2011-06-30 Kowa Co Związek aktywujący PPAR oraz kompozycja farmaceutyczna zawierająca ten związek
JP2006193426A (ja) 2003-09-05 2006-07-27 Sankyo Co Ltd 置換された縮環ピリミジン−４（３ｈ）−オン化合物
ATE460183T1 (de) 2003-10-20 2010-03-15 Nsgene As Viraler vektor zur verwendung in der in-vivo- gentherapie von morbus parkinson
US20050113419A1 (en) 2003-10-31 2005-05-26 Huang Shaei Y. Therapeutic compounds for treating dyslipidemic conditions
AU2004298486A1 (en) 2003-12-12 2005-06-30 Wyeth Quinolines useful in treating cardiovascular disease
FR2865736B1 (fr) 2004-02-02 2006-07-14 Synt Em Inhibiteurs de l'angiogenese, compositions les contenant et leur utilisation pour le traitement des maladies liees a une deregulation de l'angiogenese
JP2007523087A (ja) 2004-02-11 2007-08-16 アイアールエム・リミテッド・ライアビリティ・カンパニー Ｌｘｒモジュレーターとしての化合物および組成物
WO2005077124A2 (en) 2004-02-11 2005-08-25 Irm Llc Compounds and compositions as lxr modulators
DE602005009811D1 (de) 2004-03-26 2008-10-30 Hoffmann La Roche Tetrahydrocarbazole und derivate
PL1756096T3 (pl) 2004-05-03 2010-01-29 Hoffmann La Roche Pochodne indolilowe jako modulatory wątrobowych receptorów X
WO2005112620A2 (en) 2004-05-18 2005-12-01 Massachusetts Institute Of Technology A cre-lox based method for conditional rna interference
WO2005113499A1 (ja) 2004-05-20 2005-12-01 Sankyo Company, Limited インドール化合物
WO2006000323A1 (en) 2004-06-28 2006-01-05 F.Hoffmann-La Roche Ag Novel hexafluoroisopropanol derivatives
WO2006003923A1 (ja) 2004-06-30 2006-01-12 Sankyo Company, Limited 置換ベンゼン化合物
CA2572872C (en) 2004-07-02 2013-10-22 Sankyo Company Limited Tissue factor production inhibitor
US7649009B2 (en) 2004-07-07 2010-01-19 Merck & Co., Inc. Pyrazole amide derivatives, compositions containing such compounds and methods of use
BRPI0514017A (pt) 2004-08-03 2008-05-27 Wyeth Corp indazóis úteis no tratamento de doenças cardiovasculares
US20060058311A1 (en) 2004-08-14 2006-03-16 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation
US20060178398A1 (en) 2004-09-16 2006-08-10 Adams Alan D Therapeutic compounds for treating dyslipidemic conditions
ATE415385T1 (de) 2004-10-01 2008-12-15 Hoffmann La Roche Hexafluorisopropanolsubstituierte etherderivate
CA2585623C (en) 2004-10-27 2012-06-05 Daiichi Sankyo Company Limited Ortho-substituted benzene derivatives
KR100883693B1 (ko) 2004-12-22 2009-02-12 에프. 호프만-라 로슈 아게 신규 사이클로헥세인 유도체
WO2006073364A1 (en) 2005-01-10 2006-07-13 Astrazeneca Ab Derivatives of isothiazol-3 (2h)-thione 1,1-dioxides as liver x receptor modulators
SE0500058D0 (sv) 2005-01-10 2005-01-10 Astrazeneca Ab Therapeutic agents 5
SE0500055D0 (sv) 2005-01-10 2005-01-10 Astrazeneca Ab Therapeutic agents 3
SE0500056D0 (sv) 2005-01-10 2005-01-10 Astrazeneca Ab Therapeutic agents 4
CA2592771A1 (en) 2005-01-10 2006-07-13 Astrazeneca Ab Derivatives of isothiazol-3(2h)-one 1,1-dioxides as liver x receptor modulators
JP2006232703A (ja) 2005-02-23 2006-09-07 Dai Ichi Seiyaku Co Ltd フェニルエーテル誘導体及びそれを用いた医薬
CA2599688A1 (en) 2005-03-01 2006-09-08 Wyeth Cinnoline compounds and their use as liver x receptor modulators
US8318760B2 (en) 2005-03-21 2012-11-27 Merck Sharp & Dohme Corp. Substituted aryl and heteroaryl derivatives, compositions containing such compounds and methods of use
WO2006109633A1 (ja) 2005-04-07 2006-10-19 Daiichi Sankyo Company, Limited 置換インドール化合物
US8569352B2 (en) 2005-06-27 2013-10-29 Exelixis Patent Company Llc Imidazole based LXR modulators
WO2007022563A1 (en) 2005-08-24 2007-03-01 Graham Scott Package with bitter taste aversive agent for infant deterrant
HRP20110498T1 (hr) 2005-10-07 2011-08-31 Exelixis Azetidini kao inhibitori mek za liječenje proliferativnih bolesti
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7790745B2 (en) 2005-10-21 2010-09-07 Bristol-Myers Squibb Company Tetrahydroisoquinoline LXR Modulators
WO2007050271A2 (en) 2005-10-25 2007-05-03 Wyeth 5-lipoxygenase modulators
US20090062260A1 (en) 2005-11-14 2009-03-05 Irm Llc Compounds and compositions as lxr modulators
WO2007081335A1 (en) 2006-01-12 2007-07-19 Merck & Co., Inc. Therapeutic compounds for treating dyslipidemic conditions
WO2007108749A1 (en) 2006-03-20 2007-09-27 Cepep Iii Ab Chimeric constructs between cancer-homing peptides and cell-penetrating peptides coupled to anticancer drugs and/or diagnostic agent/agents
WO2007110755A1 (en) * 2006-03-27 2007-10-04 Medical Therapies Limited Prophylaxis or treatment of cardiovascular inflammation
WO2008011071A2 (en) 2006-07-19 2008-01-24 The Regents Of The University Of California Interactions of hedgehog and liver x receptor signaling pathways
US20080085879A1 (en) 2006-08-31 2008-04-10 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods of treating estrogen-responsive conditions by orphan nuclear receptor activation
TW200825054A (en) 2006-10-18 2008-06-16 Wyeth Corp Quinoline compounds
US8324367B2 (en) 2006-11-03 2012-12-04 Medtronic, Inc. Compositions and methods for making therapies delivered by viral vectors reversible for safety and allele-specificity
EP1925621A1 (en) * 2006-11-27 2008-05-28 Novartis AG Crystalline forms of zoledronic acid
ATE544756T1 (de) 2006-11-30 2012-02-15 Kowa Co Substituierte carbinolverbindungen
CN101679297B (zh) 2006-12-08 2012-01-11 埃克塞利希斯股份有限公司 Lxr和fxr调节剂
JP2008179562A (ja) 2007-01-24 2008-08-07 Kowa Co Ｌｘｒアゴニスト
US8993628B2 (en) 2007-02-23 2015-03-31 City Of Hope Synthetic ligands selective for LXRβ over LXRα, identification and methods of use thereof
JP2010527930A (ja) 2007-05-18 2010-08-19 ワイス・エルエルシー キナゾリン化合物
EP2170363B1 (en) 2007-06-29 2018-08-08 Sarepta Therapeutics, Inc. Tissue specific peptide conjugates and methods
CN101778831B (zh) 2007-08-13 2014-08-20 霍夫曼-拉罗奇有限公司 哌嗪酰胺衍生物
TW200922582A (en) 2007-08-20 2009-06-01 Organon Nv N-benzyl, N'-arylcarbonylpiperazine derivatives
US8039493B2 (en) 2007-09-27 2011-10-18 Hoffmann-La Roche Inc. Biaryl sulfonamide derivatives
MY156951A (en) 2007-10-04 2016-04-15 Santaris Pharma As Micromirs
US7902147B2 (en) 2007-11-05 2011-03-08 Duke University Chronic lymphocytic leukemia prognosis and treatment
JP5809415B2 (ja) 2007-11-09 2015-11-10 ペレグリン ファーマシューティカルズ，インコーポレーテッド 抗ｖｅｇｆ抗体の組成物および方法
WO2009075836A2 (en) 2007-12-10 2009-06-18 The Brigham And Women's Hospital, Inc. Rap variants for drug delivery
EP2071509A1 (en) 2007-12-13 2009-06-17 Gemalto SA Method and apparatus to mark a document using a combination between guilloches and watermarking, method and apparatus to read previous combination
BRPI0822237A2 (pt) 2007-12-21 2015-06-30 Wyeth Llc Compostos de imidazo [1,2-a] piridina
BRPI0822239A2 (pt) 2007-12-21 2015-06-30 Wyeth Llc Composto de pirazolo[1,5-a] pirimidina
BRPI0822240A2 (pt) 2007-12-21 2015-06-30 Wyeth Llc Composto imidazo [1,2-b] piridazina como moduladores de receptores x hepáticos
US20110034526A1 (en) 2007-12-21 2011-02-10 Wyeth Llc Benzimidazole Compounds
EP2248811B1 (en) 2008-02-29 2012-11-14 Kowa Company, Ltd. 2-oxochromene derivative
US7951822B2 (en) 2008-03-31 2011-05-31 Kowa Company, Ltd. 1,3-dihydroisobenzofuran derivatives
WO2009133692A1 (ja) 2008-04-30 2009-11-05 興和株式会社 キノリン化合物
TW201006816A (en) 2008-05-15 2010-02-16 Organon Nv Hexafluoroisopropanol derivatives
EP2286220A2 (en) 2008-05-29 2011-02-23 Bristol-Myers Squibb Company Methods for predicting patient response to modulation of the co-stimulatory pathway
EA018584B1 (ru) 2008-05-29 2013-09-30 Кова Компани, Лтд. Замещённое карбинольное соединение, содержащее циклический линкер
US8063088B2 (en) 2008-06-11 2011-11-22 Hoffmann-La Roche Inc. Imidazolidine derivatives
JP5706818B2 (ja) 2008-07-01 2015-04-22 コグノッシ， インコーポレイテッド ＡｐｏＥペプチドにより癌を治療する方法
TW201022230A (en) 2008-08-28 2010-06-16 Organon Nv 1-(4-ureidobenzoyl)piperazine derivatives
US8613367B2 (en) 2008-08-29 2013-12-24 Saint-Gobain Performance Plastics Corporation Sealing assembly and method of making such assembly
FR2935380B1 (fr) 2008-08-29 2010-09-10 Galderma Res & Dev Nouveaux composes hexafluoro-2-biphenyl-isopropanol, modulateurs des recepteurs de type lxrs, leur procede de preparation et leur application comme medicaments en medecine humaine ou veterinaire ainsi qu'en cosmetique.
US8394969B2 (en) 2008-09-26 2013-03-12 Merck Sharp & Dohme Corp. Cyclic benzimidazole derivatives useful as anti-diabetic agents
AU2009296392B2 (en) 2008-09-26 2016-06-02 Dana-Farber Cancer Institute, Inc. Human anti-PD-1, PD-L1, and PD-L2 antibodies and uses therefor
JP2012509334A (ja) 2008-11-19 2012-04-19 ワイス・エルエルシー 肝ｘ受容体（ｌｘｒ）モジュレーターとしての極性キナゾリン類
US20120156216A1 (en) 2009-03-02 2012-06-21 Youngman Oh Methods and Compositions for Treatment of Tumor Metastasis
MX2011011281A (es) 2009-04-29 2012-02-22 Kowa Co Compuesto de carbinol que tiene un enlazante heterociclico.
AU2010254082B2 (en) 2009-05-28 2015-01-29 Exelixis, Inc. LXR modulators
US8829213B2 (en) 2009-07-29 2014-09-09 The University Of Chicago Liver X receptor agonists
KR101636958B1 (ko) 2009-09-11 2016-07-06 주식회사 대웅제약 우루소데옥시콜린산-합성하이드로탈사이트-유드라짓 혼성체, 이를 함유하는 약학 조성물 및 그 제조방법
TWI513695B (zh) 2009-10-27 2015-12-21 Merck Sharp & Dohme （１，１，１，３，３，３－六氟－２－羥基丙－２－基）苯基衍生物
WO2011055391A1 (en) 2009-11-09 2011-05-12 Advinus Therapeutics Private Limited Substituted fused pyrimidine compounds, its preparation and uses thereof
SG181123A1 (en) 2009-12-04 2012-07-30 Taisho Pharmaceutical Co Ltd 2-pyridone compounds
US20120309730A1 (en) 2010-02-16 2012-12-06 The Johns Hopkins University Oxysterols that activate liver x receptor signaling and inhibit hedgehog signaling
WO2011115892A1 (en) 2010-03-15 2011-09-22 Griffin Patrick R Modulators of the retinoic acid receptor-related orphan receptors
WO2011130426A2 (en) 2010-04-13 2011-10-20 New York University Compositions and methods for treatment of melanoma
WO2011158667A1 (ja) 2010-06-16 2011-12-22 国立大学法人浜松医科大学 大腸腫瘍の検出方法
JP2013531007A (ja) 2010-07-08 2013-08-01 ワイス・エルエルシー 皮膚障害の治療に有用な新規キノリンエステル
EP2474617A1 (en) 2011-01-11 2012-07-11 InteRNA Technologies BV Mir for treating neo-angiogenesis
US20130004481A1 (en) 2011-01-12 2013-01-03 Boehringer Ingelheim International Gmbh Anticancer therapy
US20120231457A1 (en) 2011-03-10 2012-09-13 Nikolaos Tezapsidis Compositions and methods for assessing a genetic risk of developing late-onset alzheimer's disease (load)
US9629910B2 (en) 2011-03-22 2017-04-25 The Brigham And Women's Hospital, Inc. Use of Th9 cells and IL-9 for the treatment of melanoma
AR088728A1 (es) 2011-03-25 2014-07-02 Bristol Myers Squibb Co Moduladores de lxr como prodroga de imidazol
CA2848210A1 (en) 2011-09-15 2013-03-21 Novartis Ag Use of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]-1h-quinolin-2-one in the treatment of cancer in moderate hepatic impaired patients
WO2013043569A1 (en) 2011-09-20 2013-03-28 Vical Incorporated Synergistic anti-tumor efficacy using alloantigen combination immunotherapy
CN103054844B (zh) 2011-10-18 2014-04-30 中国科学院武汉病毒研究所 一种gw3965在制备治疗或预防丙型肝炎药物中的应用
JP2014530245A (ja) 2011-10-18 2014-11-17 アンセルム（アンスティチュート・ナシオナル・ドゥ・ラ・サンテ・エ・ドゥ・ラ・ルシェルシュ・メディカル） ５α−ヒドロキシ−６β−［２−（１Ｈ−イミダゾール−４−イル）エチルアミノ］コレスタン−３β−オールの酸付加塩
IN2014MN00976A (pl) 2011-11-24 2015-04-24 Inserm Inst Nat De La Santé Et De La Rech Médicale
TR201815013T4 (tr) 2012-03-02 2018-11-21 Ralexar Therapeutics Inc Dermal hastalıkların, rahatsızlıkların ve koşulların tedavisi için karaciğer x reseptör (lxr) modülatörleri.
WO2013138568A1 (en) 2012-03-16 2013-09-19 Vitae Pharmaceuticals, Inc. Liver x reception modulators
WO2013138565A1 (en) 2012-03-16 2013-09-19 Vitae Pharmaceuticals, Inc. Liver x receptor modulators
EP3626309B1 (en) 2012-08-13 2023-03-08 The Rockefeller University Lxrbeta agonist for the treatment of cancer
EP2968275B1 (en) 2013-03-15 2017-11-29 Bristol-Myers Squibb Company Lxr modulators
JP6066860B2 (ja) 2013-08-05 2017-01-25 株式会社クボタ 草刈機
WO2015065505A1 (en) 2013-10-29 2015-05-07 Duke University Use of cyp27a1 inhibitors, statin, or lxr antagonists alone or in combination with conventional therapy for the treatment of breast cancer
EP3091970B1 (en) 2014-01-10 2020-10-28 Rgenix, Inc. Lxr agonists and uses thereof
HRP20210388T4 (hr) 2014-02-07 2024-10-11 Global Blood Therapeutics, Inc. Kristalni polimorf slobodne baze od 2-hidroksi-6-((2-(1-izopropil-1h-pirazol-5-il)piridin-3-il)metoksi)benzaldehida
US10869926B2 (en) 2014-07-15 2020-12-22 The Johns Hopkins University Suppression of myeloid derived suppressor cells and immune checkpoint blockade
WO2016100619A2 (en) 2014-12-17 2016-06-23 Rgenix, Inc. Treatment and diagnosis of cancer
WO2016149299A1 (en) 2015-03-16 2016-09-22 Epinova Therapeutics Corp. Therapeutic compounds that suppress protein arginine methyltransferase activity for reducing tumor cell proliferation
US20170056352A1 (en) 2015-08-25 2017-03-02 Rgenix, Inc. PHARMACEUTICALLY ACCEPTABLE SALTS OF beta-GUANIDINOPROPIONIC ACID WITH IMPROVED PROPERTIES AND USES THEREOF
KR20180068999A (ko) 2015-10-06 2018-06-22 알렉터 엘엘씨 항-trem2 항체 및 그의 사용방법
US11058700B2 (en) 2015-10-28 2021-07-13 City Of Hope Macrocyclic lactones and uses thereof as modulators of purinergic receptors
JP7025022B2 (ja) 2016-01-11 2022-02-24 ザ ロックフェラー ユニバーシティー 骨髄系由来抑制細胞関連障害の治療のための方法
EP3412295A4 (en) 2016-02-05 2019-09-25 Taiho Pharmaceutical Co., Ltd. METHOD FOR THE TREATMENT OF CANCER PATIENTS WITH HEAVY NIER FUNCTION TROUBLESHOOTING
WO2017161188A1 (en) 2016-03-16 2017-09-21 The Regents Of The University Of California Detection and treatment of anti-pd-1 therapy resistant metastatic melanomas
WO2017181163A2 (en) 2016-04-16 2017-10-19 Oncocyte Corporation Methods and compositions for detection and diagnosis of breast cancer
KR102561356B1 (ko) 2016-09-14 2023-08-03 애브비 바이오테라퓨틱스 인크. 항-pd-1 항체 및 이의 용도
WO2018160178A1 (en) 2017-03-01 2018-09-07 Rgenix, Inc. Pharmaceutically acceptable salts of b-guanidinopropionic acid with improved properties and uses thereof
KR20240032149A (ko) * 2017-03-03 2024-03-08 인스피르나, 인크. 향상된 안정성을 갖는 제제
EP3713575A4 (en) 2017-11-21 2021-08-25 Rgenix, Inc. POLYMORPHS AND THEIR USES
CN109251974A (zh) 2018-02-14 2019-01-22 重庆京因生物科技有限责任公司 基于poct模式的apoe2和apoe4基因型快速检测试剂盒
WO2020176846A2 (en) 2019-02-28 2020-09-03 The Rockefeller University Apoe genotyping in cancer prognostics and treatment
BR112021019466A2 (pt) 2019-03-29 2022-01-18 Biontech Us Inc Biomarcadores de câncer para benefícios clínicos duráveis
PL4073025T3 (pl) 2019-12-13 2024-09-16 Inspirna, Inc. Sole metali i ich zastosowania

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