CN102908630B - 6-修饰的双环核酸类似物 - Google Patents

6-修饰的双环核酸类似物 Download PDF

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Publication number
CN102908630B
CN102908630B CN201210112347.6A CN201210112347A CN102908630B CN 102908630 B CN102908630 B CN 102908630B CN 201210112347 A CN201210112347 A CN 201210112347A CN 102908630 B CN102908630 B CN 102908630B
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nucleoside
group
oligomeric compounds
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CN102908630A (zh
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埃里克·E·斯威兹
普内特·P·塞思
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Ionis Pharmaceuticals Inc
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Isis Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201210112347.6A 2006-01-27 2007-01-27 6-修饰的双环核酸类似物 Active CN102908630B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US76272206P 2006-01-27 2006-01-27
US60/762,722 2006-01-27
US80566006P 2006-06-23 2006-06-23
US60/805,660 2006-06-23

Related Parent Applications (1)

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CN2007800105660A Division CN101410406B (zh) 2006-01-27 2007-01-27 6-修饰的双环核酸类似物

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CN102908630A CN102908630A (zh) 2013-02-06
CN102908630B true CN102908630B (zh) 2014-11-19

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CN201210111246.7A Active CN102766630B (zh) 2006-01-27 2007-01-27 6-修饰的双环核酸类似物

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US (3) US7399845B2 (US07741457-20100622-C00053.png)
EP (3) EP2332951A3 (US07741457-20100622-C00053.png)
JP (2) JP5342881B2 (US07741457-20100622-C00053.png)
KR (2) KR20130042043A (US07741457-20100622-C00053.png)
CN (2) CN102908630B (US07741457-20100622-C00053.png)
AT (1) ATE482965T1 (US07741457-20100622-C00053.png)
AU (1) AU2007211080B9 (US07741457-20100622-C00053.png)
CA (1) CA2640171C (US07741457-20100622-C00053.png)
DE (1) DE602007009487D1 (US07741457-20100622-C00053.png)
DK (2) DK2314594T3 (US07741457-20100622-C00053.png)
ES (1) ES2516815T3 (US07741457-20100622-C00053.png)
PL (2) PL2314594T3 (US07741457-20100622-C00053.png)
WO (1) WO2007090071A2 (US07741457-20100622-C00053.png)

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