MX2020008290A - Oligonucleotidos para modular la expresion de tmem106b. - Google Patents
Oligonucleotidos para modular la expresion de tmem106b.Info
- Publication number
- MX2020008290A MX2020008290A MX2020008290A MX2020008290A MX2020008290A MX 2020008290 A MX2020008290 A MX 2020008290A MX 2020008290 A MX2020008290 A MX 2020008290A MX 2020008290 A MX2020008290 A MX 2020008290A MX 2020008290 A MX2020008290 A MX 2020008290A
- Authority
- MX
- Mexico
- Prior art keywords
- oligonucleotides
- modulating
- tmem106b
- expression
- tmem106b expression
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/341—Gapmers, i.e. of the type ===---===
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
- C12N2310/3521—Methyl
Abstract
La presente invención se refiere a oligonucleótidos que modulan y son complementarios de la expresión de TMEM106B. Asimismo, la presente invención se refiere a conjugados de las composiciones de oligonucleótidos y farmacéuticas y métodos para el tratamiento de trastornos neurológicos con el uso del oligonucleótido.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP18156142 | 2018-02-09 | ||
US201862669251P | 2018-05-09 | 2018-05-09 | |
PCT/EP2019/053116 WO2019154979A1 (en) | 2018-02-09 | 2019-02-08 | Oligonucleotides for modulating tmem106b expression |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2020008290A true MX2020008290A (es) | 2020-09-25 |
Family
ID=65433647
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020008290A MX2020008290A (es) | 2018-02-09 | 2019-02-08 | Oligonucleotidos para modular la expresion de tmem106b. |
Country Status (17)
Country | Link |
---|---|
US (1) | US11485975B2 (es) |
EP (1) | EP3749766A1 (es) |
JP (1) | JP7281474B2 (es) |
KR (1) | KR20200108315A (es) |
CN (1) | CN111868245A (es) |
AU (1) | AU2019219194A1 (es) |
BR (1) | BR112020016170A2 (es) |
CA (1) | CA3088071A1 (es) |
CL (1) | CL2020002038A1 (es) |
CR (1) | CR20200346A (es) |
IL (1) | IL276357A (es) |
MA (1) | MA51795A (es) |
MX (1) | MX2020008290A (es) |
PE (1) | PE20211197A1 (es) |
RU (1) | RU2020125769A (es) |
SG (1) | SG11202007093YA (es) |
WO (1) | WO2019154979A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4058152A1 (en) * | 2019-11-14 | 2022-09-21 | The Board of Regents of the University of Oklahoma | Oligonucleotide interference treatments of prostate cancer |
WO2021231211A1 (en) * | 2020-05-11 | 2021-11-18 | Genentech, Inc. | Complement component c1s inhibitors for treating a neurological disease, and related compositions, systems and methods of using same |
WO2023141507A1 (en) * | 2022-01-20 | 2023-07-27 | Genentech, Inc. | Antisense oligonucleotides for modulating tmem106b expression |
Family Cites Families (44)
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JP3756313B2 (ja) | 1997-03-07 | 2006-03-15 | 武 今西 | 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体 |
IL135000A0 (en) | 1997-09-12 | 2001-05-20 | Exiqon As | Bi- and tri-cyclic nucleoside, nucleotide and oligonucleotide analogues |
EP1152009B2 (en) | 1999-02-12 | 2017-09-06 | Daiichi Sankyo Company, Limited | Novel nucleosides and oligonucleotide analogues |
KR100782896B1 (ko) | 1999-05-04 | 2007-12-06 | 엑시콘 에이/에스 | L-리보-lna 유사체 |
US6617442B1 (en) | 1999-09-30 | 2003-09-09 | Isis Pharmaceuticals, Inc. | Human Rnase H1 and oligonucleotide compositions thereof |
TR200401292T3 (tr) | 2000-12-01 | 2004-07-21 | Max@Planck@Gesellschaft�Zur�F�Rderung�Der�Wissenschaften | RNAÁgirişimineÁyolÁaçanÁküçükÁRNAÁmolekülleri |
WO2002079495A2 (en) | 2001-03-27 | 2002-10-10 | University Of Delaware | Genomics applications for modified oligonucleotides |
CA2921821A1 (en) | 2001-07-12 | 2003-01-23 | University Of Massachusetts | In vivo production of small interfering rnas that mediate gene silencing |
JP2006507841A (ja) * | 2002-11-14 | 2006-03-09 | ダーマコン, インコーポレイテッド | 機能的siRNAおよび超機能的siRNA |
DK2284269T3 (en) | 2002-11-18 | 2017-10-23 | Roche Innovation Ct Copenhagen As | Antisense design |
DK2141234T3 (en) | 2003-03-21 | 2016-06-20 | Roche Innovation Ct Copenhagen As | Short interfering RNA (siRNA) analogues |
CA2566286A1 (en) | 2004-05-11 | 2005-12-08 | Rnai Co., Ltd. | Polynucleotide causing rna interfere and method of regulating gene expression with the use of the same |
US7919472B2 (en) | 2004-09-17 | 2011-04-05 | Isis Pharmaceuticals, Inc. | Enhanced antisense oligonucleotides |
WO2007031091A2 (en) | 2005-09-15 | 2007-03-22 | Santaris Pharma A/S | Rna antagonist compounds for the modulation of p21 ras expression |
KR20130042043A (ko) | 2006-01-27 | 2013-04-25 | 아이시스 파마수티컬즈 인코포레이티드 | 6-변형된 바이시클릭 핵산 유사체 |
US8329888B2 (en) | 2006-03-23 | 2012-12-11 | Santaris Pharma A/S | Small internally segmented interfering RNA |
DK2066684T3 (da) | 2006-05-11 | 2012-10-22 | Isis Pharmaceuticals Inc | 5´-Modificerede bicycliske nukleinsyreanaloge |
US7666854B2 (en) | 2006-05-11 | 2010-02-23 | Isis Pharmaceuticals, Inc. | Bis-modified bicyclic nucleic acid analogs |
EP2410053B2 (en) | 2006-10-18 | 2020-07-15 | Ionis Pharmaceuticals, Inc. | Antisense compounds |
WO2008150729A2 (en) | 2007-05-30 | 2008-12-11 | Isis Pharmaceuticals, Inc. | N-substituted-aminomethylene bridged bicyclic nucleic acid analogs |
WO2008154401A2 (en) | 2007-06-08 | 2008-12-18 | Isis Pharmaceuticals, Inc. | Carbocyclic bicyclic nucleic acid analogs |
WO2009006478A2 (en) | 2007-07-05 | 2009-01-08 | Isis Pharmaceuticals, Inc. | 6-disubstituted bicyclic nucleic acid analogs |
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KR20110110776A (ko) | 2008-12-18 | 2011-10-07 | 다이서나 파마수이티컬, 인크. | 유전자 발현의 특이적 억제를 위한 연장된 다이서 기질 제제 및 방법 |
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CN104450621B (zh) * | 2014-09-30 | 2018-10-19 | 首都医科大学附属北京口腔医院 | Wdr63基因在间充质干细胞骨向和牙向分化过程中的调控方法 |
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RU2017127609A (ru) * | 2015-02-04 | 2019-03-04 | Ф. Хоффманн-Ля Рош Аг | Антисмысловые олигомеры тау-белка и их применение |
-
2019
- 2019-02-08 CR CR20200346A patent/CR20200346A/es unknown
- 2019-02-08 WO PCT/EP2019/053116 patent/WO2019154979A1/en unknown
- 2019-02-08 CA CA3088071A patent/CA3088071A1/en not_active Abandoned
- 2019-02-08 RU RU2020125769A patent/RU2020125769A/ru not_active Application Discontinuation
- 2019-02-08 JP JP2020542377A patent/JP7281474B2/ja active Active
- 2019-02-08 CN CN201980020478.1A patent/CN111868245A/zh active Pending
- 2019-02-08 MX MX2020008290A patent/MX2020008290A/es unknown
- 2019-02-08 SG SG11202007093YA patent/SG11202007093YA/en unknown
- 2019-02-08 KR KR1020207022883A patent/KR20200108315A/ko not_active Application Discontinuation
- 2019-02-08 BR BR112020016170-5A patent/BR112020016170A2/pt not_active Application Discontinuation
- 2019-02-08 EP EP19705306.9A patent/EP3749766A1/en active Pending
- 2019-02-08 AU AU2019219194A patent/AU2019219194A1/en not_active Abandoned
- 2019-02-08 PE PE2020001186A patent/PE20211197A1/es unknown
- 2019-02-08 MA MA051795A patent/MA51795A/fr unknown
-
2020
- 2020-07-28 IL IL276357A patent/IL276357A/en unknown
- 2020-08-05 CL CL2020002038A patent/CL2020002038A1/es unknown
- 2020-08-06 US US16/987,030 patent/US11485975B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CL2020002038A1 (es) | 2020-10-23 |
US11485975B2 (en) | 2022-11-01 |
AU2019219194A1 (en) | 2020-08-06 |
EP3749766A1 (en) | 2020-12-16 |
RU2020125769A3 (es) | 2022-03-10 |
CN111868245A (zh) | 2020-10-30 |
JP7281474B2 (ja) | 2023-05-25 |
US20210054383A1 (en) | 2021-02-25 |
CA3088071A1 (en) | 2019-08-15 |
SG11202007093YA (en) | 2020-08-28 |
JP2021514182A (ja) | 2021-06-10 |
BR112020016170A2 (pt) | 2020-12-15 |
IL276357A (en) | 2020-09-30 |
RU2020125769A (ru) | 2022-03-10 |
KR20200108315A (ko) | 2020-09-17 |
PE20211197A1 (es) | 2021-07-01 |
MA51795A (fr) | 2020-12-16 |
CR20200346A (es) | 2020-10-19 |
WO2019154979A1 (en) | 2019-08-15 |
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