JOP20210332A1 - عقاقير أولية لمعدلات المستقبل nmda - Google Patents
عقاقير أولية لمعدلات المستقبل nmdaInfo
- Publication number
- JOP20210332A1 JOP20210332A1 JOP/2021/0332A JOP20210332A JOP20210332A1 JO P20210332 A1 JOP20210332 A1 JO P20210332A1 JO P20210332 A JOP20210332 A JO P20210332A JO P20210332 A1 JOP20210332 A1 JO P20210332A1
- Authority
- JO
- Jordan
- Prior art keywords
- modulators
- nmda receptor
- prodrugs
- compounds
- directed
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
يتعلق الاختراع الحالي بعقاقير أولية جديدة بالصيغة (I) لمعدلات المستقبل NMDA. وتتعلق جوانب منفصلة من الاختراع بتركيبات صيدلية تحتوي على المركبات المذكورة، واستخدامات المركبات لعلاج الاضطرابات العصبية أو الاضطرابات النفسية العصبية مثل الاكتئاب.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA201900822 | 2019-07-03 | ||
PCT/EP2020/068513 WO2021001420A1 (en) | 2019-07-03 | 2020-07-01 | Prodrugs of modulators of the nmda receptor |
Publications (1)
Publication Number | Publication Date |
---|---|
JOP20210332A1 true JOP20210332A1 (ar) | 2023-01-30 |
Family
ID=71614856
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JOP/2021/0332A JOP20210332A1 (ar) | 2019-07-03 | 2020-07-01 | عقاقير أولية لمعدلات المستقبل nmda |
Country Status (20)
Country | Link |
---|---|
US (2) | US11358971B2 (ar) |
EP (1) | EP3994140A1 (ar) |
JP (1) | JP2022538180A (ar) |
KR (1) | KR20220034052A (ar) |
CN (1) | CN114008053A (ar) |
AR (1) | AR119341A1 (ar) |
AU (1) | AU2020299410A1 (ar) |
BR (1) | BR112021003983A2 (ar) |
CA (1) | CA3144303A1 (ar) |
CL (1) | CL2021003534A1 (ar) |
CO (1) | CO2021017154A2 (ar) |
CR (1) | CR20210663A (ar) |
EC (1) | ECSP22003599A (ar) |
IL (1) | IL289576A (ar) |
JO (1) | JOP20210332A1 (ar) |
MA (1) | MA56450A (ar) |
MX (1) | MX2021015752A (ar) |
PE (1) | PE20220136A1 (ar) |
TW (1) | TW202116780A (ar) |
WO (1) | WO2021001420A1 (ar) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11466027B2 (en) | 2019-07-03 | 2022-10-11 | H. Lundbeck A/S | Modulators of the NMDA receptor |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5026700A (en) | 1989-05-16 | 1991-06-25 | Merrell Dow Pharmaceuticals | Certain quinolines and thienopyridines as excitatory amino acid antagonists |
US5252581A (en) | 1992-07-20 | 1993-10-12 | Hoechst-Roussel Pharmaceuticals Inc. | Substituted aminothienopyridines, pharmaceutical composition and use |
US6071970A (en) | 1993-02-08 | 2000-06-06 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
EP0743853B1 (en) | 1994-02-08 | 2001-05-02 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
AU723349B2 (en) | 1996-06-07 | 2000-08-24 | Nps Pharmaceuticals, Inc. | Coumpounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
WO1998056752A1 (en) | 1997-06-11 | 1998-12-17 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
CL2003002287A1 (es) | 2002-11-25 | 2005-01-14 | Wyeth Corp | COMPUESTOS DERIVADOS DE TIENO[3,2-b]-PIRIDINA-6-CARBONITRILOS Y TIENEO[2,3-b]-PIRIDINA-5-CARBONITRILOS, COMPOSICION FARMACEUTICA, PROCEDIMIENTO DE PREPARACION Y COMPUESTOS INTERMEDIARIOS, Y SU USO EN EL TRATAMIENTO DEL CANCER, APOPLEJIA, OSTEOPOROSIS |
GB0401332D0 (en) | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
GB0420719D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
US9340555B2 (en) | 2009-09-03 | 2016-05-17 | Allergan, Inc. | Compounds as tyrosine kinase modulators |
US8993591B2 (en) * | 2010-11-08 | 2015-03-31 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a] pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors |
US9271967B2 (en) * | 2010-11-08 | 2016-03-01 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
PT3386591T (pt) * | 2015-12-09 | 2020-10-01 | Cadent Therapeutics Inc | Moduladores de recetores nmda heteroaromáticos e suas utilizações |
US11274107B2 (en) * | 2016-12-22 | 2022-03-15 | Cadent Therapeutics, Inc. | NMDA receptor modulators and uses thereof |
US11466027B2 (en) | 2019-07-03 | 2022-10-11 | H. Lundbeck A/S | Modulators of the NMDA receptor |
-
2020
- 2020-06-30 US US16/916,681 patent/US11358971B2/en active Active
- 2020-07-01 TW TW109122238A patent/TW202116780A/zh unknown
- 2020-07-01 KR KR1020217042180A patent/KR20220034052A/ko unknown
- 2020-07-01 MX MX2021015752A patent/MX2021015752A/es unknown
- 2020-07-01 BR BR112021003983A patent/BR112021003983A2/pt not_active Application Discontinuation
- 2020-07-01 MA MA056450A patent/MA56450A/fr unknown
- 2020-07-01 AU AU2020299410A patent/AU2020299410A1/en active Pending
- 2020-07-01 PE PE2021002224A patent/PE20220136A1/es unknown
- 2020-07-01 CA CA3144303A patent/CA3144303A1/en active Pending
- 2020-07-01 CN CN202080045404.6A patent/CN114008053A/zh active Pending
- 2020-07-01 WO PCT/EP2020/068513 patent/WO2021001420A1/en unknown
- 2020-07-01 CR CR20210663A patent/CR20210663A/es unknown
- 2020-07-01 JO JOP/2021/0332A patent/JOP20210332A1/ar unknown
- 2020-07-01 JP JP2021577276A patent/JP2022538180A/ja active Pending
- 2020-07-01 EP EP20740249.6A patent/EP3994140A1/en not_active Withdrawn
- 2020-07-02 AR ARP200101879A patent/AR119341A1/es unknown
-
2021
- 2021-12-15 CO CONC2021/0017154A patent/CO2021017154A2/es unknown
- 2021-12-28 CL CL2021003534A patent/CL2021003534A1/es unknown
-
2022
- 2022-01-02 IL IL289576A patent/IL289576A/en unknown
- 2022-01-17 EC ECSENADI20223599A patent/ECSP22003599A/es unknown
- 2022-01-25 US US17/583,333 patent/US20220213117A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
PE20220136A1 (es) | 2022-01-27 |
ECSP22003599A (es) | 2022-02-25 |
CA3144303A1 (en) | 2021-01-07 |
CR20210663A (es) | 2022-02-22 |
TW202116780A (zh) | 2021-05-01 |
AR119341A1 (es) | 2021-12-09 |
IL289576A (en) | 2022-03-01 |
US20210047342A1 (en) | 2021-02-18 |
EP3994140A1 (en) | 2022-05-11 |
AU2020299410A1 (en) | 2022-02-03 |
CL2021003534A1 (es) | 2022-08-19 |
CN114008053A (zh) | 2022-02-01 |
BR112021003983A2 (pt) | 2022-03-15 |
US11358971B2 (en) | 2022-06-14 |
MA56450A (fr) | 2022-05-11 |
CO2021017154A2 (es) | 2022-01-17 |
WO2021001420A1 (en) | 2021-01-07 |
US20220213117A1 (en) | 2022-07-07 |
MX2021015752A (es) | 2022-01-27 |
JP2022538180A (ja) | 2022-08-31 |
KR20220034052A (ko) | 2022-03-17 |
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