CN101389622B - 用作pi-3激酶抑制剂的嘧啶衍生物 - Google Patents

用作pi-3激酶抑制剂的嘧啶衍生物 Download PDF

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Publication number
CN101389622B
CN101389622B CN2007800063742A CN200780006374A CN101389622B CN 101389622 B CN101389622 B CN 101389622B CN 2007800063742 A CN2007800063742 A CN 2007800063742A CN 200780006374 A CN200780006374 A CN 200780006374A CN 101389622 B CN101389622 B CN 101389622B
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pyrimidine
compound
amine
unsubstituted
amino
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CN101389622A (zh
Inventor
T·皮克
P·巴尔桑尼
E·伊瓦什凯维奇
W·范特尔
T·亨德里克森
M·纳普
H·梅里特
C·沃尔特娃
M·维斯曼
X·辛
M·比尔热
Z·倪
S·佩基
G·阿塔略
S·巴尔图利斯
K·弗雷泽
A·史密斯
J·韦尔哈根
Y·张
A·韦格曼
S·额
K·菲斯特
D·蓬
A·路易
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Novartis AG
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Novartis AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN2007800063742A 2006-01-20 2007-01-22 用作pi-3激酶抑制剂的嘧啶衍生物 Active CN101389622B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US76078906P 2006-01-20 2006-01-20
US60/760,789 2006-01-20
PCT/US2007/001708 WO2007084786A1 (en) 2006-01-20 2007-01-22 Pyrimidine derivatives used as pi-3 kinase inhibitors

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CN101389622A CN101389622A (zh) 2009-03-18
CN101389622B true CN101389622B (zh) 2013-04-17

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US (2) US8217035B2 (OSRAM)
EP (2) EP1984350B1 (OSRAM)
JP (1) JP5161110B2 (OSRAM)
KR (1) KR101353829B1 (OSRAM)
CN (1) CN101389622B (OSRAM)
AR (2) AR059087A1 (OSRAM)
AT (1) ATE478064T1 (OSRAM)
AU (1) AU2007206048B2 (OSRAM)
BR (1) BRPI0707189B1 (OSRAM)
CA (1) CA2636993C (OSRAM)
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CY (1) CY1111091T1 (OSRAM)
DE (1) DE602007008529D1 (OSRAM)
DK (2) DK1984350T3 (OSRAM)
EA (1) EA018083B1 (OSRAM)
EC (1) ECSP088630A (OSRAM)
ES (2) ES2427624T3 (OSRAM)
GE (1) GEP20115147B (OSRAM)
GT (1) GT200800143A (OSRAM)
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HR (2) HRP20100603T1 (OSRAM)
IL (1) IL192763A (OSRAM)
JO (1) JO2660B1 (OSRAM)
MA (1) MA30208B1 (OSRAM)
ME (2) MEP3908A (OSRAM)
MY (1) MY144233A (OSRAM)
NO (1) NO342183B1 (OSRAM)
NZ (1) NZ569771A (OSRAM)
PE (1) PE20071322A1 (OSRAM)
PL (2) PL2261223T3 (OSRAM)
PT (2) PT1984350E (OSRAM)
RS (2) RS52928B (OSRAM)
SI (2) SI2261223T1 (OSRAM)
SM (1) SMP200800048B (OSRAM)
SV (1) SV2008002984A (OSRAM)
TN (1) TNSN08305A1 (OSRAM)
TW (2) TWI385170B (OSRAM)
UA (1) UA96284C2 (OSRAM)
WO (1) WO2007084786A1 (OSRAM)
ZA (1) ZA200806017B (OSRAM)

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