CA3139492C - Modified antibody constant region - Google Patents

Modified antibody constant region Download PDF

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Publication number
CA3139492C
CA3139492C CA3139492A CA3139492A CA3139492C CA 3139492 C CA3139492 C CA 3139492C CA 3139492 A CA3139492 A CA 3139492A CA 3139492 A CA3139492 A CA 3139492A CA 3139492 C CA3139492 C CA 3139492C
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Canada
Prior art keywords
amino acid
numbering system
antibody
igg2
seq
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Active
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CA3139492A
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English (en)
French (fr)
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CA3139492A1 (en
Inventor
Tomoyuki Igawa
Hirotake Shiraiwa
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Chugai Pharmaceutical Co Ltd
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Chugai Pharmaceutical Co Ltd
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40511493&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA3139492(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Priority to CA3222170A priority Critical patent/CA3222170A1/en
Publication of CA3139492A1 publication Critical patent/CA3139492A1/en
Application granted granted Critical
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA3139492A 2007-09-26 2008-09-26 Modified antibody constant region Active CA3139492C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3222170A CA3222170A1 (en) 2007-09-26 2008-09-26 Modified antibody constant region

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2007250147 2007-09-26
JP2007-250147 2007-09-26
CA3066453A CA3066453C (en) 2007-09-26 2008-09-26 Modified antibody constant region

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA3066453A Division CA3066453C (en) 2007-09-26 2008-09-26 Modified antibody constant region

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3222170A Division CA3222170A1 (en) 2007-09-26 2008-09-26 Modified antibody constant region

Publications (2)

Publication Number Publication Date
CA3139492A1 CA3139492A1 (en) 2009-04-02
CA3139492C true CA3139492C (en) 2024-04-30

Family

ID=40511493

Family Applications (5)

Application Number Title Priority Date Filing Date
CA3139492A Active CA3139492C (en) 2007-09-26 2008-09-26 Modified antibody constant region
CA3066453A Active CA3066453C (en) 2007-09-26 2008-09-26 Modified antibody constant region
CA2700394A Active CA2700394C (en) 2007-09-26 2008-09-26 Modified antibody constant region
CA3222170A Pending CA3222170A1 (en) 2007-09-26 2008-09-26 Modified antibody constant region
CA2978687A Active CA2978687C (en) 2007-09-26 2008-09-26 Modified antibody constant region

Family Applications After (4)

Application Number Title Priority Date Filing Date
CA3066453A Active CA3066453C (en) 2007-09-26 2008-09-26 Modified antibody constant region
CA2700394A Active CA2700394C (en) 2007-09-26 2008-09-26 Modified antibody constant region
CA3222170A Pending CA3222170A1 (en) 2007-09-26 2008-09-26 Modified antibody constant region
CA2978687A Active CA2978687C (en) 2007-09-26 2008-09-26 Modified antibody constant region

Country Status (22)

Country Link
US (3) US9688762B2 (https=)
EP (4) EP2194066B1 (https=)
JP (9) JP5484060B2 (https=)
KR (6) KR101922788B1 (https=)
CN (1) CN101874041B (https=)
AR (4) AR068563A1 (https=)
AU (1) AU2008304748C1 (https=)
CA (5) CA3139492C (https=)
CL (1) CL2008002886A1 (https=)
DK (2) DK2194066T3 (https=)
ES (2) ES2687808T3 (https=)
IL (1) IL204537A0 (https=)
MX (2) MX342551B (https=)
MY (3) MY193526A (https=)
PE (1) PE20090711A1 (https=)
PH (3) PH12021552811A1 (https=)
PL (1) PL3059246T3 (https=)
RU (2) RU2526512C2 (https=)
SG (2) SG10201605394SA (https=)
TW (2) TWI464262B (https=)
WO (1) WO2009041613A1 (https=)
ZA (1) ZA201002422B (https=)

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