CA2870087C - Substituted isoquinolin-1(2h)-one compounds and their use as phosphoinositide 3-kinase (pi3k) inhibitors - Google Patents

Substituted isoquinolin-1(2h)-one compounds and their use as phosphoinositide 3-kinase (pi3k) inhibitors Download PDF

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CA2870087C
CA2870087C CA2870087A CA2870087A CA2870087C CA 2870087 C CA2870087 C CA 2870087C CA 2870087 A CA2870087 A CA 2870087A CA 2870087 A CA2870087 A CA 2870087A CA 2870087 C CA2870087 C CA 2870087C
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compound
alkyl
heteroaryl
substituted
aryl
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French (fr)
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CA2870087A1 (en
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Alfredo C. Castro
Katrina Chan
Catherine A. Evans
Somarajannair Janardanannair
Andre Lescarbeau
Liansheng Li
Tao Liu
Yi Liu
Pingda Ren
Daniel A. Snyder
Martin R. Tremblay
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TWELVE THERAPEUTICS, INC.
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Infinity Pharmaceuticals Inc
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CA2870087A 2012-04-10 2013-04-03 Substituted isoquinolin-1(2h)-one compounds and their use as phosphoinositide 3-kinase (pi3k) inhibitors Active CA2870087C (en)

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Application Number Priority Date Filing Date Title
US201261622259P 2012-04-10 2012-04-10
US61/622,259 2012-04-10
US201261713404P 2012-10-12 2012-10-12
US61/713,404 2012-10-12
PCT/US2013/035069 WO2013154878A1 (en) 2012-04-10 2013-04-03 Heterocyclic compounds and uses thereof

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CA2870087A1 CA2870087A1 (en) 2013-10-17
CA2870087C true CA2870087C (en) 2021-02-02

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US (3) US8940742B2 (https=)
EP (1) EP2836487B1 (https=)
JP (1) JP6309505B2 (https=)
CN (1) CN104703979B (https=)
AU (1) AU2013205238B2 (https=)
CA (1) CA2870087C (https=)
HK (1) HK1207069A1 (https=)
WO (1) WO2013154878A1 (https=)

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EP3219705B1 (en) 2005-12-28 2020-03-11 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of the amorphous form of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
EP3613743B1 (en) 2008-01-04 2022-03-16 Intellikine, LLC Processes for the preparation of 1h-pyrazolo[3,4-d]pyrimidin-4-amine derivatives
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US8940742B2 (en) 2015-01-27
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US20160207940A1 (en) 2016-07-21
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WO2013154878A1 (en) 2013-10-17
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