CA2243459C - Human antibodies that bind human tnf.alpha. - Google Patents

Human antibodies that bind human tnf.alpha. Download PDF

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Publication number
CA2243459C
CA2243459C CA002243459A CA2243459A CA2243459C CA 2243459 C CA2243459 C CA 2243459C CA 002243459 A CA002243459 A CA 002243459A CA 2243459 A CA2243459 A CA 2243459A CA 2243459 C CA2243459 C CA 2243459C
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Prior art keywords
seq
antibody
amino acid
human
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002243459A
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English (en)
French (fr)
Other versions
CA2243459A1 (en
Inventor
Jochen G. Salfeld
Deborah J. Allen
Hendricus R. J. M. Hoogenboom
Zehra Kaymakcalan
Boris Labkovsky
John A. Mankovich
Brian T. Mcguinness
Andrew J. Roberts
Paul Sakorafas
David Schoenhaut
Tristan J. Vaughan
Michael White
Alison J. Wilton
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AbbVie Biotechnology Ltd
Original Assignee
BASF SE
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26707297&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2243459(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/599,226 external-priority patent/US6090382A/en
Application filed by BASF SE filed Critical BASF SE
Priority to CA002389943A priority Critical patent/CA2389943C/en
Publication of CA2243459A1 publication Critical patent/CA2243459A1/en
Application granted granted Critical
Publication of CA2243459C publication Critical patent/CA2243459C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241Tumor Necrosis Factors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C07K2317/00Immunoglobulins specific features
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    • C07K2317/565Complementarity determining region [CDR]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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CA002243459A 1996-02-09 1997-02-10 Human antibodies that bind human tnf.alpha. Expired - Lifetime CA2243459C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002389943A CA2389943C (en) 1996-02-09 1997-02-10 Human antibodies that bind human tnf.alpha.

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/599,226 US6090382A (en) 1996-02-09 1996-02-09 Human antibodies that bind human TNFα
US08/599,226 1996-02-09
US3147696P 1996-11-25 1996-11-25
US60/031,476 1996-11-25
PCT/US1997/002219 WO1997029131A1 (en) 1996-02-09 1997-02-10 HUMAN ANTIBODIES THAT BIND HUMAN TNF$g(a)

Related Child Applications (1)

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CA002389943A Division CA2389943C (en) 1996-02-09 1997-02-10 Human antibodies that bind human tnf.alpha.

Publications (2)

Publication Number Publication Date
CA2243459A1 CA2243459A1 (en) 1997-08-14
CA2243459C true CA2243459C (en) 2002-09-17

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CA002243459A Expired - Lifetime CA2243459C (en) 1996-02-09 1997-02-10 Human antibodies that bind human tnf.alpha.

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