BRPI0210866B8 - compostos beta-amino tetra-hidroimidazo (1,2-a) pirazina e tetra-hidrotriazolo (4,3-a) pirazina, usos dos mesmos e composição farmacêutica - Google Patents

compostos beta-amino tetra-hidroimidazo (1,2-a) pirazina e tetra-hidrotriazolo (4,3-a) pirazina, usos dos mesmos e composição farmacêutica

Info

Publication number
BRPI0210866B8
BRPI0210866B8 BRPI0210866A BR0210866A BRPI0210866B8 BR PI0210866 B8 BRPI0210866 B8 BR PI0210866B8 BR PI0210866 A BRPI0210866 A BR PI0210866A BR 0210866 A BR0210866 A BR 0210866A BR PI0210866 B8 BRPI0210866 B8 BR PI0210866B8
Authority
BR
Brazil
Prior art keywords
compounds
pyrazine
peptidase
pharmaceutical composition
treatment
Prior art date
Application number
BRPI0210866A
Other languages
English (en)
Portuguese (pt)
Other versions
BRPI0210866B1 (pt
BR0210866A (pt
Inventor
E Weber Ann
Kim Dooseop
R Parmee Emma
Xu Jinyou
Maccoss Malcolm
H Fisher Michael
D Edmondson Scott
Original Assignee
Merck & Co Inc
Merck Sharp & Dohme
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23172273&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0210866(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc, Merck Sharp & Dohme, Schering Corp filed Critical Merck & Co Inc
Publication of BR0210866A publication Critical patent/BR0210866A/pt
Publication of BRPI0210866B1 publication Critical patent/BRPI0210866B1/pt
Publication of BRPI0210866B8 publication Critical patent/BRPI0210866B8/pt

Links

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
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BRPI0210866A 2001-07-06 2002-07-05 compostos beta-amino tetra-hidroimidazo (1,2-a) pirazina e tetra-hidrotriazolo (4,3-a) pirazina, usos dos mesmos e composição farmacêutica BRPI0210866B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30347401P 2001-07-06 2001-07-06
PCT/US2002/021349 WO2003004498A1 (en) 2001-07-06 2002-07-05 Beta-amino tetrahydroimidazo (1, 2-a) pyrazines and tetrahydrotrioazolo (4, 3-a) pyrazines as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes

Publications (3)

Publication Number Publication Date
BR0210866A BR0210866A (pt) 2004-06-29
BRPI0210866B1 BRPI0210866B1 (pt) 2016-07-05
BRPI0210866B8 true BRPI0210866B8 (pt) 2021-05-25

Family

ID=23172273

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0210866A BRPI0210866B8 (pt) 2001-07-06 2002-07-05 compostos beta-amino tetra-hidroimidazo (1,2-a) pirazina e tetra-hidrotriazolo (4,3-a) pirazina, usos dos mesmos e composição farmacêutica

Country Status (45)

Country Link
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US7544511B2 (en) * 1996-09-25 2009-06-09 Neuralstem Biopharmaceuticals Ltd. Stable neural stem cell line methods
US20030176357A1 (en) * 1998-10-06 2003-09-18 Pospisilik Andrew J. Dipeptidyl peptidase IV inhibitors and their uses for lowering blood pressure levels
EP1382607B1 (en) * 1998-12-31 2009-08-19 Ipsen Pharma Prenyl transferase inhibitors
AU2002310465B2 (en) 2001-06-20 2006-06-15 Merck & Co., Inc. Dipeptidyl peptidase inhibitors for the treatment of diabetes
JP2004535433A (ja) 2001-06-20 2004-11-25 メルク　エンド　カムパニー　インコーポレーテッド 糖尿病治療用のジペプチジルペプチダーゼ阻害薬
ES2296979T3 (es) 2001-06-27 2008-05-01 Smithkline Beecham Corporation Fluoropirrolidinas como inhibidores de dipeptidil peptidasa.
UA74912C2 (en) * 2001-07-06 2006-02-15 Merck & Co Inc Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes
WO2003068805A2 (en) * 2002-02-14 2003-08-21 Bayer Pharmaceuticals Corporation Formulation strategies in stabilizing peptides in organic solvents and in dried states
ATE373660T1 (de) * 2002-03-25 2007-10-15 Merck & Co Inc Heterocyclische beta-aminoverbindungen als inhibitoren der dipeptidylpeptidase zur behandlung bzw. prävention von diabetes
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