BG103392A - Serine protease inhibitors, in particular of hepatitis with virus ns3 protease - Google Patents

Serine protease inhibitors, in particular of hepatitis with virus ns3 protease

Info

Publication number
BG103392A
BG103392A BG103392A BG10339299A BG103392A BG 103392 A BG103392 A BG 103392A BG 103392 A BG103392 A BG 103392A BG 10339299 A BG10339299 A BG 10339299A BG 103392 A BG103392 A BG 103392A
Authority
BG
Bulgaria
Prior art keywords
virus
protease
hepatitis
serine
inhibitors
Prior art date
Application number
BG103392A
Other languages
Bulgarian (bg)
English (en)
Inventor
Roger Tung
Scott Harbeson
David DEININGER
Mark Murcko
Govinda BHISETTI
Luc Farmer
Original Assignee
Vertex Pharmaceuticals Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Incorporated filed Critical Vertex Pharmaceuticals Incorporated
Publication of BG103392A publication Critical patent/BG103392A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
BG103392A 1996-10-18 1999-05-11 Serine protease inhibitors, in particular of hepatitis with virus ns3 protease BG103392A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2829096P 1996-10-18 1996-10-18
PCT/US1997/018968 WO1998017679A1 (en) 1996-10-18 1997-10-17 Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease

Publications (1)

Publication Number Publication Date
BG103392A true BG103392A (en) 2000-01-31

Family

ID=21842625

Family Applications (1)

Application Number Title Priority Date Filing Date
BG103392A BG103392A (en) 1996-10-18 1999-05-11 Serine protease inhibitors, in particular of hepatitis with virus ns3 protease

Country Status (33)

Country Link
US (5) US6265380B1 (OSRAM)
EP (3) EP2314598A1 (OSRAM)
JP (3) JP4080541B2 (OSRAM)
KR (1) KR100509388B1 (OSRAM)
CN (1) CN1133649C (OSRAM)
AP (1) AP1019A (OSRAM)
AT (1) ATE212037T1 (OSRAM)
BG (1) BG103392A (OSRAM)
BR (1) BR9712544B1 (OSRAM)
CA (1) CA2268391A1 (OSRAM)
CZ (1) CZ298749B6 (OSRAM)
DE (1) DE69709671T2 (OSRAM)
DK (1) DK0932617T3 (OSRAM)
EA (1) EA001915B1 (OSRAM)
EE (1) EE04023B1 (OSRAM)
ES (1) ES2169880T3 (OSRAM)
GE (1) GEP20012471B (OSRAM)
HU (1) HU227742B1 (OSRAM)
ID (1) ID21649A (OSRAM)
IL (3) IL129407A0 (OSRAM)
IN (1) IN183120B (OSRAM)
IS (1) IS5028A (OSRAM)
MX (1) MXPA05003026A (OSRAM)
NO (2) NO329751B1 (OSRAM)
NZ (1) NZ335276A (OSRAM)
PL (2) PL192280B1 (OSRAM)
PT (1) PT932617E (OSRAM)
SK (1) SK286105B6 (OSRAM)
TR (1) TR199901602T2 (OSRAM)
TW (1) TW530065B (OSRAM)
UA (2) UA79749C2 (OSRAM)
WO (1) WO1998017679A1 (OSRAM)
ZA (1) ZA979327B (OSRAM)

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