BE2015C055I2 - - Google Patents

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BE2015C055I2
BE2015C055I2 BE2015C055C BE2015C055C BE2015C055I2 BE 2015C055 I2 BE2015C055 I2 BE 2015C055I2 BE 2015C055 C BE2015C055 C BE 2015C055C BE 2015C055 C BE2015C055 C BE 2015C055C BE 2015C055 I2 BE2015C055 I2 BE 2015C055I2
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BE
Belgium
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general formula
following general
compound represented
compound
repr
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BE2015C055C
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English (en)
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Eisai R&D Man Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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Families Citing this family (274)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7517880B2 (en) * 1997-12-22 2009-04-14 Bayer Pharmaceuticals Corporation Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
EP1158985B1 (fr) 1999-01-13 2011-12-28 Bayer HealthCare LLC DIPHENYLE UREES A SUBSTITUTION OMEGA-CARBOXY ARYLE EN TANT QU'INHIBITEURS DE LA KINASE p38
ATE399766T1 (de) 2000-10-20 2008-07-15 Eisai R&D Man Co Ltd Stickstoff enthaltende aromatische heterozyklen
KR100879669B1 (ko) * 2001-04-27 2009-01-21 기린 파마 가부시끼가이샤 아졸릴기를 갖는 퀴놀린 유도체 및 퀴나졸린 유도체
ES2259707T3 (es) * 2001-05-14 2006-10-16 Novartis Ag Oxazolo y furopirimidinas y su uso en medicamentos contra tumores.
CA2454538A1 (fr) 2001-06-22 2003-01-03 Kirin Beer Kabushiki Kaisha Derives de la quinoleine et de la quinozoline pouvant inhiber l'auto- phosphorylation des recepteurs du facteur de croissance des hepatocytes, et composition pharmaceutique ainsi constituee
US7323469B2 (en) 2001-08-07 2008-01-29 Novartis Ag 7H-pyrrolo[2,3-d]pyrimidine derivatives
GB0119249D0 (en) 2001-08-07 2001-10-03 Novartis Ag Organic compounds
US7495104B2 (en) 2001-10-17 2009-02-24 Kirin Beer Kabushiki Kaisha Quinoline or quinazoline derivatives inhibiting auto-phosphorylation of fibroblast growth factor receptors
AU2003209119A1 (en) 2002-02-11 2003-09-04 Bayer Pharmaceuticals Corporation Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors
SI1478358T1 (sl) 2002-02-11 2013-09-30 Bayer Healthcare Llc Sorafenib tozilat za zdravljenje bolezni, značilnih po abnormalni angiogenezi
WO2003074045A1 (fr) * 2002-03-05 2003-09-12 Eisai Co., Ltd. Agent antitumoral comprenant une combinaison d'un compose heterocyclique contenant un sulfamide et d'un inhibiteur d'angiogenese
EP1535910A4 (fr) * 2002-05-01 2007-03-14 Kirin Brewery Derives de quinoleine et derives de quinazoline inhibiteurs de l'autophosphorylation du recepteur du facteur stimulant la proliferation des macrophages
PE20040522A1 (es) * 2002-05-29 2004-09-28 Novartis Ag Derivados de diarilurea dependientes de la cinasa de proteina
TW200410945A (en) 2002-08-08 2004-07-01 Amgen Inc Vanilloid receptor ligands and their use in treatments"
EP1522540A4 (fr) * 2002-08-30 2011-08-10 Eisai R&D Man Co Ltd Derives d'azaarene
EP1559715B1 (fr) * 2002-10-21 2007-09-26 Kirin Beer Kabushiki Kaisha Sel de n- {2-chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl} -n'-(5-methyl-3-isoxazolyl)uree sous forme cristalline
EP1566379A4 (fr) * 2002-10-29 2005-11-09 Kirin Brewery DERIVES DE QUINOLINE ET DE QUINAZOLINE INHIBANT L'AUTOPHOSPHORYLATION DE Flt3 ET COMPOSITIONS MEDICALES LES CONTENANT
AR041992A1 (es) * 2002-11-06 2005-06-08 Smithkline Beecham Corp Compuesto de piridinil benzoheterociclico, composicion farmaceutica que lo comprende y su uso para prepararla
UY28213A1 (es) 2003-02-28 2004-09-30 Bayer Pharmaceuticals Corp Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos.
EP1604665B1 (fr) * 2003-03-10 2011-05-11 Eisai R&D Management Co., Ltd. Inhibiteur de kinase c-kit
EP1611088B1 (fr) * 2003-04-07 2009-06-17 Pharmacyclics, Inc. Hydroxamates et leur utilisation comme agents therapeutiques
ATE332292T1 (de) * 2003-04-16 2006-07-15 Huntsman Adv Mat Switzerland 1-imidazolylmethyl-substituirte-2-naphtol unh ihre verwendung als niedertemperatur- härtungsbeschleuniger
WO2004101526A1 (fr) * 2003-04-22 2004-11-25 Eisai Co., Ltd. Cristal polymorphe de 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide et procede de preparation
US7253166B2 (en) 2003-04-22 2007-08-07 Irm Llc 6-phenyl-7H-pyrrolo[2,3-d]pyrimidine compounds that induce neuronal differentiation in embryonic stem cells
TW200519106A (en) 2003-05-02 2005-06-16 Novartis Ag Organic compounds
DK1636585T3 (da) 2003-05-20 2008-05-26 Bayer Pharmaceuticals Corp Diarylurinstoffer med kinasehæmmende aktivitet
US8309562B2 (en) 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
CL2004001834A1 (es) 2003-07-23 2005-06-03 Bayer Pharmaceuticals Corp Compuesto 4-{4-[3-(4-cloro-3-trifluorometilfenil)-ureido]-3-fluorofenoxi}-piridin-2-metilamida, inhibidor de la raf, vegfr, p38 y pdgfr quinasas, sus sales; composiicon farmaceutica; combinacion farmaceutica; y su uso para tratar trastornos hiperprol
ATE353319T1 (de) * 2003-08-20 2007-02-15 Axys Pharm Inc Acetylenderivate als inhibitoren von histondeacetylase
ES2925655T3 (es) 2003-09-26 2022-10-19 Exelixis Inc Moduladores c-Met y métodos de uso
AU2004278382B2 (en) * 2003-09-30 2008-09-18 Amgen Inc. Vanilloid receptor ligands and their use in treatments
US7683172B2 (en) 2003-11-11 2010-03-23 Eisai R&D Management Co., Ltd. Urea derivative and process for preparing the same
US20050171172A1 (en) * 2003-11-13 2005-08-04 Ambit Biosciences Corporation Amide derivatives as PDGFR modulators
RU2006122853A (ru) * 2003-11-28 2008-01-10 Новартис АГ (CH) Производные диарилмочевины для лечения заболеваний, зависимых от протеинкиназы
DE10357510A1 (de) * 2003-12-09 2005-07-07 Bayer Healthcare Ag Heteroarylsubstituierte Benzole
GEP20084572B (en) 2003-12-23 2008-12-25 Pfizer Novel quinoline derivatives
WO2005063713A1 (fr) * 2003-12-25 2005-07-14 Eisai Co., Ltd. Cristaux de sel de 4-(3-chloro-4-(cyclopropylaminocarbonyl)amino-phenoxy)-7-methoxy-6-quinolinecarboxamide ou de ses solvate, et leur procede de production
AU2005206571B8 (en) * 2004-01-23 2010-09-02 Amgen Inc. Compounds and methods of use
EP1711495A2 (fr) * 2004-01-23 2006-10-18 Amgen Inc. Quinolines, chinazolines, pyridines et pyrimidines et leur utilsation dans le traitement d'inflammation, angiogenèse et le cancer
MY139645A (en) 2004-02-11 2009-10-30 Amgen Inc Vanilloid receptor ligands and their use in treatments
JP2007522233A (ja) 2004-02-11 2007-08-09 アムジエン・インコーポレーテツド バニロイド受容体リガンド及び治療におけるそれらの使用
TW200530236A (en) 2004-02-23 2005-09-16 Chugai Pharmaceutical Co Ltd Heteroaryl phenylurea
EP1719763A4 (fr) * 2004-02-27 2008-01-09 Eisai R&D Man Co Ltd Nouveau derivade la pyridine et derivade la pyrimidine (2)
DE102004017438A1 (de) * 2004-04-08 2005-11-03 Bayer Healthcare Ag Hetaryloxy-substituierte Phenylaminopyrimidine
US7459562B2 (en) 2004-04-23 2008-12-02 Bristol-Myers Squibb Company Monocyclic heterocycles as kinase inhibitors
TW200538453A (en) 2004-04-26 2005-12-01 Bristol Myers Squibb Co Bicyclic heterocycles as kinase inhibitors
CN101010315A (zh) 2004-04-30 2007-08-01 拜耳制药公司 用于治疗癌症的取代的吡唑基脲衍生物
PT1746999E (pt) * 2004-05-06 2012-01-11 Warner Lambert Co 4-fenilamino-quinazolin-6-il-amidas
WO2005113494A2 (fr) 2004-05-07 2005-12-01 Amgen Inc. Modulateurs de proteines kinases et procede d'utilisation
WO2005121125A1 (fr) * 2004-06-09 2005-12-22 Pfizer Inc. Composes heteroaryle a liaison ether
US7173031B2 (en) * 2004-06-28 2007-02-06 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
US7432373B2 (en) 2004-06-28 2008-10-07 Bristol-Meyers Squibb Company Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors
US7439246B2 (en) 2004-06-28 2008-10-21 Bristol-Myers Squibb Company Fused heterocyclic kinase inhibitors
CA2572331A1 (fr) * 2004-07-02 2006-02-09 Exelixis, Inc. Modulateurs de c-met et leur methode d'utilisation
US7507748B2 (en) * 2004-07-22 2009-03-24 Amgen Inc. Substituted aryl-amine derivatives and methods of use
KR101257343B1 (ko) * 2004-07-30 2013-04-23 메틸진 인코포레이티드 Ｖｅｇｆ 수용체 및 ｈｇｆ 수용체 신호전달 억제제
US8772269B2 (en) 2004-09-13 2014-07-08 Eisai R&D Management Co., Ltd. Use of sulfonamide-including compounds in combination with angiogenesis inhibitors
WO2006030941A1 (fr) 2004-09-13 2006-03-23 Eisai R & D Management Co., Ltd. Utilisation concomitante d'un compose contenant du sulfonamide et d'un inhibiteur d'angiogenese
PE20060664A1 (es) 2004-09-15 2006-08-04 Novartis Ag Amidas biciclicas como inhibidores de cinasa
KR20070053205A (ko) * 2004-09-17 2007-05-23 에자이 알앤드디 매니지먼트 가부시키가이샤 의약 조성물
GB0421525D0 (en) * 2004-09-28 2004-10-27 Novartis Ag Inhibitors of protein kineses
US20070054916A1 (en) * 2004-10-01 2007-03-08 Amgen Inc. Aryl nitrogen-containing bicyclic compounds and methods of use
WO2006049304A1 (fr) 2004-11-02 2006-05-11 Banyu Pharmaceutical Co., Ltd Dérivés de benzimidazole aryloxy-substitués
EP1827434B1 (fr) 2004-11-30 2014-01-15 Amgen Inc. Heterocycles substitues et leurs procedes d'utilisation
US8258145B2 (en) 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
CA2592900A1 (fr) 2005-01-03 2006-07-13 Myriad Genetics Inc. Composes et utilisation therapeutique associee
CN101142218B (zh) * 2005-02-03 2013-02-06 沃泰克斯药物股份有限公司 可用作蛋白激酶抑制剂的吡咯并嘧啶
US7301022B2 (en) 2005-02-15 2007-11-27 Amgen Inc. Vanilloid receptor ligands and their use in treatments
JO2787B1 (en) 2005-04-27 2014-03-15 امجين إنك, Alternative amide derivatives and methods of use
EP2354139A1 (fr) 2005-05-20 2011-08-10 Vertex Pharmaceuticals Incorporated Pyrrolopyridines en tant qu'inhibiteurs de kinase
JP5148499B2 (ja) * 2005-05-20 2013-02-20 メチルジーン インコーポレイテッド Ｖｅｇｆ受容体およびｈｇｆ受容体シグナル伝達の阻害剤
US7550483B2 (en) 2005-06-23 2009-06-23 Eisai R&D Management Co., Ltd. Amorphous salt of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide and process for preparing the same
AU2006260148B9 (en) * 2005-06-23 2009-09-17 Eisai R&D Managment Co., Ltd. Amorphous salt of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)- 7-methoxy-6-quinolinecarboxamide and process for producing the same
AU2006265835B2 (en) * 2005-06-30 2012-05-03 Amgen Inc. Bis-aryl kinase inhibitors and their use in the treatment of inflammation, angiogenesis and cancer
TW200740820A (en) * 2005-07-05 2007-11-01 Takeda Pharmaceuticals Co Fused heterocyclic derivatives and use thereof
EP1905769B1 (fr) 2005-07-13 2017-03-29 Msd K.K. Dérivé du benzimidazole à substitution par un hétérocycle
WO2007015569A1 (fr) 2005-08-01 2007-02-08 Eisai R & D Management Co., Ltd. Procédé de prédiction de l’efficacité d’un inhibiteur de vascularisation
EP1925676A4 (fr) 2005-08-02 2010-11-10 Eisai R&D Man Co Ltd Procédé d'analyse de l' effet d 'un inhibiteur de vascularisation
EP1921078B1 (fr) * 2005-08-05 2013-01-09 Chugai Seiyaku Kabushiki Kaisha Inhibiteur de multikinase
JP5305905B2 (ja) * 2005-08-08 2013-10-02 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ チアゾロピリミジンキナーゼ阻害剤
EP1889836B1 (fr) 2005-08-24 2013-06-12 Eisai R&D Management Co., Ltd. Nouveau dérivé pyridine et dérivé pyrimidine (3)
CN102716490A (zh) * 2005-09-01 2012-10-10 卫材R&D管理有限公司 药物组合物的崩解性的改善方法
GT200600411A (es) * 2005-09-13 2007-05-21 Novartis Ag Combinaciones que comprenden un inhibidor del receptor del factor de crecimiento endotelial vascular
AU2006295645B2 (en) 2005-09-30 2011-09-29 Msd K.K. 2-heteroaryl-substituted indole derivative
ATE444294T1 (de) * 2005-10-28 2009-10-15 Irm Llc Verbindungen und zusammensetzungen als proteinkinaseinhibitoren
AU2006309551B2 (en) * 2005-11-07 2012-04-19 Eisai R & D Management Co., Ltd. Use of combination of anti-angiogenic substance and c-kit kinase inhibitor
WO2007061130A1 (fr) * 2005-11-22 2007-05-31 Eisai R & D Management Co., Ltd. Agent antitumeur pour myelomes multiples
TW201018662A (en) * 2005-12-12 2010-05-16 Astrazeneca Ab Alkylsulphonamide quinolines
CA2634047C (fr) * 2005-12-21 2016-04-12 Novartis Ag Derives pyrimidinyl-aryluree constituant des inhibiteurs des facteurs de croissance des fibroblastes (fgf)
JP5331485B2 (ja) * 2005-12-21 2013-10-30 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 癌および他の障害の処置に有用な置換ピリミジン誘導体
TW200804349A (en) * 2005-12-23 2008-01-16 Kalypsys Inc Novel substituted pyrimidinyloxy ureas as inhibitors of protein kinases
US7868177B2 (en) 2006-02-24 2011-01-11 Amgen Inc. Multi-cyclic compounds and method of use
EP1991531A1 (fr) * 2006-02-28 2008-11-19 Amgen Inc. Cinnoline et derives de quinoxaline en tant qu'inhibiteurs de phosphodiesterase 10
UY30183A1 (es) * 2006-03-02 2007-10-31 Astrazeneca Ab Derivados de quinolina
GB0604937D0 (en) * 2006-03-10 2006-04-19 Novartis Ag Organic compounds
GB0605120D0 (en) 2006-03-14 2006-04-26 Novartis Ag Organic Compounds
PE20080145A1 (es) 2006-03-21 2008-02-11 Janssen Pharmaceutica Nv Tetrahidro-pirimidoazepinas como moduladores de trpv1
US7692024B2 (en) * 2006-05-05 2010-04-06 Tk Holdings, Inc. Gas generant compositions
EP2021319A2 (fr) 2006-05-05 2009-02-11 TK Holdings Inc. Compositions génératrices de gaz
EP2036557B1 (fr) * 2006-05-18 2015-10-21 Eisai R&D Management Co., Ltd. Agent antitumoral destiné au cancer de la thyroïde
US20080004273A1 (en) * 2006-05-30 2008-01-03 Stephane Raeppel Inhibitors of protein tyrosine kinase activity
JPWO2008001956A1 (ja) * 2006-06-29 2009-12-03 エーザイ・アール・アンド・ディー・マネジメント株式会社 肝線維症治療剤
EP2044086A2 (fr) * 2006-06-30 2009-04-08 Janssen Pharmaceutica N.V. Modulateurs de trpv1 à base de thiazolopyrimidine
CL2007002261A1 (es) 2006-08-04 2008-05-02 Takeda Pharmaceutical Compuestos derivados de imidazo[1,2-b]piridazina, inhibidores de quinasa; composicion farmaceutica; y uso en el tratamiento o prevencion del cancer.
AU2007288793B2 (en) 2006-08-23 2012-04-19 Eisai R & D Management Co., Ltd. Salt of phenoxypyridine derivative or crystal thereof and process for producing the same
WO2008026748A1 (fr) 2006-08-28 2008-03-06 Eisai R & D Management Co., Ltd. Agent antitumoral pour cancer gastrique non différencié
US7790885B2 (en) * 2006-08-31 2010-09-07 Eisai R&D Management Co., Ltd. Process for preparing phenoxypyridine derivatives
KR101432318B1 (ko) 2006-08-31 2014-08-20 에자이 알앤드디 매니지먼트 가부시키가이샤 페녹시피리딘 유도체의 제조 방법
US8002915B2 (en) * 2006-09-30 2011-08-23 Tk Holdings, Inc. Gas generant compositions
EP2077262A4 (fr) 2006-10-23 2011-12-28 Takeda Pharmaceutical Dérivé de l'iminopyridine et son utilisation
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
MX2009006543A (es) 2006-12-20 2009-06-26 Amgen Inc Compuestos heterociclicos y su uso en el tratamiento de la inflamacion, angiogenesis y cancer.
ATE485280T1 (de) * 2006-12-22 2010-11-15 Hoffmann La Roche Pyrimidylderivate als proteinkinaseinhibitoren
AU2007340129B2 (en) * 2006-12-26 2012-02-02 Pharmacyclics Llc Method of using histone deacetylase inhibitors and monitoring biomarkers in combination therapy
US20100048503A1 (en) * 2007-01-19 2010-02-25 Eisai R & D Management Co., Ltd. Composition for treatment of pancreatic cancer
US8962655B2 (en) 2007-01-29 2015-02-24 Eisai R&D Management Co., Ltd. Composition for treatment of undifferentiated gastric cancer
WO2008095050A1 (fr) * 2007-01-30 2008-08-07 Pharmacyclics, Inc. Procédés permettant de déterminer la résistance du cancer aux inhibiteurs de l'histone déacétylase
AU2008215490A1 (en) * 2007-02-09 2008-08-21 Takeda Pharmaceutical Company Limited Fused ring compounds as partial agonists of PPAR-gamma
US8148532B2 (en) 2007-03-14 2012-04-03 Guoqing Paul Chen Spiro substituted compounds as angiogenesis inhibitors
US20110189167A1 (en) * 2007-04-20 2011-08-04 Flynn Daniel L Methods and Compositions for the Treatment of Myeloproliferative Diseases and other Proliferative Diseases
US8143293B2 (en) * 2007-04-20 2012-03-27 Deciphera Pharmaceuticals, Llc Kinase inhibitors useful for the treatment of myleoprolific diseases and other proliferative diseases
US20110160305A1 (en) * 2007-05-01 2011-06-30 Marty Jones Oral Delivery of Therapeutic Doses of Glutathione
AR066845A1 (es) 2007-06-05 2009-09-16 Takeda Pharmaceutical Derivados de triazolopiridina e imidazopiridina una composicion farmaceutica que los comprende y su uso en la preparacion de un medicamento para el tratamiento del cancer
US8324395B2 (en) * 2007-08-23 2012-12-04 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
CN105777776B (zh) 2007-08-29 2021-06-08 梅特希尔基因公司 蛋白酪氨酸激酶活性的抑制剂
WO2009035949A2 (fr) * 2007-09-13 2009-03-19 Arete Therapeutics, Inc. Inhibiteurs de l'époxyde hydrolase soluble
KR101546111B1 (ko) 2007-10-11 2015-08-20 글락소스미스클라인 엘엘씨 신규한 ｓＥＨ 억제제 및 그의 용도
AU2008319366B2 (en) * 2007-10-29 2012-03-01 Amgen Inc. Benzomorpholine derivatives and methods of use
TWI440638B (zh) * 2007-10-30 2014-06-11 Otsuka Pharma Co Ltd 雜環化合物及其藥學組成物
AU2008325608B2 (en) 2007-11-09 2013-03-14 Eisai R & D Management Co., Ltd. Combination of anti-angiogenic substance and anti-tumor platinum complex
ES2552733T3 (es) 2007-11-16 2015-12-01 Rigel Pharmaceuticals, Inc. Compuestos de carboxamida, sulfonamida y amina para trastornos metabólicos
WO2009064938A1 (fr) * 2007-11-16 2009-05-22 Abbott Laboratories Procédé de traitement de l'arthrite
JP2009132660A (ja) 2007-11-30 2009-06-18 Eisai R & D Management Co Ltd 食道癌治療用組成物
JP5650540B2 (ja) 2007-12-12 2015-01-07 ライジェル ファーマシューティカルズ， インコーポレイテッド 代謝障害のためのカルボキサミド、スルホンアミド、およびアミン化合物
CL2008003749A1 (es) 2007-12-17 2010-01-15 Janssen Pharmaceutica Nv Compuestos derivados de imidazol, oxazol, y tiazol pirimidina, moduladores de trpv1, proceso de preparacion, composicion farmaceutica y su uso en el tratamiento de enfermedades, trastornos o condicion de dolor, prurito, artritis, tos, asma, trastorno del oido interno y enfermedad inflamatoria intestinal, entre otras.
ES2437595T3 (es) 2007-12-20 2014-01-13 Novartis Ag Derivados de tiazol usados como inhibidores de la PI 3 quinasa
KR101608096B1 (ko) 2008-01-23 2016-03-31 브리스톨-마이어스 스큅 컴퍼니 ４-피리디논 화합물 및 암을 위한 그의 용도
EP2248804A4 (fr) * 2008-01-29 2014-09-10 Eisai R&D Man Co Ltd Utilisation combinée d'un inhibiteur de l'angiogenèse et d'un taxane
US20090227556A1 (en) * 2008-01-31 2009-09-10 Eisai R&D Management Co., Ltd. Receptor tyrosine kinase inhibitors comprising pyridine and pyrimidine derivatives
EP2248810A4 (fr) * 2008-02-18 2011-05-25 Eisai R&D Man Co Ltd Procédé de fabrication d'un dérivé de phénoxypyridine
NZ589336A (en) * 2008-03-05 2011-12-22 Methylgene Inc Pyridine derivatives as inhibitors of protein tyrosine kinase activity
PL2268623T3 (pl) * 2008-03-17 2015-10-30 Ambit Biosciences Corp Pochodne chinazoliny jako modulatory kinazy RAF oraz sposoby ich zastosowania
BRPI0911679B8 (pt) * 2008-04-10 2021-05-25 Taiho Pharmaceutical Co Ltd composto aciltioureia ou um sal do mesmo, uso do dito composto para tratar câncer, bem como agente farmacêutico, agente antitumoral e composição farmacêutica compreendendo dito composto
MX2010011450A (es) 2008-04-21 2010-11-10 Lexicon Pharmaceuticals Inc Inhibidores del limk2, composiciones que los comprenden y metodos para su uso.
US8314107B2 (en) 2008-04-23 2012-11-20 Rigel Pharmaceuticals, Inc. Carboxamide compounds and methods for using the same
US8481569B2 (en) 2008-04-23 2013-07-09 Takeda Pharmaceutical Company Limited Iminopyridine derivatives and use thereof
US20110039892A1 (en) * 2008-04-23 2011-02-17 Takeda Pharmaceutical Company Limited Iminopyridine derivative and use thereof
MX2010011652A (es) * 2008-04-23 2010-12-06 Takeda Pharmaceutical Derivados de iminopiridina y uso de los mismos.
DK2276346T3 (en) * 2008-04-30 2017-02-27 Nat Health Research Institutes FUSED BICYCLIC PYRIMIDINE COMPOUNDS AS AURORAKINASE INHIBITORS
ES2548134T3 (es) 2008-05-05 2015-10-14 Actelion Pharmaceuticals Ltd. Derivados de piperidina 3,4-sustituida como inhibidores de renina
WO2009151910A2 (fr) * 2008-05-25 2009-12-17 Wyeth Produit de combinaison d'un inhibiteur de tyrosine kinase de récepteur et d'un inhibiteur d'acide gras synthase pour le traitement du cancer
EA201100126A1 (ru) * 2008-07-03 2011-08-30 Мерк Патент Гмбх Нафтиридиноны в качестве ингибиторов протеинкиназ
US8211911B2 (en) 2008-08-19 2012-07-03 Guoqing Paul Chen Compounds as kinase inhibitors
PT2384326E (pt) 2008-08-20 2014-06-09 Zoetis Llc Compostos de pirrolo[2,3-d]pirimidina
UA104147C2 (uk) 2008-09-10 2014-01-10 Новартис Аг Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань
EP2331530B8 (fr) 2008-09-26 2013-12-25 National Health Research Institutes Composés multicycliques fusionnés en tant qu inhibiteurs des protéines kinases
RU2011119478A (ru) * 2008-10-14 2012-11-27 Нин Си Соединения и способы применения
WO2010064611A1 (fr) 2008-12-01 2010-06-10 武田薬品工業株式会社 Composé hétérocyclique et applications
JO3101B1 (ar) 2008-12-02 2017-09-20 Takeda Pharmaceuticals Co مشتقات بنزوثيازول كعوامل مضادة للسرطان
JO3265B1 (ar) 2008-12-09 2018-09-16 Novartis Ag مثبطات بيريديلوكسى اندولات vegf-r2 واستخدامها لعلاج المرض
TWI447108B (zh) 2009-01-16 2014-08-01 Exelixis Inc Ｎ－（４－｛〔６，７雙（甲氧基）喹啉－４－基〕氧基｝苯基）－ｎ’－（４－氟苯基）環丙烷－１，１－二甲醯胺之蘋果酸鹽及其結晶型
AU2010229147B2 (en) * 2009-03-21 2012-07-05 Sunshine Lake Pharma Co., Ltd. Amino ester derivatives, salts thereof and methods of use
WO2010108503A1 (fr) 2009-03-24 2010-09-30 Life & Brain Gmbh Promotion de l'intégration neuronale dans des greffons de cellules souches neurales
US8603521B2 (en) 2009-04-17 2013-12-10 Pharmacyclics, Inc. Formulations of histone deacetylase inhibitor and uses thereof
CN101671301B (zh) * 2009-05-05 2014-02-26 江苏省药物研究所有限公司 杂环取代的二苯脲类衍生物及其用途
US8293753B2 (en) 2009-07-02 2012-10-23 Novartis Ag Substituted 2-carboxamide cycloamino ureas
US20110112121A1 (en) * 2009-07-06 2011-05-12 Joerg Berghausen Pharmaceutical Compositions and Solid Forms
UA108618C2 (uk) 2009-08-07 2015-05-25 Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку
US20120077842A1 (en) * 2009-08-19 2012-03-29 Eisai R&D Management Co., Ltd. Quinoline derivative-containing pharmaceutical composition
RU2012109233A (ru) * 2009-09-03 2013-10-10 Аллерган, Инк. Соединения как модуляторы тирозинкиназы
US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
KR20130056244A (ko) 2010-04-22 2013-05-29 버텍스 파마슈티칼스 인코포레이티드 시클로알킬카르복스아미도-인돌 화합물의 제조 방법
ES2573515T3 (es) 2010-06-25 2016-06-08 Eisai R&D Management Co., Ltd. Agente antitumoral que emplea compuestos con efecto inhibitorio de cinasas combinados
US20130225581A1 (en) 2010-07-16 2013-08-29 Kyowa Hakko Kirin Co., Ltd Nitrogen-containing aromatic heterocyclic derivative
KR101032732B1 (ko) * 2010-07-29 2011-05-06 김선자 방범 창호프레임
EP2423208A1 (fr) * 2010-08-28 2012-02-29 Lead Discovery Center GmbH Composants actifs pharmaceutiquement en tant qu'inhibiteurs Axl
CA2826773C (fr) * 2011-02-24 2019-07-16 Emory University Compositions antagonistes de jab1 pour ossification et procedes associes a celles-ci
RU2580609C2 (ru) * 2011-04-18 2016-04-10 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Противоопухолевое терапевтическое средство
ES2705950T3 (es) 2011-06-03 2019-03-27 Eisai R&D Man Co Ltd Biomarcadores para predecir y valorar la capacidad de respuesta de sujetos con cáncer de tiroides y de riñón a compuestos de lenvatinib
SG194219A1 (en) 2011-06-10 2013-11-29 Merck Patent Gmbh Compositions and methods for the production of pyrimidine and pyridine compounds with btk inhibitory activity
RU2609833C2 (ru) 2011-09-13 2017-02-06 Фармасайкликс Элэлси Лекарственные формы ингибитора гистондиацетилазы в комбинации с бендамутином и их применение
WO2013048949A2 (fr) * 2011-09-26 2013-04-04 Bristol-Myers Squibb Company Antagonistes du nr2b sélectifs
TWI594986B (zh) * 2011-12-28 2017-08-11 Taiho Pharmaceutical Co Ltd Antineoplastic agent effect enhancer
CN103508961B (zh) * 2012-06-26 2015-07-22 中美冠科生物技术（太仓）有限公司 抗肿瘤药物
CN104602690A (zh) * 2012-08-29 2015-05-06 默克专利股份有限公司 用于治疗骨关节炎的ddr2抑制剂
EP2937337A4 (fr) * 2012-12-21 2016-06-22 Eisai R&D Man Co Ltd Forme amorphe de dérivé de quinoline et son procédé de production
AR094812A1 (es) 2013-02-20 2015-08-26 Eisai R&D Man Co Ltd Derivado de piridina monocíclico como inhibidor del fgfr
AU2014255512A1 (en) 2013-04-19 2015-11-12 Astrazeneca Ab A NK3 receptor antagonist compound (NK3RA) for use in a method for the treatment of polycystic ovary syndrome (PCOS)
NZ714049A (en) * 2013-05-14 2020-05-29 Eisai R&D Man Co Ltd Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds
BR112015029386B1 (pt) 2013-06-26 2023-11-14 Eisai R&D Management Co., Ltd. Uso de eribulina e lenvatinibe como terapia de combinação e kit
JP6800750B2 (ja) 2013-08-02 2020-12-16 ファーマサイクリックス エルエルシー 固形腫瘍の処置方法
CN103509005B (zh) * 2013-09-26 2015-04-08 苏州海特比奥生物技术有限公司 喹唑啉类化合物及其制备方法与应用
RS58597B1 (sr) * 2014-04-04 2019-05-31 Pfizer Biciklično-spojena heteroaril ili aril jedinjenja i njihova upotreba kao irak4 inhibitora
PL3925607T3 (pl) 2014-04-15 2023-10-30 Vertex Pharmaceuticals Incorporated Kompozycje farmaceutyczne do leczenia chorób, w których pośredniczy mukowiscydozowy przezbłonowy regulator przewodnictwa
CN106660997B (zh) 2014-08-18 2019-05-21 卫材R&D管理有限公司 单环吡啶衍生物的盐及其晶体
TWI721954B (zh) * 2014-08-28 2021-03-21 日商衛材R&D企管股份有限公司 高純度喹啉衍生物及其生產方法
MA40774A (fr) * 2014-10-01 2017-08-08 Respivert Ltd Dérivés de diaryle-urée en tant qu'inhibiteurs de kinase p38
CN105985289B (zh) * 2015-02-15 2018-12-21 正大天晴药业集团股份有限公司 一种乐伐替尼的制备方法
RU2017128583A (ru) 2015-02-25 2019-03-25 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Способ ослабления горечи хинолинового производного
CA2978226A1 (fr) 2015-03-04 2016-09-09 Merck Sharpe & Dohme Corp. Association d'un antagoniste de pd-1 et d'un inhibiteur des tyrosines kinases vegfr/fgfr/ret pour traiter le cancer
EP3293177A4 (fr) * 2015-04-07 2018-12-12 Guangdong Zhongsheng Pharmaceutical Co., Ltd Inhibiteur de la tyrosine kinase et composition pharmaceutique le comprenant
AU2016279474B2 (en) 2015-06-16 2021-09-09 Eisai R&D Management Co., Ltd. Anticancer agent
CA2994925C (fr) 2015-08-20 2023-08-29 Eisai R&D Management Co., Ltd. Agent therapeutique pour tumeur
SI3341367T1 (sl) * 2015-08-27 2021-05-31 Pfizer Inc. Biciklične kondenzirane heteroarilne ali arilne sestavine kot modulatorji IRAK-4
CN107266363A (zh) * 2016-04-06 2017-10-20 杭州华东医药集团新药研究院有限公司 甲磺酸乐伐替尼药物杂质的制备方法
CZ2016240A3 (cs) 2016-04-27 2017-11-08 Zentiva, K.S. Soli lenvatinibu
KR20230109185A (ko) 2016-06-07 2023-07-19 자코바이오 파마슈티칼스 컴퍼니 리미티드 Shp2 억제제로서 유용한 신규한 헤테로환형 유도체
CN106243124B (zh) * 2016-07-29 2018-03-09 湖北民族学院 一种噻吩并嘧啶脲类化合物及其制备方法和应用
US9957233B1 (en) 2016-08-05 2018-05-01 Calitor Sciences, Llc Process for preparing substituted quinolin-4-ol compounds
WO2018028591A1 (fr) * 2016-08-09 2018-02-15 殷建明 Dérivé de quinoléine et son utilisation
TWI603962B (zh) 2016-09-10 2017-11-01 國立清華大學 含硫噁嗪化合物及其合成方法
EP3521276B1 (fr) * 2016-09-30 2021-03-10 Guangdong Raynovent Biotech Co., Ltd. Forme cristalline, forme de sel, et procédé de préparation d'inhibiteur de tyrosine kinase
CN106854180B (zh) * 2016-11-30 2018-08-31 济南轩德化工有限公司 一种4-氯-7-甲氧基喹啉-6-酰胺的制备方法
EP3548007A4 (fr) 2016-12-01 2020-08-12 Ignyta, Inc. Méthodes de traitement du cancer
BR112019013581A2 (pt) * 2016-12-29 2020-01-07 Dr. Reddy’S Laboratories Limited Formas no estado sólido de mesilato de lenvatinibe
CN108299294A (zh) * 2017-01-11 2018-07-20 江苏恒瑞医药股份有限公司 一种乐伐替尼杂质的制备方法
CN106810512B (zh) * 2017-01-18 2019-09-10 江苏省中医药研究院 Idh2突变体抑制剂及其用途
US10800741B2 (en) 2017-02-07 2020-10-13 Ancureall Pharmaceutical (Shanghai) Co., Ltd. Quinoline compound, preparation method and medical use therefor
BR112019014127A2 (pt) 2017-02-08 2020-02-11 Eisai R&D Management Co., Ltd. Composição farmacêutica para tratamento de tumores
CN110312511B (zh) 2017-02-15 2023-10-27 大鹏药品工业株式会社 医药组合物
WO2018157411A1 (fr) * 2017-02-28 2018-09-07 深圳市塔吉瑞生物医药有限公司 Composé aromatique contenant de l'azote substitué et application de celui-ci
JP6878615B2 (ja) 2017-03-23 2021-05-26 ジャコバイオ ファーマスーティカルズ カンパニー リミテッドＪａｃｏｂｉｏ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｃｏ．， Ｌｔｄ． Ｓｈｐ２阻害剤として有用な新規な複素環式誘導体
CN107115344B (zh) * 2017-03-23 2019-06-14 广东众生睿创生物科技有限公司 酪氨酸激酶抑制剂在制备用于预防和/或治疗纤维化疾病的药物中的用途
EP3384901A1 (fr) 2017-04-04 2018-10-10 Synthon B.V. Composition pharmaceutique contenant du lenvatinib mesylate
CA3064975A1 (fr) * 2017-05-26 2018-11-29 Glenmark Pharmaceuticals S.A. Nouveaux inhibiteurs de map4k1
CN107513057A (zh) * 2017-09-06 2017-12-26 南京医科大学 一类乐伐替尼的乏氧活化前药及其应用
ES2932805T3 (es) 2017-09-28 2023-01-26 Chongqing Pharmaceutical Industrial Res Institute Co Ltd Derivado de quinolina y aplicación del mismo como inhibidor de la tirosina quinasa
CN107739335A (zh) * 2017-12-01 2018-02-27 南京奇可药业有限公司 一种乐伐替尼的合成方法
MA51285A (fr) * 2017-12-18 2021-04-28 Chiesi Farm Spa Dérivés d'azaindole comme inhibiteurs de rho-kinase
AU2017444054B2 (en) * 2017-12-21 2021-10-07 Hefei Institutes Of Physical Science, Chinese Academy Of Sciences Class of pyrimidine derivative kinase inhibitors
BR112020014112A2 (pt) 2018-01-10 2020-12-01 Eisai R&D Management Co., Ltd. terapias de combinação para o tratamento de carcinoma hepatocelular
CN117603138A (zh) * 2018-01-26 2024-02-27 埃克塞里艾克西斯公司 用于治疗激酶依赖性病症的化合物
CN111936487A (zh) 2018-01-26 2020-11-13 埃克塞里艾克西斯公司 用于治疗激酶依赖性病症的化合物
US10583133B2 (en) 2018-03-12 2020-03-10 Shilpa Medicare Limited Pharmaceutical compositions of lenvatinib
CN108623521B (zh) * 2018-03-22 2020-09-04 盐城师范学院 一种乐伐替尼的制备方法
MX2020008610A (es) 2018-03-28 2020-09-21 Eisai R&D Man Co Ltd Agente terapeutico para carcinoma hepatocelular.
EP3793557A1 (fr) 2018-05-14 2021-03-24 Merck Sharp & Dohme Corp. Biomarqueurs pour polythérapie comprenant du lenvatinib et un antagoniste de pd-1
CN110483482A (zh) 2018-05-15 2019-11-22 北京诺诚健华医药科技有限公司 吲哚啉-1-甲酰胺类化合物、其制备方法及其在医药学上的应用
CN110590839B (zh) * 2018-06-13 2022-04-05 四川海思科制药有限公司 一种乐伐替尼衍生物及制备方法和用途
CN108570044A (zh) * 2018-07-02 2018-09-25 秦继伟 一种酰胺类化合物及其合成方法和治疗癌症的用途
CN108690013A (zh) * 2018-07-02 2018-10-23 秦继伟 苯并[d]噻唑衍生物及其作为EGFR抑制剂在癌症治疗中的应用
CN110845408A (zh) * 2018-08-20 2020-02-28 润佳（苏州）医药科技有限公司 同位素富集的乐伐替尼
SI3620452T1 (sl) 2018-09-07 2021-08-31 Indena S.P.A. Postopek za pripravo lenvatiniba
AU2019346550A1 (en) 2018-09-25 2021-04-22 Black Diamond Therapeutics, Inc. Quinazoline derivatives as tyrosine kinase inhibitor, compositions, methods of making them and their use
WO2020070144A1 (fr) 2018-10-04 2020-04-09 Synthon B.V. Formes cristallines et procédés de lenvatinib besylate
ES2922903T3 (es) 2018-10-04 2022-09-21 Synthon Bv Composición farmacéutica que comprende sales de lenvatinib
WO2020071457A1 (fr) 2018-10-05 2020-04-09 Eisai R&D Management Co., Ltd. Biomarqueurs pour une polythérapie comprenant du lenvatinib et de l'évérolimus
US20210333281A1 (en) 2018-10-05 2021-10-28 Eisai R&D Management Co., Ltd. Biomarkers for a therapy comprising a sorafenib compound
CN111116468A (zh) * 2018-10-31 2020-05-08 正大天晴药业集团股份有限公司 用于治疗胰腺癌的喹啉类化合物或其药学上可接受的盐
EP3903828A4 (fr) 2018-12-21 2022-10-05 Daiichi Sankyo Company, Limited Combinaison d'un conjugué anticorps-médicament et d'un inhibiteur de kinase
JP2020100598A (ja) 2018-12-25 2020-07-02 公益財団法人応用生化学研究所 レンバチニブ誘導体、並びにそれを用いた医薬研究用組成物及び腫瘍治療剤
IL299831A (en) 2019-03-19 2023-03-01 Voronoi Inc The heteroaryl derivative, a method for its production and a pharmaceutical preparation containing it as an effective ingredient
KR20210144767A (ko) 2019-04-01 2021-11-30 치오메 바이오사이언스 가부시키가이샤 암 치료용 의약
MX2021012124A (es) * 2019-04-03 2021-12-10 Primegene Beijing Co Ltd Compuestos que contienen quinolilo y composicion farmaceutica, y uso de los mismos.
CN114144410A (zh) 2019-07-19 2022-03-04 阿纳格纳斯生物技术股份有限公司 多芳基脲衍生物及其在治疗肌肉疾病中的用途
CA3146777A1 (fr) 2019-08-02 2021-02-11 CTTQ-Akeso (ShangHai) Biomed. Tech. Co., Ltd. Anticorps anti-pd-1 et utilisation medicale associee
EP4008730A4 (fr) 2019-08-02 2023-09-06 Akeso Pharmaceuticals, Inc. Anticorps anti-ctla4-anti-pd-1 bispécifique et ses utilisations
CN110437223B (zh) * 2019-08-06 2022-11-25 江苏千之康生物医药科技有限公司 乐伐替尼酸的噻唑酮衍生物及其应用
WO2021217537A1 (fr) * 2020-04-30 2021-11-04 天津睿创康泰生物技术有限公司 Forme cristalline de base libre de lenvatinib et son procédé de préparation
WO2021226547A2 (fr) * 2020-05-08 2021-11-11 Halia Therapeutics, Inc. Inhibition ciblée de nek7 pour la modulation de l'inflammasome nlrp3
CN112194623A (zh) * 2020-10-16 2021-01-08 四川伊诺达博医药科技有限公司 一种乐伐替尼衍生物关键中间体的合成方法
EP4276100A1 (fr) * 2020-12-29 2023-11-15 Txinno Bioscience Inc. Nouveau dérivé de naphthyridinone ayant une activité inhibitrice contre l'ectonucléotide pyrophosphatase/phosphodiestérase et son utilisation
EP4029501A1 (fr) 2021-01-19 2022-07-20 Anagenesis Biotechnologies Combinaison de dérivés polyaromatiques de l'urée et d'inhibiteur glucocorticoïde ou hdac pour le traitement de maladies ou d'affections associées aux cellules musculaires et/ou aux cellules satellites
WO2022226182A1 (fr) * 2021-04-22 2022-10-27 Halia Therapeutics, Inc. Inhibiteurs de nek7
CN113372270A (zh) * 2021-06-24 2021-09-10 江西国药有限责任公司 一种仑伐替尼及其制备方法
CN113582924A (zh) * 2021-09-09 2021-11-02 四川国康药业有限公司 一种多靶点酪氨酸激酶抑制剂及其制备方法和用途
EP4147689A1 (fr) 2021-09-13 2023-03-15 Lotus Pharmaceutical Co., Ltd. Formulation de lenvatinib
CA3237696A1 (fr) 2021-11-08 2023-05-11 Progentos Therapeutics, Inc. Inhibiteurs du recepteur du facteur de croissance derive des plaquettes (pdgfr) alpha et leurs utilisations
CN115124534B (zh) * 2021-11-23 2023-09-15 中山大学 非核苷酸类prmt5小分子抑制剂、制备方法及用途
WO2023225300A2 (fr) * 2022-05-20 2023-11-23 Emory University Composés et compositions pharmaceutiques utiles pour la prise en charge de la drépanocytose et d'états pathologiques associés
WO2023228095A1 (fr) 2022-05-24 2023-11-30 Daiichi Sankyo Company, Limited Schéma posologique d'un conjugué anticorps anti-cdh6-médicament
EP4289427A1 (fr) * 2022-06-10 2023-12-13 Anagenesis Biotechnologies Dihydro[1,8]naphthyridin-7-one et pyrido[3,2-b][1,4]oxazin-3-one pour une utilisation dans le traitement du cancer, et des métastases en particulier.

Family Cites Families (193)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US189629A (en) * 1877-04-17 Improvement in adjustable elastic buckets for chain-pumps
CU22545A1 (es) 1994-11-18 1999-03-31 Centro Inmunologia Molecular Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
DE3587022T2 (de) 1984-02-17 1993-06-17 Genentech Inc Menschlicher transformationswachstumsfaktor und vorlaeufer oder fragment hiervon, zellen, dna, vektoren und verfahren zu ihrer herstellung, zusammensetzungen und produkte, die diese enthalten, sowie davon abgeleitete antikoerper und diagnostizierverfahren.
US4716102A (en) * 1984-08-15 1987-12-29 Regents Of The University Of California Purified AIDS-associated virus ARV-2
DE3587500T2 (de) * 1984-12-04 1993-12-16 Lilly Co Eli Tumorbehandlung bei Säugetieren.
JPS62168137A (ja) * 1985-12-20 1987-07-24 Fuji Photo Film Co Ltd ハロゲン化銀カラ−写真感光材料およびその処理方法
CA1339136C (fr) 1987-07-01 1997-07-29 Sailesh Amilal Varia Forme amorphe de l'aztreonam
AU4128089A (en) 1988-09-15 1990-03-22 Rorer International (Overseas) Inc. Monoclonal antibodies specific to human epidermal growth factor receptor and therapeutic methods employing same
US4983615A (en) 1989-06-28 1991-01-08 Hoechst-Roussel Pharmaceuticals Inc. Heteroarylamino- and heteroaryloxypyridinamine compounds which are useful in treating skin disorders
JPH0340486A (ja) 1989-07-07 1991-02-21 Asahi Chem Ind Co Ltd 印刷配線基板
JP2980326B2 (ja) 1989-08-31 1999-11-22 株式会社東芝 ディスク制御装置
US5180818A (en) * 1990-03-21 1993-01-19 The University Of Colorado Foundation, Inc. Site specific cleavage of single-stranded dna
GB9105677D0 (en) 1991-03-19 1991-05-01 Ici Plc Heterocyclic compounds
US5367057A (en) * 1991-04-02 1994-11-22 The Trustees Of Princeton University Tyrosine kinase receptor flk-2 and fragments thereof
WO1992020642A1 (fr) 1991-05-10 1992-11-26 Rhone-Poulenc Rorer International (Holdings) Inc. Composes aryle et heteroaryle bis monocycliques et/ou bicycliques qui inhibent la tyrosine kinase d'un recepteur du egf et/ou du pdgf
US5710158A (en) 1991-05-10 1998-01-20 Rhone-Poulenc Rorer Pharmaceuticals Inc. Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
US5721237A (en) 1991-05-10 1998-02-24 Rhone-Poulenc Rorer Pharmaceuticals Inc. Protein tyrosine kinase aryl and heteroaryl quinazoline compounds having selective inhibition of HER-2 autophosphorylation properties
JPH04341454A (ja) 1991-05-16 1992-11-27 Canon Inc シート収納装置
US5750376A (en) 1991-07-08 1998-05-12 Neurospheres Holdings Ltd. In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny
AU678764B2 (en) 1992-06-03 1997-06-12 Case Western Reserve University Bandage for continuous application of biologicals
GB9221220D0 (en) 1992-10-09 1992-11-25 Sandoz Ag Organic componds
GB9323290D0 (en) 1992-12-10 1994-01-05 Zeneca Ltd Quinazoline derivatives
JPH07176103A (ja) 1993-12-20 1995-07-14 Canon Inc 光磁気記録再生システムならびにこれに用いる磁気ヘッド及び光磁気記録媒体
GB9326136D0 (en) 1993-12-22 1994-02-23 Erba Carlo Spa Biologically active 3-substituted oxindole derivatives useful as anti-angiogenic agents
IL112249A (en) 1994-01-25 2001-11-25 Warner Lambert Co Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
US6811779B2 (en) * 1994-02-10 2004-11-02 Imclone Systems Incorporated Methods for reducing tumor growth with VEGF receptor antibody combined with radiation and chemotherapy
JP3660391B2 (ja) 1994-05-27 2005-06-15 株式会社東芝 半導体装置の製造方法
JPH0848078A (ja) 1994-08-05 1996-02-20 Nippon Paper Ind Co Ltd 感熱記録体
GB9510757D0 (en) 1994-09-19 1995-07-19 Wellcome Found Therapeuticaly active compounds
US5656454A (en) 1994-10-04 1997-08-12 President And Fellows Of Harvard College Endothelial cell-specific enhancer
IL115256A0 (en) * 1994-11-14 1995-12-31 Warner Lambert Co 6-Aryl pyrido (2,3-d) pyrimidines and naphthyridines and their use
GB9424249D0 (en) 1994-12-01 1995-01-18 T & N Technology Ltd Brake pads
JPH08176138A (ja) 1994-12-19 1996-07-09 Mercian Corp イソクマリン誘導体
US5658374A (en) 1995-02-28 1997-08-19 Buckman Laboratories International, Inc. Aqueous lecithin-based release aids and methods of using the same
US5624937A (en) 1995-03-02 1997-04-29 Eli Lilly And Company Chemical compounds as inhibitors of amyloid beta protein production
US6579314B1 (en) 1995-03-10 2003-06-17 C.R. Bard, Inc. Covered stent with encapsulated ends
DE69536015D1 (de) 1995-03-30 2009-12-10 Pfizer Prod Inc Chinazolinone Derivate
GB9508538D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
WO1996040142A1 (fr) 1995-06-07 1996-12-19 Pfizer Inc. Derives de pyrimidine heterocycliques a noyaux condenses
US5880141A (en) * 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
GB9514265D0 (en) 1995-07-13 1995-09-13 Wellcome Found Hetrocyclic compounds
JP3493903B2 (ja) * 1995-09-29 2004-02-03 株式会社デンソー 半導体装置
AR004010A1 (es) 1995-10-11 1998-09-30 Glaxo Group Ltd Compuestos heterociclicos
GB9520822D0 (en) 1995-10-11 1995-12-13 Wellcome Found Therapeutically active compounds
US6346398B1 (en) * 1995-10-26 2002-02-12 Ribozyme Pharmaceuticals, Inc. Method and reagent for the treatment of diseases or conditions related to levels of vascular endothelial growth factor receptor
DE69622183D1 (de) * 1995-11-07 2002-08-08 Kirin Brewery Chinolinderivate und chinazolinderivate welche die autophosphorylierung des von blutplättchen abstammenden wachstumsfaktorrezeptors inhibiren und sie enthaltende pharmazeutische zusammensetzungen
US5849759A (en) 1995-12-08 1998-12-15 Berlex Laboratories, Inc. Naphthyl-substituted benzimidazole derivatives as anti-coagulants
JPH09176103A (ja) 1995-12-28 1997-07-08 Nitto Chem Ind Co Ltd ハロメチルビフェニル誘導体の製造方法
GB9604361D0 (en) 1996-02-29 1996-05-01 Pharmacia Spa 4-Substituted pyrrolopyrimidine compounds as tyrosine kinase inhibitors
ATE269312T1 (de) 1996-04-17 2004-07-15 Bristol Myers Squibb Pharma Co N-(amidinophenyl)-n'-(subst.)-3h-2,4- benzodiazepin-3-on derivative als faktor xa inhibitoren
AU721130B2 (en) 1996-06-28 2000-06-22 Merck & Co., Inc. Fibrinogen receptor antagonists
BR9710362A (pt) 1996-07-13 1999-08-17 Glaxo Group Ltd Composto formula-ao farmaceutica utiliza-ao de um composto processos de tratamento de um ser humano ou animal sofrendo de uma mediada por atividade anormal de cinase de proteina tirosina e para a prepara-ao de um composto
AU3766897A (en) 1996-07-13 1998-02-09 Glaxo Group Limited Fused heterocyclic compounds as protein tyrosine kinase inhibitors
HRP970371A2 (en) 1996-07-13 1998-08-31 Kathryn Jane Smith Heterocyclic compounds
ATE300521T1 (de) 1996-09-25 2005-08-15 Astrazeneca Ab Chinolin-derivate die den effekt von wachstumsfaktoren wie vegf vezögern
CN1072657C (zh) 1996-09-30 2001-10-10 日本农药株式会社 1,2,3－噻二唑衍生物和其盐以及农业园艺病毒防治剂及其使用方法
EP0837063A1 (fr) 1996-10-17 1998-04-22 Pfizer Inc. Dérivés de 4-aminoquinazoline
AU4718997A (en) 1996-11-27 1998-06-22 Pfizer Inc. Fused bicyclic pyrimidine derivatives
EP1014971A4 (fr) 1997-01-29 2000-07-05 Lilly Co Eli Traitement des troubles dysphoriques premenstruels
CO4950519A1 (es) 1997-02-13 2000-09-01 Novartis Ag Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion
ATE345339T1 (de) * 1997-02-19 2006-12-15 Berlex Lab N-heterocyclische derivate als nos inhibitoren
US6090556A (en) 1997-04-07 2000-07-18 Japan Science & Technology Corporation Method for quantitatively determining the expression of a gene
AU7526798A (en) 1997-04-18 1998-11-27 Smithkline Beecham Plc Acetamide and urea derivatives, process for their preparation and their use in the treatment of cns disorders
PT1019040E (pt) 1997-05-23 2005-01-31 Bayer Pharmaceuticals Corp Inibicao da actividade de p38-quinase por meio de arilureias
US6093742A (en) 1997-06-27 2000-07-25 Vertex Pharmaceuticals, Inc. Inhibitors of p38
AU8283898A (en) 1997-06-30 1999-01-25 University Of Maryland At Baltimore Heparin binding-epidermal growth factor in the diagnosis of interstitial cystitis
JP3765918B2 (ja) 1997-11-10 2006-04-12 パイオニア株式会社 発光ディスプレイ及びその駆動方法
JP4194678B2 (ja) * 1997-11-28 2008-12-10 キリンファーマ株式会社 キノリン誘導体およびそれを含む医薬組成物
KR100571588B1 (ko) 1997-12-22 2006-04-17 바이엘 코포레이션 치환 헤테로시클릭 우레아를 이용한 ｒａｆ 키나제의 억제
ATE346600T1 (de) 1997-12-22 2006-12-15 Bayer Pharmaceuticals Corp Inhibierung der p38 kinase-aktivität durch die verwendung von aryl- und heteroarylsubstituierten harnstoffen
CA2315720A1 (fr) 1997-12-22 1999-07-01 Bayer Corporation Inhibition de l'activite de p38 kinase au moyen d'urees heterocycliques substituees
EP1049664B1 (fr) 1997-12-22 2005-03-16 Bayer Pharmaceuticals Corporation Inhibition de raf kinase au moyen de diphenylurees substituees symetriques et asymetriques
GB9800569D0 (en) 1998-01-12 1998-03-11 Glaxo Group Ltd Heterocyclic compounds
GB9800575D0 (en) 1998-01-12 1998-03-11 Glaxo Group Ltd Heterocyclic compounds
EA003876B1 (ru) 1998-02-25 2003-10-30 Дженетикс Инститьют, Ллс Ингибиторы фосфолипазных ферментов
UA60365C2 (uk) 1998-06-04 2003-10-15 Пфайзер Продактс Інк. Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця
NZ512189A (en) 1998-11-19 2003-10-31 Warner Lambert Co N-[4-(3-chloro-4-fluoro-phenylamino)-7-(3-morpholin-4- yl-propoxy)-quinazolin-6-yl]-acrylamide useful as an irreversible inhibitor of tyrosine kinases
EP1140840B1 (fr) 1999-01-13 2006-03-22 Bayer Pharmaceuticals Corp. Diphenylurees a substituants -g(v)-carboxyaryles, inhibitrices de kinase raf
UA73492C2 (en) 1999-01-19 2005-08-15 Aromatic heterocyclic compounds as antiinflammatory agents
PL206627B1 (pl) * 1999-01-22 2010-09-30 Kirin Pharma Kk Pochodna chinazoliny, jej zastosowanie i kompozycja farmaceutyczna
UA71945C2 (en) 1999-01-27 2005-01-17 Pfizer Prod Inc Substituted bicyclic derivatives being used as anticancer agents
JP3270834B2 (ja) 1999-01-27 2002-04-02 ファイザー・プロダクツ・インク 抗がん剤として有用なヘテロ芳香族二環式誘導体
CZ306810B6 (cs) * 1999-02-10 2017-07-19 Astrazeneca Ab Použití chinazolinového derivátu jako inhibitoru angiogeneze
GB9904103D0 (en) 1999-02-24 1999-04-14 Zeneca Ltd Quinoline derivatives
JP2000328080A (ja) 1999-03-12 2000-11-28 Shin Etsu Chem Co Ltd シートベルト用低摩擦化処理剤
RS49836B (sr) * 1999-03-31 2008-08-07 Pfizer Products Inc., Postupci i intermedijeri za dobijanje anti-kancernih jedinjenja
JP4926320B2 (ja) * 1999-04-28 2012-05-09 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム Ｖｅｇｆの選択的阻害による癌処置のための組成物および方法
AU4778500A (en) 1999-05-20 2000-12-12 Takeda Chemical Industries Ltd. Composition containing ascorbic acid salt
JP4304357B2 (ja) 1999-05-24 2009-07-29 独立行政法人理化学研究所 完全長ｃＤＮＡライブラリーの作成法
PE20010306A1 (es) 1999-07-02 2001-03-29 Agouron Pharma Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
US6534535B1 (en) 1999-08-12 2003-03-18 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
AR025752A1 (es) 1999-09-28 2002-12-11 Bayer Corp Piridinas y piridacinas sustituidas con actividad de inhibicion de angiogenesis
UA75054C2 (uk) 1999-10-13 2006-03-15 Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг Заміщені в положенні 6 індолінони, їх одержання та їх застосування як лікарського засобу
JP2001131071A (ja) 1999-10-29 2001-05-15 Meiji Seika Kaisha Ltd 非晶質および非晶質を含有する医薬組成物
US20080241835A1 (en) * 1999-11-01 2008-10-02 Genentech, Inc. Differentially expressed genes involved in angiogenesis, the polypeptides encoded thereby, and methods of using the same
JP2003525595A (ja) 1999-11-01 2003-09-02 キュラゲン コーポレイション 脈管形成に含まれる差動発現遺伝子、それにコードされるポリペプチド、及びそれを用いた方法
ES2292488T3 (es) * 1999-11-16 2008-03-16 Boehringer Ingelheim Pharmaceuticals Inc. Derivados de la urea, como agentes antiinflamatorios.
UA75055C2 (uk) 1999-11-30 2006-03-15 Пфайзер Продактс Інк. Похідні бензоімідазолу, що використовуються як антипроліферативний засіб, фармацевтична композиція на їх основі
PT1255536E (pt) 1999-12-22 2006-09-29 Sugen Inc Derivados de indolinona para a modulacao da tirosina proteina cinase de tipo c-kit
DE60018216T2 (de) * 1999-12-24 2006-02-16 Kyowa Hakko Kogyo Co., Ltd. Kondensierte purinderivate
US7135466B2 (en) * 1999-12-24 2006-11-14 Kirin Beer Kabushiki Kaisha Quinoline and quinazoline derivatives and drugs containing the same
EA005996B1 (ru) * 2000-02-15 2005-08-25 Сьюджен, Инк. Пирролзамещенный 2-индолинон, фармацевтическая композиция (варианты), способ модулирования каталитической активности протеинкиназы, способ лечения или профилактики нарушения в организме, связанного с протеинкиназой
JP2004512023A (ja) 2000-06-09 2004-04-22 コリクサ　コーポレイション 結腸癌の治療および診断のための組成物および方法
WO2002016348A1 (fr) 2000-08-09 2002-02-28 Astrazeneca Ab Derives bicycliques antiangiogeniques
ATE399766T1 (de) 2000-10-20 2008-07-15 Eisai R&D Man Co Ltd Stickstoff enthaltende aromatische heterozyklen
TWI283575B (en) * 2000-10-31 2007-07-11 Eisai Co Ltd Medicinal compositions for concomitant use as anticancer agent
TW558430B (en) * 2000-11-01 2003-10-21 Kao Corp Cleaning device
ATE369894T1 (de) 2000-11-22 2007-09-15 Novartis Pharma Gmbh Kombination enthaltend ein mittel zur verminderung von vegf-aktivität und ein mittel zur verminderung von egf-aktivität
AU2002232439A1 (en) 2000-11-29 2002-06-11 Glaxo Group Limited Benzimidazole derivatives useful as tie-2 and/or vegfr-2 inhibitors
WO2002072578A2 (fr) 2001-03-08 2002-09-19 Millennium Pharmaceuticals Composes de quinoline heterocycliques contenant de l'azote
DE60228699D1 (de) 2001-04-06 2008-10-16 Wyeth Corp Antineoplastische kombinationspräparate enthaltend cci-779 (rapamycin derivat) zusammen mit gemcitabin oder fluoro-uracil
KR100879669B1 (ko) 2001-04-27 2009-01-21 기린 파마 가부시끼가이샤 아졸릴기를 갖는 퀴놀린 유도체 및 퀴나졸린 유도체
JP4477303B2 (ja) 2001-05-16 2010-06-09 ノバルティス アーゲー Ｎ−｛５−［４−（４−メチル−ピペラジノ−メチル）−ベンゾイルアミド］−２−メチルフェニル｝−４−（３−ピリジル）−２−ピリミジン−アミンおよび化学療法剤を含んでなる併用剤
CA2454538A1 (fr) 2001-06-22 2003-01-03 Kirin Beer Kabushiki Kaisha Derives de la quinoleine et de la quinozoline pouvant inhiber l'auto- phosphorylation des recepteurs du facteur de croissance des hepatocytes, et composition pharmaceutique ainsi constituee
GB0117144D0 (en) 2001-07-13 2001-09-05 Glaxo Group Ltd Process
GB0119467D0 (en) * 2001-08-09 2001-10-03 Smithkline Beecham Plc Novel compound
EP2405019A1 (fr) 2001-09-10 2012-01-11 Meso Scale Technologies LLC Procédés, réactifs, kits et appareil pour l'analyse de fonction de protéine
US20040242601A1 (en) 2001-09-20 2004-12-02 Alain Moussy Use of potent, selective and non toxic c-kit inhibitors for treating interstitial cystitis
US6765012B2 (en) 2001-09-27 2004-07-20 Allergan, Inc. 3-(Arylamino)methylene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors
WO2003028711A2 (fr) 2001-09-27 2003-04-10 Novartis Ag Utilisation d'inhibiteurs de c-kit pour traiter un myelome
WO2003030908A2 (fr) * 2001-10-09 2003-04-17 The University Of Cincinnati Methode de traitement du cancer thyroidien
US7495104B2 (en) * 2001-10-17 2009-02-24 Kirin Beer Kabushiki Kaisha Quinoline or quinazoline derivatives inhibiting auto-phosphorylation of fibroblast growth factor receptors
AR037438A1 (es) 2001-11-27 2004-11-10 Wyeth Corp 3-cianoquinolinas como inhibidores de egf-r y her2 quinasas, un proceso para su preparacion, composiciones farmaceuticas y el uso de dichos compuestos para la fabricacion de medicamentos
GB0201508D0 (en) * 2002-01-23 2002-03-13 Novartis Ag Organic compounds
WO2003074045A1 (fr) 2002-03-05 2003-09-12 Eisai Co., Ltd. Agent antitumoral comprenant une combinaison d'un compose heterocyclique contenant un sulfamide et d'un inhibiteur d'angiogenese
EP1488239A2 (fr) 2002-03-20 2004-12-22 Dana-Farber Cancer Institute, Inc. Methodes et compositions d'identification, d'evaluation, et de traitement du cancer du poumon a petites cellules
EP1535910A4 (fr) 2002-05-01 2007-03-14 Kirin Brewery Derives de quinoleine et derives de quinazoline inhibiteurs de l'autophosphorylation du recepteur du facteur stimulant la proliferation des macrophages
UA77303C2 (en) * 2002-06-14 2006-11-15 Pfizer Derivatives of thienopyridines substituted by benzocondensed heteroarylamide useful as therapeutic agents, pharmaceutical compositions and methods for their use
AU2003251968A1 (en) 2002-07-16 2004-02-02 Children's Medical Center Corporation A method for the modulation of angiogenesis
US7169936B2 (en) * 2002-07-23 2007-01-30 Boehringer Ingelheim Pharma Gmbh & Co. Kg Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments
EP1522540A4 (fr) 2002-08-30 2011-08-10 Eisai R&D Man Co Ltd Derives d'azaarene
CA2499682A1 (fr) 2002-10-09 2004-04-22 Kosan Biosciences, Inc. Epo d + 5-fu/gemcitabine
GB0223380D0 (en) 2002-10-09 2002-11-13 Astrazeneca Ab Combination therapy
ES2534713T3 (es) 2002-10-16 2015-04-27 Takeda Pharmaceutical Company Limited Preparaciones sólidas estables
JP4749660B2 (ja) 2002-10-16 2011-08-17 武田薬品工業株式会社 安定な固形製剤
EP1566379A4 (fr) 2002-10-29 2005-11-09 Kirin Brewery DERIVES DE QUINOLINE ET DE QUINAZOLINE INHIBANT L'AUTOPHOSPHORYLATION DE Flt3 ET COMPOSITIONS MEDICALES LES CONTENANT
EP1558289A1 (fr) 2002-11-06 2005-08-03 Cyclacel Limited Composition pharmaceutique a base de gemcitabine et d'un inhibiteur de cdk
GB0226434D0 (en) 2002-11-13 2002-12-18 Astrazeneca Ab Combination product
ITSV20020056A1 (it) * 2002-11-14 2004-05-15 Alstom Transp Spa Dispositivo e metodo di verifica di motori software logici di comando di impianti ferroviari, in particolare di impianti di stazione
AR042042A1 (es) 2002-11-15 2005-06-08 Sugen Inc Administracion combinada de una indolinona con un agente quimioterapeutico para trastornos de proliferacion celular
MXPA05007513A (es) 2003-01-14 2005-09-21 Cytokinetics Inc Compuestos, composiciones y metodos.
NL1022425C2 (nl) 2003-01-17 2004-08-03 Trespa Int Bv Fenolhars, toepassing van een dergelijk fenolhars alsmede een daarmee vervaardigd vormdeel.
JP3581361B1 (ja) 2003-02-17 2004-10-27 株式会社脳機能研究所 脳活動測定装置
TWI355936B (en) 2003-02-18 2012-01-11 Helsinn Healthcare Sa Uses of palonosetron hydrochloride
KR20050117533A (ko) 2003-03-05 2005-12-14 셀진 코포레이션 디페닐에틸렌 화합물 및 그의 용도
EP1604665B1 (fr) 2003-03-10 2011-05-11 Eisai R&D Management Co., Ltd. Inhibiteur de kinase c-kit
JP4736043B2 (ja) 2003-03-14 2011-07-27 小野薬品工業株式会社 含窒素複素環誘導体およびそれらを有効成分とする薬剤
AU2004220156B2 (en) 2003-03-14 2007-04-19 Taisho Pharmaceutical Co., Ltd. Monoclonal antibody and hybridoma producing the same
DE10317649A1 (de) 2003-04-17 2004-11-04 Robert Bosch Gmbh Verfahren und Vorrichtung zum Betreiben eines Verbrennungsmotors im Schiebebetrieb
WO2004101526A1 (fr) 2003-04-22 2004-11-25 Eisai Co., Ltd. Cristal polymorphe de 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide et procede de preparation
JP2005008534A (ja) * 2003-06-17 2005-01-13 Soc De Conseils De Recherches & D'applications Scientifiques (Scras) 抗癌剤及び癌の治療方法
NZ544458A (en) 2003-07-10 2009-04-30 Astrazeneca Ab Use of the quinazoline derivative ZD6474 combined with platinum compounds and optionally ionising radiation in the treatment of diseases associated with angiogenesis and/or increased vascular permeability
US20070032521A1 (en) * 2003-08-15 2007-02-08 Ab Science Use of c-kit inhibitors for treating type II diabetes
US7521448B2 (en) 2003-08-21 2009-04-21 Osi Pharmaceuticals, Inc. N-substituted benzimidazolyl c-Kit inhibitors
US20080085902A1 (en) 2003-09-23 2008-04-10 Guido Bold Combination Of A Vegf Receptor Inhibitor Or With A Chemotherapeutic Agent
ES2925655T3 (es) 2003-09-26 2022-10-19 Exelixis Inc Moduladores c-Met y métodos de uso
JP2005124034A (ja) 2003-10-20 2005-05-12 Nippon Telegr & Teleph Corp <Ntt> 発信者の特定及び発信者への呼び返しを可能とする回線設定方法
US7683172B2 (en) 2003-11-11 2010-03-23 Eisai R&D Management Co., Ltd. Urea derivative and process for preparing the same
RU2006122853A (ru) 2003-11-28 2008-01-10 Новартис АГ (CH) Производные диарилмочевины для лечения заболеваний, зависимых от протеинкиназы
TW200531979A (en) 2003-12-05 2005-10-01 Compound Therapeutics Inc Inhibitors of type 2 vascular endothelial growth factor receptors
WO2005063713A1 (fr) 2003-12-25 2005-07-14 Eisai Co., Ltd. Cristaux de sel de 4-(3-chloro-4-(cyclopropylaminocarbonyl)amino-phenoxy)-7-methoxy-6-quinolinecarboxamide ou de ses solvate, et leur procede de production
EP1719763A4 (fr) 2004-02-27 2008-01-09 Eisai R&D Man Co Ltd Nouveau derivade la pyridine et derivade la pyrimidine (2)
KR20050091462A (ko) 2004-03-12 2005-09-15 한국과학기술연구원 푸로피리미딘 화합물 및 이를 포함하는 ｄｄｒ2 티로신키나아제 활성 저해제
AU2005249205A1 (en) * 2004-06-03 2005-12-15 F. Hoffmann-La Roche Ag Treatment with gemcitabine and an EGFR-inhibitor
WO2006030941A1 (fr) 2004-09-13 2006-03-23 Eisai R & D Management Co., Ltd. Utilisation concomitante d'un compose contenant du sulfonamide et d'un inhibiteur d'angiogenese
US8772269B2 (en) * 2004-09-13 2014-07-08 Eisai R&D Management Co., Ltd. Use of sulfonamide-including compounds in combination with angiogenesis inhibitors
KR20070053205A (ko) 2004-09-17 2007-05-23 에자이 알앤드디 매니지먼트 가부시키가이샤 의약 조성물
JP2008514635A (ja) * 2004-09-27 2008-05-08 コーザン バイオサイエンシス インコーポレイテッド 特異的キナーゼ阻害剤
AU2005336924A1 (en) 2004-11-22 2007-04-12 King Pharmaceuticals Research & Development, Inc. Enhancing treatment of cancer and HIF-1 mediated disoders with adenosine A3 receptor antagonists
EP1824843A2 (fr) 2004-12-07 2007-08-29 Locus Pharmaceuticals, Inc. Inhibiteurs de proteines kinases
EP1859793B1 (fr) 2005-02-28 2011-04-20 Eisai R&D Management Co., Ltd. Nouvelle utilisation combinee d'un compose de sulfonamide dans le traitment du cancer
WO2006090931A1 (fr) 2005-02-28 2006-08-31 Eisai R & D Management Co., Ltd. Nouvelle utilisation concomitante d'un compose de sulfonamide avec un agent anti-cancer
DE102005017446B4 (de) * 2005-04-15 2008-06-05 Südzucker AG Mannheim/Ochsenfurt Temperaturführung bei der alkalischen Extraktion
US7550483B2 (en) * 2005-06-23 2009-06-23 Eisai R&D Management Co., Ltd. Amorphous salt of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide and process for preparing the same
AU2006260148B9 (en) 2005-06-23 2009-09-17 Eisai R&D Managment Co., Ltd. Amorphous salt of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)- 7-methoxy-6-quinolinecarboxamide and process for producing the same
US20080219977A1 (en) 2005-07-27 2008-09-11 Isaiah Josh Fidler Combinations Comprising Gemcitabine and Tyrosine Kinase Inhibitors for the Treatment of Pancreatic Cancer
WO2007015569A1 (fr) 2005-08-01 2007-02-08 Eisai R & D Management Co., Ltd. Procédé de prédiction de l’efficacité d’un inhibiteur de vascularisation
EP1925676A4 (fr) 2005-08-02 2010-11-10 Eisai R&D Man Co Ltd Procédé d'analyse de l' effet d 'un inhibiteur de vascularisation
AU2006309551B2 (en) 2005-11-07 2012-04-19 Eisai R & D Management Co., Ltd. Use of combination of anti-angiogenic substance and c-kit kinase inhibitor
WO2007061130A1 (fr) 2005-11-22 2007-05-31 Eisai R & D Management Co., Ltd. Agent antitumeur pour myelomes multiples
AR059066A1 (es) * 2006-01-27 2008-03-12 Amgen Inc Combinaciones del inhibidor de la angiopoyetina -2 (ang2) y el inhibidor del factor de crecimiento endotelial vascular (vegf)
EP2036557B1 (fr) * 2006-05-18 2015-10-21 Eisai R&D Management Co., Ltd. Agent antitumoral destiné au cancer de la thyroïde
US8238322B2 (en) * 2006-06-30 2012-08-07 Nokia Corporation Optimizing of channel allocation in a wireless communications system
WO2008026748A1 (fr) 2006-08-28 2008-03-06 Eisai R & D Management Co., Ltd. Agent antitumoral pour cancer gastrique non différencié
US20080057195A1 (en) * 2006-08-31 2008-03-06 United Technologies Corporation Non-line of sight coating technique
US20100048503A1 (en) 2007-01-19 2010-02-25 Eisai R & D Management Co., Ltd. Composition for treatment of pancreatic cancer
US8962655B2 (en) * 2007-01-29 2015-02-24 Eisai R&D Management Co., Ltd. Composition for treatment of undifferentiated gastric cancer
WO2008108386A1 (fr) 2007-03-05 2008-09-12 Kyowa Hakko Kirin Co., Ltd. Composition pharmaceutique
TW200901975A (en) 2007-03-05 2009-01-16 Kyowa Hakko Kogyo Kk Pharmaceutical composition
AU2008325608B2 (en) 2007-11-09 2013-03-14 Eisai R & D Management Co., Ltd. Combination of anti-angiogenic substance and anti-tumor platinum complex
JP2011516412A (ja) * 2008-03-05 2011-05-26 ビカス セラピューティクス，エルエルシー 癌および粘膜炎の治療のための組成物および方法
US20110104161A1 (en) 2008-05-14 2011-05-05 Burgess Teresa L Combinations vegf(r) inhibitors and hepatocyte growth factor (c-met) inhibitors for the treatment of cancer

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