ZA200509521B - Modified fluorinated nucleoside analogues - Google Patents
Modified fluorinated nucleoside analogues Download PDFInfo
- Publication number
- ZA200509521B ZA200509521B ZA200509521A ZA200509521A ZA200509521B ZA 200509521 B ZA200509521 B ZA 200509521B ZA 200509521 A ZA200509521 A ZA 200509521A ZA 200509521 A ZA200509521 A ZA 200509521A ZA 200509521 B ZA200509521 B ZA 200509521B
- Authority
- ZA
- South Africa
- Prior art keywords
- alkyl
- acyl
- alkenyl
- alkynyl
- optionally substituted
- Prior art date
Links
- 229940127073 nucleoside analogue Drugs 0.000 title description 3
- 125000000217 alkyl group Chemical group 0.000 claims description 660
- 229910052731 fluorine Inorganic materials 0.000 claims description 232
- 239000002777 nucleoside Substances 0.000 claims description 153
- 239000003112 inhibitor Substances 0.000 claims description 101
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 101
- 238000011282 treatment Methods 0.000 claims description 100
- 150000001875 compounds Chemical class 0.000 claims description 97
- 150000003839 salts Chemical class 0.000 claims description 73
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- 150000003833 nucleoside derivatives Chemical class 0.000 claims description 65
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims description 62
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 61
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- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims description 57
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- IWUCXVSUMQZMFG-RGDLXGNYSA-N 1-[(2s,3s,4r,5s)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide Chemical compound N1=C(C(=O)N)N=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 IWUCXVSUMQZMFG-RGDLXGNYSA-N 0.000 claims description 38
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- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
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