TWI753848B - 利用抗-cd19之嵌合抗原受體之癌症治療 - Google Patents
利用抗-cd19之嵌合抗原受體之癌症治療 Download PDFInfo
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- TWI753848B TWI753848B TW104111176A TW104111176A TWI753848B TW I753848 B TWI753848 B TW I753848B TW 104111176 A TW104111176 A TW 104111176A TW 104111176 A TW104111176 A TW 104111176A TW I753848 B TWI753848 B TW I753848B
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- ADZBMFGQQWPHMJ-RHSMWYFYSA-N CNC(c1cc(Oc2ccc3nc(N[C@H](CCCC4)[C@@H]4O)[s]c3c2)ccn1)=O Chemical compound CNC(c1cc(Oc2ccc3nc(N[C@H](CCCC4)[C@@H]4O)[s]c3c2)ccn1)=O ADZBMFGQQWPHMJ-RHSMWYFYSA-N 0.000 description 1
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Applications Claiming Priority (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461976396P | 2014-04-07 | 2014-04-07 | |
| US61/976,396 | 2014-04-07 | ||
| US201462007309P | 2014-06-03 | 2014-06-03 | |
| US62/007,309 | 2014-06-03 | ||
| US201462036493P | 2014-08-12 | 2014-08-12 | |
| US62/036,493 | 2014-08-12 | ||
| US201462076238P | 2014-11-06 | 2014-11-06 | |
| US62/076,238 | 2014-11-06 | ||
| US201462087888P | 2014-12-05 | 2014-12-05 | |
| US62/087,888 | 2014-12-05 | ||
| US201462097278P | 2014-12-29 | 2014-12-29 | |
| US62/097,278 | 2014-12-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201600092A TW201600092A (zh) | 2016-01-01 |
| TWI753848B true TWI753848B (zh) | 2022-02-01 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW104111176A TWI753848B (zh) | 2014-04-07 | 2015-04-07 | 利用抗-cd19之嵌合抗原受體之癌症治療 |
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| EP (3) | EP3129470B1 (enExample) |
| JP (4) | JP6765966B2 (enExample) |
| KR (3) | KR102651707B1 (enExample) |
| CN (2) | CN107075482B (enExample) |
| AU (3) | AU2015244039B2 (enExample) |
| CA (1) | CA2940671A1 (enExample) |
| DK (2) | DK3888674T3 (enExample) |
| ES (2) | ES2988631T3 (enExample) |
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| HR (2) | HRP20240874T1 (enExample) |
| HU (2) | HUE054588T2 (enExample) |
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| MX (2) | MX395149B (enExample) |
| MY (1) | MY191608A (enExample) |
| PL (2) | PL3888674T3 (enExample) |
| PT (2) | PT3888674T (enExample) |
| RU (1) | RU2718542C2 (enExample) |
| SG (2) | SG10202109752XA (enExample) |
| SI (2) | SI3888674T1 (enExample) |
| TW (1) | TWI753848B (enExample) |
| WO (1) | WO2015157252A1 (enExample) |
| ZA (1) | ZA201605657B (enExample) |
Families Citing this family (214)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10155038B2 (en) | 2007-02-02 | 2018-12-18 | Yale University | Cells prepared by transient transfection and methods of use thereof |
| US9249423B2 (en) | 2007-02-02 | 2016-02-02 | Yale University | Method of de-differentiating and re-differentiating somatic cells using RNA |
| US8415150B2 (en) * | 2009-02-24 | 2013-04-09 | The Trustees Of The University Of Pennsylvania | Methods for treating progressive multifocal leukoencephalopathy (PML) |
| US11951139B2 (en) | 2015-11-30 | 2024-04-09 | Seed Health, Inc. | Method and system for reducing the likelihood of osteoporosis |
| US10940169B2 (en) | 2015-11-30 | 2021-03-09 | Joseph E. Kovarik | Method for reducing the likelihood of developing cancer in an individual human being |
| US12257272B2 (en) | 2015-12-24 | 2025-03-25 | Seed Health, Inc. | Method and system for reducing the likelihood of developing depression in an individual |
| US11998479B2 (en) | 2011-02-04 | 2024-06-04 | Seed Health, Inc. | Method and system for addressing adverse effects on the oral microbiome and restoring gingival health caused by sodium lauryl sulphate exposure |
| US11951140B2 (en) | 2011-02-04 | 2024-04-09 | Seed Health, Inc. | Modulation of an individual's gut microbiome to address osteoporosis and bone disease |
| US11844720B2 (en) | 2011-02-04 | 2023-12-19 | Seed Health, Inc. | Method and system to reduce the likelihood of dental caries and halitosis |
| US12279989B2 (en) | 2011-02-04 | 2025-04-22 | Seed Health, Inc. | Method and system for increasing beneficial bacteria and decreasing pathogenic bacteria in the oral cavity |
| WO2014100615A1 (en) | 2012-12-20 | 2014-06-26 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| CN111139256A (zh) | 2013-02-20 | 2020-05-12 | 诺华股份有限公司 | 使用人源化抗EGFRvIII嵌合抗原受体治疗癌症 |
| US9573988B2 (en) | 2013-02-20 | 2017-02-21 | Novartis Ag | Effective targeting of primary human leukemia using anti-CD123 chimeric antigen receptor engineered T cells |
| US9745368B2 (en) * | 2013-03-15 | 2017-08-29 | The Trustees Of The University Of Pennsylvania | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
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| US12128069B2 (en) | 2015-04-23 | 2024-10-29 | The Trustees Of The University Of Pennsylvania | Treatment of cancer using chimeric antigen receptor and protein kinase a blocker |
| AU2016297014B2 (en) | 2015-07-21 | 2021-06-17 | Novartis Ag | Methods for improving the efficacy and expansion of immune cells |
| WO2017027392A1 (en) | 2015-08-07 | 2017-02-16 | Novartis Ag | Treatment of cancer using chimeric cd3 receptor proteins |
| US11747346B2 (en) | 2015-09-03 | 2023-09-05 | Novartis Ag | Biomarkers predictive of cytokine release syndrome |
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| EP3380620B1 (en) * | 2015-11-23 | 2024-07-03 | Novartis AG | Optimized lentiviral transfer vectors and uses thereof |
| AU2017341047B2 (en) * | 2016-10-07 | 2024-10-10 | Novartis Ag | Chimeric antigen receptors for the treatment of cancer |
| WO2019213282A1 (en) * | 2018-05-01 | 2019-11-07 | Novartis Ag | Biomarkers for evaluating car-t cells to predict clinical outcome |
| WO2019227003A1 (en) * | 2018-05-25 | 2019-11-28 | Novartis Ag | Combination therapy with chimeric antigen receptor (car) therapies |
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| PL3820573T3 (pl) * | 2018-07-10 | 2024-02-19 | Novartis Ag | Pochodne 3-(5-hydroksy-1-oksoizoindolin-2-ylo)piperydyno-2,6-dionu i ich zastosowanie w leczeniu chorób zależnych od palca cynkowego z rodziny ikaros 2 (ikzf2) |
| EP4065158A2 (en) * | 2019-11-26 | 2022-10-05 | Novartis AG | Chimeric antigen receptors binding bcma and cd19 and uses thereof |
| AR120563A1 (es) * | 2019-11-26 | 2022-02-23 | Novartis Ag | Receptores de antígeno quimérico cd19 y cd22 y sus usos |
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